Grantee Research Project Results
Publications Details for Grant Number R835736
Vanderbilt - Pittsburgh Resource for Organotypic Models for Predictive Toxicology
RFA:
Organotypic Culture Models for Predictive Toxicology Center (2013)
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| Reference Type | Citation | Progress Report Year | Document Sources |
|---|---|---|---|
| Abstract | Gibson C, Codreanu S, Schrimpe-Rutledge A, Retzlaff C, Wright J, Mortlock D, Sherrod S, McLean J, Blakely R. Global untargeted serum metabolomic analyses nominate metabolic pathways responsive to loss of expression of the orphan metallo-lactamase, MBLAC1. MOLECULAR OMICS 2017;14:142-155 |
R835736 (Final) |
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| Abstract | Nichols C, May J, Sherrod S, McLean J. Automated flow injection method for the high precision determination of drift tube ion mobility collision cross sections. ANALYST 2018;143(7):1556-1559 |
R835736 (Final) |
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| Abstract | Rose B, Leaptrot K, Harris R, Sherrod S, May J, McLean J. High Confidence Shotgun Lipidomics Using Structurally Selective Ion Mobility-Mass Spectrometry. MASS SPECTROMETRY-BASED LIPIDOMICS 2021;2306:11-37 |
R835736 (Final) |
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| Book Chapter | PHillips S, Dodds J, May J, McLean J. Isomeric and Conformational Analysis of Small Drug and Drug-Like Molecules by Ion Mobility-Mass Spectrometry (IM-MS). In: Larson, R., Oprea, T. (eds) Bioinformatics and Drug Discovery. Methods in Molecular Biology, Humana Press, New York, NY.2019, pp161-178 |
R835736 (Final) |
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| Journal Article | Alexander PG, Clark KL, Tuan RS. Prenatal exposure to environmental factors and congenital limb defects. Birth Defects Research, Part C: Embryo Today: Reviews 2016;108(3):243-273. |
R834513 (Final) R835736 (2015) R835736 (2016) R835736 (2017) R835736C002 (2016) |
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| Journal Article | Anders AP, Gaddy JA, Doster RS, Aronoff DM. Current concepts in maternal-fetal immunology: recognition and response to microbial pathogens by decidual stromal cells. American Journal of Reproductive Immunology 2017;77(3):e12623 (14 pp.). |
R835736 (2016) |
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| Journal Article | Argemie J, Latasa M, Atkinson S, Blokhin I, Massey V, Gue J, Cabezas J, Lozano J, Booven D, Bell A, Cao S, Vernetti L, Arab J. Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis. Nature Communications 2019;10(1):3126. |
R835736 (2018) |
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| Journal Article | Bruner-Tran KL, Duleba AJ, Taylor HS, Osteen KG. Developmental toxicant exposure is associated with transgenerational adenomyosis in a murine model. Biology of Reproduction 2016;95(4):73 (10 pp.). |
R835736 (2015) R835736 (2016) R835736C003 (2018) |
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| Journal Article | Bruner-Tran KL, Gnecco J, Ding T, Glore DR, Pensabene V, Osteen KG. Exposure to the environmental endocrine disruptor TCDD and human reproductive dysfunction: translating lessons from murine models. Reproductive Toxicology 2017;68:59-71. |
R826300 (Final) R835736 (2015) R835736 (2016) R835736 (2017) R835736C003 (2016) R835736C003 (2017) R835736C003 (2018) |
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| Journal Article | Cyr KJ, Avaldi OM, Wikswo JP. Circadian hormone control in a human-on-a-chip:in vitro biology’s ignored component? Experimental Biology and Medicine 2017;242(17):1714-1731. |
R835736 (2017) R835736C005 (2017) |
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| Journal Article | Ding T, Lambert LA, Aronoff DM, Osteen KG, Bruner-Tran KL. Sex-dependent influence of developmental toxicant exposure on group B Streptococcus -mediated preterm birth in a murine model. Reproductive Sciences 2018;25(5):662-673. |
R835736 (2017) R835736C003 (2017) R835736C003 (2018) |
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| Journal Article | Dodds JN, May JC, McLean JA. Investigation of the complete suite of the leucine and isoleucine isomers: toward prediction of ion mobility separation capabilities. Analytical Chemistry 2017;89(1):952-959. |
R835736 (2015) R835736 (2016) R835736 (2017) |
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| Journal Article | Ellis B, Fischer C, Martin L, Bachmann B, McLean J. Spatiochemically Profiling Microbial Interactions with Membrane Scaffolded Desorption Electrospray Ionization-Ion Mobility-Imaging Mass Spectrometry and Unsupervised Segmentation. Analytical Chemistry 2019;91(21):13703-13711. |
R835736 (2018) |
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| Journal Article | Ellis B, Babele P, May J, Johnson C, Pfleger B, Young J, McLean J. Accelerating strain phenotyping with desorption electrospray ionization-imaging mass spectrometry and untargeted analysis of intact microbial colonies. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2022;118(49):e2109633118. |
R835736 (Final) |
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| Journal Article | Ellis B, Babele P, May J, Johnson C, Pfleger B, Young J, McLean J. Molecular Gatekeeper Discovery:Workflow for Linking Multiple Exposure Biomarkers to Metabolomics br. ENVIRONMENTAL SCIENCE & TECHNOLOGY 2022;56(10):6162-6171. |
R835736 (Final) |
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| Journal Article | Gnecco JS, Anders AP, Cliffel D, Pensabene V, Rogers LM, Osteen K, Aronoff DM. Instrumenting a fetal membrane on a chip as emerging technology for preterm birth research. Current Pharmaceutical Design 2017;23(40):6115-6124. |
R835736 (2016) R835736 (2017) R835736C003 (2016) R835736C003 (2017) R835736C003 (2018) |
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| Journal Article | Gnecco JS, Pensabene V, Li DJ, Ding T, Hui EE, Bruner-Tran KL, Osteen KG. Compartmentalized culture of perivascular stroma and endothelial cells in a microfluidic model of the human endometrium. Annals of Biomedical Engineering 2017;45(7):1758-1769. |
R835736 (2017) R835736C003 (2016) |
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| Journal Article | Gnecco JS, Pensabene V, Li DJ, Ding T, Hui EE, Bruner-Tran KL, Osteen KG. Compartmentalized culture of perivascular stroma and endothelial cells in a microfluidic model of the human endometrium. Annals of Biomedical Engineering 2017;45(7):1758-1769. |
R835736 (2015) R835736 (2016) R835736C003 (2017) R835736C003 (2018) |
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| Journal Article | Gough A, Vernetti L, Bergenthal L, Shun TY, Taylor DL. The MicroPhysiology Systems Database for analyzing and modeling compound interactions with human and animal organ models. Applied In Vitro Toxicology 2016;2(2):103-117. |
R835736 (2017) |
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| Journal Article | Gough A, Vernetti L, Bergenthal L, Shun TY, Taylor DL. The MicroPhysiology Systems Database for analyzing and modeling compound interactions with human and animal organ models. Applied In Vitro Toxicology 2016;2(2):103-117. |
R835736 (2015) R835736 (2016) R835736C004 (2017) |
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| Journal Article | Hawkins K, Casolaro C, Brown JA, Edwards D, WIksow J. The Microbiome and the Gut-Liver-Brain Axis for Central Nervous System Clinical Pharmacology:Challenges in Specifying and Integrating In Vitro and In Silico Models. Clinical Pharmacology & Theraputics 2020 |
R835736 (2018) |
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| Journal Article | Hutson MS, Alexander PG, Allwardt V, Aronoff DM, Bruner-Tran KL, Cliffel DE, Davidson JM, Gough A, Markov DA, McCawley LJ, McKenzie JR, McLean JA, Osteen KG, Pensabene V, Samson PC, Senutovitch NK, Sherrod SD, Shotwell MS, Taylor DL, Tetz LM, Tuan RS, Vernetti LA, Wikswo JP. Organs-on-chips as bridges for predictive toxicology. Applied In Vitro Toxicology 2016;2(2):97-102. |
R835736 (2015) R835736 (2016) R835736 (2017) R835736C001 (2018) R835736C003 (2016) R835736C003 (2017) R835736C003 (2018) |
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| Journal Article | Hutson MS, Leung MCK, Baker NC, Spencer RM, Knudsen TB. Computational model of secondary palate fusion and disruption. Chemical Research in Toxicology 2017;30(4):965-979. |
R835736 (2015) R835736 (2016) R835736 (2017) |
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| Journal Article | Iannetti L, D'Urso G, Conoscenti G, Cutri E, Tuan RS, Raimondi MT, Gottardi R, Zunino P. Distributed and Lumped Parameter Models for the Characterization of High Throughput Bioreactors. PLoS One 2016;11(9):e0162774 (25 pp.). |
R835736 (2016) |
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| Journal Article | Kimmel DW, Rogers LM, Aronoff DM, Cliffel DE. Prostaglandin E2 regulation of macrophage innate immunity. Chemical Research in Toxicology 2016;29(1):19-25. |
R835736 (2016) R835738 (2017) |
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| Journal Article | Leung MC, Hutson MS, Seifert AW, Spencer RM, Knudsen TB. Computational modeling and simulation of genital tubercle development. Reproductive Toxicology 2016;64:151-161. |
R835736 (2015) R835736 (2016) R835736C005 (2016) |
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| Journal Article | Leung MCK, Hutson MS, Seifert AW, Spencer RM, Knudsen TB. Computational modeling and simulation of genital tubercle development. Reproductive Toxicology 2016;64:151-161. |
R835736 (2017) |
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| Journal Article | May JC, Morris CB, McLean JA. Ion mobility collision cross section compendium. Analytical Chemistry 2017;89(2):1032-1044. |
R835736 (2016) |
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| Journal Article | May J, Jurneczko E, Stow A, Kratochvil I, Kalhof S, McLean J. Conformational landscapes of ubiquitin, cytochrome c, and myoglobin: Uniform field ion mobility measurements in helium and nitrogen drift gas. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY 2018;427:79-90 |
R835736 (Final) |
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| Journal Article | Melow S, Miller D, Gizzie E, Cliffel D. A low-interference, high-resolution multianalyte electrochemical biosensor. Analytical Methods 2020;12(31):3873-3882. |
R835736 (Final) |
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| Journal Article | MHarris R, May J, Stinson C, Xia Y, McLean J. Determining Double Bond Position in Lipids Using Online Ozonolysis Coupled to Liquid Chromatography and Ion Mobility-Mass Spectrometry. ANALYTICAL CHEMISTRY 2018;90(3):1959-1924 |
R835736 (Final) |
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| Journal Article | Morris C, May J, Leaptrot K, McLean J. Evaluating Separation Selectivity and Collision Cross Section Measurement Reproducibility in Helium, Nitrogen, Argon, and Carbon Dioxide Drift Gases for Drift Tube Ion Mobility-Mass Spectrometry. JOURNAL OF THE AMERICAN SOCIETY FO MASS SPECTROMETRY 2019;30(6):1059-1068 |
R835736 (Final) |
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| Journal Article | Nichols C, May J, Sherrod S, McLead J. Automated flow injection method for the high precision determination of drift tube ion mobility collision cross sections. ANALYST 2018;143(7):1556-1559 |
R835736 (Final) |
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| Journal Article | Nichols C, Dodds J, Rose B, Piache J, Morris C, Codreau S, May J, Sherrod S, McLean J. Untargeted Molecular Discovery in Primary Metabolism: Collision Cross Section as a Molecular Descriptor in Ion Mobility-Mass Spectrometry. ANALYTICAL CHEMISTRY 2018;90(24):14484-14492 |
R835736 (Final) |
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| Journal Article | Richardson L, Gnecco J, Ding T, Osteen K, Rogers L, Arnoff DM, Menon R. Fetal Membrane Organ-On-Chip:An Innovative Approach to Study Cellular Interactions. Reproductive Sciences 2020;. |
R835736 (2018) |
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| Journal Article | Sakolish C, Luo Y, Valdiviezo A, Vernetti L, Rusyn I, Chiu W. Prediction of hepatic drug clearance with a human microfluidic four-cell liver acinus microphysiology system. Toxicology 2021;463. |
R835736 (Final) |
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| Journal Article | Sakolish C, Reese CE, Luo YS, Valdiviezo A, Schurdak ME, Gough A, Taylor DL, Chiu WA, Venetti LA, Rusyn I. Analysis of reproducibility and robustness of a human microfluidic four-cell liver acinus microphysiology system (LAMPS). Toxicology 2021;448. |
R835736 (Final) R840032 (2021) |
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| Journal Article | Schurdak M, Vernetti L, Bergenthal L, Wolter Q, Shun T, Karcher S, Taylor D, Gough A. Applications of the microphysiology systems database for experimental ADME-Tox and disease models. LAB ON A CHIP 2020;20(8):1472-1492. |
R835736 (2018) |
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| Journal Article | Senutovitch N, Vernetti L, Boltz R, DeBiasio R, Gough A, Taylor DL. Fluorescent protein biosensors applied to microphysiological systems. Experimental Biology and Medicine 2015;240(6):795-808. |
R835736 (2015) R835736 (2016) R835736C004 (2015) R835736C004 (2016) |
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| Journal Article | Soto-Gutierrez A, Gough A, Vernetti LA, Taylor DL, Monga SP. Pre-clinical and clinical investigations of metabolic zonation in liver diseases: the potential of microphysiology systems. Experimental Biology and Medicine 2017;242(16):1605-1616. |
R835736 (2017) R835736C004 (2017) |
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| Journal Article | Stocks MM, Crispens MA, Ding T, Mokshagundam S, Bruner-Tran KL, Osteen KG. Therapeutically targeting the inflammasome product in a chimeric model of endometriosis-related surgical adhesions. Reproductive Sciences 2017;24(8):1121-1128. |
R835736 (2015) R835736 (2016) |
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| Journal Article | Stow S, Onifer T, Forsythe J, Jefzger H, Keiecien N, May J, McLean J, Hercules D. Structural Characterization of Methylenedianiline Regioisomers by Ion Mobility-Mass Spectrometry and Tandem Mass Spectrometry. 4. 3-Ring and 4-Ring Isomers. ANALYTICAL CHEMISTRY 2015;87(12):6288-6296 |
R835736 (Final) |
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| Journal Article | Stow S, Causon T, Zheng X, Krulugama R, Meringer T, May J, Rennie E, Baker E, Smith R, McLean J, Hann S, Fjeldsted J. An Interlaboratory Evaluation of Drift Tube Ion Mobility-Mass Spectrometry Collision Cross Section Measurements. ANALYTICAL CHEMISTRY 2017;89(17):9048-9055 |
R835736 (Final) |
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| Journal Article | Vernetti LA, Senutovitch N, Boltz R, DeBiasio R, Shun TY, Gough A, Taylor DL. A human liver microphysiology platform for investigating physiology, drug safety, and disease models. Experimental Biology and Medicine 2016;241(1):101-114. |
R835736 (2015) R835736 (2016) R835736 (2017) R835736C004 (2015) R835736C004 (2016) R835736C004 (2017) R835736C004 (2018) |
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| Journal Article | Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. Scientific Reports 2017;7:42296 (14 pp.). |
R835736 (2017) R835736C004 (2018) R835738C002 (2017) R835738C005 (2017) |
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| Journal Article | Vernetti LA, Vogt A, Gough A, Taylor DL. Evolution of experimental models of the liver to predict human drug hepatotoxicity and efficacy. Clinics in Liver Disease 2017;21(1):197-214. |
R835736 (2015) R835736 (2016) R835736 (2017) R835736C004 (2017) R835736C004 (2018) |
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| Journal Article | Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. Scientific Reports 2017;7:42296 (15 pp.). |
R835736 (2015) R835736 (2016) R835736C004 (2016) R835736C005 (2016) R835738 (2016) R835738C003 (2017) R835738C005 (2017) |
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| Journal Article | Watson DE, Hunziker R, Wikswo JP. Fitting tissue chips and microphysiological systems into the grand scheme of medicine, biology, pharmacology, and toxicology. Experimental Biology and Medicine 2017;242(16):1559-1572. |
R835736 (2017) R835736C005 (2017) |
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| Journal Article | Miller DR, McClain ES, Cliffel DE. Electrochemical Microphysiometry Detects Cellular Glutamate Up-take. Journal of The Electrochemical Society 2018;165(12):G3120-G3124. |
R835736 (Final) R835736C005 (2018) R835736C005 (Final) |
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| Presentation | Alexander PG. VPROMPT: technological innovations. Poster presented at the Society of Toxicology 2016 Satellite Meeting: 3D or Not 3D: That is the [Predictive Toxicology] Question, New Orleans, LA, March 17, 2016. |
R835736 (2016) R835736 (2017) |
not available |
| Presentation | Arosh JA, Lee J, Meagher M, Bruner-Tran KL, Osteen KG, Banu SK. Prostaglandin E2 signaling and peripheral and central pain mechanisms in endometriosis. Poster presented at the 13th World Congress on Endometriosis, Vancouver, British Columbia, Canada, May 17-20, 2017. |
R835736 (2017) |
not available |
| Presentation | Bruner-Tran KL, Gnecco JS, Osteen KG. Exposure to an environmental endocrine disrupting chemical promotes transgenerational reproductive dysfunction. Presented at PPTOX V, 5th Conference on Prenatal Programming and Toxicity, Kitakyushu, Fukuoka, Japan, November 13-16, 2016. |
R835736 (2016) R835736 (2017) R835736C003 (2017) |
not available |
| Presentation | Bruner-Tran KL, Stocks M, Arosh JA, Osteen KG. Therapeutically targeting the inflammasome product in a chimeric model of post-surgical adhesions. Poster presented at the 13th World Congress on Endometriosis, Vancouver, British Columbia, Canada, May 17-20, 2017. |
R835736 (2017) |
not available |
| Presentation | Ding T, Archibong A, Osteen KG, Bruner-Tran KL. Paternal developmental exposure to TCDD alters the adult sperm and placental epigenome and negatively effects pregnancy outcomes in control partners. Presented at PPTOX V, 5th Conference on Prenatal Programming and Toxicity, Kitakyushu, Fukuoka, Japan, November 13-16, 2016. |
R835736 (2016) R835736 (2017) R835736C003 (2017) R835736C003 (2018) |
not available |
| Presentation | Gnecco JS, Ding TB, Pensabene V, Arosh J, Bruner-Tran KL, Osteen KG. TCDD exposure alters monocyte and macrophage behavior: a combined murine and microfluidic human cell approach to understanding the immune/endocrine microenvironment of endometriosis. Poster presented at the Annual Meeting of the Society for the Study of Reproduction, San Juan, Puerto Rico, June 18-22, 2015. |
R835736 (2016) R835736 (2017) R835736C003 (2015) R835736C003 (2017) R835736C003 (2018) |
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| Presentation | Gnecco JS, Ding TB, Pensabene V, Arosh J, Bruner-Tran KL, Osteen KG. TCDD exposure alters monocyte and macrophage behavior: a combined murine and microfluidic human cell approach to understanding the immune/endocrine microenvironment of endometriosis. Presented at the Annual Meeting of the Society for the Study of Reproduction, San Juan, Puerto Rico, June 18-22, 2015. |
R835736 (2015) R835736 (2016) R835736 (2017) |
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| Presentation | Gnecco JS, Cook C, Hill A, Pensabene V, Ding T, Aronoff D, Griffith L, Osteen KG. Implementation of PEG hydrogels for microfluidic models of the human female reproductive tract. Presented at the Infection and Immunology Symposium, Vanderbilt University Medical Center, Nashville, TN, April 8, 2016. |
R835736 (2016) R835736 (2017) R835736C003 (2017) R835736C003 (2018) |
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| Presentation | Gnecco JS, Ding T, Pensabene V, Aronoff D, Bruner-Tran KL, Osteen KG. A novel microfluidic model of the human endometrial perivascular stroma crosstalk. Poster presented at the Society for Reproductive Investigation (SRI) 63rd Annual Scientific Meeting, Montreal, Quebec, Canada, March 16-19, 2016. |
R835736 (2016) R835736 (2017) R835736C003 (2017) R835736C003 (2018) |
not available |
| Presentation | Gnecco JS, Ding T, Aronoff D, Bruner-Tran KL, Osteen KG. Exposure of human fetal membranes to dioxin ex vivo is associated with a hyperinflammatory response: potential relevance to preterm birth. Poster presented at PPTOX V, 5th Conference on Prenatal Programming and Toxicity, Kitakyushu, Fukuoka, Japan, November 13-16, 2016. |
R835736 (2016) R835736 (2017) R835736C003 (2017) R835736C003 (2018) |
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| Presentation | Gnecco JS, Ding T, Smith C, Bruner-Tran KL, Osteen KG. Shear stress-induced prostaglandins enhance progesterone action in the perivascular stroma of the human endometrium. Poster presented at the Vanderbilt Translational Research Forum, Nashville, TN, October 13, 2017. |
R835736 (2017) R835736C003 (2018) |
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| Presentation | Gough AH. A human liver microphysiology platform for investigating physiology, drug safety and disease models. Presented at the 2nd Tissue Models & Phenotypic Screening Conference, Berlin, Germany, May 5-6, 2015. |
R835736 (2016) R835736 (2017) |
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| Presentation | Gough A. Mining cellular heterogeneity for mechanistic insights in phenotypic profiling and drug discovery. Presented at the ThermoFisher Regional User Group Symposium, Cambridge, MA, October 29, 2015. |
R835736 (2016) R835736 (2017) |
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| Presentation | Gough A. Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery. Presented at the New England Cytometry User Group Meeting, Cambridge, MA, October 6, 2015. |
R835736 (2016) R835736 (2017) |
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| Presentation | Lambert LA, Ding T, Aronoff D, Osteen KG, Bruner-Tran KL. Influence of developmental toxicant exposure on infection-mediated preterm birth. Poster presented at the Vanderbilt Symposium on Infection and Immunology, Nashville, TN, April 13, 2017. |
R835736 (2017) |
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| Presentation | Markov DA, Block III FE, Brown JA, McCawley LJ, Wikswo JP. Compact mechanatronic system for the perfusion, control, analysis, and maintenance of organ-on-chip microbioreactors. Presented at SLAS2016, the 5th Annual Society for Laboratory Automation and Screening International Conference & Exhibition, San Diego, CA, January 23-27, 2016. |
R835736 (2016) R835736 (2017) R835736C001 (2016) R835736C001 (2018) |
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| Presentation | Markov DA. Advances in the development of organ-on-chip microbioreactors. Presented at the Aalborg University Medical Center, Aalborg, Denmark, June 2016. |
R835736 (2016) R835736 (2017) R835736C001 (2016) R835736C001 (2018) |
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| Presentation | Markov DA, Fryman P, McCawley LJ. Toxicant bioavailability when using low volume polymer based organ-on-a-chip bioreactors to study exposures to chemical contaminants. Poster presented at the Society of Toxicology 55th Annual Meeting & ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835736 (2016) R835736 (2017) R835736C001 (2016) R835736C001 (2018) |
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| Presentation | McCawley LJ. Physical dynamics of cancer response to chemotherapy in 3D microenvironments: a platform to examine complex physical and chemical microenvironments. Presented at the 7th Annual Symposium: Annual Physics of Cancer, Leipzig, Germany, October 4-6, 2016. |
R835736 (2016) R835736 (2017) R835736C001 (2016) R835736C001 (2017) R835736C001 (2018) |
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| Presentation | Mokshagundam S, Ding T, Lambert LA, Rinaudo P, Osteen KG, Bruner-Tran KL. Paternal developmental toxicant exposure induces transgenerational placental dysfunction. Poster presented at the Vanderbilt Translational Research Forum, Nashville, TN, October 13, 2017. |
R835736 (2017) |
not available |
| Presentation | Osteen, KG and Bruner-Tran KL. Is it in your genes or the environment? Envisioning a modifiable "endometriosis phenotype." Presented at the American Society for Reproductive Medicine Annual Meeting, International Endometriosis Association Sponsored Forum, Baltimore, MD, October 17-21, 2015. |
R835736 (2015) R835736 (2016) R835736 (2017) R835736C003 (2015) R835736C003 (2017) R835736C003 (2018) |
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| Presentation | Osteen KG, Gnecco JS, Bruner-Tran KL. Envisioning a modifiable systemic endometriosis phenotype: the future of endometriosis. Presented at the Massachusetts Institute of Technology, Cambridge, MA, July 2016. |
R835736 (2016) R835736 (2017) R835736C003 (2017) R835736C003 (2018) |
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| Presentation | Osteen KG. Building an organ-on-a-chip model of the human menstrual cycle. Presented at Rutgers University, NJ, April 2017. |
R835736 (2017) R835736C003 (2018) |
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| Presentation | Osteen K. Inflammatory triggers of the systemic endometriosis/pre-term birth phenotype. Presented at the University of California, San Diego, CA, February 2017. |
R835736 (2017) R835736C003 (2018) |
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| Presentation | Taylor DL. Human microphysiology platform for liver safety and efficacy testing. Presented at the AAPS/ITC Joint Workshop on Drug Transporters in ADME: From the Bench to the Bedside, Baltimore, MD, April 15-16, 2015. |
R835736 (2016) R835736 (2017) |
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| Presentation | Taylor DL. Potential and challenges in developing and applying 3D microtissues. Presented at SLAS2015, the 4th Annual Society for Laboratory Automation and Screening Conference & Exhibition, Washington, DC, February 7-11, 2015. |
R835736 (2016) R835736 (2017) |
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| Presentation | Taylor DL. Technology and market developments drive biotechnology company formation: a personal view. Presented at the Biotechnology Entrepreneurship Boot Camp 2015, Philadelphia, PA, June 15-18, 2015. |
R835736 (2016) R835736 (2017) |
not available |
| Presentation | Taylor DL. Human microphysiology platform for liver safety and efficacy testing. Presented at the Annual Symposium for the Johns Hopkins Digestive Diseases Basic and Translational Research Core Center, Baltimore, MD, June 2015. |
R835736 (2016) R835736 (2017) |
not available |
| Presentation | Taylor DL. Intellectual property and patents. Presented at the Scientific Ethics and the Responsible Conduct of Research Course, Pittsburgh, PA, June 2015. |
R835736 (2016) R835736 (2017) |
not available |
| Presentation | Taylor DL. Human microphysiology platform for liver efficacy and safety testing and linkage to other organ systems. Presented at the McGowan Institute for Regenerative Medicine Retreat, Nemacolin Woodlands Resort, Farmington, PA, March 8-10, 2015. |
R835736 (2016) R835736 (2017) |
not available |
| Presentation | Taylor DL. A quantitative systems biology platform for drug discovery. Presented at the Quantitative Systems Pharmacology (QSP) Congress, Boston, MA, October 20, 2015. |
R835736 (2016) R835736 (2017) |
not available |
| Presentation | Taylor DL. Implementing a quantitative systems pharmacology platform. Presented at Novartis, Pittsburgh, PA, October 2015. |
R835736 (2016) R835736 (2017) |
not available |
| Presentation | Taylor DL. Innovations in cellular imaging. Presented at Carnegie Mellon University, Pittsburgh, PA, October 2015. |
R835736 (2016) R835736 (2017) |
not available |
| Presentation | Taylor DL. Liver microphysiology system and integration with intestine and kidney MPS. Presented at GlaxoSmithKline, Collegeville, PA, October 2015. |
R835736 (2016) R835736 (2017) |
not available |
| Presentation | Taylor DL. Implementing a quantitative systems pharmacology platform for drug discovery in academia. Presented at Discovery on Target, Boston, MA, September 21-24, 2015. |
R835736 (2016) R835736 (2017) |
not available |
| Presentation | Taylor DL. [title not provided]. Presented at the University of Pittsburgh School of Medicine, Board of Visitors Meeting, Pittsburgh, PA, September 2015. |
R835736 (2016) R835736 (2017) |
not available |
| Presentation | Taylor DL. Using systems pharmacology to identify predictive responses within 3D tissue models to enhance the drug discovery process. Presented at the 3D Tissue Models Conference, San Diego, CA, August 29-31, 2016. |
R835736 (2016) R835736 (2017) |
not available |
| Presentation | Taylor DL. Evolution of a human liver MPS platform. Presented at the Society for Experimental Biology and Medicine (SEBM) Annual Meeting, Chicago, IL, April 24, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. Spatial tumor biology for phenotyping, immunotyping and recapitulating tumor microenvironments. Presented at the Melanoma Specialized Programs of Research Excellence (SPORE) Meeting at the University of Pittsburgh, Pittsburgh, PA, August 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL, Vernetti LA. Functional application of liver organotypic culture models. Presented via the EPA Virtual Tissue Models Meeting Webinar, February 22, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. Role of human liver microphysiology systems as part of a quantitative systems pharmacology platform for investigating ADMET and liver disease progression. Presented at the Eli Lilly meeting, Indianapolis, IN, July 24, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. The evolution, challenges and recent application of high content screening. Presented at the Servier Pharmaceutical Company Presentation, Paris, France, June 9, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. The next technology wave: biosensors, extreme computing, and organ chips for predicting cardiovascular toxicity. Presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. Quantitative systems pharmacology of liver diseases: human liver microphysiology system (MPS). Presented at the Astra-Zeneca Review of AZ MPS Program, Boston, MA, March 23, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. Evolution of a human liver microphysiology system. Presented at the National Center for Advancing Translational Sciences (NCATS), The National Institues of Health, Bethesda, MD, May 5, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. The application of quantitative systems pharmacology to investigate liver diseases and toxicology. Presented at the Tsinghua Seminar, Pittsburgh, PA, May 8, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. Investigating human liver disease progression with 3D microfluidic models. Presented at the High-Content Analysis and Phenotypic Screening Conference, Boston, MA, November 6, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. [title not provided]. Presented at the National Academy of Sciences Roundtable, Washington, DC, October 5, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL, Gough A. A human liver-on-a-chip as a key experimental component of the application of quantitative systems pharmacology. Presented at the Roche Seminar, Basel, Switzerland, October 6, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. Quantitative systems pharmacology (QSP) in drug discovery. Presented at the NCI Online Principles of Clinical Pharmacology Course, Pittsburgh, PA, September 18, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. Metastatic breast cancer explored in a human, 3D, microfluidic liver chip. Presented at the Charles River Conference, Boston, MA, September 26, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. Role of human liver microphysiology systems as part of a quantitative systems pharmacology platform for investigating ADMET and liver disease progression. Presented via the Health and Environmental Sciences Institute Webinar, September 5, 2017. |
R835736 (2017) R835736C004 (2017) |
not available |
| Presentation | Taylor DL. Development and application of a human, 3D, 4 cell type, microfluidic, liver model for toxicity and efficacy testing. Presented at the Drug-Induced Liver Injury (DILI) Conference XVI, East Hyattsville, MD, March 23-24, 2016. |
R835736 (2016) R835736 (2017) |
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| Presentation | Tuan R. Adult stem cells and biomimetic materials for tissue engineering and modeling: repair, restore, and create. Presented at the 13th Annual Meeting of the International Federation for Adipose Therapeutics and Science (IFATS), New Orleans, LA, November 5-8, 2015 (keynote). |
R835736 (2016) R835736 (2017) R835736C002 (2015) R835736C002 (2016) |
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| Presentation | Tuan R. Adult stem cells and biomimetic materials for tissue engineering and modeling: repair, restore, and re-create. Presented at the American Society for Investigative Pathology PISA 2015 - Pathways to Translational Medicine: Recent Advances in Cell Injury, Inflammation, and Neoplasia, Baltimore, MD, October 8-10, 2015 (keynote). |
R835736 (2015) R835736 (2016) R835736 (2017) R835736C002 (2015) R835736C002 (2016) |
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| Presentation | Vernetti LA. Development of an integrated liver microphysiological system. Presented at the 20th North American International Society for the Study of Xenobiotics (ISSX) Meeting, Orlando, FL, October 18-22, 2015. |
R835736 (2016) R835736 (2017) R835736C004 (2018) |
not available |
| Presentation | Vernetti LA. Predicting human toxicity from MOA based high content imaging in 2D and 3D microphysiology systems. Presented at Thermo Fisher, Princeton, NJ, October 13, 2016. |
R835736 (2016) R835736 (2017) R835736C004 (2018) |
not available |
| Presentation | Vernetti L. Application and challenges to constructing a competent human liver on a chip. Presented at the Society of Toxicology 2016 Satellite Meeting 3D or Not 3D: That is the [Predictive Toxicology] Question, New Orleans, LA, March 17, 2016 (invited). |
R835736 (2016) R835736 (2017) R835736C004 (2018) |
not available |
| Presentation | Wikswo JP. Nanoscience and biology: connecting nano to micro and milli for in vitro interrogation and control. Presented at the NSF-sponsored Annual Nanoscale Science and Engineering Grantees Conference, Arlington, VA, December 9-10, 2015 (invited). |
R835736 (2015) R835736C005 (2015) |
not available |
| Presentation | Wikswo JP. Organs on chips: bioreactors, sensors, controls and interconnects to support constructionist biology. Presented to the Department of Biomedical Engineering, Northwestern University, Evanston, IL, April 27-28, 2016 (invited). |
R835736 (2016) R835736 (2017) R835736C005 (2016) |
not available |
| Presentation | Wikswo JP. Hands on with organ-on-a-chip workshop. Presented at the 3D Tissue Models Conference, San Diego, CA, August 29-31, 2016 (invited). |
R835736 (2016) R835736C005 (2016) |
not available |
| Presentation | Wikswo JP. In vitro modeling of the blood brain barrier using complex 3D models. Presented at the 3D Tissue Models Conference, San Diego, CA, August 29-31, 2016 (invited). |
R835736 (2016) R835736 (2017) R835736C005 (2016) |
not available |
| Presentation | Wikswo JP. Organs-on-chips, metabolomics, systems biology, and closing the hermeneutic circle of biology. Presented at the University of Tennessee Health Science Center, Memphis, TN, December 15, 2016 (invited). |
R835736 (2017) R835736C005 (2016) |
not available |
| Presentation | Wikswo JP. Organs on chips for drug development, toxicology, and systems biology: a distributed yet interconnected modular approach. Presented at the Organ-on-a-Chip World Congress 2016 & 3D-Culture, Boston, MA, July 7-8, 2016 (invited). |
R835736 (2016) R835736 (2017) R835736C005 (2016) |
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| Presentation | Wikswo JP. Human neurovascular unit on-a-chip: microscale systems for tissue-level response. Presented at the 56th Annual Meeting of the Teratology Society, San Antonio, TX, June 25-29, 2016 (invited). |
R835736 (2016) R835736 (2017) R835736C005 (2016) |
not available |
| Presentation | Wikswo JP. Probing the complexities of biology and medicine: closing the hermeneutic circle with in vitro and in silico models. Presented at the Eighth Scientific Meeting of the TMJ Association, Bethesda, MD, September 11-13, 2016 (invited). |
R835736 (2016) R835736 (2017) R835736C005 (2016) |
not available |
| Presentation | Wikswo JP. Hormonal modulation of organs-on-chips to recapitulate in vivo ADME tox profiles in vitro. Presented at the 3D Tissue Models Summit, Boston, MA, August 29-30, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
not available |
| Presentation | Wikswo JP. Organs-on-chips: a developer's masterclass. Presented at the 3D Tissue Models Summit, Boston, MA, August 29-30, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
not available |
| Presentation | Wikswo JP. Modular architectures and control strategies for coupled microphysiological systems. Presented at Eli Lilly, Indianapolis, IN, January 4, 2017 (invited). |
R835736 (2016) R835736 (2017) R835736C005 (2016) R835736C005 (2017) |
not available |
| Presentation | Wikswo JP. Fitting iPSCs, 3D cell culture, tissue chips and microphysiological systems into the grand scheme of biology, medicine, pharmacology, and toxicology. Presented at the Select Biosciences Organ-on-a-Chip World Congress & 3D-Culture Conference, Boston. MA, July 10, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
not available |
| Presentation | Wikswo JP. Scientific and technical strengths and limitations of MPS for drug toxicity testing. Presented at The Toxicology Forum 43rd Annual Summer Meeting, Annapolis, MD, July 12, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
not available |
| Presentation | Wikswo JP. Analytical chemistry for understanding the physiology and pathology of 3D cellular models. Presented at the World Preclinical Congress, Boston, MA, June 13-15, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
not available |
| Presentation | Wikswo JP. Multichannel microformulators suitable for massively parallel automated design of biological experiments. Presented at the American Physical Society Meeting, New Orleans, LA, March 13-17, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
not available |
| Presentation | Wikswo JP. Topologies, analytics, and automation for microphysiological systems. Presented at the Select Biosciences Organ-on-a-Chip Europe Conference, Munich, Germany, May 10-11, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
not available |
| Presentation | Wikswo JP. Organs on chips for oncology research: neurovascular unit, support hardware, and analytics. Presented at the Physical Sciences Oncology Network Annual Meeting, Koch Institute, MIT, Boston, MA, October 17-19, 2017. |
R835736 (2017) |
not available |
| Presentation | Wikswo JP. Strengths, limitations and applications of microphysiological systems for drug development. Presented at the FDA Toxicology Working Group Meeting, Washington, DC, October 26, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
not available |
| Presentation | Yu S, Tan J, Clark K, Alexander PG, Tuan R. High density human stem cell micromass to model teratogen-induced limb malformations. Poster presented at the Society of Toxicology 55th Annual Meeting & ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835736 (2016) R835736 (2017) |
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| Video | Cohn S. Endo what? Educational documentary video, 55 minutes, 2016. |
R835736 (2016) |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.