Grantee Research Project Results

Research Project C: Perinatal Environmental Exposure Disparity and Neonatal Respiratory Health

EPA Grant Number: R833293C003
Subproject: this is subproject number 003 , established and managed by the Center Director under grant R833293
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: The Center for Study of Neurodevelopment and Improving Children's Health
Center Director: Murphy, Susan K.
Title: Research Project C: Perinatal Environmental Exposure Disparity and Neonatal Respiratory Health
Investigators: Auten, Richard , Foster, W. Michael
Institution: Duke University
EPA Project Officer: Callan, Richard
Project Period: May 1, 2007 through April 30, 2012 (Extended to April 30, 2014)
RFA: Centers for Children’s Environmental Health and Disease Prevention Research (2005) RFA Text | Recipients Lists
Research Category: Human Health , Children's Health

Objective:

To determine whether maternal exposure to airborne particulates (PM) and/or ozone (1st hit) restricts fetal growth and/or postnatal growth, and impairs lung development/function in newborn mice;
To determine whether PM and/or ozone exposure ‘re-programs’ maternal inflammatory responses;
To determine whether postnatal (2nd hit) ozone exposure further impairs postnatal somatic and lung development/function following maternal PM and/or ozone exposures;
To determine whether genetic or developmental susceptibility to airway hyperreactivity exacerbates maternal and/or postnatal exposure effects on postnatal somatic and lung development/function.

Publications and Presentations:

Publications have been submitted on this subproject: View all 18 publications for this subproject | View all 163 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 6 journal articles for this subproject | View all 76 journal articles for this center

Supplemental Keywords:

Airway hyperreactivity, diesel exhaust particles, air pollution, lung function,

Progress and Final Reports:

Main Center Abstract and Reports:

R833293 The Center for Study of Neurodevelopment and Improving Children's Health

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R833293C001 Research Project A: Mapping Disparities in Birth Outcomes
R833293C002 Research Project B: Healthy Pregnancy, Healthy Baby: Studying Racial Disparities in Birth Outcomes
R833293C003 Research Project C: Perinatal Environmental Exposure Disparity and Neonatal Respiratory Health
R833293C004 Community Outreach and Translation Core
R833293C005 Geographic Information System and Statistical Analysis Core

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.