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Grantee Research Project Results

Research Centers
Center for Integrative Research on Childhood Leukemia and the Environment (CIRCLE)

University of California - Berkeley

Leukemia, or cancer of the white blood cells, is the most common type of childhood cancer. Scientists at this center are examining how early exposure to toxic chemicals might contribute to leukemia in children.

Research at this center focuses on the effects of pesticides, tobacco-related contaminants, polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs, or brominated flame retardants) in the womb and early in life. To determine if and how, early exposure to such chemicals might cause childhood leukemia, scientists are trying to identify which chemicals are associated with a higher risk for leukemia and are looking at how these chemicals interact with genes known to be involved in leukemia development.

Researchers at this children’s center are evaluating environmental exposures in the womb and in early childhood, using existing home dust samples and biospecimens from the Northern California Childhood Leukemia Study. They are also examining environmental and genetic influences for distinct leukemia subtypes and sharing their findings with other researchers and the public to help prevent childhood leukemia and improve children's health.

View Projects in Tabular Format

Main Center Abstract and Reports:

Western Region Hazardous Substance Research Center for Developing In-Situ Processes for VOC Remediation in Groundwater and Soil
  • Original Abstract
  • 2002 Progress Report
  • 2003 Progress Report
  • 2004 Progress Report
  • 2005 Progress Report
  • Final Report
Western Region Hazardous Substance Research Center
  • Original Abstract
Centers of Excellence in Children's Environmental Health and Disease Prevention Research
  • Original Abstract
  • 2001 Progress Report
  • 2002 Progress Report
The Center for Advancing Microbial Risk Assessment (CAMRA)
  • Original Abstract
  • 2007 Progress Report
  • Final Report
Center for Integrating Statistical and Environmental Science
  • Original Abstract
  • 2004 Progress Report
  • 2006 Progress Report
  • Final Report
Center for Children's Environmental Health Research
  • Original Abstract
  • 2004 Progress Report
  • 2005 Progress Report
  • Final Report
The Center for Environmental Implications of Nanotechnology (CEINT)
  • Original Abstract
Center for Integrative Research on Childhood Leukemia and the Environment (CIRCLE)
  • Original Abstract
  • 2010 Progress Report
  • 2011 Progress Report
  • 2012 Progress Report
  • 2013 Progress Report
  • 2014 Progress Report
  • Final Report
Center for Children’s Environmental Health and DiseasePreventionResearch (P01) (joint EPA and NIEHS) - CHAMACOS
  • Original Abstract
  • 2010 Progress Report
  • 2011 Progress Report
  • 2012 Progress Report
  • 2013 Progress Report
  • 2014 Progress Report
  • 2015 Progress Report
  • 2016 Progress Report
  • Final Report
Children's Environmental Health and Disease Prevention Research Centers: Formative Centers
  • Original Abstract
  • 2010 Progress Report
  • 2011 Progress Report
  • 2012 Progress Report
  • Final Report
Berkeley/Stanford Children’s Environmental Health Center
  • Original Abstract
  • 2010 Progress Report
  • 2011 Progress Report
  • 2012 Progress Report
  • Final Report
Water Environment and Reuse Foundation (WE&RF)'s National Center for Resource Recovery and Nutrient Management
  • Original Abstract
  • 2014 Progress Report
  • 2015 Progress Report
  • 2016 Progress Report
  • 2017 Progress Report
  • Final Report
UC Berkeley/Stanford Children's Environmental Health Center
  • Original Abstract
  • 2014 Progress Report
  • 2015 Progress Report
  • 2016 Progress Report
  • 2017 Progress Report
  • 2018 Progress Report
  • Final Report
The UCSF Pregnancy Exposures to Environmental Chemicals (PEEC) Children's Center
  • Original Abstract
  • 2013 Progress Report
  • 2014 Progress Report
  • 2015 Progress Report
  • 2016 Progress Report
  • 2017 Progress Report
  • Final Report
Children's Environmental Health & Disease Prevention Research Center at Dartmouth
  • Original Abstract
  • 2014 Progress Report
  • 2015 Progress Report
  • 2016 Progress Report
  • 2017 Progress Report
  • 2018 Progress Report
  • Final Report
SEARCH: Solutions to Energy, AiR, Climate, and Health
  • Original Abstract
  • 2016 Progress Report
  • 2017 Progress Report
  • 2018 Progress Report
  • 2019 Progress Report
  • 2020 Progress Report
  • 2021 Progress Report
  • Final Report
Center for Integrative Research on Childhood Leukemia and the Environment
  • Original Abstract
  • 2016 Progress Report
  • 2017 Progress Report
  • 2018 Progress Report
  • 2019 Progress Report
  • Final Report

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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Last updated April 28, 2023
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