Grantee Research Project Results
Research Centers
University of California — Center for Environmental Implications of Nanotechnology (UC—CEIN)
University of California - Los Angeles
Establishing a predictive science is a timely approach for nanotechnology-based enterprises wishing to avoid the problems faced by the chemical industry, where only a few hundred of the ca. 50,000 industrial chemicals have undergone toxicity testing, making it very challenging to control their toxicological impact in the environment. There is also growing recognition in Europe and Asia that a paradigm shift in toxicology is required to deal with anthropogenic activity. The UC-CEIN proposes to conduct predictive toxicological science for engineered nanomaterials (NMs) through the founding of the Center for Environmental Implications of Nanotechnology (CEIN) at UC Los Angeles (UCLA) in partnership with UC Santa Barbara (UCSB), UC Davis (UCD), UC Riverside (UCR), Columbia University (New York), University of Texas (El Paso, TX), Nanyang Technological University (NTU, Singapore), the Molecular Foundry at Lawrence Berkeley National Laboratory (LBNL), Lawrence Livermore National Laboratory (LLNL), Sandia National Laboratory (SNL), the University of Bremen (Germany), University College Dublin (UCD, Ireland), and the Universitat Rovira i Virgili (URV, Spain). This Center unites a highly integrated, multidisciplinary, synergistic team with the skill set to solve the complexities of environmental science, eco-toxicity, materials science, nanotechnology, biological mechanisms of injury, and the environmental fate and transport of NMs.
The goal of the Center is to develop a broad-based model of predictive toxicology premised on quantitative structure–activity relationships (QSARs) and NM injury paradigms at the biological level. This predictive scientific model will consider: (i) the NMs most likely to come into contact with the environment; (ii) their distribution in the environment; (iii) representative environmental life forms serving as early sentinels to monitor the spread and bio-accumulation of hazardous NMs; (iv) biological screening assays allowing QSARs to be developed based on the bio-physicochemical properties of NMs; (v) High throughput screening (HTS) of a combinatorial NM library; and (vi) a self-learning computational system providing a framework for predictive risk analysis. These research activities will be combined with educational programs informing the public, future generations of scientists, public agencies, and industrial stakeholders of the importance of safe implementation of nanotechnology in the environment. The overall impact will be to reduce uncertainty about the possible consequences of NMs in the environment, while at the same time providing guidelines for their safe design to prevent environmental hazards.
Identifier | Abstract | Principal Investigator |
Annual/ Final Reports |
Pubs Count | Institution | Grant Representative |
Grant Amount |
Project Period |
|
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1 |
R826708
Centers - Main center abstract - Great Lakes Air Center for Integrative Environmental Research |
CECEHDPR - University of Southern California |
Gong, Henry Avol, Edward L. Diaz-Sanchez, David Gauderman, William Gilliland, Frank D. Hinds, William C. Jones, Craig McConnell, Rob Scot Peters, John M. - Principal Investigators listed are sub-PIs determined by the center. |
Row 1: 2000
|
Row 1 Total Pubs:
100 Row 1 Journals: 70 Row 1 Books: 2 |
University of California - Los Angeles | Hahn, Intaek | $2,895,926 |
August 01, 1998 - July 31, 2003 |
2 |
R827352
Centers - Main center abstract - Southern California Particle Center |
Southern California Particle Center and Supersite (SCPCS) |
Froines, John R. Arey, Janet Atkinson, Roger Avol, Edward L. Berhane, Kiros Cass, Glen Charles, Judith M. Cho, Arthur K. Cohen, Yoram Colome, Steven D. Eastmond, David A. Eldering, Annmarie Friedlander, Sheldon Fukuto, Jon Gauderman, William Gong, Henry Grosser, Stella C. Hankinson, Oliver Harkema, Jack Hinds, William C. Kleinman, Michael T. Kumagai, Yoshito Kunzli, Nino Langholz, Brian Linn, William S. Lurmann, Fred McConnell, Rob Scot Miguel, Antonio Nel, Andre E. Peters, John M. Phalen, Robert Que Hee, Shane S. Ritz, Beate R. Schiestl, Robert H. Sioutas, Constantinos Stram, Dan Thomas, Duncan C. Turco, Richard Venkatesan, M. Indira Winer, Arthur M. Yu, Rong Chun Ziemann, Paul J. - Principal Investigators listed are sub-PIs determined by the center. |
Row 2: 2003
|
Row 2 Total Pubs:
150 Row 2 Journals: 149 -- Row 2: No Books -- |
University of California - Los Angeles, Michigan State University, Rancho Los Amigos Medical Center, University of California - Davis, University of California - Irvine, University of California - Riverside, University of Southern California, University of Tsukuba | Chung, Serena | $8,715,583 |
June 01, 1999 - May 31, 2005 (Extended to May 31, 2006) |
3 |
R827354
Centers - Main center abstract - Airborne PM - Rochester PM Center |
Ultrafine Particles: Characterization, Health Effects and Pathophysiological Mechanisms |
Oberdörster, Günter Beckett, William Cass, Glen Cox, Christopher Ensor, David Finkelstein, Jacob N. Frampton, Mark W. Heyder, Joachim Looney, John Marder, Victor J. Morrow, P. E. O'Reilly, Michael OReilly, Michael Peters, Annette Phipps, Richard Prather, Kimberly A. Schwarz, Edward Sharp, Zachary Stripp, Barry Utell, Mark J. Wichmann, Heinz-Erich Yu, C. P. Zareba, Wojciech - Principal Investigators listed are sub-PIs determined by the center. |
Row 3: 2004
|
Row 3 Total Pubs:
104 Row 3 Journals: 90 Row 3 Books: 7 |
University of Rochester, GSF- Institute for Epidemiologie, Georgia Institute of Technology, Research Triangle Institute, University of California - Los Angeles, University of California - San Diego | Chung, Serena | $8,302,447 |
June 01, 1999 - May 31, 2005 (Extended to May 31, 2006) |
4 |
R830117
Centers - Main center abstract - Great Lakes Air Center for Integrative Environmental Research |
University of California – Center for Environmental Implications of Nanotechnology (UC-CEIN) |
Nel, Andre E.
- Principal Investigators listed are sub-PIs determined by the center. |
University of California - Los Angeles | Hahn, Intaek | $4,000,000 |
September 01, 2008 - August 31, 2013 |
||
5 |
R831861
Centers - Main center abstract - Southern California Children's Environmental Health Center |
Children’s Environmental Health Center |
Gilliland, Frank D. Avol, Edward L. Berhane, Kiros Diaz-Sanchez, David Dubeau, Louis Froines, John R. Gauderman, William Gong, Henry Hricko, Andrea M. Kuenzli, Nino Linn, William S. Lurmann, Fred McConnell, Rob Scot Peters, John M. Riedl, Marc A - Principal Investigators listed are sub-PIs determined by the center. |
Row 5: 2004
|
Row 5 Total Pubs:
200 Row 5 Journals: 129 Row 5 Books: 1 |
University of Southern California, University of California - Los Angeles | Callan, Richard | $3,802,622 |
November 01, 2003 - October 31, 2008 (Extended to October 31, 2010) |
6 |
R832413
Centers - Main center abstract - Southern California Particle Center |
Southern California Particle Center (SCPC) |
Froines, John R. Cho, Arthur K. Delfino, Ralph Fine, Philip M. Fukuto, Jon Harkema, Jack Hinds, William C. Kleinman, Michael T. Kumagai, Yoshito Lusis, Aldons Miguel, Antonio Nel, Andre E. Neuhausen, Susan Schauer, James J. Shafer, Martin M. Sioutas, Constantinos Staimer, Norbert Stram, Dan Vaziri, Nosratola D Vaziri, Nostratola Zhu, Yifang - Principal Investigators listed are sub-PIs determined by the center. |
Row 6: 2006
|
Row 6 Total Pubs:
154 Row 6 Journals: 139 -- Row 6: No Books -- |
Michigan State University, University of California - Los Angeles, University of California - Irvine, University of Southern California, University of Tsukuba, University of Wisconsin - Madison | Chung, Serena | $7,999,994 |
October 01, 2005 - September 30, 2010 (Extended to September 30, 2012) |
7 |
R834797
Centers - Main center abstract - Center for Research on Early Childhood Exposure and Development in Puerto Rico |
Great Lakes Air Center for Integrative Environmental Research (GLACIER) |
Brook, Robert D. Brooks, Robert P. Araujo, Jesus Kaplan, Marianna J. Oral, Elif - Principal Investigators listed are sub-PIs determined by the center. |
Row 7: 2011
|
Row 7 Total Pubs:
140 Row 7 Journals: 64 -- Row 7: No Books -- |
Michigan State University, The Ohio State University, University of California - Los Angeles, University of Michigan | Chung, Serena | $7,999,875 |
January 01, 2011 - December 31, 2015 (Extended to December 31, 2016) |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.