Grantee Research Project Results
Final Report: Research Project B: Healthy Pregnancy, Healthy Baby: Studying Racial Disparities in Birth Outcomes
EPA Grant Number: R833293C002Subproject: this is subproject number 002 , established and managed by the Center Director under grant R833293
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: The Center for Study of Neurodevelopment and Improving Children's Health
Center Director: Murphy, Susan K.
Title: Research Project B: Healthy Pregnancy, Healthy Baby: Studying Racial Disparities in Birth Outcomes
Investigators: Williams, Redford , Miranda , Marie Lynn , Ashley-Koch, Allison , Gibson-Davis, Christina , Swamy, Geeta , Reiter, Jerome , Maxson, Pamela
Institution: Duke University
EPA Project Officer: Callan, Richard
Project Period: May 1, 2007 through April 30, 2012 (Extended to April 30, 2014)
RFA: Centers for Children’s Environmental Health and Disease Prevention Research (2005) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
- Conduct a cohort study of pregnant women in Durham, NC, designed to correlate birth weight, gestation, and birth weight x gestation with environmental, social, and host factors;
- Develop community-level measures of environmental and social factors by inventorying neighborhood quality and the built environment in partnership with local community groups;
- Create a comprehensive data architecture, spatially resolved at the tax parcel level, of environmental, social, and host factors affecting pregnant women by linking data from the cohort study and neighborhood assessments with additional environmental and socioeconomic data; and
- Determine whether and to what extent differential exposures explain health disparities in birth outcomes by applying innovative spatial and genetic statistical methods to:
- Identify environmental, social, and host factors that cluster to predict birth outcomes in the entire sample;
- Determine whether these clusters are more or less present in African-American versus white populations and quantify the proportion of health disparities explained by differences in cluster frequency; and
- Identify environmental, social, and host factors that cluster to predict birth outcomes within the African-American and white sub-samples and compare these clusters across racial groups.
Summary/Accomplishments (Outputs/Outcomes):
- Psychosocial measures: CES-D, perceived stress, self-efficacy, interpersonal support, paternal support, perceived racism, perceived community standing, pregnancy intention, John Henryism Active Coping Scale, NEO Five Factor Inventory of personality.
- Environmental exposure survey measures: short survey on fish consumption, smoking pattern and exposure to second-hand smoke, and drinking water source.
- Maternal and neonatal medical record abstraction: detailed pre-pregnancy medical and social history, antepartum complications, birth outcomes, and neonatal complications.
- Blood samples for genetic and environmental analysis to assess candidate genes related to environmental contaminant (nicotine, cotinine, cadmium, lead, mercury, arsenic, and manganese) metabolism, inflammation, vascular dysfunction, and stress response.
- Cord blood and placental samples currently are being stored for future genetic analysis and evaluation of activity at the maternal-fetal interface.
Residential mobility. With our access to the North Carolina Detailed Birth Record (DBR) in Project A (R833293C001), we have been able to link participants in Project B (R833293C002) with their birth certificate data. Using maternal and infant identifying information, including name, place, and date of birth, we have been able to link 991 (99.9%) of participants who completed the study and had a live birth by December 31, 2008, and 59 (76.6%) of participants who were lost-to-follow-up but with an expected delivery date on or before December 31, 2008. This linkage allowed us to determine who is moving during pregnancy (by comparing the address at enrollment and the DBR address at delivery) and the nature of those moves, including the quality of the new location compared to the previous location (and thus changes in environment or exposure).
Journal Articles on this Report : 26 Displayed | Download in RIS Format
Other subproject views: | All 51 publications | 26 publications in selected types | All 26 journal articles |
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Other center views: | All 163 publications | 77 publications in selected types | All 76 journal articles |
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Burgette LF, Reiter JP. Multiple imputation for missing data via sequential regression trees. American Journal of Epidemiology 2010;172(9):1070-1076. |
R833293 (2008) R833293 (2009) R833293 (2010) R833293 (Final) R833293C002 (2009) R833293C002 (2010) R833293C002 (Final) |
Exit Exit Exit |
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Burgette LF, Reiter JP, Miranda ML. Exploratory quantile regression with many covariates: an application to adverse birth outcomes. Epidemiology 2011;22(6):859-866. |
R833293 (2010) R833293 (2011) R833293 (Final) R833293C002 (2010) R833293C002 (2011) R833293C002 (Final) |
Exit Exit |
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Burgette LF, Reiter JP. Nonparametric Bayesian multiple imputation for missing data due to mid-study switching of measurement methods. Journal of the American Statistical Association 2012;107(498):439-449. |
R833293 (2010) R833293 (2011) R833293 (Final) R833293C002 (2010) R833293C002 (2011) R833293C002 (Final) |
Exit Exit Exit |
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Burgette LF, Reiter JP. Modeling adverse birth outcomes via confirmatory factor quantile regression. Biometrics 2012;68(1):92-100. |
R833293 (2010) R833293 (2011) R833293 (Final) R833293C002 (2010) R833293C002 (2011) R833293C002 (Final) |
Exit Exit Exit |
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Buttke DE, Wolkin A, Stapleton HM, Miranda ML. Associations between serum levels of polybrominated diphenyl ether (PBDE) flame retardants and environmental and behavioral factors in pregnant women. Journal of Exposure Science & Environmental Epidemiology 2013;23(2):176-182. |
R833293 (2011) R833293 (Final) R833293C002 (2011) R833293C002 (Final) |
Exit |
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Chang HH, Reich BJ, Miranda ML. Chang et al. Respond to “Environmental exposures and preterm birth." American Journal of Epidemiology 2012;175(2):111-112. |
R833293 (2011) R833293 (Final) R833293C002 (2011) R833293C002 (Final) |
Exit Exit Exit |
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Chang HH, Reich BJ, Miranda ML. Time-to-event analysis of fine particle air pollution and preterm birth: results from North Carolina, 2001-2005. American Journal of Epidemiology 2012;175(2):91-98. |
R833293 (2010) R833293 (2011) R833293 (Final) R833293C001 (2010) R833293C001 (2011) R833293C001 (Final) R833293C002 (2011) R833293C002 (Final) R833863 (2011) |
Exit Exit Exit |
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Chang HH, Reich BJ, Miranda ML. A spatial time-to-event approach for estimating associations between air pollution and preterm birth. Journal of the Royal Statistical Society--Series C (Applied Statistics) 2013;62(2):167-179. |
R833293 (2011) R833293 (2012) R833293 (Final) R833293C001 (2011) R833293C001 (Final) R833293C002 (2011) R833293C002 (Final) R834799 (2014) R834799 (2016) R834799 (Final) R834799C002 (2014) R834799C003 (2013) R834799C003 (2014) |
Exit Exit |
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Maxson PJ, Edwards SE, Ingram A, Miranda ML. Psychosocial differences between smokers and non-smokers during pregnancy. Addictive Behaviors 2012;37(2):153-159. |
R833293 (2011) R833293 (Final) R833293C002 (2011) R833293C002 (Final) |
Exit |
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Maxson P, Miranda ML. Pregnancy intention, demographic differences, and psychosocial health. Journal of Women's Health 2011;20(8):1215-1223. |
R833293 (2010) R833293 (2011) R833293 (Final) R833293C002 (2010) R833293C002 (2011) R833293C002 (Final) |
Exit |
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Messer LC, Maxson P, Miranda ML. The urban built environment and associations with women's psychosocial health. Journal of Urban Health 2013;90(5):857-871. |
R833293 (2011) R833293 (2012) R833293 (Final) R833293C002 (2011) R833293C002 (Final) |
Exit |
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Miranda ML, Edwards SE, Swamy GK, Paul CJ, Neelon B. Blood lead levels among pregnant women: historical versus contemporaneous exposures. International Journal of Environmental Research and Public Health 2010;7(4):1508-1519. |
R833293 (2008) R833293 (2009) R833293 (2010) R833293 (Final) R833293C002 (2009) R833293C002 (2010) R833293C002 (Final) |
Exit Exit |
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Miranda ML, Edwards S, Maxson PJ. Mercury levels in an urban pregnant population in Durham County, North Carolina. International Journal of Environmental Research in Public Health 2011;8(3):698-712. |
R833293 (2010) R833293 (Final) R833293C002 (2010) R833293C002 (Final) |
Exit Exit |
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Miranda ML, Edwards SE, Chang HH, Auten RL. Proximity to roadways and pregnancy outcomes. Journal of Exposure Science & Environmental Epidemiology 2013;23(1):32-38. |
R833293 (2011) R833293 (2012) R833293 (Final) R833293C001 (2011) R833293C001 (Final) R833293C002 (2011) R833293C002 (Final) R833293C003 (2011) R833293C003 (Final) |
Exit Exit |
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Neelon B, Swamy GK, Burgette LF, Miranda ML. A Bayesian growth mixture model to examine maternal hypertension and birth outcomes. Statistics in Medicine 2011;30(22):2721-2735. |
R833293 (2010) R833293 (2011) R833293 (Final) R833293C001 (2011) R833293C001 (Final) R833293C002 (2010) R833293C002 (2011) R833293C002 (Final) |
Exit |
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Neelon B, Gelfand AE, Miranda ML. A multivariate spatial mixture model for areal data: examining regional differences in standardized test scores. Journal of the Royal Statistical Societ--Series C (Applied Statistics) 2014;63(5):737-761. |
R833293 (Final) R833293C001 (Final) R833293C002 (Final) |
Exit Exit |
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Sanders A, Smeester L, Rojas D, DeBussycher T, Wu M, Wright F, Zhou Y-H, Laine J, Rager J, Swamy G, Ashley-Koch A, Miranda ML, Fry R. Cadmium exposure and the epigenome: exposure-associated patterns of DNA methylation in leukocytes from mother-baby pairs. Epigenetics 2014;9(2):212-221. |
R833293 (Final) R833293C002 (Final) |
Exit Exit |
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Schwartz SL, Gelfand AE, Miranda ML. Joint Bayesian analysis of birthweight and censored gestational age using finite mixture models. Statistics in Medicine 2010;29(16):1710-1723. |
R833293 (2008) R833293 (2009) R833293 (2010) R833293 (Final) R833293C001 (2009) R833293C001 (2010) R833293C001 (Final) R833293C002 (Final) |
Exit Exit |
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Schwartz S, Li F, Reiter JP. Sensitivity analysis for unmeasured confounding in principal stratification settings with binary variables. Statistics in Medicine 2012;31(10):949-962. |
R833293 (2010) R833293 (2011) R833293 (Final) R833293C002 (2010) R833293C002 (2011) R833293C002 (Final) |
Exit |
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Stapleton HM, Eagle S, Anthopolos R, Wolkin A, Miranda ML. Associations between polybrominated diphenyl ether (PBDE) flame retardants, phenolic metabolites, and thyroid hormones during pregnancy. Environmental Health Perspectives 2011;119(10):1454-1459. |
R833293 (2011) R833293 (Final) R833293C002 (2011) R833293C002 (Final) |
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Swamy GK, Garrett ME, Miranda ML, Ashley-Koch AE. Maternal vitamin D receptor genetic variation contributes to infant birthweight among black mothers. American Journal of Medical Genetics Part A 2011;155A(6):1264-1271. |
R833293 (2009) R833293 (2010) R833293 (2011) R833293 (Final) R833293C002 (2010) R833293C002 (2011) R833293C002 (Final) |
Exit |
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Swamy GK, Edwards S, Gelfand A, James SA, Miranda ML. Maternal age, birth order, and race: differential effects on birthweight. Journal of Epidemiology and Community Health 2012;66(2):136-142. |
R833293 (2009) R833293 (2010) R833293 (2011) R833293 (Final) R833293C001 (2010) R833293C001 (Final) R833293C002 (2011) R833293C002 (Final) |
Exit |
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Zhou X, Reiter JP. A note on Bayesian inference after multiple imputation. The American Statistician 2010;64(2):159-163. |
R833293 (2008) R833293 (2009) R833293 (Final) R833293C002 (2009) R833293C002 (Final) |
Exit Exit |
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Zhu B, Dunson DB, Ashley-Koch AE. Adverse subpopulation regression for multivariate outcomes with high-dimensional predictors. Statistics in Medicine 2012;31(29):4102-4113. |
R833293 (2011) R833293 (2012) R833293 (Final) R833293C002 (2011) R833293C002 (Final) |
Exit Exit |
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Zhu B, Ashley-Koch AE, Dunson DB. Generalized admixture mapping for complex traits. G3--Genes, Genomes, Genetics 2013;3(7):1165-1175. |
R833293 (2012) R833293 (Final) R833293C002 (Final) |
Exit Exit Exit |
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Miranda ML, Anthopolos R, Wolkin A, Stapleton HM. Associations of birth outcomes with maternal polybrominated diphenyl ethers and thyroid hormones during pregnancy. Environment International 2015;85:244-253. |
R833293 (Final) R833293C002 (Final) |
Exit Exit Exit |
Supplemental Keywords:
pregnancy, preterm birth, low birth weight, racial disparity, African American, environmental stressors, gene-environment interactions, psychosocial stressors, genes, single nucleotide polymorphismsProgress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R833293 The Center for Study of Neurodevelopment and Improving Children's Health Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R833293C001 Research Project A: Mapping Disparities in Birth Outcomes
R833293C002 Research Project B: Healthy Pregnancy, Healthy Baby: Studying Racial Disparities in Birth Outcomes
R833293C003 Research Project C: Perinatal Environmental Exposure Disparity and Neonatal Respiratory Health
R833293C004 Community Outreach and Translation Core
R833293C005 Geographic Information System and Statistical Analysis Core
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
26 journal articles for this subproject
Main Center: R833293
163 publications for this center
76 journal articles for this center