Grantee Research Project Results
Research Centers
Human Models for Analysis of Pathways (H MAPs) Center
University of Wisconsin Madison
The need for human, organotypic culture models coupled with the requirements of contemporary toxin screening (i.e. reproducibility, high throughput, transferability of data, clear mechanisms of action, defined adverse outcomes) frame an opportunity for a paradigm shift. We propose to establish the Human Models for Analysis of Pathways (H-MAPs) Center to advance the next generation of toxicity testing formats, and to develop a broadly applicable set of tools for toxin screening.
Center Publications:
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View Projects in Tabular Format
Main Center Abstract and Reports:
Southern California Particle Center (SCPC)
Center for Integrating Statistical and Environmental Science
- Original Abstract
- 2006 Progress Report
- 2007 Progress Report
- 2008 Progress Report
- 2009 Progress Report
- 2010 Progress Report
- Final Report
Human Models for Analysis of Pathways (H MAPs) Center
Center Research Projects:
R825370C032 - Means for Producing an Entirely New Generation of Lignin-Based Plastics
- Original Abstract
- 1996 Progress Report
- 1997 Progress Report
- 1998 Progress Report
- 1999 Progress Report
R825370C042 - Environmentally Conscious Design for Construction
R825370C046 - Clean Process Advisory System (CPAS) Core Activities
R825370C048 - Investigation of the Partial Oxidation of Methane to Methanol in a Simulated Countercurrent Moving Bed Reactor
R825370C054 - Predictive Tool for Ultrafiltration Performance
R825370C055 - Heuristic Reactor Design for Clean Synthesis and Processing - Separative Reactors
R825370C056 - Characterization of Selective Solid Acid Catalysts Towards the Rational Design of Catalytic Reactions
R825370C057 - Environmentally Conscious Manufacturing: Prediction of Processing Waste Streams for Discrete Products
R825370C064 - The Physical Properties Management System (PPMS™): A P2 Engineering Aid to Support Process Design and Analysis
R825370C065 - Development and Testing of Pollution Prevention Design Aids for Process Analysis and Decision Making
R825370C066 - Design Tools for Chemical Process Safety: Accident Probability
R825370C067 - Environmentally Conscious Manufacturing: Design for Disassembly (DFD) in De-Manufacturing of Products
R825370C068 - An Economic Comparison of Wet and Dry Machining
R825370C069 - In-Line Copper Recovery Technology
R825370C070 - Selective Catalytic Hydrogenation of Lactic Acid
R825370C071 - Biosynthesis of Polyhydroxyalkanoate Polymers from Industrial Wastewater
R825370C072 - Tin Zeolites for Partial Oxidation Catalysis
R825370C073 - Development of a High Performance Photocatalytic Reactor System for the Production of Methanol from Methane in the Gas Phase
R825370C074 - Recovery of Waste Polymer Generated by Lost Foam Technology in the Metal Casting Industry
R825370C075 - Industrial Implementation of the P2 Framework
R825370C076 - Establishing Automated Linkages Between Existing P2-Related Software Design Tools
R825370C077 - Integrated Applications of the Clean Process Advisory System to P2-Conscious Process Analysis and Improvement
R825370C078 - Development of Environmental Indices for Green Chemical Production and Use
R829479C001 - Plant Genes and Agrobacterium T-DNA Integration
R829479C002 - Designing Promoters for Precision Targeting of Gene Expression
R829479C003 aka R829479C011 - Biological Effects of Epoxy Fatty Acids
R829479C004 - Negative Sense Viral Vectors for Improved Expression of Foreign Genes in Insects and Plants
R829479C005 - Development of Novel Plastics From Agricultural Oils
R829479C006 - Conversion of Paper Sludge to Ethanol
R829479C007 - Enhanced Production of Biodegradable Plastics in Plants
R829479C008 - Engineering Design of Stable Immobilized Enzymes for the Hydrolysis and Transesterification of Triglycerides
R829479C009 - Discovery and Evaluation of SNP Variation in Resistance-Gene Analogs and Other Candidate Genes in Cotton
R829479C010 - Woody Biomass Crops for Bioremediating Hydrocarbons and Metals
R829479C011 - Biological Effects of Epoxy Fatty Acids
R829479C012 - High Strength Degradable Plastics From Starch and Poly(lactic acid)
R829479C013 - Development of Herbicide-Tolerant Energy and Biomass Crops
R829479C014 - Identification of Receptors of Bacillus Thuringiensis Toxins in Midguts of the European Corn Borer
R829479C015 - Coordinated Expression of Multiple Anti-Pest Proteins
R829479C016 - A Novel Fermentation Process for Butyric Acid and Butanol Production from Plant Biomass
R829479C017 - Molecular Improvement of an Environmentally Friendly Turfgrass
R829479C018 - Woody Biomass Crops for Bioremediating Hydrocarbons and Metals. II.
R829479C019 - Transgenic Plants for Bioremediation of Atrazine and Related Herbicides
R829479C020 - Root Exudate Biostimulation for Polyaromatic Hydrocarbon Phytoremediation
R829479C021 - Phytoremediation of Heavy Metal Contamination by Metallohistins, a New Class of Plant Metal-Binding Proteins
R829479C022 - Development of Herbicide-Tolerant Energy and Biomass Crops
R829479C023 - A Novel Fermentation Process for Butyric Acid and Butanol Production from Plant Biomass
R829479C024 - Development of Vectors for the Stoichiometric Accumulation of Multiple Proteins in Transgenic Crops
R829479C025 - Chemical Induction of Disease Resistance in Trees
R829479C026 - Development of Herbicide-Tolerant Hardwoods
R829479C027 - Environmentally Superior Soybean Genome Development
R829479C028 - Development of Efficient Methods for the Genetic Transformation of Willow and Cottonwood for Increased Remediation of Pollutants
R829479C029 - Development of Tightly Regulated Ecdysone Receptor-Based Gene Switches for Use in Agriculture
R829479C030 - Engineered Plant Virus Proteins for Biotechnology
R829515C001 - Redox Transformations, Complexation and Soil/Sediment Interactions of Inorganic Forms of As and Se in Aquatic Environments: Effects of Natural Organic Matter
R829515C002 - Fate and Transport of Metals and Sediment in Surface Water
R829515C003 - Metal Removal Capabilities of Passive Bioreactor Systems: Effects of Organic Matter and Microbial Population Dynamics
R829515C004 - Evaluating Recovery of Stream Ecosystems from Mining Pollution: Integrating Biochemical, Population, Community and Ecosystem Indicators
R829515C005 - Rocky Mountain Regional Hazardous Substance Research Center Training and Technology Transfer Program
- Original Abstract
- 2002 Progress Report
- 2003 Progress Report
- 2004 Progress Report
- 2005 Progress Report
R829515C006 - Technical Outreach Services for Communities and Technical Assistance to Brownfields
R829515C007 - Evaluation of Hydrologic Models for Alternative Covers at Mine Waste Sites
R829515C008 - Microbial Reduction of Uranium in Mine Leachate by Fermentative and Iron-Reducing Bacteria
R829515C009 - Development and Characterization of Microbial Inocula for High-Performance Passive Treatment of Acid Mine Drainage
R829515C010 - Reactive Transport Modeling of Metal Removal From Anaerobic Biozones
R829515C011 - Assessment of Electrokinetic Injection of Amendments for Remediation of Acid Mine Drainage
R829515C012 - Metal Toxicity Thresholds for Important Reclamation Plant Species of the Rocky Mountains
R829515C013 - An Improved Method for Establishing Water Quality Criteria for Mining Impacted Streams
R832413C001 - Contribution of Primary and Secondary PM Sources to Exposure & Evaluation of Their Relative Toxicity
- Original Abstract
- 2006 Progress Report
- 2007 Progress Report
- 2008 Progress Report
- 2009 Progress Report
- 2010 Progress Report
- Final Report
R832413C002 - Project 2: The Role of Oxidative Stress in PM-induced Adverse Health Effects
- Original Abstract
- 2006 Progress Report
- 2007 Progress Report
- 2008 Progress Report
- 2009 Progress Report
- 2010 Progress Report
- Final Report
R832413C003 - The Chemical Properties of PM and their Toxicological Implications
- Original Abstract
- 2006 Progress Report
- 2007 Progress Report
- 2008 Progress Report
- 2009 Progress Report
- 2010 Progress Report
- Final Report
R832413C004 - Oxidative Stress Responses to PM Exposure in Elderly Individuals With Coronary Heart Disease
- Original Abstract
- 2006 Progress Report
- 2007 Progress Report
- 2008 Progress Report
- 2009 Progress Report
- 2010 Progress Report
- Final Report
R832413C005 - Ultrafine Particles on and Near Freeways
- Original Abstract
- 2006 Progress Report
- 2007 Progress Report
- 2008 Progress Report
- 2009 Progress Report
- 2010 Progress Report
- Final Report
R835737C001 - Liver MAPs
R835737C002 - Brain MAPs
R835737C003 - Cancer MAPs: A 3D Organotypic Microfluidic Culture System to Identify Chemicals that Impact Progression and Development of Breast Cancer
R835737C004 - Vascular MAPs: Vascular and Neurovascular Tissue Models
R835737C005 - Pathway Analysis Core
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.