Grantee Research Project Results
Final Report: Research Project C: Perinatal Environmental Exposure Disparity and Neonatal Respiratory Health
EPA Grant Number: R833293C003Subproject: this is subproject number 003 , established and managed by the Center Director under grant R833293
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: The Center for Study of Neurodevelopment and Improving Children's Health
Center Director: Murphy, Susan K.
Title: Research Project C: Perinatal Environmental Exposure Disparity and Neonatal Respiratory Health
Investigators: Auten, Richard , Foster, W. Michael
Institution: Duke University
EPA Project Officer: Callan, Richard
Project Period: May 1, 2007 through April 30, 2012 (Extended to April 30, 2014)
RFA: Centers for Children’s Environmental Health and Disease Prevention Research (2005) RFA Text | Recipients Lists
Research Category: Human Health , Children's Health
Objective:
- To determine whether maternal exposure to airborne particulates (PM) and/or ozone (1st hit) restricts fetal growth and/or postnatal growth, and impairs lung development/function in newborn mice;
- To determine whether PM and/or ozone exposure re-programs maternal inflammatory responses;
- To determine whether postnatal (2nd hit) ozone exposure further impairs postnatal somatic and lung development/function following maternal PM and/or ozone exposures;
- To determine whether genetic or developmental susceptibility to airway hyperreactivity exacerbates maternal and/or postnatal exposure effects on postnatal somatic and lung development/function.
Summary/Accomplishments (Outputs/Outcomes):
Journal Articles on this Report : 6 Displayed | Download in RIS Format
Other subproject views: | All 18 publications | 6 publications in selected types | All 6 journal articles |
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Other center views: | All 163 publications | 77 publications in selected types | All 76 journal articles |
Type | Citation | ||
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Auten RL, Foster WM. Biochemical effects of ozone on asthma during postnatal development. Biochimica et Biophysica Acta 2011;1810(11):1114-1119. |
R833293 (2009) R833293 (2010) R833293 (Final) R833293C003 (2010) R833293C003 (Final) |
Exit |
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Block ML, Elder A, Auten RL, Bilbo SD, Chen H, Chen J-C, Cory-Slechta DA, Costa D, Diaz-Sanchez D, Dorman DC, Gold DR, Gray K, Jeng HA, Kaufman JD, Kleinman MT, Kirshner A, Lawler C, Miller DS, Nadadur SS, Ritz B, Semmens EO, Tonelli LH, Veronesi B, Wright RO, Wright RJ. The outdoor air pollution and brain health workshop. NeuroToxicology 2012;33(5):972-984. |
R833293 (2011) R833293 (2012) R833293 (Final) R833293C003 (2011) R833293C003 (Final) |
Exit Exit Exit |
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Bolton JL, Smith SH, Huff NC, Gilmour MI, Foster WM, Auten RL, Bilbo SD. Prenatal air pollution exposure induces neuroinflammation and predisposes offspring to weight gain in adulthood in a sex-specific manner. FASEB Journal 2012;26(11):4743-4754. |
R833293 (2011) R833293 (Final) R833293C003 (2011) R833293C003 (Final) |
Exit Exit Exit |
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Bolton JL, Huff NC, Smith SH, Mason SN, Foster WM, Auten RL, Bilbo SD. Maternal stress and effects of prenatal air pollution on offspring mental health outcomes in mice. Environmental Health Perspectives 2013;121(9):1075-1082. |
R833293 (2012) R833293 (Final) R833293C003 (Final) |
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Brown JS, Graham JA, Chen LC, Postlethwait EM, Ghio AJ, Foster WM, Gordon T. Panel discussion review: session four--assessing biological plausibility of epidemiological findings in air pollution research. Journal of Exposure Science and Environmental Epidemiology 2007;17(Suppl 2):S97-S105. |
R833293 (2007) R833293 (2008) R833293 (Final) R833293C003 (Final) |
Exit Exit |
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Miranda ML, Edwards SE, Chang HH, Auten RL. Proximity to roadways and pregnancy outcomes. Journal of Exposure Science & Environmental Epidemiology 2013;23(1):32-38. |
R833293 (2011) R833293 (2012) R833293 (Final) R833293C001 (2011) R833293C001 (Final) R833293C002 (2011) R833293C002 (Final) R833293C003 (2011) R833293C003 (Final) |
Exit Exit |
Supplemental Keywords:
airway hyperreactivity, diesel exhaust particles, air pollution, lung function, epigenetic, innate immunity, Nqo1, neuroinflammation, maternal stressProgress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R833293 The Center for Study of Neurodevelopment and Improving Children's Health Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R833293C001 Research Project A: Mapping Disparities in Birth Outcomes
R833293C002 Research Project B: Healthy Pregnancy, Healthy Baby: Studying Racial Disparities in Birth Outcomes
R833293C003 Research Project C: Perinatal Environmental Exposure Disparity and Neonatal Respiratory Health
R833293C004 Community Outreach and Translation Core
R833293C005 Geographic Information System and Statistical Analysis Core
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
6 journal articles for this subproject
Main Center: R833293
163 publications for this center
76 journal articles for this center