Grantee Research Project Results
2010 Progress Report: Research Project B: Healthy Pregnancy, Healthy Baby: Studying Racial Disparities in Birth Outcomes
EPA Grant Number: R833293C002Subproject: this is subproject number 002 , established and managed by the Center Director under grant R833293
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: The Center for Study of Neurodevelopment and Improving Children's Health
Center Director: Murphy, Susan K.
Title: Research Project B: Healthy Pregnancy, Healthy Baby: Studying Racial Disparities in Birth Outcomes
Investigators: Williams, Redford , Miranda , Marie Lynn , Ashley-Koch, Allison , Swamy, Geeta , Reiter, Jerome , Maxson, Pamela , Auten, Richard
Current Investigators: Williams, Redford , Miranda , Marie Lynn , Ashley-Koch, Allison , Gibson-Davis, Christina , Swamy, Geeta , Reiter, Jerome , Maxson, Pamela
Institution: Duke University
EPA Project Officer: Callan, Richard
Project Period: May 1, 2007 through April 30, 2012 (Extended to April 30, 2014)
Project Period Covered by this Report: May 1, 2010 through April 30,2011
RFA: Centers for Children’s Environmental Health and Disease Prevention Research (2005) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
- To develop and operate an interdisciplinary children’s health research center with a focus on understanding how biological, physiological, environmental, and social aspects of vulnerability contribute to health disparities;
- To enhance research in children’s health at Duke by promoting research interactions among programs in biomedicine, pediatric and obstetric care, environmental health, and the social sciences and establishing an infrastructure to support and extend interdisciplinary research;
- To develop new methodologies for incorporating innovative statistical analysis into children’s environmental health research and policy practice, with a particular emphasis on spatial, genetic and proteomic analysis;
- To serve as a technical and educational resource to the local community, region, the nation, and to international agencies in the area of children’s health and health disparities; and,
- To translate the results of the Center into direct interventions in clinical care and practice.
- Conduct a cohort study of pregnant women in Durham, NC designed to correlate birth weight, gestation, and birth weight x gestation with environmental, social, and host factors;
- Develop community-level measures of environmental and social factors by inventorying neighborhood quality and the built environment in partnership with local community groups;
- Create a comprehensive data architecture, spatially resolved at the tax parcel level, of environmental, social, and host factors affecting pregnant women by linking data from the cohort study and neighborhood assessments with additional environmental and socioeconomic data; and
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Determine whether and to what extent differential exposures explain health disparities in birth outcomes by applying innovative spatial and genetic statistical methods to:
a. Identify environmental, social, and host factors that cluster to predict birth outcomes in the entire sample,b. Determine whether these clusters are more or less present in African-American versus white populations and quantify the proportion of health disparities explained by differences in cluster frequency, andc. Identify environmental, social, and host factors that cluster to predict birth outcomes within the African-American and white sub-samples and compare these clusters across racial groups.
Progress Summary:
Future Activities:
In the next year, we will focus on data analysis and further statistical methods innovation. Our primary interest is in bringing these two pieces together. The statistical methods innovation is driven by the needs of our data analysis and thus will continue to explore means to reduce the dimensionality of the genetic and other data, as well as impute missing data. Our overall goal is to identify complex interactions amongst the three sides of the triangle we hypothesize influence pregnancy outcomes: host, social, and environmental contributors.
Journal Articles on this Report : 10 Displayed | Download in RIS Format
Other subproject views: | All 51 publications | 26 publications in selected types | All 26 journal articles |
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Other center views: | All 163 publications | 77 publications in selected types | All 76 journal articles |
Type | Citation | ||
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Burgette LF, Reiter JP. Multiple imputation for missing data via sequential regression trees. American Journal of Epidemiology 2010;172(9):1070-1076. |
R833293 (2008) R833293 (2009) R833293 (2010) R833293 (Final) R833293C002 (2009) R833293C002 (2010) R833293C002 (Final) |
Exit Exit Exit |
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Burgette LF, Reiter JP, Miranda ML. Exploratory quantile regression with many covariates: an application to adverse birth outcomes. Epidemiology 2011;22(6):859-866. |
R833293 (2010) R833293 (2011) R833293 (Final) R833293C002 (2010) R833293C002 (2011) R833293C002 (Final) |
Exit Exit |
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Burgette LF, Reiter JP. Nonparametric Bayesian multiple imputation for missing data due to mid-study switching of measurement methods. Journal of the American Statistical Association 2012;107(498):439-449. |
R833293 (2010) R833293 (2011) R833293 (Final) R833293C002 (2010) R833293C002 (2011) R833293C002 (Final) |
Exit Exit Exit |
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Burgette LF, Reiter JP. Modeling adverse birth outcomes via confirmatory factor quantile regression. Biometrics 2012;68(1):92-100. |
R833293 (2010) R833293 (2011) R833293 (Final) R833293C002 (2010) R833293C002 (2011) R833293C002 (Final) |
Exit Exit Exit |
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Maxson P, Miranda ML. Pregnancy intention, demographic differences, and psychosocial health. Journal of Women's Health 2011;20(8):1215-1223. |
R833293 (2010) R833293 (2011) R833293 (Final) R833293C002 (2010) R833293C002 (2011) R833293C002 (Final) |
Exit |
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Miranda ML, Edwards SE, Swamy GK, Paul CJ, Neelon B. Blood lead levels among pregnant women: historical versus contemporaneous exposures. International Journal of Environmental Research and Public Health 2010;7(4):1508-1519. |
R833293 (2008) R833293 (2009) R833293 (2010) R833293 (Final) R833293C002 (2009) R833293C002 (2010) R833293C002 (Final) |
Exit Exit |
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Miranda ML, Edwards S, Maxson PJ. Mercury levels in an urban pregnant population in Durham County, North Carolina. International Journal of Environmental Research in Public Health 2011;8(3):698-712. |
R833293 (2010) R833293 (Final) R833293C002 (2010) R833293C002 (Final) |
Exit Exit |
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Neelon B, Swamy GK, Burgette LF, Miranda ML. A Bayesian growth mixture model to examine maternal hypertension and birth outcomes. Statistics in Medicine 2011;30(22):2721-2735. |
R833293 (2010) R833293 (2011) R833293 (Final) R833293C001 (2011) R833293C001 (Final) R833293C002 (2010) R833293C002 (2011) R833293C002 (Final) |
Exit |
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Schwartz S, Li F, Reiter JP. Sensitivity analysis for unmeasured confounding in principal stratification settings with binary variables. Statistics in Medicine 2012;31(10):949-962. |
R833293 (2010) R833293 (2011) R833293 (Final) R833293C002 (2010) R833293C002 (2011) R833293C002 (Final) |
Exit |
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Swamy GK, Garrett ME, Miranda ML, Ashley-Koch AE. Maternal vitamin D receptor genetic variation contributes to infant birthweight among black mothers. American Journal of Medical Genetics Part A 2011;155A(6):1264-1271. |
R833293 (2009) R833293 (2010) R833293 (2011) R833293 (Final) R833293C002 (2010) R833293C002 (2011) R833293C002 (Final) |
Exit |
Supplemental Keywords:
Progress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R833293 The Center for Study of Neurodevelopment and Improving Children's Health Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R833293C001 Research Project A: Mapping Disparities in Birth Outcomes
R833293C002 Research Project B: Healthy Pregnancy, Healthy Baby: Studying Racial Disparities in Birth Outcomes
R833293C003 Research Project C: Perinatal Environmental Exposure Disparity and Neonatal Respiratory Health
R833293C004 Community Outreach and Translation Core
R833293C005 Geographic Information System and Statistical Analysis Core
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
26 journal articles for this subproject
Main Center: R833293
163 publications for this center
76 journal articles for this center