Selected Publications for Center:

The Center for Study of Neurodevelopment and Improving Children's Health

Grant Number R835437

Book Chapter (6)
Journal Article (48)
Reference Type Citation Progress Report Year Document Sources
Book Chapter Levin ED. Developmental toxicology and children’s environmental health. In: Landrigan PJ, Etzel RA, eds. Textbook of Children’s Environmental Health. New York, NY: Oxford University Press, December 13, 2013, Chapter 9, pp. 83-88.
abstract available    
R835437 (2014)
R835437 (Final)
Book Chapter Levin ED. Chronic nicotine effects on memory and nicotine self-administration: age of exposure is key. In: Aschner M, Costa LG, eds. Advances in Neurotoxicology, Volume 2, San Diego, CA: Academic Press, 2018, Chapter 6, pp. 189-196.
abstract available    
R835437 (2017)
R835437 (Final)
Book Chapter Levin ED, Abreu-Villaca Y. Developmental neurotoxicity of nicotine and tobacco. In: Slikker Jr. W, Paule MG,Wang C, eds. Handbook of Developmental Neurotoxicology, 2nd Edition, San Diego, CA: Academic Press, 2018, Chapter 39, pp. 439-452.
abstract available    
R835437 (2017)
R835437 (Final)
Book Chapter Moylan CA, Murphy SK. DNA methylation: basic principles. In: Tollefsbol T, ed. Medical Epigenetics. London: Elsevier, Academic Press, 2016, Chapter 2, pp. 11-31.
abstract available    
R835437 (2015)
R835437 (Final)
Book Chapter Taylor MM, Murphy SK. Systems biology and the epigenome. In: Fry R, ed. Systems Biology in Toxicology and Environmental Health. Amsterdam: Elsevier, Academic Press, 2015, Chapter 3, pp. 43-56.
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R835437 (2014)
R835437 (Final)
Book Chapter Levin ED, Y Abreu-Villaça. Developmental neurotoxicity of nicotine and tobacco. In Handbook of Developmental Neurotoxicology, (C. Wang, M. Paule, and W. Slikker, Jr. eds.), Academic Press, San Diego, 2017, 439-452 pp
abstract available    
R831711 (Final)
R835437 (2016)
Journal Article Breton CV, Marsit CJ, Faustman E, Nadeau K, Goodrich JM, Dolinoy DC, Herbstman J, Holland N, LaSalle JM, Schmidt R, Yousefi P, Perera F, Joubert BR, Wiemels J, Taylor M, Yang IV, Chen R, Hew KM, Freeland DM, Miller R, Murphy SK. Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. Environmental Health Perspectives 2017;125(4):511-526.
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R835432 (2016)
R835432 (2017)
R835436 (Final)
R835437 (Final)
R835442 (2017)
R836159 (Final)
Journal Article Breton CV, Marsit CJ, Faustman E, Nadeau K, Goodrich JM, Dolinoy DC, Herbstman J, Holland N, LaSalle JM, Schmidt R, Yousefi P, Perera F, Joubert BR, Wiemels J, Taylor M, Yang IV, Chen R, Hew KM, Freeland DM, Miller R, Murphy SK. Small-magnitude effect sizes in epigenetic end points are important in children's environmental health studies:the Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. Environmental Health Perspectives 2017;125(4):511-526.
abstract available     full text available
R835436 (2017)
R835437 (Final)
R836159 (2018)
RD834515 (Final)
Journal Article Breton CV, Marsit CJ, Faustman E, Nadeau K, Goodrich JM, Dolinoy DC, Herbstman J, Holland N, LaSalle JM, Schmidt R, Yousefi P, Perera F, Joubert BR, Wiemels J, Taylor M, Yang IV, Chen R, Hew KM, Hussey Freeland DM, Miller R, Murphy SK. Small-magnitude effect sizes in epigenetic end points are important in children’s environmental health studies: the Children’s Environmental Health and Disease Prevention Research Center’s Epigenetics Working Group. Environmental Health Perspectives 2017;125(4):511-526.
abstract available     full text available
R835437 (2017)
Journal Article Small Magnitude Effect Sizes in Epigenetic Endpoints are Important in Children's Environmental Health Studies:The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. Environmental Health Perspectives 2017; 125(4):511-526.
abstract available    
R835436 (Final)
R835437 (2016)
R835437 (Final)
Journal Article Cauley M, Hall BJ, Abreu-Villaca Y, Junaid S, White H, Kiany A, Slotkin TA, Levin ED. Critical developmental periods for effects of low-level tobacco smoke exposure on behavioral performance. Neurotoxicology 2018;68:81-87.
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R835437 (2017)
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Journal Article Fleisch AF, Kloog I, Luttmann-Gibson H, Gold DR, Oken E, Schwartz JD. Air pollution exposure and gestational diabetes mellitus among pregnant women in Massachusetts: a Cohort Study. Environmental Health 2016;15(1):40 (9 pp.).
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R834798 (2016)
R834798 (Final)
R834798C004 (Final)
R835437 (Final)
Journal Article Fleisch AF, Kloog I, Luttmann-Gibson H, Gold DR, Oken E, and Schwartz JD. Air Pollution Exposure and Gestational Diabetes Mellitus Among Pregnant Women in Massachusetts:a Cohort Study. Environmental Health 2016; 15:40-48.
R834798C005 (Final)
R835437 (2016)
Journal Article Fuemmeler BF, Wang L, Iversen ES, Maguire R, Murphy SK, Hoyo C. Association between prepregnancy body mass index and gestational weight gain with size, tempo, and velocity of infant growth: analysis of the Newborn Epigenetic Study cohort. Childhood Obesity 2016;12(3):210-218.
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R835437 (2015)
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Journal Article Fuemmeler BF, Lee CT, Soubry A, Iversen ES, Huang Z, Murtha AP, Schildkraut JP, Jirtle RL, Murphy SK, Hoyo C. DNA methylation of regulatory regions of imprinted genes at birth and its relation to infant temperament. Genetics and Epigenetics 2016;8:59-67.
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Journal Article Fuemmeler BF, Zucker N, Sheng Y, Sanchez CE, Maguire R, Murphy SK, Kollins SH, Hoyo C. Pre-Pregnancy Weight and Symptoms of Attention Deficit Hyperactivity Disorder and Executive Functioning Behaviors in Preschool Children. International Journal of Environmental Research and Public Health 2019 Feb;16(4):667-681. doi:10.3390/ijerph16040667. PubMed PMID:30823531; PubMed Central PMCID:PMC6406951.
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R835437 (Final)
Journal Article Gao L, Liu X, Millstein J, Siegmund KD, Dubeau L, Maguire RL, Zhang JJ, Fuemmeler BF, Kollins SH, Hoyo C, Murphy SK, Breton CV. Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes. Clinical Epigenetics 2018;10(1):98 (11 pp.).
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Journal Article Green AJ, Hoyo C, Mattingly CJ, Luo Y, Tzeng JY, Murphy SK, Buchwalter DB, Planchart A. Cadmium exposure increases the risk of juvenile obesity:a human and zebrafish comparative study. International Journal of Obesity (London) 2018 Jul;42(7):1285-1295. doi:10.1038/s41366-018-0036-y. PubMed PMID:29511319; PubMed Central PMCID:PMC6054604.
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R835437 (Final)
Journal Article Hall BJ, Cauley M, Burke D, Kiany A, Slotkin TA, Levin ED. Cognitive and behavioral impairments evoked by low-level exposure to tobacco smoke components: comparison with nicotine alone. Toxicological Sciences 2016;151(2):236-244.
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Journal Article Hall BJ, Abreu-Villaca Y, Cauley M, Junaid S, White H, Kiany A, Levin ED. The ventral hippocampal muscarinic cholinergic system plays a key role in sexual dimorphisms of spatial working memory in rats. Neuropharmacology 2017;117:106-113.
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Journal Article Hawkey A, Junaid S, Yao L, Spiera Z, White H, Cauley M, Levin ED. Gestational exposure to nicotine and/or benzo[a]pyrene causes long-lasting neurobehavioral consequences. Birth Defects Research 2019 Jul 31. doi:10.1002/bdr2.1568. [Epub ahead of print] PubMed PMID:31368242.
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R835437 (Final)
Journal Article House JS, Mendez M, Maguire RL, Gonzalez-Nahm S, Huang Z, Daniels J, Murphy SK, Fuemmeler BF, Wright FA, Hoyo C. Periconceptional Maternal Mediterranean Diet Is Associated With Favorable Offspring Behaviors and Altered CpG Methylation of Imprinted Genes. Frontiers in Cell and Developmental Biology 2018 Sep 7;6:107. doi:10.3389/fcell.2018.00107. eCollection 2018. PubMed PMID:30246009; PubMed Central PMCID:PMC6137242.
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R835437 (Final)
Journal Article King KE, Kane JB, Scarbrough P, Hoyo C, Murphy SK. Neighborhood and family environment of expectant mothers may influence prenatal programming of adult cancer risk: discussion and an illustrative DNA methylation example. Biodemography and Social Biology 2016;62(1):87-104.
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Journal Article Lee W-C, Shen L, Catalano PJ, Mickley LJ, and Koutrakis P. Effects of Future Temperature Change on PM2.5 Infiltration in the Greater Boston Area. Atmospheric Environment 2017;150:98-105.
abstract available    
R835437 (2016)
Journal Article Lee W-C, Shen L, Catalano PJ, Mickley LJ, Koutrakis P. Effects of future temperature change on PM2.5 infiltration in the Greater Boston area. Atmospheric Environment 2017;150:98-105.
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R834798 (Final)
R835437 (Final)
R835755 (2016)
R835755 (2017)
R835755 (Final)
Journal Article Levin ED. Learning about cognition risk with the radial-arm maze in the developmental neurotoxicology battery. Neurotoxicology and Teratology 2015;52(Pt A):88-92.
abstract available     full text available
R835437 (2014)
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Journal Article Murphy SK, Erginer E, Huang Z, Visco Z, Hoyo C. Genotype-epigenotype interaction at the IGF2 DMR. Genes 2015;6(3):777-789.
abstract available     full text available
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Journal Article Nye MD, Fry RC, Hoyo C, Murphy SK. Investigating epigenetic effects of prenatal exposure to toxic metals in newborns: challenges and benefits. Medical Epigenetics 2014;2(1):53-59.
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Journal Article Nye MD, Hoyo C, Murphy SK. In vitro lead exposure changes DNA methylation and expression of IGF2 and PEG1/MEST. Toxicology In Vitro 2015;29(3):544-550.
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Journal Article Nye MD, King KE, Darrah TH, Maguire R, Jima DD, Huang Z, Mendez MA, Fry RC, Jirtle RL, Murphy SK, Hoyo C. Maternal blood lead concentrations, DNA methylation of MEG3 DMR regulating the DLK1/MEG3 imprinted domain and early growth in a multiethnic cohort. Environmental Epigenetics 2016;2(1):1-8.
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Journal Article Schechter JC, Kollins SH. Prenatal smoke exposure and ADHD: advancing the field. Pediatrics 2017;139(2):e20163481 (2 pp.).
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Journal Article Schechter JC, Fuemmeler, BF, Hoyo C, Murphy SK, Zhang JJ, Kollins SH. Impact of smoking ban on passive smoke exposure in pregnant non-smokers: using cotinine as a biomarker of exposure. International Journal of Environmental Research and Public Health 2018;15(1):E83 (16 pp.).
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Journal Article Slotkin TA, Card J, Seidler FJ. Adverse benzo[a]pyrene effects on neurodifferentiation are altered by other neurotoxicant coexposures: interactions with dexamethasone, chlorpyrifos, or nicotine in PC12 cells. Environmental Health Perspectives 2013;121(7):825-831.
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Journal Article Slotkin TA, Card J, Seidler FJ. Nicotine administration in adolescence reprograms the subsequent response to nicotine treatment and withdrawal in adulthood: sex-selective effects on cerebrocortical serotonergic function. Brain Research Bulletin 2014;102:1-8.
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Journal Article Slotkin TA, Card J, Stadler A, Levin ED, Seidler FJ. Effects of tobacco smoke on PC12 cell neurodifferentiation are distinct from those of nicotine or benzo[a]pyrene. Neurotoxicology and Teratology 2014;43:19-24.
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Journal Article Slotkin TA, Skavicus S, Card J, Levin ED, Seidler FJ. Amelioration strategies fail to prevent tobacco smoke effects on neurodifferentiation: nicotinic receptor blockade, antioxidants, methyl donors. Toxicology 2015;333:63-75.
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Journal Article Slotkin TA, Skavicus S, Card J, Stadler A, Levin ED, Seidler FJ. Developmental neurotoxicity of tobacco smoke directed toward cholinergic and serotonergic systems: more than just nicotine. Toxicological Sciences 2015;147(1):178-189.
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Journal Article Slotkin TA, Stadler A, Skavicus S, Seidler FJ. Adolescents and adults differ in the immediate and long-term impact of nicotine administration and withdrawal on cardiac norepinephrine. Brain Research Bulletin 2016;122:71-75.
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R835437 (2015)
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Journal Article Slotkin TA, Skavicus S, Card J, Levin ED, Seidler FJ. Diverse neurotoxicants target the differentiation of embryonic neural stem cells into neuronal and glial phenotypes. Toxicology 2016;372:42-51.
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Journal Article Slotkin TA, Stadler A, Skavicus S, Card J, Ruff J, Levin ED, Seidler FJ. Is there a critical period for the developmental neurotoxicity of low-level tobacco smoke exposure? Toxicological Sciences 2017;155(1):75-84.
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Journal Article Slotkin TA, Skavicus S, Ko A, Levin ED, Seidler FJ. Corrigendum to "The Developmental Neurotoxicity of Tobacco Smoke Can Be Mimicked by a Combination of Nicotine and Benzo[a]pyrene:Effects on Cholinergic and Serotonergic Systems. Toxicological Sciences 2019 Mar 1;168(1):280. doi:10.1093/toxsci/kfy304. PubMed PMID:30615185.
R835437 (Final)
Journal Article Slotkin, T.A., Stadler, A., Skavicus, S., Card, J., Ruff, J., Levin, E.D., Seidler, F.J. 2016. Is there a critical period for the developmental neurotoxicity of low-level tobacco smoke exposure? Toxicological Sciences. DOW:10.1093.
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R835437 (Final)
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Journal Article Smeester L, Yosim AE, Nye MD, Hoyo C, Murphy SK, Fry RC. Imprinted genes and the environment: links to the toxic metals arsenic, cadmium, lead and mercury. Genes 2014;5(2):477-496.
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Journal Article Sorrow P, Maguire R, Murphy SK, Belcher SM, Hoyo C. Elevated metabolites of acetaminophen in cord blood of children with obesity. Pediatr Obes. 2019 Jan;14(1). doi:10.1111/ijpo.12465. Epub 2018 Sep 25. PubMed PMID:30253079.
R835437 (Final)
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Journal Article Soubry A, Hoyo C, Jirtle RL, Murphy SK. A paternal environmental legacy: evidence for epigenetic inheritance through the male germ line. BioEssays 2014;36(4):359-371.
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Journal Article Tindula G, Murphy SK, Grenier C, Huang Z, Huen K, Escudero-Fung M, Bradman A, Eskenazi B, Hoyo C, Holland N. DNA methylation of imprinted genes in Mexican-American newborn children with prenatal phthalate exposure. Epigenomics 2018;10(7):1011-1026.
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Journal Article Vidal AC, Benjamin Neelon SE, Liu Y, Tuli AM, Fuemmeler BF, Hoyo C, Murtha AP, Huang Z, Schildkraut J, Overcash F, Kurtzberg J, Jirtle RL, Iversen ES, Murphy SK. Maternal stress, preterm birth, and DNA methylation at imprint regulatory sequences in humans. Genetics and Epigenetics 2014;6:37-44.
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Journal Article Barry CM, Sabhlok A, Saba VC, Majors AD, Schechter JC, Levine EL, Streicher M, Bennett GG, Kollins SH, Fuemmeler BF. An Automated Text-Messaging Platform for Enhanced Retention and Data Collection in a Longitudinal Birth Cohort:Cohort Management Platform Analysis. JMIR Public Health Surveillance 2019 Apr 2;5(2):e11666. doi:10.2196/11666. PubMed PMID:30938689; PubMed Central PMCID:PMC6465978.
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R835437 (Final)
Journal Article Dozmorov MG, Bilbo SD, Kollins SH, Zucker N, Do EK, Schechter JC, Zhang JJ, Murphy SK, Hoyo C, Fuemmeler BF. Associations between maternal cytokine levels during gestation and measures of child cognitive abilities and executive functioning. Brain Behavior, and Immunity 2018;70:390-397. doi:10.1016/j.bbi.2018.03.029. PubMed PMID:29588230; PubMed Central PMCID:PMC6471612.
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R835437 (Final)
Journal Article Gonzalez-Nahm S, Mendez MA, Benjamin-Neelon SE, Murphy SK, Hogan VK, Rowley DL, Hoyo C. DNA methylation of imprinted genes at birth is associated with child weight status at birth, 1 year, and 3 years.Clinical Epigenetics 2018 Jun 28;10:90. doi:10.1186/s13148-018-0521-0. eCollection 2018. PubMed PMID:29988473; PubMed Central PMCID:PMC6025828.
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Journal Article Schechter J, Do EK, Zhang JJ, Hoyo C, Murphy SK, Kollins SH, Fuemmeler B. Effect of Prenatal Smoke Exposure on Birth Weight:The Moderating Role of Maternal Depressive Symptoms. Nicotine and Tobacco Research 2018 Dec 24. doi:10.1093/ntr/nty267. [Epub ahead of print] PubMed PMID:30590728.
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Journal Article Martin CL, Jima D, Sharp GC, McCullough LE, Park SS, Gowdy KM, Skaar D, Cowley M, Maguire RL, Fuemmeler B, Collier D, Relton CL, Murphy SK, Hoyo C. Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood:an epigenome-wide association study. Epigenetics 2019 Apr;14(4):325-340. doi:10.1080/15592294.2019.1581594. Epub 2019 Mar 26. PubMed PMID:30773972; PubMed Central PMCID:PMC6557549.
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R835437 (Final)
Journal Article Hawkey AB, White H, Pippen E, Greengrove E, Rezvani AH, Murphy SK, Levin ED. Paternal nicotine exposure in rats produces long-lasting neurobehavioral effects in the offspring. Neurotoxicology and Teratology. 2019 Jul-Aug;74:106808. doi:10.1016/j.ntt.2019.05.001. Epub 2019 May 16. PubMed PMID:31103693; PubMed Central PMCID:PMC6642846.
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R835437 (Final)
Journal Article Slotkin TA, Skavicus S, Ko A, Levin ED, Seidler FJ. The Developmental Neurotoxicity of Tobacco Smoke Can Be Mimicked by a Combination of Nicotine and Benzo[a]Pyrene:Effects on Cholinergic and Serotonergic Systems. Toxicological Sciences 2019 Jan 1;167(1):293-304. doi:10.1093/toxsci/kfy241. Erratum in:Toxicological Sciences 2019 Mar 1;168(1):280. PubMed PMID:30247698; PubMed Central PMCID:PMC6681680.
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R835437 (Final)