Health Effects

EPA Grant Number: R827355C002
Subproject: this is subproject number 002 , established and managed by the Center Director under grant R827355
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: Airborne PM - Northwest Research Center for Particulate Air Pollution and Health
Center Director: Koenig, Jane Q.
Title: Health Effects
Investigators: Koenig, Jane Q. , Sheppard, Lianne (Elizabeth) A. , Kaufman, Joel D. , Larson, Timothy V. , Trenga, Carol , Sullivan, Jeff , Jansen, Karen , Liu, Sally , Lumley, Thomas
Current Investigators: Koenig, Jane Q. , Lippmann, Morton , Sheppard, Lianne (Elizabeth) A. , Larson, Timothy V. , Jansen, Karen , Allen, Ryan , Mar, Therese , Lumley, Thomas
Institution: University of Washington
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2004 (Extended to May 31, 2006)
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text |  Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air


This research project is a health effects panel study that involves comprehensive health monitoring of one healthy and three susceptible subpopulations in Seattle, Spokane, and other cities. The susceptible individuals proposed for study are adults who are 65 years of age or older and have chronic obstructive pulmonary disease (COPD) or cardiovascular disease or children with asthma. The health endpoints to be measured in adult subjects are peak flow, pulse rate, pulse oximetry, blood pressure, and heart rate variability. The health endpoints to be measured in the children with asthma are pulmonary function and symptoms. Personal exposure measurements necessary for associating the health effects with air pollutants will be collected on study participants in Project 2b.

Publications and Presentations:

Publications have been submitted on this subproject: View all 27 publications for this subprojectView all 209 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 18 journal articles for this subprojectView all 109 journal articles for this center

Supplemental Keywords:

ambient particles, fine particles, combustion, health, exposure, biostatistics, susceptibility., RFA, Health, Scientific Discipline, Air, Waste, Geographic Area, particulate matter, Toxicology, air toxics, Environmental Chemistry, Health Risk Assessment, State, Epidemiology, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Northwest, Biochemistry, genetic susceptability, indoor air, Incineration/Combustion, biostatistics, health effects, asthma, risk assessment, ambient aerosol, particulates, sensitive populations, ambient air quality, health risks, cardiopulmonary responses, human health effects, exposure and effects, air pollutants, morbidity, airway disease, ambient air, exposure, combustion emissions, animal model, Human Health Risk Assessment, children, air pollution, particle exposure, human exposure, cardiopulmonary response, inhalation, atmospheric aerosols, ambient particle health effects, combustion, elderly, human susceptibility, age dependent response, allergens, incineration, indoor air quality, mortality, California (CA), environmental hazard exposures, toxics, air quality, particle transport, cardiovascular disease, human health risk, combustion contaminants, aerosols, atmospheric chemistry

Progress and Final Reports:

  • 1999 Progress Report
  • 2000 Progress Report
  • 2001 Progress Report
  • 2002 Progress Report
  • 2003 Progress Report
  • 2004 Progress Report
  • Final Report

  • Main Center Abstract and Reports:

    R827355    Airborne PM - Northwest Research Center for Particulate Air Pollution and Health

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R827355C001 Epidemiologic Study of Particulate Matter and Cardiopulmonary Mortality
    R827355C002 Health Effects
    R827355C003 Personal PM Exposure Assessment
    R827355C004 Characterization of Fine Particulate Matter
    R827355C005 Mechanisms of Toxicity of Particulate Matter Using Transgenic Mouse Strains
    R827355C006 Toxicology Project -- Controlled Exposure Facility
    R827355C007 Health Effects Research Core
    R827355C008 Exposure Core
    R827355C009 Statistics and Data Core
    R827355C010 Biomarker Core
    R827355C011 Oxidation Stress Makers