Grantee Research Project Results
Publications Details for Grant Number R835738
Predictive Toxicology Center for Organotypic Cultures and Assessment ofAOPs for Engineered Nanomaterials
RFA:
Organotypic Culture Models for Predictive Toxicology Center (2013)
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| Reference Type | Citation | Progress Report Year | Document Sources |
|---|---|---|---|
| Abstract | Altemeier WA, Haick A, Mittelsteadt KL, Kavanagh TJ. Primary mouse airway epithelial cells are resistant to silver nanoparticles. The Toxicologist 2016;150(S-1):10. |
R835738 (2016) R835738 (2017) R835738C001 (2016) |
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| Abstract | Chang S, Voellinger JL, White C, Kelly EJ, Eaton DL. A tissue-engineered rat/human liver microphysiological system for drug and chemical testing. The Toxicologist 2015;144(S-1):151. |
R835738 (2016) R835738 (2017) R835738C003 (2015) |
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| Abstract | Faustman EM. Testicular cells co-culture as an alternative model for male reproductive toxicity. The Toxicologist 2017;151(1):144 (Abstract 1613). |
R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
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| Abstract | Shaffer, RM, Wilder CS, Ryu SY, Park JL, Hong S, White CC, Workman T, Griffith WC, Faustman EM. Lifestage-specific modeling platform for adverse outcome pathways of male reproductive and developmental processes. The Toxicologist 2017;151(1):420 (Abstract 2786). |
R835738 (2017) R835738C004 (2017) |
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| Book Chapter | Van Ness K, Kelly E. Excretory processes in toxicology:drug transporters in drug development. In:McQueen CA, ed. Comprehensive Toxicology, Third Edition. Volume 1:General Principles, Oxford, UK:Elsevier Ltd., 2018, Chapter 8, pp. 143-164. |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) |
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| Journal Article | Cartwright MM, Schmuck SC, Corredor C, Wang B, Scoville DK, Chisholm CR, Wilkerson HW, Afsharinejad Z, Bammler TK, Posner JD, Shutthanandan V, Baer DR, Mitra S, Altemeier WA, Kavanagh TJ. The pulmonary inflammatory response to multiwalled carbon nanotubes is influenced by gender and glutathione synthesis. Redox Biology 2016;9:264-275. |
R835738 (2016) R835738 (2017) R835738C001 (2016) |
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| Journal Article | Chang S-Y, Weber EJ, Van Ness KP, Eaton DL, Kelly EJ. Liver and kidney on chips: microphysiological models to understand transporter function. Clinical Pharmacology & Therapeutics 2016;100(5):464-478. |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C003 (2016) R835738C003 (2017) R835738C005 (2017) |
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| Journal Article | Chang S-Y, Weber EJ, Sidorenko VS, Chapron A, Yeung CK, Gao C, Mao Q, Shen D, Wang J, Rosenquist TA, Dickman KG, Neumann T, Grollman AP, Kelly EJ, Himmelfarb J, Eaton DL. Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity. JCI Insight 2017;2(22):95978 (15 pp.). |
R835738 (2017) R835738C002 (2017) R835738C002 (2018) |
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| Journal Article | Chang S-Y, Voellinger JL, Van Ness KP, Chapron B, Shaffer RM, Neumann T, White CC, Kavanagh TJ, Kelly EJ, Eaton DL. Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity. Toxicology In Vitro 2017;40:170-183. |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C002 (2017) R835738C003 (2016) R835738C003 (2017) |
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| Journal Article | Harris S, Hermsen SA, Yu X, Hong SW, Faustman EM. Comparison of toxicogenomic responses to phthalate ester exposure in an organotypic testis co-culture model and responses observed in vivo. Reproductive Toxicology 2015;58:149-159. |
R834514 (Final) R834514C003 (2015) R834514C003 (Final) R835738 (2016) R835738 (2017) R835738C004 (2015) R835738C004 (2017) |
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| Journal Article | Harris S, Wegner S, Hong SW, Faustman EM. Phthalate metabolism and kinetics in an in vitro model of testis development. Toxicology in Vitro 2016;32:123-131. |
R833772 (2009) R834514 (Final) R834514C003 (Final) R835738 (2016) R835738 (2017) R835738C004 (2015) R835738C004 (2016) R835738C004 (2017) |
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| Journal Article | Harris S, Shubin SP, Wegner S, Van Ness K, Green F, Hong SW, Faustman EM. The presence of macrophages and inflammatory responses in an in vitro testicular co-culture model of male reproductive development enhance relevance to in vivo conditions. Toxicology In Vitro 2016;36:210-215. |
R834514 (Final) R834514C003 (Final) R835738 (2016) R835738 (2017) R835738C004 (2016) R835738C004 (2017) |
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| Journal Article | Kim YH, Jo MS, Kim JK, Shin JH, Baek JE, Park HS, An HJ, Lee JS, Kim BW, Kim HP, Ahn KH, Jeon KS, Oh SM, Lee JH, Workman T, Faustman EM, Yu IJ. Short-term inhalation study of graphene oxide nanoplates. Nanotoxicology 2018;12(3):224-238. |
R835738 (2017) R835738C001 (2018) R835738C004 (2018) R835738C005 (2018) |
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| Journal Article | Kimmel DW, Rogers LM, Aronoff DM, Cliffel DE. Prostaglandin E2 regulation of macrophage innate immunity. Chemical Research in Toxicology 2016;29(1):19-25. |
R835736 (2016) R835738 (2017) |
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| Journal Article | Knudsen TB, Keller DA, Sander M, Carney EW, Doerrer NG, Eaton DL, Fitzpatrick SC, Hastings KL, Mendrick DL, Tice RR, Watkins PB, Whelan M. FutureTox II: in vitro data and in silico models for predictive toxicology. Toxicological Sciences 2015;143(2):256-267. |
R835738 (2016) R835738C005 (2017) |
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| Journal Article | Lee JH, Han JH, Kim JH, Kim B, Bello D, Kim JK, Lee GH, Sohn EK, Lee K, Ahn K, Faustman EM, Yu IJ. Exposure monitoring of graphene nanoplatelets manufacturing workplaces. Inhalation Toxicology 2016;28(6):281-291. |
R835738 (2016) |
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| Journal Article | Lee JH, Sung JH, Ryu HR, Song KS, Song NW, Park HM, Shin BS, Ahn K, Gulumian M, Faustman EM, Yu IJ. Tissue distribution of gold and silver after subacute intravenous injection of co-administered gold and silver nanoparticles of similar sizes. Archives of Toxicology 2018;92(4):1393-1405. |
R835738 (2017) R835738C004 (2018) |
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| Journal Article | Nicholas T, Haik A, Bammler T, Workman T, Kavanaugh T, Faustman E, Gharib S, Altemeier W. The effects of genotype x phenotype interactions on transcriptional response to silver nanoparticle Toxicity in organotypic cultures of marine tracheal epithelial cells. Toxicological Sciences 2020;173(1):131-143. |
R835738 (2018) |
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| Journal Article | Nocholas T, Haick A, Workman T, Griffith W, Nolin J, Kanahagh T, Faustman E, ALtemeir W. The effects of genotype x phenotype interactions on silver nanoparticle toxicity in organotypic cultures of murine tracheal epithelial cells. Nanotoxicology 2020;14(7):908-928 |
R835738 (2019) |
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| Journal Article | Nolin JD, Lai Y, Ogden HL, Manicone AM, Murphy RC, An D, Frevert CW, Ghomashchi F, Naika GS, Gelb MH, Gauvreau GM, Piliponsky AM, Altemeier WA, Hallstrand TS. Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen. JCI Insight 2017;2(21):e94929 (18 pp.). |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) |
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| Journal Article | Park JJ, Weldon BA, Hong S, Workman T, Griffith WC, Park JH, Faustman EM. Characterization of 3D embryonic C57BL/6 and A/J mouse midbrain micromass in vitro culture systems for developmental neurotoxicity testing. Toxicology In Vitro 2018;48:33-44. |
R835738 (2017) R835738C001 (2018) R835738C004 (2018) R835738C005 (2018) |
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| Journal Article | Ramaiahgari SC, Waidyanatha S, Dixon D, DeVito MJ, Paules RS, Ferguson SS. From the cover: three-dimensional (3D) hepaRG spheroid model with physiologically relevant xenobiotic metabolism competence and hepatocyte functionality for liver toxicity screening. Toxicological Sciences 2017;159(1):124-136. |
R835738 (2017) |
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| Journal Article | Rountree A, Karkamkar A, Khalil G, Folch A, Cook DL, Sweet IR. BaroFuse, a novel pressure-driven, adjustable-throughput perfusion system for tissue maintenance and assessment. Heliyon 2016;2(12):e00210 (18 pp.). |
R835738 (2017) |
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| Journal Article | Scoville DK, Botta D, Galdanes K, Schmuck SC, White CC, Stapleton PL, Bammler TK, MacDonald JW, Altemeier WA, Hernandez M, Kleeberger SR, Chen LC, Gordon T, Kavanagh TJ. Genetic determinants of susceptibility to silver nanoparticle-induced acute lung inflammation in mice. FASEB Journal 2017;31(10):4600-4611. |
R835738 (2017) R835738C001 (2017) R835738C001 (2018) R835738C002 (2017) |
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| Journal Article | Shaffer R, Smith MN, Faustman EM. Developing the regulatory utility of the exposome: mapping exposures for risk assessment through Lifestage Exposome Snapshots (LEnS). Environmental Health Perspectives 2017;123(8):085003 (8 pp.). |
R835738 (2017) R835738C004 (2018) R835738C005 (2017) |
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| Journal Article | Smith MN, Grice J, Cullen A, Faustman EM. A toxicological framework for the prioritization of Children’s Safe Product Act data. International Journal of Environmental Research and Public Health 2016;13(4):431 (24 pp.). |
R834514 (Final) R835738 (2016) R835738 (2017) R835738C005 (2015) R835738C005 (2016) R835738C005 (2017) |
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| Journal Article | Smith M, Hubal E, Faustman E. A Case study on the utility of predictive toxicology tools in alternatives assessments for hazardous chemicals in children's consumer products. JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY 2020;30(1):160-170. |
R835738 (2018) |
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| Journal Article | Van Ness KP, Chang SY, Weber EJ, Zumpano D, Eaton DL, Kelly EJ. Microphysiological systems to assess nonclinical toxicity. Current Protocols in Toxicology 2017;73(1):14.18.1-14.18.28. |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) R835738C002 (2018) R835738C004 (2018) R835738C005 (2017) |
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| Journal Article | Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. Scientific Reports 2017;7:42296 (14 pp.). |
R835736C004 (2017) R835738 (2017) R835738C002 (2016) |
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| Journal Article | Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. Scientific Reports 2017;7:42296 (15 pp.). |
R835736 (2015) R835736 (2016) R835736C004 (2016) R835736C005 (2016) R835738 (2016) R835738C003 (2017) R835738C005 (2017) |
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| Journal Article | Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. Corrigendum: Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. Scientific Reports 2017;7:44517. |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C002 (2017) R835738C005 (2017) |
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| Journal Article | Wallace JC, Port JA, Smith MN, Faustman EM. FARME DB:a functional antibiotic resistance element database. Database 2017;2017(1):1-7. |
R835738 (2016) |
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| Journal Article | Weber EJ, Chapron A, Chapron BD, Voellinger JL, Lidberg KA, Yeung CK, Wang Z, Yamaura Y, Hailey DW, Neumann T, Shen DD, Thummel KE, Muczynski KA, Himmelfarb J, Kelly EJ. Development of a microphysiological model of human kidney proximal tubule function. Kidney International 2016;90(3):627-637. |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C002 (2017) |
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| Journal Article | Weber EJ, Himmelfarb J, Kelly EJ. Concise review: current and emerging biomarkers of nephrotoxicity. Current Opinion in Toxicology 2017;4:16-21. |
R835738 (2017) R835738C002 (2017) R835738C002 (2018) |
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| Journal Article | Wegner SH, Yu X, Pacheco Shubin S, Griffith WC, Faustman EM. Stage-specific signaling pathways during murine testis development and spermatogenesis: a pathway-based analysis to quantify developmental dynamics. Reproductive Toxicology 2015;51:31-39. |
R834514 (2015) R834514 (Final) R834514C003 (2015) R834514C003 (Final) R835738 (2016) R835738 (2017) R835738C004 (2015) R835738C004 (2017) |
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| Journal Article | Wegner S, Park J, Workman T, Workman T, Hermsan S, Wallace J, Stanaway I, Kim H, Griffith W, Hong S, Faustman E. Anchoring a dynamic in vitro model of human neuronal differentiation to key processes of early brain development in vivo. Reproductive Toxicology 2020;91:116-130. |
R834514 (Final) R835738 (2018) |
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| Journal Article | Wegner S, Workman T, Park J, Harris S, Wallace J, Stanaway I, Hong S, Hansen B, Griffith W, Faustman E. A dynamic in vitro developing testis model reflects structures and functions of testicular development in vivo. REPRODUCTIVE TOXICOLOGY 2023;118(108362) |
R834514 (Final) R835738 (Final) |
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| Journal Article | Weldon BA, Faustman EM, Oberdorster G, Workman T, Griffith WC, Kneuer C, Yu IJ. Occupational exposure limit for silver nanoparticles: considerations on the derivation of a general health-based value. Nanotoxicology 2016;10(7):945-956. |
R835738 (2015) R835738 (2016) R835738 (2017) R835738C005 (2015) R835738C005 (2016) R835738C005 (2017) |
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| Journal Article | Weldon BA, Park JJ, Hong S, Workman T, Dills R, Lee JH, Griffith WC, Kavanagh TJ, Faustman EM. Using primary organotypic mouse midbrain cultures to examine developmental neurotoxicity of silver nanoparticles across two genetic strains. Toxicology and Applied Pharmacology 2018:354;215-224 |
R835738 (2017) R835738C004 (2017) R835738C004 (2018) R835738C005 (2017) R835738C005 (2018) |
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| Journal Article | ZImaoka T, Yang J, Wang L, McDonald M, Afsharinejad Z, Bammler T, Van Ness K, Yeung C, Rettie A, Himmelfarb J. Microphysiological system modeling of ochratoxin A-associated nephrotoxicity. Toxicology 2020;444. |
R835738 (2019) |
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| Journal Article | Weldon BA, Griffith WC, Workman T, Scoville DK, Kavanagh TJ, Faustman EM. 2018. In vitro to in vivo benchmark dose comparisons to inform risk assessment of quantum dot nanomaterials. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology 2018;10(4):e1507. |
R835738 (2017) R835738C001 (2018) R835738C004 (2017) R835738C004 (2018) R835738C005 (2017) R835738C005 (2018) |
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| Presentation | Altemeier WA, Haick A, Mittelsteadt KL, Kavanagh TJ. Primary mouse airway epithelial cells are resistant to silver nanoparticles. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835738 (2016) R835738 (2017) R835738C001 (2016) |
not available |
| Presentation | Altemeier WA, Nolin JD, Lai Y, Mulligan MS, Hallstrand TS. Development of human organotypic culture systems to model airway biology. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C001 (2018) |
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| Presentation | Altemeier WA. Development of human organotypic culture systems to model airway biology. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 21, 2017. |
R835738 (2017) R835738C002 (2017) |
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| Presentation | Botta D, Schaupp CM, White CC, Dempsey JL, and Kavanagh TJ. Development of an immortalized glutathione deficient mouse hepatocyte cell line with Nrf2 reporter activity. Presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore MD, March 12-16, 2017. |
R835738 (2016) R835738 (2017) |
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| Presentation | Botta D, White CC, Melnikov F, Schaupp CM, Gallagher EG, Brooks BW, Kostal J, Voutchkova-Kostal, AM, Anastas PT and Kavanagh TJ. Using immortalized hepatocytes from wild-type and Gclm knock out mice to investigate the relative toxicity and Nrf2 activation of SN2 reactive electrophiles. Presented at the Society of Toxicology 57th Annual Meeting and ToxExpo, San Antonio, TX, March 11-15, 2018. |
R835738 (2017) R835738C003 (2017) R835738C003 (2018) |
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| Presentation | Chang SY, Weber E, Kelly EJ, Eaton DL. Microphysiological systems to identify organ-organ interactions in toxicology: hepatic metabolism enhances nephrotoxicity of aristolochic acid. Presented at the Pacific Northwest Association of Toxicologists Annual Meeting, Woodinville, WA, September 17-18, 2015. |
R835738 (2016) R835738 (2017) R835738C002 (2017) R835738C003 (2015) R835738C005 (2017) |
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| Presentation | Chang SY, Weber E, Neumann T, Kelly EJ, Eaton DL. Microphysiological Systems (MPS) to identify organ-organ interactions in tToxicology: hepatic metabolism enhances nephrotoxicity of aristolochic acid. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835738 (2016) R835738 (2017) R835738C002 (2017) R835738C003 (2015) R835738C005 (2017) |
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| Presentation | Eaton D. New frontiers for linked microphysiological systems: integrated liver-kidney systems on a chip. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C002 (2017) R835738C002 (2018) R835738C003 (2018) R835738C005 (2017) |
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| Presentation | Faustman EM. Testicular cells co-culture as an alternative model for male reproductive toxicity. Presented workshop at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835738 (2016) R835738 (2017) R835738C002 (2017) R835738C004 (2017) |
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| Presentation | Faustman EM, Smith MN. Neurodevelopmental disorders and disease & opportunities for new chemical testing data: understanding new tools from federal chemical testing programs. Presented to the California EPA via webinar, August 14, 2015. |
R834514 (2015) R834514 (Final) R835738 (2016) R835738 (2017) R835738C004 (2015) R835738C005 (2017) |
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| Presentation | Faustman EM, Kavanagh TJ, Altemeier W, Kelly E, Griffith WC, Gao X, Van Ness K, Eaton DL. Predictive Toxicology Center for Organotypic Cultures and Assessment of AOPs for Engineered Nanomaterials. Poster presented at the Society of Toxicology 54th Annual Meeting and ToxExpo, San Diego, CA, March 22-26, 2015. |
R835738 (2016) R835738 (2017) R835738C002 (2017) R835738C004 (2017) R835738C005 (2017) |
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| Presentation | Faustman EM, Kavanagh TJ. University of Washington Predictive Toxicology Center update. Presented at the Society of Toxicology 54th Annual Meeting and ToxExpo, San Diego, CA, March 22-26, 2015. |
R835738 (2016) R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
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| Presentation | Faustman EM, Kavanagh TJ, Altemeier W, Kelly E, Griffith WC, Gao X, Van Ness K, Eaton DL. Organotypic Cultures and Assessment of AOPs for Engineered Nanomaterials: results from the University of Washington Predictive Toxicology Center (PTC). Poster presented at the Society of Toxicology Contemporary Concepts in Toxicology's FutureTox III: Bridges for Translation Conference, Arlington, VA, November 19-20, 2015. |
R835738 (2016) R835738 (2017) R835738C002 (2017) R835738C004 (2017) R835738C005 (2017) |
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| Presentation | Faustman EM. Integrating in vitro studies for risk assessment of quantum dots:applications of dosimetry and benchmark evaluation methods. Presented at the 7th International Symposium on Nanotechnology, Occupational and Environmental Health (NanOEH 2015), University of Witwatersrand, Limpopo Province, South Africa, October 18-22, 2015. |
R835738 (2015) R835738 (2016) R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
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| Presentation | Faustman EM. 3D testis culture: challenges and opportunities for informing AOP. Presented at a seminar in Seattle, WA, August 2016. |
R835738 (2016) R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
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| Presentation | Faustman EM. Virtual tissue modeling. Poster presented at the University of Washington’s Predictive Toxicology Center: Metal and Engineered Nanomaterials Quarterly Update, Seattle WA, August 2016. |
R835738 (2016) R835738 (2017) R835738C005 (2017) |
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| Presentation | Faustman EM, Smith M. Prioritizing toxic chemicals in children’s consumer products. Presented via the Pediatric Environmental Health Specialty Units (PEHSU) National Classroom Grand Rounds Webinar, December 14, 2016. |
R835738 (2016) R835738 (2017) R835738C004 (2017) R835738C005 (2016) R835738C005 (2017) |
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| Presentation | Faustman EM. Virtual tissue modeling. Poster presented at the University of Washington’s Predictive Toxicology Center: Metal and Engineered Nanomaterials Quarterly Update, Seattle WA, February 2016. |
R835738 (2016) R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
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| Presentation | Faustman EM. Framing our birth defects questions with systems biology: learning from our mentors. Presented at the 56th Annual Teratology Society Meeting, San Antonio, TX, June 26, 2016 (Josef Warkany lecture). |
R835738 (2016) R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
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| Presentation | Faustman EM. Exposomes for children's studies: importance of life stage considerations. Presented at the NIEHS/EPA Children’s Centers Webinar Series: Exposome, Research Triangle Park, NC, May 11, 2016. |
R835738 (2016) R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
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| Presentation | Faustman EM. Children matter: using a lifecourse approach to understanding safety assessment needs for children. Presented via webinar at the Society of Toxicology (SOT)/U.S. Food and Drug Administration (FDA) Colloquia on Emerging Toxicological Science: Challeges in Food and Ingredients Safety, College Park, MD, May 20, 2016. |
R835738 (2016) R835738 (2017) R835738C005 (2017) |
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| Presentation | Faustman EM. Virtual tissue modeling. Poster presented at the University of Washington’s Predictive Toxicology Center: Metal and Engineered Nanomaterials Quarterly Update, Seattle WA, May 2016. |
R835738 (2016) R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
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| Presentation | Faustman EM. Systems biology methods for translation of scientific findings across model platforms: identifying normal development versus chemical signals in complex systems. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) R835738C004 (2017) R835738C004 (2018) R835738C005 (2017) |
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| Presentation | Faustman EM. Using systems biology for linking genes and environment for alcohol research. Presented at the Fetal Alcohol Spectrum Disorders Study Group Meeting, Denver, CO, June 24, 2017 (keynote speaker). |
R835738 (2017) R835738C002 (2017) R835738C004 (2018) |
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| Presentation | Faustman EM. Integrating systems biology and public health to implement 3Rs–what have we learned and what do we need to do? Presented at the Institutional Animal Care and Use Committee (IACUC) Conference, New Orleans, LA, March 19-20, 2017 (keynote speaker). |
R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
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| Presentation | Faustman E, French E, Eaton D, Kelly E, Kavanagh T. Using systems based approaches for refinement, integration and translation. Minicourse presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20, 2017. |
R835738 (2017) R835738C001 (2018) R835738C002 (2018) R835738C003 (2018) |
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| Presentation | Faustman E, Weber E. MPS-related research. Presented to high school students (typically in STEM programs) on a monthly basis in collaboration with UW Medical Center Community Outreach, Seattle, WA, 2017. |
R835738 (2017) R835738C002 (2017) R835738C002 (2018) |
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| Presentation | Fitzpatrick SC. Incorporating in vitro reproductive and developmental assays into regulatory risk assessment. Presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835738 (2016) R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
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| Presentation | Kavanagh TJ, Schaupp CM, Botta D, Schmuck S, White CC, Chisholm C. Measuring chemically-induced oxidative stress in genetically modified cultured mammalian liver cells. Presented at the Northwest Green Chemistry Conference, Troutdale, OR, April 23-24, 2015. |
R835738 (2016) R835738 (2017) R835738C003 (2015) |
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| Presentation | Kavanagh T. Comparing engineered nanomaterial toxicity across species, partcles and cell types: the benefit of 3D over 2D in vitro systems, and the role of genetics in predicting ENM adverse outcome. Presented at a seminar, Seattle, WA, August 2016. |
R835738 (2016) R835738 (2017) R835738C005 (2016) R835738C005 (2017) |
not available |
| Presentation | Kavanagh T. Educational tools for designing safer chemicals and predicting toxicity. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C002 (2018) R835738C003 (2018) R835738C005 (2017) |
not available |
| Presentation | Kavanagh T. Experiences with collaborative cross for assessing gene X environment interactions for engineered nanomaterials: can we capture human variability in vitro-lessons from the Predictive Toxicology Center. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C002 (2017) R835738C003 (2018) R835738C005 (2017) |
not available |
| Presentation | Kelly EJ. Kidney on a chip: from toxicology to therapeutics. Presented at the American Society of Nephrology Annual Meeting, San Diego, CA, November 3-8, 2015. |
R835738 (2017) R835738C002 (2015) R835738C002 (2017) |
not available |
| Presentation | Kelly EJ. Development of a 3D human kidney microphysiological system for drug safety testing. Presented at the Functional Analysis & Screening Technologies (FAST) Congress, Boston, MA, November 9-11, 2015. |
R835738 (2017) R835738C002 (2015) R835738C002 (2017) |
not available |
| Presentation | Kelly EJ. Human kidney microphysiological system for drug and xenobiotic toxicity testing. Presented at the 20th Meeting of the North American International Society for the Study of Xenobiotics (ISSX) Annual Meeting, Orlando, FL, October 18-22, 2015 (Symposium Chair). |
R835738 (2017) R835738C002 (2015) R835738C002 (2017) |
not available |
| Presentation | Kelly EJ. Human kidney microphysiological system for drug and xenobiotic toxicity testing. Presented at the University of California, San Francisco, CA, October 27, 2015. |
R835738 (2017) R835738C002 (2015) R835738C002 (2017) |
not available |
| Presentation | Kelly EJ. 3D culture system for in vitro nephrotoxicity testing. Presented at Bayer Corporation, San Francisco, CA, 2015. |
R835738 (2017) R835738C002 (2015) R835738C002 (2017) |
not available |
| Presentation | Kelly EJ. The 3 R’s of toxicology and the role of microphysiological systems. Presented at the Institute for Stem Cell and Regenerative Medicine (ISCRM) Seminar Series, Seattle, WA, December 13, 2016. |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C002 (2017) R835738C005 (2017) |
not available |
| Presentation | Kelly EJ. Utility of predictive toxicity testing in a 3D microphysiological model of the human kidney proximal tubule. Presented at the Environmental Pathology/Toxicology (EP/T) Training Grant Winter Symposium, Seattle, WA, December 2, 2016 (keynote speaker). |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C002 (2017) |
not available |
| Presentation | Kelly EJ. Predictive toxicity testing in a 3D microphysiological model of the human kidney proximal tubule. Presented at the Cambridge Healthtech Institute’s (CHI) 14th Annual High Content Analysis & 3D Screening Conference: Organ-on-a-Chip, Boston, MA, October 31, 2016. |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C002 (2017) |
not available |
| Presentation | Kelly EJ. Organs on chips and reducing the need for animal studies. Presented at the Pacific Northwest Association of Toxicologists (PANWAT) Annual Meeting, Oregon State University, Corvallis, OR, September 29-30, 2016. |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C002 (2017) R835738C005 (2017) |
not available |
| Presentation | Kelly EJ. Human kidney microphysiological system for drug and xenobiotic toxicity testing. Presented at the University of Washington, School of Public Health, Seattle, WA, 2016. |
R835738 (2017) R835738C002 (2015) R835738C002 (2017) |
not available |
| Presentation | Kelly EJ. Identification and discrimination of cellular responses to new molecular entities utilizing a 3D model of the human kidney proximal tubule. Presented at the 10th World Congress on Alternatives and Animals in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C002 (2017) R835738C002 (2018) |
not available |
| Presentation | Kelly EJ. Predictive toxicity testing in a microphysiological model of the human kidney proximal tubule. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C002 (2017) R835738C002 (2018) |
not available |
| Presentation | Kelly EJ. Preclinical approaches for addressing complex human health issues: aristolochic acid nephropathy. Presented at the BRIDG Retreat, Seattle, WA, January 6, 2017 (keynote speaker). |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C002 (2017) |
not available |
| Presentation | Kelly EJ. Emergent technologies for evaluating drug and xenobiotic disposition. Presented at the 21st North American ISSX Meeting of the International Society for the Study of Xenobiotics (ISSX), Providence, RI, September 24-28, 2017 (symposium co-chair). |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) R835738C002 (2018) R835738C005 (2017) |
not available |
| Presentation | Kelly E. Bioengineered ex vivo models of human organs for predictive toxicity testing. Presented at the New England Drug Metabolism Discussion Group Meeting, Walkersville, MD, December 6, 2017 |
R835738 (2017) R835738C002 (2017) R835738C002 (2018) R835738C003 (2018) R835738C005 (2017) |
not available |
| Presentation | Klieforth B, Shaffer RM, Smith M, Faustman EM. Microphysiological system models and the Lautenberg Chemical Safety for the 21st Century Act. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) R835738C002 (2018) R835738C004 (2017) R835738C004 (2018) R835738C005 (2017) |
not available |
| Presentation | Lee, JH, Han JH, Kim JH, Kim BW, Bello D, Kim JK, Lee GH, Ahn K, Faustman EM, Park JD, Yu IJ. Exposure monitoring of graphene manufactureing workplace. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835738 (2016) R835738 (2017) R835738C004 (2017) |
not available |
| Presentation | Lidberg KA, Iversen PL, Himmelfarb J, Kelly EJ. Evaluation of antisense oligonucleotide nephrotoxicity using a 3D microphysiological system. Poster presented at the Pacific Northwest Association of Toxicologists (PANWAT) Annual Meeting, Oregon State University, Corvallis, OR, September 29-30, 2016. |
R835738 (2016) R835738 (2017) R835738C002 (2016) |
not available |
| Presentation | Nicholas T, Haick A, Faustman E, Altemeier WA. Optimization of airway epithelium organotypic culture models as a platform for adverse outcome pathway assessment of engineered nanomaterials. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C001 (2017) R835738C001 (2018) R835738C002 (2017) |
not available |
| Presentation | Nicholas T, Haick A, Kavanagh TJ, Faustman E, Altemeier WA. Optimization of three-dimensional airway epithelium co-culture system as a platform for adverse outcome pathway assessment of engineered nanomaterials. Poster presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835738 (2016) R835738 (2017) R835738C001 (2016) R835738C002 (2017) |
not available |
| Presentation | Nicholas T, Haick A, Kavangh TJ, Faustman E, Altemeier WA. Differentiation state of airway epithelium organotypic culture models is a potential mediator of silver nanoparticle-induced toxicity. Presented at the Society of Toxicology 57th Annual Meeting and ToxExpo, San Antonio, TX, March 11-15, 2018. |
R835738 (2017) R835738C001 (2018) |
not available |
| Presentation | Park JJ, Kim HY, Wegner SH, Van Ness KP, Pacheco SE, Workman T, Hong S, Griffith WC, Faustman EM. Histon modifications in proliferating and differentiating human neuronal progenitor cells after acute chlorpyrifos and arsenic exposures. Poster presented at the 56th Annual Meeting of the Teratology Society, San Antonio, TX, June 25-29, 2016. |
R835738 (2016) R835738 (2017) |
not available |
| Presentation | Park JJ, Weldon BA, Park JH, Cruishank W, Workman T, Hong S, Ward T, Griffith W, Kavanagh T, Faustman EM. C57BL/6 fetal mouse midbrain micromass culture: a case study of silver nanoparticles. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835738 (2016) R835738 (2017) |
not available |
| Presentation | Park JJ, Weldon BA, Hong S, Workman T, Dills R, Griffith WC, Kavanagh TJ, Faustman EM. Silver nanoparticles dosimetry-response comparison in in vitro primary organotypic C57BL/6 and A/J mouse midbrain micromass cultures at various developmental stages. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C005 (2017) |
not available |
| Presentation | Park S, Lee JH, Wilder C, Wegner S, Harris S, Hong S, Faustman EM. Organotypic modeling platform for identifying adverse response in testicular development. Poster presented at the University of Washington Undergraduate Research Symposium, Seattle, WA, May 2016. |
R835738 (2016) R835738 (2017) R835738C004 (2017) |
not available |
| Presentation | Pekow C, Altemeier WA. Practical promotion of the 3Rs in animal models of lung disease. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C001 (2017) R835738C001 (2018) R835738C005 (2017) |
not available |
| Presentation | Shaffer RM, Welder CS, Ryu C, Yi HS, Park SY, Hong S, White CC, Workman T, Griffith WC, Faustman EM. Lifestage-specific organotypic modeling platform for adverse outcome pathways of male reproductive and developmental processes. Poster presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C004 (2017) R835738C004 (2018) R835738C005 (2017) |
not available |
| Presentation | Shaffer R, Wilder CS, Ryu C, Yi HS, Park SY, Hong S, White CC, Workman T, Griffith WC, Faustman EM. Lifestage-specific modeling platform for adverse outcome pathways of male reproductive and developmental processes. Poster presented at the Pacific Northwest Association of Toxicologists (PANWAT) Annual Meeting, Oregon State University, Corvallis, OR, September 29-30, 2016. |
R835738 (2016) R835738 (2017) R835738C002 (2017) R835738C004 (2017) R835738C005 (2017) |
not available |
| Presentation | Smith MN, Faustman EM, Grice J. Developing a toxicological framework for the interpretation of the Children's Safe Product Act data. Presented at the Northwest Environmental Health Conference, Portland, OR, April 17, 2015. |
R834514 (2015) R835738 (2016) R835738 (2017) R835738C004 (2017) |
not available |
| Presentation | Smith MN, Faustman EM, Grice J. Developing a toxicological framework for the interpretation of the Children’s Safe Product Act data. Presented at the 7th Annual Northwest Environmental Health Conference, Portland, OR, April 17, 2015. |
R834514 (Final) R835738 (2015) R835738C005 (2015) |
not available |
| Presentation | Smith MN, Grice J, Faustman EM. Using a toxicological framework for chemical prioritization from the Children’s Safe Product Act. Presented at the Society for Risk Analysis (SRA) Annual Meeting, Arlington, VA, December 7, 2015. |
R835738 (2015) R835738 (2016) R835738 (2017) R835738C005 (2015) |
not available |
| Presentation | Smith MN. Developing a toxicological framework for the prioritization of the Children’s Safe Product Act data. Presented via the Interstate Chemical Clearinghouse (IC2) Meeting, May 18, 2016. |
R835738 (2016) R835738 (2017) R835738C005 (2016) |
not available |
| Presentation | Smith MN, Shaffer RM, Cohen Hubal E, Faustman EM. Using in vitro data to compare endocrine disruption potential in hazardous chemicals currently found in children’s products and their proposed alternatives. Poster presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C002 (2017) |
not available |
| Presentation | Song H, Kim K, Park JJ, Hong S, Faustman EM. Neuronal developmental differences between C57BL/6 and A/J mice in micromass culture of mouse embryonic midbrain cell. Presented at the University of Washington Undergraduate Symposium, Seattle, WA, May 20, 2016. |
R835738 (2016) R835738 (2017) |
not available |
| Presentation | Van Ness KP, Weber EJ, Neumann T, Kelly EJ. Nephrotoxicity of engineered nanoparticles: exposure effects of silver nanoparticles in a kidney microphysiological system. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835738 (2016) R835738 (2017) R835738C002 (2015) R835738C002 (2017) |
not available |
| Presentation | Van Ness KP, Kavanagh TJ Kelly EJ. Microphysiological system assessment of nephrotoxicity of quantum dot with a cadmium/selenium core. Poster presented at the Pacific Northwest Association of Toxicologists (PANWAT) Annual Meeting, Oregon State University, Corvallis, OR, September 29-30, 2016. |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C002 (2017) |
not available |
| Presentation | Van Ness KP, Kavanagh TJ, Kelly EJ. Microphysiological system assessment of nephrotoxicity of CdCl2 and quantum dots with a cadmium/selenium core. Poster presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C002 (2017) R835738C002 (2018) |
not available |
| Presentation | Van Ness KP, Kavanagh TJ, Kelly EJ. Microphysiological system assessment of nephrotoxicity of CdCl2 and quantum dots with a cadmium/selenium core. Poster presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835738 (2017) R835738C002 (2017) |
not available |
| Presentation | Van Ness KP, Kavanagh TJ Kelly EJ. Microphysiological system assessment of nephrotoxicity of quantum dot with a cadmium/selenium core. Poster presented at the Pacific Northwest Association of Toxicologists (PANWAT) Conference, Bothell, WA, October 1-2, 2017. |
R835738 (2017) R835738C002 (2017) |
not available |
| Presentation | Van Ness KP, Kavanagh TJ, Kelly EJ. Microphysiological system assessment of nephrotoxicity of CdCl2 and quantum dots with a cadmium/selenium core. Poster presented at the Society of Toxicology 57th Annual Meeting and ToxExpo, San Antonio, TX, March 11-15, 2018. |
R835738 (2017) R835738C002 (2017) R835738C002 (2018) |
not available |
| Presentation | Weber EJ, Freedman BS, Himmelfarb J, Kelly EJ. Sourcing of renal tubular epithelial cells from human stem cell-derived kidney organoids. Poster presented at the American Society of Nephrology Annual Meeting, San Diego, CA, November 3-8, 2015. |
R835738 (2017) R835738C002 (2015) R835738C002 (2017) |
not available |
| Presentation | Weber EJ, Vaara M, Vaara T, Neumann T, Himmelfarb J, Kelly EJ. Ex vivo induction of polymyxin-induced nephrotoxicity in a 3D microphysiological model of a human kidney proximal tubule. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835738 (2016) R835738 (2017) R835738C002 (2015) R835738C002 (2017) |
not available |
| Presentation | Weber EJ, Vaara M, Vaara T, Neumann T, Himmelfarb J, Kelly EJ. Safety assessment of Polymyxin B structural variants using a 3D nephrotoxin-sensitive microphysiological system. Presented at the Pacific Northwest Association of Toxicologists (PANWAT) Annual Meeting, Oregon State University, Corvallis, OR, September 29-30, 2016. |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C002 (2017) |
not available |
| Presentation | Weber E, Vaara M,Vaara T, Neumann T, Himmelfarb J, Kelly E. Polycationic antibiotic exposure validates clinical findings using a 3D microphysiological kidney-on-a-chip. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C002 (2017) |
not available |
| Presentation | Weldon BA, Faustman EM, Oberdorster G, Workman T, Griffith WC, Kneuer C, Yu IJ. A framework for the derivation of a health-based occupation exposure limit for silver nanoparticles. Poster presented at the Pacific Northwest Association of Toxicologists (PANWAT) Annual Meeting, Woodinville, WA, September 17-18, 2015. |
R835738 (2015) R835738 (2016) R835738 (2017) R835738C005 (2015) R835738C005 (2017) |
not available |
| Presentation | Weldon BA, Faustman EM, Oberdorster G, Workman T, Griffith WC, Kneuer C, Yu IJ. A framework for the derivation of a health-based occupation exposure limit for silver nanoparticles. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835738 (2015) R835738 (2016) R835738 (2017) R835738C005 (2015) R835738C005 (2017) |
not available |
| Presentation | White CC, Botta D, Schaupp CM, Kavanagh TJ. Toxicological assessment of glutathione content, mitochondrial membrane potential and cardiolipin in an immortalized glutathione-deficient mouse hepatocyte cell line. Presented at the 32nd Congress of the International Society for Advancement of Cytometry, Boston, MA, June 10-14, 2017. |
R835738 (2016) R835738 (2017) R835738C003 (2018) |
not available |
| Presentation | Wilder CS, Wegner SH, Smith MN, Harris S, Hong SW, Griffith WC, Faustman EM. Organotypic modeling platform for adverse outcome pathways of male reproductive and developmental processes. Presented at the 56th Annual Meeting of the Teratology Society, San Antonio, TX, June 25-29, 2016. |
R835738 (2016) R835738 (2017) R835738C004 (2017) |
not available |
| Presentation | Wilder CS, Wegner SH, Organotypic modeling platform for adverse outcome pathways of male reproductive and developmental processes. Presented webinar at Virtual Tissues Meeting, Research Triangle Park, NC, May 2016. |
R835738 (2016) R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
not available |
| Presentation | Wilder C. Organotypic modeling platform for adverse outcome pathways of male reproductive and developmental processes. Presented at the University of Washington, Department of Environmental and Occupational Health Science Student Research Day, Seattle, WA, May 2016. |
R835738 (2016) R835738 (2017) R835738C004 (2017) |
not available |
| Presentation | Faustman EM, Kavanagh TJ., Altemeier W, Kelly E, Griffith WC, Gao X, Van Ness K, Eaton DL. Organotypic Cultures and Assessment of AOPs for Engineered Nanomaterials; Results from the University of Washington Predictive Toxicology Center (PTC). Poster presented at the Society of Toxicology Contemporary Concepts in Toxicology's FutureTox III: Bridges for Translation Conference, Arlington, VA, November19-20, 2015. |
R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
not available |
| Symposium | Kelly E. Symposium Co-Chair of the 21st North American ISSX Meeting, Emergent Technologies for Evaluating Drug and Xenobiotic Disposition, Providence, RI, September 24-28, 2017. |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) R835738C005 (2017) R835738C005 (2018) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.