Grantee Research Project Results

Epidemiologic Study of Particulate Matter and Cardiopulmonary Mortality

EPA Grant Number: R827355C001
Subproject: this is subproject number 001 , established and managed by the Center Director under grant R827355
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Center for Air, Climate, and Energy Solutions
Center Director: Robinson, Allen
Title: Epidemiologic Study of Particulate Matter and Cardiopulmonary Mortality
Investigators: Kaufman, Joel D. , Sheppard, Lianne (Elizabeth) A. , Koenig, Jane Q. , Siscovick, David , Checkoway, Harvey
Current Investigators: Kaufman, Joel D. , Sheppard, Lianne (Elizabeth) A. , Karr, Catharine J. , Schreuder, Astrid , Siscovick, David , Sullivan, Jeff , Shepherd, Kristine , Miller, Kristine , Ishikawa, Naomi
Institution: University of Washington
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2004 (Extended to May 31, 2006)
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text | Recipients Lists
Research Category: Particulate Matter , Air Quality and Air Toxics , Air

Objective:

This project consists of two related study designs addressing associations between ambient PM exposure and cardiorespiratory disease risks. The first is a time-series analysis of cause-specific mortality in Seattle that relates daily mortality with changes in PM and co-pollutant levels. Its emphasis is cardiovascular and respiratory disease mortality. In parallel with this analysis, we also are performing similar time-series analyses of mortality in Spokane, Washington, and Anchorage, Alaska. The contrasts of results between Seattle, Spokane, and Anchorage, which have different PM compositions, should add significant new information about the relative contributions of particle count, size, and chemical composition to cardiorespiratory mortality. The second design is a "case-crossover" study of roughly 1,100 out-of-hospital sudden cardiac arrest (SCA) cases in Seattle. This design compares PM levels in the days immediately preceding SCA events with levels at previous reference time points.

Publications and Presentations:

Publications have been submitted on this subproject: View all 21 publications for this subproject | View all 209 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 14 journal articles for this subproject | View all 109 journal articles for this center

Supplemental Keywords:

ambient particles, fine particles, combustion, health, exposure, biostatistics, susceptibility., RFA, Health, Scientific Discipline, Air, PHYSICAL ASPECTS, Geographic Area, Susceptibility/Sensitive Population/Genetic Susceptibility, Health Risk Assessment, Physical Processes, Risk Assessments, State, particulate matter, genetic susceptability, Environmental Chemistry, Incineration/Combustion, Epidemiology, Allergens/Asthma, Children's Health, indoor air, Northwest, Atmospheric Sciences, Biochemistry, Toxicology, air toxics, aerosols, air quality, combustion contaminants, hazardous air pollutants, health effects, health risks, Human Health Risk Assessment, hydrocarbons, incineration, indoor air quality, sensitive populations, California (CA), epidemelogy, epidemeology, environmental hazard exposures, allergen, ambient aerosol, asthma, biological markers, harmful environmental agents, indoor environment, airway inflammation, combustion emissions, atmospheric chemistry, human exposure, mortality, risk assessment, biological response, cardiopulmonary responses, combustion, morbidity, animal model, PAHs, children, exposure, particulates, allergens, ambient particle health effects, air pollutants, airborne pollutants, ambient air, biostatistics, atmospheric aerosols, particle transport, toxics, children's vulnerablity, air pollution, ambient air quality, cardiovascular disease, human health effects, human health risk, assessment of exposure, human susceptibility, acute cardiovascular effects, airway disease, cardiopulmonary response, exposure assessment, inhalation, particle exposure, exposure and effects

Progress and Final Reports:

Main Center Abstract and Reports:

R827355 Center for Air, Climate, and Energy Solutions

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827355C001 Epidemiologic Study of Particulate Matter and Cardiopulmonary Mortality
R827355C002 Health Effects
R827355C003 Personal PM Exposure Assessment
R827355C004 Characterization of Fine Particulate Matter
R827355C005 Mechanisms of Toxicity of Particulate Matter Using Transgenic Mouse Strains
R827355C006 Toxicology Project -- Controlled Exposure Facility
R827355C007 Health Effects Research Core
R827355C008 Exposure Core
R827355C009 Statistics and Data Core
R827355C010 Biomarker Core
R827355C011 Oxidation Stress Makers

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.