Grantee Research Project Results
Publications Details for Grant Number R835737
Human Models for Analysis of Pathways (H MAPs) Center
RFA:
Organotypic Culture Models for Predictive Toxicology Center (2013)
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| Reference Type | Citation | Progress Report Year | Document Sources |
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| Abstract | Ghanian Z, Mehvar S, Jamali N, Sheibani N, Ranji M. Time-lapse microscopy of oxidative stress demonstrates metabolic sensitivity of retinal pericytes under high glucose condition. JOURNAL OF BIOPHOTONICS 2018;11(9):e201700289 |
R835737 (Final) |
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| Abstract | Li C, Yu J, Schehr J, Berry S, Leal T, Lang J, Beebe D. Exclusive Liquid Repellency: An Open Multi-Liquid-Phase Technology for Rare Cell Culture and Single-Cell Processing. APPLIED MATERIALS & INTERFACES 2018;10(20):17065-17070 |
R835737 (Final) |
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| Abstract | Li C, Yu J, Paine P, Juang D, Berry S, Beebe D. Double-exclusive liquid repellency (double-ELR): an enabling technology for rare phenotype analysis. LAB ON A CHIP 2018;18(18):2710-2719 |
R835737 (Final) |
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| Abstract | Saghiri M, Asatourian A, Nguyn E, Wang S, Sheibani N. Hydrogel Arrays and Choroidal Neovascularization Models for Evaluation of Angiogenic Activity of Vital Pulp Therapy Biomaterials. JOURNAL OF ENDODONTICS 2018;44(5):773-779 |
R835737 (Final) |
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| Journal Article | Aboualizadeh E, Ranji M, Sorenson CM, Sepehr R, Sheibani N, Hirschmugl CJ. Retinal oxidative stress at the onset of diabetes determined by synchrotron FTIR widefield imaging:towards diabetes pathogenesis. Analyst 2017;142(7):1061-1072. |
R835737 (2017) |
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| Journal Article | Aboualizadeh E, Sorenson CM, Schofield AJ, Unger M, Sheibani N, Hirschmugl CJ. Temporal diabetes-induced biochemical changes in distinctive layers of mouse retina. Scientific Reports 2018;8(1):1096. |
R835737 (2017) |
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| Journal Article | Aisenbrey E, Murphy W. Synthetic alternatives to Matrigel. Nature Reviews Materials 2020 |
R835737 (Final) |
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| Journal Article | Bakooshli M, Lippmann E, Mulcahy B, Iyer N, Nguyen C, Tung K, Stewart B, van den Dorpel H, Fuehrmann T, Gilbert P, Shoichet M, Bigot A, Pegoraro E, Ahn H, Ginsberg H, Zhen M, Ashton R, Gilbert P. A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction. DEVELOPMENTAL BIOLOGHY, STEM CELLS AND REGENERATIVE MEDICINE 2019;8(e44530) |
R835737 (Final) |
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| Journal Article | Barry C, Schmitz MT, Propson NE, Hou Z, Zhang J, Nguyen BK, Bolin JM, Jiang P, McIntosh BE, Probasco MD, Swanson S, Stewart R, Thomson JA, Schwartz MP, Murphy WL. Uniform neural tissue models produced on synthetic hydrogels using standard culture techniques. Experimental Biology and Medicine 2017;242(17):1679-1689. |
R835737 (2017) R835737C001 (2017) |
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| Journal Article | Belair DG, Schwartz MP, Knudsen T, Murphy WL. Human iPSC-derived endothelial cell sprouting assay in synthetic hydogel arrays. Acta Biomaterialia 2016;39:12-24. |
R835737 (2016) R835737 (2017) R835737C004 (2015) |
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| Journal Article | Belair DG, Miller MJ, Wang S, Darjatmoko SR, Binder BYK, Sheibani N, Murphy WL. Differential regulation of angiogenesis using degradable VEGF-binding microspheres. Biomaterials 2016;93:27-37. |
R835737 (2015) R835737 (2016) R835737 (2017) R835737C004 (2015) R835737C004 (2016) |
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| Journal Article | Belair DG, Le NN, Murphy WL. Regulating VEGF signaling in platelet concentrates via specific VEGF sequestering. Biomaterials Science 2016;4(5):819-825. |
R835737 (2015) R835737 (2016) R835737 (2017) R835737C004 (2015) |
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| Journal Article | Chasman D, Walters KB, Lopes TJ, Eisfeld AJ, Kawaoka Y, Roy S. Integrating transcriptomic and proteomic data using predictive regulatory network models of host response to pathogens. PLoS Computational Biology2016;12(7):e1005013. |
R835737 (2015) R835737 (2016) R835737 (2017) R835737C005 (2015) |
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| Journal Article | Chasman D, Fotuhi Siahpirani A, Roy S. Network-based approaches for analysis of complex biological systems. Current Opinion in Biotechnology 2016;39:157-166. |
R835737 (2015) R835737 (2016) R835737 (2017) R835737C005 (2015) |
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| Journal Article | Chasman D, Roy S. Inference of cell type specific regulatory networks on mammalian lineages. Current Opinion in Systems Biology 2017;2:130-139. |
R835737 (2017) R835737C004 (2017) R835737C005 (2016) R835737C005 (2017) |
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| Journal Article | Clements AE, Groves ER, Chamberlain CS, Vanderby R, Murphy WL. Microparticles locally deliver active interleukin-1 receptor antagonist in vivo. Advanced Healthcare Materials 2018;7(16):1800263. |
R835737 (Final) |
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| Journal Article | Dinu D, Chu C, Veith A, Lingappan K, Couroucli X, Jefcoate CR, Sheibani N, Moorthy B. Mechanistic role of cytochrome P450 (CYP)1B1 in oxygen-mediated toxicity in pulmonary cells:a novel target for prevention of hyperoxic lung injury. Biochemical and Biophysical Research Communications 2016;476(4):346-351. |
R835737 (2016) R835737 (2017) R835737C004 (2016) |
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| Journal Article | Estevez-Silva M, Sreeram A, Cuskey S, Fedorchak N, Layer N, Ashton R. Single-injection ex ovo transplantation method for broad spinal cord engraftment of human pluripotent stem cell-derived motor neurons. JOURNAL OF NEUROSCIENCE METHODS 2018;298:16-23 |
R835737 (Final) |
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| Journal Article | Falero-Perez J, Park S, Sorenson CM, Sheibani N. PEDF expression affects retinal endothelial cell proangiogenic properties through alterations in cell adhesive mechanisms. American Journal of Physiology-Cell Physiology 2017;313(4):C405-C420. |
R835737 (2017) |
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| Journal Article | Falero-Perez J, Sorenson C, Sheibani N. Cyp1b1-deficient retinal astrocytes are more proliferative and migratory and are protected from oxidative stress and inflammation. AMERICAN JOURNAL OF PHYSIOLOGY 2019;306(6):C767-C781 |
R835737 (Final) |
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| Journal Article | Farnoodian M, Halbach C, Slinger C, Pattnaik BR, Sorenson CM, Sheibani N. High glucose promotes the migration of retinal pigment epithelial cells through increased oxidative stress and PEDF expression. American Journal of Physiology-Cell Physiology 2016;311(3):C418-C436. |
R835737 (2016) R835737 (2017) R835737C004 (2016) |
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| Journal Article | Farnoodian M, Wang S, Dietz J, Nickells RW, Sorenson CM, Sheibani N. Negative regulators of angiogenesis: important targets for treatment of exudative AMD. Clinical Science 2017;131(15):1763-1780. |
R835737 (2017) |
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| Journal Article | Farnoodian M, Sorenson CM, Sheibani N. PEDF expression affects the oxidative and inflammatory state of choroidal endothelial cells. American Journal of Physiology-Cell Physiology 2018;314(4):C456-C472. |
R835737 (2017) |
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| Journal Article | Fontana G, Gershlak J, Adamski M, Lee J-S, Matsumoto S, Le HD, Binder B, Wirth J, Gaudette G, Murphy WL. Biofunctionalized plants as diverse biomaterials for human cell culture. Advanced Healthcare Materials 2017;6(8):1601225. |
R835737 (2016) R835737 (2017) |
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| Journal Article | Garcia K, Chasman D, Roy S, Ane J-M. Physiological responses and gene co-expression network of mycorrhizal roots under K+ deprivation. Plant Physiology 2017;173(3):1811-1823. |
R835737 (2017) R835737C004 (2017) R835737C005 (2017) |
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| Journal Article | Ghanian Z, Staniszewski K, Jamali N, Sepehr R, Wang S, Sorenson CM, Sheibani N, Ranji M. Quantitative assessment of retinopathy using multi-parameter image analysis. Journal of Medical Signals and Sensors 2016;6(2):71-80. |
R835737 (2016) R835737 (2017) R835737C004 (2016) |
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| Journal Article | Gurel Z, Sheibani N. O-Linked β-N -acetylglucosamine (O-GlcNAc) modification: a new pathway to decode pathogenesis of diabetic retinopathy. Clinical Science 2018;132(2):185-198. |
R835737 (2017) |
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| Journal Article | Ibrahim AS, Saleh H, El-Shafey M, Hussein KA, El-Masry K, Baban B, Sheibani N, Wang MH, Tawfik A, Al-Shabrawey M. Targeting of 12/15-lipoxygenase in retinal endothelial cells, but not in monocytes/macrophages, attenuates high glucose-induced retinal leukostasis. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids 2017;1862(6):636-645. |
R835737 (2017) |
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| Journal Article | Iyer N, Shin J, Cuskey S, Tian Y, Nicol N, Doersch T, Seipel F, McCalla S, Roy S, Ashton R. Modular derivation of diverse, regionally discrete human posterior CNS neurons enables discovery of transcriptomic patterns. SCIENCE ADVANCES 2022;8(39):eabn7430 |
R835737 (Final) |
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| Journal Article | Jamali N, Wang S, Darjatmoko SR, Sorenson CM, Sheibani N. Vitamin D receptor expression is essential during retinal vascular development and attenuation of neovascularization by 1, 25(OH)2 D3 . PLoS One 2017;12(12):e0190131. |
R835737 (2017) |
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| Journal Article | Jamali N, Sorenson CM, Sheibani N. Vitamin D and regulation of vascular cell function. American Journal of Physiology-Heart and Circulatory Physiology 2017;314(4):H753-H765. |
R835737 (2017) |
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| Journal Article | Johnson B, VItek R, Morgan M, Fink D, Beames T, Geiger P, Beebe D, Lipinski R. A Microphysiological Approach to Evaluate Effectors of Intercellular Hedgehog Signaling in Development. Frontiers in Cell and Developmental Biology 2021;9:71. |
R835737 (Final) |
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| Journal Article | Kauschik G, Gupta K, Harms V, Torr E, Evans J, Johnson H, Soref C, Acevedo-Acevedo S, Antosiewicz-Bourget J, Mamott D. Engineered Perineural Vascular Plexus for Modeling Developmental Toxicity. Advanced Healcare Materials 2020;(2000825). |
R835737 (Final) |
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| Journal Article | Khalil AS, Yu X, Xie AW, Fontana G, Umhoefer JM, Johnson HJ, Hookway TA, McDevitt TC, Murphy WL. Functionalization of microparticles with mineral coatings enhances non-viral transfection of primary human cells. Scientific Reports 2017;7(1):14211. |
R835737 (2017) |
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| Journal Article | Khalil A, Yu X, Umhoefer J, Chamberlain C, COnnie S, Wildenauer L, Diarra G, Hacker T, Murphy W. Single-dose mRNA therapy via biomaterial-mediated sequestration of overexpressed proteins. Science Advances 2020;6(27):eaba2422. |
R835737 (Final) |
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| Journal Article | Knight GT, Sha J, Ashton RS. Micropatterned, clickable culture substrates enable in situ spatiotemporal control of human PSC-derived neural tissue morphology. Chemical Communications 2015;51(25):5238-5241. |
R835737 (2015) R835737 (2016) R835737C002 (2015) R835737C002 (2016) |
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| Journal Article | Knight GT, Lundin BF, Iyer N, Ashton LMT, Sethares WA, Willett RM, Ashton RS. Engineering induction of singular neural rosette emergence within jPSC-derived tissues. eLIFE 2018;7:e37549 (23 pp.). |
R835737 (2017) R835737 (Final) R835737C002 (2017) |
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| Journal Article | Krutty JD, Schmitt SK, Gopalan P, Murphy WL. Surface functionalization and dynamics of polymeric cell culture substrates. Current Opinion in Biotechnology 2016;40:164-169. |
R835737 (2017) |
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| Journal Article | Lavine JA, Farnoodian M, Wang S, Darjatmoko SR, Wright LS, Gamm DM, Ip MS, Sorenson CM, Sheibani N. β2-adrenergic receptor antagonism attenuates CNV through inhibition of VEGF and IL-6 expression. Investigative Ophthalmology & Visual Science 2017;58(1):299-308. |
R835737 (2017) R835737 (Final) |
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| Journal Article | Lei J, Murphy W, Temenoff J. Combination of Heparin Binding Peptide and Heparin Cell Surface Coatings for Mesenchymal Stem Cell Spheroid Assembly. BIOCONJUGATE CHEMISTRY 2018;29(4):878-884 |
R835737 (Final) |
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| Journal Article | Lemke KA, Aghayee A, Ashton RS. Deriving, regenerating, and engineering CNS tissues using human pluripotent stem cells. Current Opinion in Biotechnology 2017;47:36-42. |
R835737 (2017) R835737C002 (2017) |
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| Journal Article | Lewis S, Takimoto T, Mehrvar S, Higuchi H, Doebley A, Stokes G, Sheibani N, Ideda S, Ranji M, Ikeda A. The effect of Tmem135 overexpression on the mouse heart. PLOS ONE 2018;13(8):e0201986 |
R835737 (Final) |
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| Journal Article | Li C, Hurley A, Hu W, Warrick J, Lozano G, Ayuso J, Pan W, Handlesman J, Beebe D. Social motility of biofilm-like microcolonies in a gliding bacterium. Nature Communications 2021;12(1). |
R835737 (Final) |
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| Journal Article | Li H, Liu W, Sorenson CM, Sheibani N, Albert DM, Senanayake T, Vinogradov S, Henkin J, Zhang HF. Sustaining intravitreal residence with L-arginine peptide-conjugated nanocarriers. Investigative Ophthalmolology & Visual Science 2017;58(12):5142-5150. |
R835737 (2017) |
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| Journal Article | Lippmann E, Estevez-Silva M, Ashton R. Chemically defined differentiation of human pluripotent stem cells to hindbrain and spinal cord neural stem cells with defined regional identities. Protocol Exchange 2015; 27 pp. |
R835737 (2015) R835737 (2016) |
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| Journal Article | LIvingston M, Morgan M, Daly W, Murphy W, Johnson B, Virumbrales-Munoz M. Evaluation of PEG-Based Hydrogel Influence on Estrogen-Receptor-Driven Responses in MCF7 Breast Cancer Cells. ACS Publications 2019;5(11):6089-6098. |
R835737 (2018) R835737C003 (Final) |
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| Journal Article | Mahony C, Ashton R, Birk B, Boobis A, Cull T, Datson G, Ewart L, Knudsen T, Manou I, Maurer-Stroh S. New ideas for non-animal approaches to predict repeated-dose systemic toxicity:Report from an EPAA Blue Sky Workshop. Regulatory Toxicology and Pharmacology 2020;114(UNSP 104668). |
R835737 (Final) |
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| Journal Article | Majumder J, Torr E, Aisenbrey E, Lebakken C, Favreau P, Richards W, Yin Y, Chang Q, Murphy W. Human induced pluripotent stem cell-derived planar neural organoids assembled on synthetic hydrogels. JOURNAL OF TISSUE ENGINEERING 2024;15(20417314241230633) |
R835737 (Final) |
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| Journal Article | Marti-Figueroa CR, Ashton RS. The case for applying tissue engineering methodologies to instruct human organoid morphogenesis. Acta Biomaterialia 2017;54:35-44. |
R835737 (2017) R835737C002 (2017) |
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| Journal Article | Mezu-Ndubuisi O, Wang Y, Schoephoerster J, Falero_Perez J, Zaitoun I, Sheibani, Gong S. Intravitreal Delivery of VEGF-A(165)-loaded PLGA Microparticles Reduces Retinal Vaso-Obliteration in an In Vivo Mouse Model of Retinopathy of Prematurity. CURRENT EYE RESEARCH 2018;44(Full Text HTML):275-286 |
R835737 (Final) |
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| Journal Article | Mofidi Najjar F, Taghavi F, Ghadari R, Sheibani N, Moosavi-Movahedi AA. Destructive effect of non-enzymatic glycation on catalase and remediation via curcumin. Archives of Biochemistry and Biophysics 2017;630:81-90. |
R835737 (2017) |
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| Journal Article | Molugy K, Harkness T, Carlson-Tevermer J, Prestil R, Piscopo N, Seymour S, Knight G, Ashton R, Saha K. Tracking and Predicting Human Somatic Cell Reprogramming Using Nuclear Characteristics. BIOPHYSICAL JOURNAL 2020;118(9):2086-2102. |
R835737 (Final) |
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| Journal Article | Morgan MM, Johnson BP, Livingston MK, Schuler LA, Alarid ET, Sung KE, Beebe DJ. Personalized in vitro cancer models to predict therapeutic response:challenges and a framework for improvement. Pharmacology & Therapeutics 2016;165:79-92. |
R835737 (2016) R835737 (2017) R835737C003 (2015) R835737C003 (2016) |
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| Journal Article | Morgan MM, Livingston MK, Warrick JW, Stanek EM, Alarid ET, Beebe DJ, Johnson BP. Mammary fibroblasts reduce apoptosis and speed estrogen-induced hyperplasia in an organotypic MCF7-derived duct model. Scientific Reports 2018;8(1):7139. |
R835737 (2017) R835737C003 (2017) R835737C003 (Final) |
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| Journal Article | Morgan M, Arendt L, Alarid E, Beebe D, Johnson B. Mammary adipose stromal cells derived from obese women reduce sensitivity to the aromatase inhibitor anastrazole in an organotypic breast model. FASEB Journal 2019;33(7):8623-8633. |
R835737 (2018) R835737C003 (Final) |
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| Journal Article | Morgan M, Schuler L, Ciciliano J, Johnson B, Alarid E, Beebe D. Modeling chemical effects on breast cancer: the importance of the microenvironment in vitro. Integrative Biology 2020;12(2):21-33 |
R835737 (Final) |
not available |
| Journal Article | Nguyen EH, Daly WT, Le NNT, Farnoodian M, Belair DG, Schwartz MP, Lebakken CS, Ananiev GE, Saghiri MA, Knudsen TB, Sheibani N, Murphy WL. Versatile synthetic alternatives to Matrigel for vascular toxicity screening and stem cell expansion. Nature Biomedical Engineering 2017;1(7):0096. |
R835737 (2016) R835737 (2017) |
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| Journal Article | Piscopo NJ, Mueller KP, Das A, Hematti P, Murphy WL, Palecek SP, Capitini CM, Saha K. Bioengineering solutions for manufacturing challenges in CAR T cells. Biotechnology Journal 2018;13(2):1700095. |
R835737 (2017) |
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| Journal Article | Price TO, Sheibani N, Shah GN. Regulation of high glucose-induced apoptosis of brain pericytes by mitochondrial CA VA:a specific target for prevention of diabetic cerebrovascular pathology. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 2017;1863(4):929-935. |
R835737 (2017) |
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| Journal Article | Regier MC, Montanez-Sauri SI, Schwartz MP, Murphy WL, Beebe DJ, Sung KE. The influence of biomaterials on cytokine production in 3D cultures. Biomacromolecules 2017;18(3):709-718. |
R835737 (2016) R835737 (2017) |
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| Journal Article | Ren J, Liu Z, Wang Q, Giles J, Greenberg J, Sheibani N, Kent KC, Liu B. Andrographolide ameliorates abdominal aortic aneurysm progression by inhibiting inflammatory cell infiltration through downregulation of cytokine and integrin expression. Journal of Pharmacology and Experimental Therapeutics 2016;356(1):137-147. |
R835737 (2016) R835737 (2017) R835737C004 (2016) |
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| Journal Article | Saghiri MA, Orangi J, Asatourian A, Sorenson CM, Sheibani N. Functional role of inorganic trace elements in angiogenesis part III: (Ti, Li, Ce, As, Hg, Va, Nb and Pb). Critical Reviews in Oncology/Hematology 2016;98:290-301. |
R835737 (2016) R835737 (2017) R835737C004 (2016) |
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| Journal Article | Saghiri MA, Asatourian A, Garcia-Godoy F, Sheibani N. The role of angiogenesis in implant dentistry part I: review of titanium alloys, surface characteristics and treatments. Medicina Oral, Patología Oral y Cirugía Bucal 2016;21(4):e514-e525. |
R835737 (2016) R835737 (2017) R835737C004 (2016) |
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| Journal Article | Saghiri MA, Asatourian A, Garcia-Godoy F, Sheibani N. The role of angiogenesis in implant dentistry part II: the effect of bone-grafting and barrier membrane materials on angiogenesis. Medicina Oral, Patología Oral y Cirugía Bucal 2016;21(4):e526-e537. |
R835737 (2016) R835737 (2017) R835737C004 (2016) |
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| Journal Article | Saghiri MA, Asatourian A, Garcia-Godoy F, Sheibani N. Effect of biomaterials on angiogenesis during vital pulp therapy. Dental Materials Journal 2016;35(5):701-709. |
R835737 (2016) R835737 (2017) R835737C004 (2016) |
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| Journal Article | Saghiri MA, Orangi J, Asatourian A, Gutmann JL, Garcia-Godoy F, Lotfi M, Sheibani N. Calcium silicate-based cements and functional impacts of various constituents. Dental Materials Journal 2017;36(1):8-18. |
R835737 (2016) R835737 (2017) R835737C004 (2016) |
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| Journal Article | Saghiri MA, Asatourian A, Gurel Z, Sorenson CM, Sheibani N. Bcl-2 expression is essential for development and normal physiological properties of tooth hard tissue and saliva production. Experimental Cell Research 2017;358(2):94-100. |
R835737 (2017) |
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| Journal Article | Seirup M, Chu L, Sengupta S, Leng N, Browder H, Kapadia K, Shafer C, Duffin B, Elwell A, Bolin J. Reproducibility across single-cell RNA-seq protocols for spatial ordering analysis. PLOS One 2020;15(9). |
R835737 (Final) |
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| Journal Article | Seirup M, Sengupta S, Swanson S, McIntosh B, Collins M, Cu L, Cheng Z, Gorkin D, Duffin B, Bolin J, Argus C, Stewart R, Thompson J. Rapid changes in chromatin structure during dedifferentiation of primary hepatocytes in vitro. GENOMICS 2022;114(3):110330. |
R835737 (Final) |
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| Journal Article | Stallcop LE, Alvarez-Garcia YR, Reyes-Ramos AM, Ramos-Cruz KP, Morgan MM, Shi Y, Li L, Beebe DJ, Domenech M, Warrick JW. Razor-printed sticker microdevices for cell-based applications. Lab on a Chip 2018;18(3):451-462. |
R835737 (2017) R835737C003 (2017) R835737C003 (Final) |
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| Journal Article | Virumbrales-Munoz M, Ayuso J, Lacueva A, Randelovic T, Livingston M, Beebe D, Olivan S, Pereboom D, Doblare M, Fernandez L. Enabling cell recovery from 3D cell culture microfluidic devices for tumour microenvironment biomarker profiling. Scientific Reports 2020;10(1):757. |
R835737 (Final) |
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| Journal Article | Xie AW, Binder BYK, Khalil AS, Schmitt SK, Johnson HJ, Zacharias NA, Murphy WL. Controlled self-assembly of stem cell aggregates instructs pluripotency and lineage bias. Scientific Reports 2017;7(1):14070. |
R835737 (2017) |
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| Journal Article | Xie A, Zacharias N, Binder B, Murphy W. Controlled aggregation enhances immunomodulatory potential of mesenchymal stromal cell aggregates. Stem Cells Translational Medicine 2021;1(18). |
R835737 (Final) |
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| Journal Article | Ye G-J, Budzynski E, Sonnentag P, Nork TM, Sheibani N, Gurel Z, Boye SL, Peterson JJ, Boye SE, Hauswirth WW, Chulay JD. Cone-specific promoters for gene therapy of achromatopsia and other retinal diseases. Human Gene Therapy 2016;27(1):72-82. |
R835737 (2016) R835737 (2017) R835737C004 (2016) |
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| Journal Article | Yu X, Biedrzycki AH, Khalil AS, Hess D, Umhoefer JM, Markel MD, Murphy WL. Nanostructured mineral coatings stabilize proteins for therapeutic delivery. Advanced Materials 2017;29(33):1701255. |
R835737 (2017) |
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| Journal Article | Zanotelli MR, Ardalani H, Zhang J, Hou Z, Nguyen EH, Swanson S, Nguyen BK, Bolin J, Elwell A, Bischel LL, Xie AW, Stewart R, Beebe DJ, Thomson JA, Schwartz MP, Murphy WL. Stable engineered vascular networks from human induced pluripotent stem cell-derived endothelial cells cultured in synthetic hydrogels. Acta Biomaterialia 2016;35:32-41. |
R835737 (2015) R835737 (2016) R835737 (2017) R835737C001 (2017) R835737C004 (2015) |
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| Journal Article | Zhang J, Schwartz MP, Hou Z, Bai Y, Ardalani H, Swanson S, Steill J, Ruotti V, Elwell A, Nguyen BK, Bolin J, Stewart R, Thomson JA, Murphy WL. A genome-wide analysis of human pluripotent stem cell-derived endothelial cells in 2D or 3D culture. Stem Cell Reports 2017;8(4):907-918. |
R835737 (2016) R835737 (2017) R835737C001 (2017) |
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| Journal Article | Zhang J, Chu LF, Hou Z, Schwartz MP, Hacker T, Vickerman V, Swanson S, Leng N, Nguyen BK, Elwell A, Bolin J, Brown ME, Stewart R, Burlingham WJ, Murphy WL, Thomson JA. Functional characterization of human pluripotent stem cell-derived arterial endothelial cells. Proceedings of the National Academy of Sciences of the United States of America 2017;114(30):E6072-E6078. |
R835737 (2017) R835737C001 (2017) |
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| Journal Article | Roy S, Sridharan R. Chromatin module inference on cellular trajectories identifies key transition points and poised epigenetic states in diverse developmental processes. Genome Research 2017;27(7):1250-1262. |
R835737 (2017) R835737C005 (2016) |
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| Journal Article | Clements AE, Leiferman EM, Chamberlain CS, Vanderby R, Murphy WL. Addition of mineral coated microparticles to soluble interleukin-1 receptor antagonist injected subcutaneously improves and extends systemic interleukin-1 inhibition. Advanced Therapeutics 2018;1(7):1800048. |
R835737 (Final) |
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| Journal Article | Khalil AS, Xie AW, Johnson HJ, Murphy WL. Sustained release and protein stabilization reduce the growth factor dosage required for human pluripotent stem cell expansion. Biomaterials 2020:120007. |
R835737 (Final) |
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| Patent/Patent Application | Ashton RS, Knight GT. Methods and culture substrates for controlled induction of biomimetic neural tissues comprising singular rosettes structures. U.S. Patent No. 16/044236, 2019. |
R835737 (2017) R835737C002 (2017) |
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| Patent/Patent Application | Gershlak J, Gaudette G, Weathers P, Dominko T, Rolle M, Hernandez S, Murphy WL, Cramer C, Medina-Bolivar F. Decellularization of plant tissues. U.S. Patent Application filed, 2016. |
R835737 (2017) |
not available |
| Patent/Patent Application | Johnson B, Beebe D, Jimenez J. Microtiter plate and uses thereof. U.S. Patent Application No. 62/359,977, July 8, 2016. |
R835737 (2017) |
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| Patent/Patent Application | Khalil A, Stechmann Lebakken C, Murphy WL, Hogan KJ. Visible light polymerization of polyethylene glycol (PEG) hydrogels. U.S. Patent Application No. 62/512,337, May 5, 2017. |
R835737 (2017) |
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| Patent/Patent Application | Murphy W, Clements A, Chamberlain C, Vanderby R. Mineral coated microparticles for sustained delivery of biologically active molecules. U.S. Patent Application No. 62/480,710, April 3, 2017. |
R835737 (2017) |
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| Patent/Patent Application | Murphy W, Fontana G, Shiak J, Gaudette G, Weathers P, Dominko T, Rolle M, Hernandez S, Cramer C, Medina-Bolivar F. Functionalization of plant tissues for human cell expansion. U.S. Patent Application No. 62/462,653, February 23, 2017. |
R835737 (2017) |
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| Presentation | Almeldin A, Rondelli CM, Larsen MC, Sheibani N, Jefcoate CR. Cyp1b1 sustains hematopoietic progenitors and regulates macrophage polarization processes while also mediating PAH toxicity. Poster presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835737 (2017) |
not available |
| Presentation | Ashton RS. Engineering region-specific cells and tissue models for hindbrain and spinal cord regenerative medicine. Presented at the University of California, Berkeley Stem Cell Center Retreat at Asilomar Conference Center, Pacific Grove, CA, April 24, 2016 (invited). |
R835737 (2017) |
not available |
| Presentation | Ashton RS. Engineering region-specific cells and tissue models for hindbrain and spinal cord regenerative medicine. Presented to the J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, February 25, 2016 (invited). |
R835737 (2017) |
not available |
| Presentation | Ashton RS. Recapitulating CNS tissue development in vitro using engineered biomaterials. Presented at the Gordon Research Conference on Signal Transduction by Engineering Extracellular Matrices, Biddeford, ME, June 27, 2016 (invited). |
R835737 (2017) |
not available |
| Presentation | Ashton RS. Highly efficient derivation of regional motor neuron phenotypes for hindbrain and spinal cord regenerative medicine. Presented at the Regenerative Medicine Workshop, Hilton Head, SC, March 19, 2016 (invited, young faculty award keynote lecture). |
R835737 (2017) |
not available |
| Presentation | Ashton RS. Derivation of a spectrum of regional motor neuron phenotypes for hindbrain and spinal cord regenerative medicine. Presented at LifeNet Health Regenerative Medicine Institute, Virginia Beach, VA, November 9, 2016 (invited). |
R835737 (2017) |
not available |
| Presentation | Ashton RS. At the stem cell-biomaterial interface: engineering CNS tissue morphogenesis ex vivo. Presented at the University of Tubingen Women’s Hospital/Fraunhofer IGB’s Medical Technology Course, Tubingen, Germany, October 18, 2016 (invited). |
R835737 (2017) |
not available |
| Presentation | Ashton RS. Engineering CNS tissue morphogenesis ex vivo. Presented at the Department of Biomedical Engineering, Carnegie Mellon University, Pittsburg, PA, September 13, 2016 (invited). |
R835737 (2017) |
not available |
| Presentation | Ashton RS. Engineering CNS tissue morphogenesis ex vivo. Presented to the Department of Biomedical Engineering, Yale University, New Haven, CT, September 20, 2016 (invited). |
R835737 (2017) |
not available |
| Presentation | Ashton RS. Engineering CNS tissue morphogenesis ex vivo. Presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 15, 2017 (invited). |
R835737 (2017) R835737C002 (2017) |
not available |
| Presentation | Ashton RS. Engineering CNS tissue morphogenesis ex vivo. Presented to the Department of Biomedical Engineering, Rutgers University, Piscataway, NJ, March 20, 2017 (invited). |
R835737 (2017) R835737C002 (2017) |
not available |
| Presentation | Chasman D, Roy S. Network-based integration of transcriptomic and proteomic data to dissect mammalian cellular response to external perturbations. Poster presented at the 56th Annual Meeting of the Society of Toxicology, Baltimore, MD, March 12-16, 2017. |
R835737 (2016) R835737 (2017) R835737C005 (2016) R835737C005 (2017) |
not available |
| Presentation | Chasman D, Fotuhi Siahpirani A, Estevez-Silva MC, Ashton RS, Roy S. Characterizing expression state dynamics and regulatory networks in early neural development. Poster presented at the Great Lakes Bioinformatics Conference (GLBIO), Chicago, IL, May 15-17, 2017. |
R835737 (2017) R835737C004 (2017) R835737C005 (2017) |
not available |
| Presentation | Chasman D, Iyer N, Fotuhi Siahpirani A, Estevez Silva M, Lippman E, McIntosh B, Thomson J, Ashton RS, Roy S. Inference of regulatory network dynamics in early neural development. Presented at the 13th Cold Spring Harbor Conference Systems Biology: Global Regulation of Gene Expression, Cold Spring Harbor, NY, March 20-23, 2018. |
R835737 (2017) R835737C001 (2017) R835737C004 (2017) R835737C005 (2017) |
not available |
| Presentation | Daly WT. Generation of perfusable vascularized human neural organoids using a commercial mini-bioreactor and a defined synthetic extracellular matrix. Poster presented at the International Society for Stem Cell Research (ISSCR) Annual Meeting, Boston MA, June 14-17, 2017 (W-1194). |
R835737 (2017) |
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| Presentation | Daly WT, Nguyen E, Kaushik G, Livingston M, Phillips J, Murphy W. The use of synthetic extracellular matrix hydrogels for developing 3D human organotypic in vitro assays for screening of environmental toxins, drug discovery, and modelling disease progression. Poster presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835737 (2017) |
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| Presentation | Daly WT. [title not provided]. Presented at the NIH Tissue Chip Meeting, Washington DC, May 2017. |
R835737 (2017) |
not available |
| Presentation | Daly WT. [title not provided]. Presented at the U.S. Environmental Protection Agency Virtual Tissue Meeting, October 2017. |
R835737 (2017) |
not available |
| Presentation | Daly WT. [title not provided]. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences, Seattle, WA, August 20-24, 2017. |
R835737 (2017) |
not available |
| Presentation | Daly W. Progress in developing human models for analysis of pathways. Poster presented at the Society of Toxicology Annual Meeting, New Orleans, LA, March 13-17, 2016. |
R835737 (2017) |
not available |
| Presentation | Daly W. The controlled formation of human vascularized neural assemblies using synthetic hydrogel screening and their application in human neurodevelopmental disease modelling. Presented at the NIMH Workshop: Using Stem Cell-Based Assays for Biological and Drug Discovery, Stanford Consortium, La Jolla, CA, November 17-18, 2016 (invited). |
R835737 (2017) |
not available |
| Presentation | Daly W. The controlled formation of human vascularized neural assemblies using synthetic hydrogel technologies and the application of the assembled neural tissues in human neurodevelopmental disease modelling. Presented at the Nanosymposium, Society for Neuroscience, San Diego, CA, November 12-16, 2016. |
R835737 (2017) |
not available |
| Presentation | Daly W. Developing human organotypic models for toxicity testing and drug discovery. Invited Presented at the 19th Annual Land O'Lakes Conference of Drug Metabolism/Applied Pharmacokinetics, Madison, WI, September 12-15, 2016 (invited). |
R835737 (2017) |
not available |
| Presentation | Daly W. The use of embryonic and induced pluripotent stem cells to develop human models for analysis of pathways. Presented at the Cellular Dynamics iForum Annual Meeting, Philadelphia, PA, September 2016. |
R835737 (2017) |
not available |
| Presentation | Estevez Silva MC, Knight GT, Lippmann E, Chasman D , Roy S, Ashton RS. Towards an in vitro model of the human posterior CNS. Presented at the Neurological Disorders: Transforming the Landscape with hPSC Modeling Focus Session, International Society for Stem Cell Research Annual Meeting, Boston, MA, June 14, 2017 (invited). |
R835737 (2017) R835737C002 (2017) |
not available |
| Presentation | Falero-Perez J, Sorenson CM, Sheibani N. Cyp1B1 expression is essential for retinal astrocytes proliferation and migration. Poster presented at the Society of Toxicology's 56th Annual Meeting, Baltimore, MD, March 12-16, 2017. |
R835737 (2017) |
not available |
| Presentation | Falero-Perez J, Larson ML, Teixeira LBC, Sorenson CM, Jefcoate CR, Nader Sheibani N. Targeted deletion of Cyp1b1 in perivascular supporting cells is sufficient for attenuation of retinal neovascularization and trabecular meshwork dysgenesis. Poster presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835737 (2017) |
not available |
| Presentation | Gurel Z, Sorenson CM, Sheibani N. Metabolic stress and O-GlcNAc modification regulate the selective sensitivity of retinal vascular cells to hyperglycemia. Poster presented at the American Diabetes Association (ADA) 77th Scientific Sessions, San Diego, CA, June 9-13, 2017. |
R835737 (2017) |
not available |
| Presentation | Jamali N, Sorenson CM, Sheibani N. Vitamin D receptor is essential for angioinhibitory activity of Vitamin D. Poster presented at the Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, April 7, 2017. |
R835737 (2017) |
not available |
| Presentation | Jamali N, Sorenson CM, Sheibani N. 1α, 25(OH)2D3 promotes vascular maturation through Vitamin D receptor mediated VEGF production and attenuation of pericyte proliferation and migration. Presented at the Association for Research in Vision and Ophthalmology Annual Meeting, Honolulu, HI, April 29-May 3, 2018. |
R835737 (2017) |
not available |
| Presentation | Johnson B. A microphysiological approach to elucidate factors disrupting epithelial:mesenchymal interactions in orofacial clefting. Poster presented at the Tissue Engineering and Regenerative Medicine International Society (TERMIS) Annual Meeting, San Diego, CA, December 11-14, 2016. |
R835737 (2017) |
not available |
| Presentation | Johnson B. A microphysiological approach to elucidating gene-environment interactions in orofacial clefting. Presented at the U.S. Environmental Protection Agency Virtual Tissue Meeting, July 2016. |
R835737 (2017) |
not available |
| Presentation | Johnson B. Introducing metabolic competence to HTS assays via high-throughput hepatocyte co-culture in the MICRO-MT. Presented at the US-EPA Transforming Tox Testing Challenge Stage 1 Awards, July 2016. |
R835737 (2017) |
not available |
| Presentation | Johnson B. A microphysiological approach to elucidate gene-environment interactions involving Hedgehog signaling and orofacial clefting. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835737 (2017) |
not available |
| Presentation | Johnson B. A microphysiological approach to elucidate factors disrupting epithelial: mesenchymal interactions in orofacial clefting. Poster presented at the Tissue Engineering and Regenerative Medicine Society Annual Meeting, Minneapolis, MN, October 8, 2016. |
R835737 (2017) |
not available |
| Presentation | Johnson B. Pathway driven design and validation of a 3D model of Sonic Hedgehog signaling. Presenetd at the UW-Madison Developmental Biology Seminar, Madison, WI, December 2017. |
R835737 (2017) |
not available |
| Presentation | Johnson B. Orofacial clefting in response to Hedgehog pathway antagonists is recapitulated in a practical epithelial: mesenchymal 3D culture model. Poster presented at the Teratology Society 57th Annual Meeting, Denver, CO, June 24-28, 2017 (best postdoctoral poster award). |
R835737 (2017) |
not available |
| Presentation | Johnson B. Microplate-based 3D culture system to screen for Hedgehog pathway gene: environmental interactions that cause orofacial clefting. Poster presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835737 (2017) |
not available |
| Presentation | Johnson B. Microplate-based 3D culture system to screen for Hedgehog pathway gene: environmental interactions that cause orofacial clefting. Presented at the STAR Horizons and Challenges in Organotypic Culture Models for Predictive Toxicology Progress Review Meeting at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835737 (2017) |
not available |
| Presentation | Johnson B. Pathway driven design, validation and teratogenicity in a 3D microphysiological model of Sonic Hedgehog signaling. Presented at the UW-Madison qBio Systems Biology Seminar, Madison, WI, September 20, 2017. |
R835737 (2017) |
not available |
| Presentation | Knight GT, Lundin BF, Ashton LMT, Sethares WA, Willett RL, Ashton RS. Engineering human CNS morphogenesis in 2/3D:controlled induction of neural rosette formation. Presented at EDEV2017: Engineering Multicellular Self-Organization, École Polytechnique Fédérale De Lausanne, Lausanne, Switzerland, November 14, 2017 (invited). |
R835737 (2017) R835737C002 (2017) |
not available |
| Presentation | Knight G, Marti-Figueroa C, McNulty J, Tokar J, Lippmann E, Beede D, Turng L-S, Ashton RS. Engineering CNS tissue morphogenesis in vitro. Presented at the Biomedical Engineering Society Meeting, Minneapolis, MN, October 8, 2016 (invited keynote). |
R835737 (2017) |
not available |
| Presentation | Knight G, Ashton RS. Brain models for analysis of pathways brain-MAPS. Presented at the 10th World Congress of Alternatives and Animal Use in the Life Sciences, Seattle, WA August 22, 2017 (invited). |
R835737 (2017) R835737C002 (2017) |
not available |
| Presentation | Lippmann ES, Sehgal N, Estevez-Silva MC, Williams CE, Ruhl DA, Bakooshli MA, Knight GT, Lemke K, Plantz J, Chapman ER, Gilbert PM, Coon JJ, Ashton RS. Harnessing Wnt/b-catenin signaling to enable highly efficient derivation of human motor neurons from any spinal cord region. Presented at the International Society for Stem Cell Research Annual Meeting, San Francisco, CA, June 24, 2016. |
R835737 (2017) |
not available |
| Presentation | Livingston MK. Utilizing micro-scale tools to identify key factors in the microenvironment. Presented at the University of Wisconsin O'Brien Center Symposium, Madison, WI, April 2016. |
R835737 (2017) |
not available |
| Presentation | Livingston MK. A robust 3D organotypic model of human mammary ducts. Presented at the Tissue Engineering and Regenerative Medicine International Society – Americas, San Diego, CA, December 11-14, 2016. |
R835737 (2017) |
not available |
| Presentation | Livingston MK. Development of a robust 3D organotypic model of human mammary ducts. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835737 (2017) |
not available |
| Presentation | Livingston MK. Development of a robust 3D organotypic model of human mammary ducts. Presented at the University of Wisconsin HMAPs Update, Madison, WI, March 2016. |
R835737 (2017) |
not available |
| Presentation | Livingston MK, Morgan MM, Daly WT, Johnson BP, Sung KE, Schuler LA, Murphy WL, Beebe DJ. Development of a robust 3D organotypic model of human mammary ducts. Poster presented to the Graduate Student-Faculty Liaison Committee, University of Wisconsin, Madison, WI, May 2016. |
R835737 (2017) |
not available |
| Presentation | Livingston MK, Morgan MM, Daly WT, Johnson BP, Sung KE, Schuler LA, Murphy WL, Beebe DJ. Development of a robust 3D organotypic model of human mammary ducts. Presented at the Midwest Tumor Microenvironment Meeting, University of Minnesota, Minneapolis-St. Paul, MN, May 2016. |
R835737 (2017) |
not available |
| Presentation | Livingston MK. Development of a robust 3D organotypic model of human mammary ducts. Presented at the University of Dubuque Chemistry Department Seminar, Dubuque, IA, October 2016. |
R835737 (2017) |
not available |
| Presentation | Livingston MK. Human models for analysis of pathways: cancer MAPs – effects of extracellular matrix composition on mammary duct model. Presented at the U.S. Environmental Protection Agency Virtual Tissue Meeting, Research Triangle Park, NC, September 2016. |
R835737 (2017) |
not available |
| Presentation | Livingston MK. University of Wisconsin HMAPs update: development of a robust 3D organotypic model of human mammary ducts. Presented at the HMAPs Meeting, University of Wisconsin, Madison, WI, March 2016. |
R835737 (2017) |
not available |
| Presentation | Livingston MK. Synthetic hydrogels support 3D mammary duct morphogenesis. Presented at the STAR Horizons and Challenges in Organotypic Culture Models for Predictive Toxicology Progress Review Meeting at the Annual Society of Toxicology Meeting, Baltimore, MD, March 12-16, 2017. |
R835737 (2017) |
not available |
| Presentation | Martinez PA, Annalora AJ, Iversen PL, Sheibani N, Patterson AD, Marcus CB. Exploring the endogenous role of CYP1B1 in regulation of angiogenesis: insights from untargeted metabolomics and endothelial cell migration. Poster presented at the Society of Toxicology's 56th Annual Meeting, Baltimore, MD, March 12-16, 2017. |
R835737 (2017) |
not available |
| Presentation | Morgan MM, Livingston MK, Johnson BP, Schuler LA, Beebe DJ. Modeling chemical effects on estrogen receptor driven breast cancer progression in a microphysiological system. Poster presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835737 (2017) |
not available |
| Presentation | Morgan MM, Livingston MK, Johnson BP, Sung KE, Schuler LA, Beebe DJ. Investigating the impact of structure and fibroblasts on ER response in MCF7-derived mammary ducts. Poster presented at the Midwest Tumor Microenvironment Meeting, Minneapolis, MN, May 18-20, 2016. |
R835737 (2017) |
not available |
| Presentation | Morgan MM. How do stromal cells influence response to estrogen receptor ligands in an organotypic breast model? Presented at the U.S. Environmental Protection Agency Virtual Tissue Meeting, Research Triangle Park, NC, September 2016. |
R835737 (2017) |
not available |
| Presentation | Morgan MM. How do stromal cells influence response to estrogen receptor ligands in an organotypic breast model? Presented at the Human Maps for the Analysis of Pathways Meeting, Madison, WI, September 2016. |
R835737 (2017) |
not available |
| Presentation | Morgan MM, Johnson BP, Livingston MK, Linda A. Schuler LA, Alarid ET, Beebe DJ. Utilizing the adverse outcome pathway framework in the development of organotypic screening platforms: a breast cancer case study. Poster presented at the American Society for Cellular and Computational Toxicology Annual Meeting, Research Triangle Park, NC, September 2016. |
R835737 (2017) |
not available |
| Presentation | Morgan MM. Fibroblasts modulate response to estrogens on a molecular, cellular and tissue level. Presented at the Tumor Microenvironment Meeting at the University of Wisconsin, Madison, WI, October 2016. |
R835737 (2017) |
not available |
| Presentation | Morgan MM. Fibroblasts and pre-adipocytes differentially modulate estrogenic responsiveness in an organotypic breast cancer model. Presented at the University of Wisconsin-Madison Molecular and Environmental Toxicology Center Seminar, Madison, WI, January 2017. |
R835737 (2017) |
not available |
| Presentation | Morgan MM. Reconstructing the tissue microenvironment to increase understanding of fibroblasts in invasive prostate cancer. Presented at the Prostate Cancer Foundation Site Visit at University of Wisconsin, Madison, WI, July 2017. |
R835737 (2017) |
not available |
| Presentation | Morgan MM, Johnson BP, Livingston MK, Lugo-Cintron KM, Stanek EM, Schuler LA, Alarid ET, Beebe DJ. Stromal fibroblasts and adipocytes differentially modulate estrogenic responsiveness in a microphysiological model of breast cancer. Poster presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835737 (2017) |
not available |
| Presentation | Morgan MM. Utilizing an AOP-based approach in the development of a hormonally responsive organotypic breast model. Presented at the STAR Horizons and Challenges in Organotypic Culture Models for Predictive Toxicology Progress Review Meeting at Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835737 (2017) |
not available |
| Presentation | Morgan MM. Fibroblasts speed estrogen induced hyperplasia in a chemical screening breast cancer model. Presented at the U.S. Environmental Protection Agency Virtual Tissue Meeting, October 2017. |
R835737 (2017) |
not available |
| Presentation | Morgan MM. Reconstructing the tissue microenvironment to understand the role of estrogens in prostate disease progression. Presented at the Annual O’Brien Symposium at University of Wisconsin, Madison, WI, May 2017. |
R835737 (2017) |
not available |
| Presentation | Morgan MM. Evaluating the impact (and need) of the mammary microenvironment when testing estrogen receptor ligands in vitro. Presented at the University of Wisconsin-Madison Molecular and Environmental Toxicology Center Seminar, Madison, WI, February 2018. |
R835737 (2017) |
not available |
| Presentation | Morgan MM. Livingston MK, Johnson BP, Schuler LA, Beebe DJ. Modeling chemical effects on estrogen receptor driven breast cancer progression in a microphysiological system. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835737 (2017) |
not available |
| Presentation | Murphy WL. Toward design rules for bioinspired assembly of human tissues. Presented at the Gordon Research Conference, Bioinspired Materials: Materials and Biology from Many Perspectives, Les Diablerets, Switzerland, June 5-10, 2016. |
R835737 (2017) |
not available |
| Presentation | Murphy WL. Wisconsin: a biomanufacturing center of excellence. Presented at the Wisconsin BioHealth Summit, Madison, WI, September 27, 2016. |
R835737 (2017) |
not available |
| Presentation | Murphy WL. Customized biomaterials for cell and tissue therapy. Presented at the Crossing Boundaries to Propel Tissue Engineering into the Clinic Symposium, Stanford University, Stanford, CA, Fall 2016. |
R835737 (2017) |
not available |
| Presentation | Murphy WL. Human pluripotent stem cell models for predicting neural toxicity. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835737 (2017) |
not available |
| Presentation | Murphy WL. Human pluripotent stem cell-derived neural tissue models for neurotoxicity screening. Presented at the World Biomaterials Congress, Montreal, Canada, May 17-22, 2016. |
R835737 (2017) |
not available |
| Presentation | Murphy WL. Assembly of human tissues for screening applications. Presented at the Sixth AIMBE/NIH Workshop on Validation and Qualification of New In Vitro Tools and Models for the Pre-Clinical Drug Discovery Process, Bethesda, MD, May 25-26, 2017. |
R835737 (2017) |
not available |
| Presentation | Murphy WL. Assembly of human tissues for screening applications. Presented at the 21st Regenerative Medicine Workshop, Hilton Head, SC, March 1-4, 2017. |
R835737 (2017) |
not available |
| Presentation | Murphy WL. Bioinspired approaches for musculoskeletal protein and gene delivery. Presented at the Musculoskeletal Regenerative Medicine and Biology Symposium: From Development to Regeneration, St. Louis, MO, May 4-6, 2017. |
R835737 (2017) |
not available |
| Presentation | Murphy WL. Biomanufacturing of stem cell-derived human tissues for discovery and therapy. Presented via the Biomedical Engineering Society Webinar, Fall 2017. |
R835737 (2017) |
not available |
| Presentation | Murphy WL. Biomaterials for regenerative medicine. Presented at the Stanley Manne Children's Research Institute Seminar Series, Lurie Children’s Hospital, Chicago, IL, Fall 2017. |
R835737 (2017) |
not available |
| Presentation | Murphy WL. Reproducible assembly of human tissues on a chip for screening applications. Presented at the Engineering in Medicine and Biology Society (EMBS) Meeting, Chicago, IL, Spring 2017. |
R835737 (2017) |
not available |
| Presentation | Murphy WL. Stabilization and delivery of biologics for tissue regeneration. Presented at SPRI's Third Annual Vail Scientific Summit, Vail, CO, August 23-27, 2017. |
R835737 (2017) |
not available |
| Presentation | Murphy WL. Wisconsin: a biomanufacturing center of excellence. Presented at the BMES Advanced Biomanufacturing Conference, Madison, WI, August 18-19, 2017. |
R835737 (2017) |
not available |
| Presentation | Murphy WL. Bioinspired materials for orthopedic tissue regeneration. Presented at the International Section of Fracture Repair Symposium, Orthopedic Research Society Conference, New Orleans, LA, March 10-13, 2018. |
R835737 (2017) |
not available |
| Presentation | Murphy WL. Cells and microenvironment. Presented at the NIDCR 2030 Workshop, NIH, Bethesda, MD, Spring 2018. |
R835737 (2017) |
not available |
| Presentation | Nguyen E. Enhanced-throughput platforms to model neural vasculature on synthetic hydrogels. Presented at the Weekly Seminar, UW-Madison Molecular and Environmental Toxicology Center, Madison, WI, December 15, 2016. |
R835737 (2017) |
not available |
| Presentation | Nguyen E. [title not provided]. Presented at the Weekly Seminar, UW-Madison Molecular and Environmental Toxicology Center, Madison, WI, December 2016. |
R835737 (2017) |
not available |
| Presentation | Nguyen E, Daly W, Saghiri MA, Fisk D, Murphy W, Sorenson C, Sheibani N. Induced pluripotent stem cells to construct a neurovascular unit model for chemical toxicity screening. Poster presented at the iForum Meeting, Philadelphia, PA, September 12-14, 2016. |
R835737 (2017) |
not available |
| Presentation | Nguyen E. Enhanced-throughput platforms to model neural vasculature on synthetic hydrogels. Presented at the MERI Kambara Research Symposium, Madison, WI, April 7, 2017. |
R835737 (2017) |
not available |
| Presentation | Nguyen E, Sheibani N. Enhanced-throughput platforms to model neurovasculature on synthetic hydrogels. Presented at the Weekly Seminar, UW-Madison Molecular and Environmental Toxicology Center, Madison, WI, December 2017. |
R835737 (2017) |
not available |
| Presentation | Nguyen E. Enhanced-throughput platforms to model neural vasculature on synthetic hydrogels. Presented at the U.S. Environmental Protection Agency Virtual Tissue Meeting, February 15, 2017. |
R835737 (2017) |
not available |
| Presentation | Nguyen E. [title not provided]. Presented at the U.S. Environmental Protection Agency Virtual Tissue Meeting, February 2017. |
R835737 (2017) |
not available |
| Presentation | Nguyen E, Daly W, Kaushik G, Saghiri MA, Fisk D, Murphy W, Sorenson C, Sheibani N. Construction of a neurovascular system using induced pluripotent stem cells to screen for chemicals with adverse vascular effects. Poster presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835737 (2017) |
not available |
| Presentation | Nguyen E. [title not provided] Presented at the University of Wisconsin Satellite Meeting at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835737 (2017) |
not available |
| Presentation | Nguyen E, Sheibani N. Enhanced-throughput platforms to model neurovasculature on synthetic hydrogels. Presented at the Weekly Seminar, UW-Madison Molecular and Environmental Toxicology Center, Madison, WI, October 2017. |
R835737 (2017) |
not available |
| Presentation | Nguyen E, Fisk D, Sorenson CM, Sheibani N. Construction of neurovascular unit models using induced pluripotent stem cells to assess adverse outcomes of chemical exposure. Poster presented at the Society of Toxicology 57th Annual Meeting and ToxExpo, San Antonio, TX, March 11-15, 2018. |
R835737 (2017) |
not available |
| Presentation | Roy S. CMINT: Chromatin module inference on cellular trajectories identifies poised epigenetic states in reprogramming to induced pluripotent stem cells. Presented at the Regulatory Genomics Special Interest Group (RegGenSIG) at the International Society for Computational Biology (ISMB) Conference, Orlando, FL, July 8-12, 2016. |
R835737 (2017) |
not available |
| Presentation | Roy S. Biological networks: from reconstruction to interpretation. Presented at the Great Lakes Bioinformatics/Canadian Computational Biology Conference, Toronto, Canada, May 16-19, 2016 (invited). |
R835737 (2017) |
not available |
| Presentation | Roy S. Regulatory network dynamics on developmental and evolutionary lineages. Presented at the Genetics and Genome Biology Discovery Seminar series, Sick Kids Research Institute, Toronto, Canada, May 2016 (invited). |
R835737 (2017) |
not available |
| Presentation | Roy S. A prior-based integrative framework for functional transcriptional regulatory network inference. Presented at the Ninth Annual RECOMB/ISCB Conference on Regulatory and Systems Genomics, with DREAM Challenges and Cytoscape Workshop, Phoenix, AZ, November 6-9, 2016. |
R835737 (2017) |
not available |
| Presentation | Roy S, Regulatory network dynamics on developmental and evolutionary lineages. Presented at the Network Inference: New Methods and New Data, European Conference on Computational Biology, The Hague, The Netherlands, September 3-7, 2016 (keynote). |
R835737 (2017) |
not available |
| Presentation | Roy S. Chromatin module inference on cellular trajectories identifies key transition points and poised epigenetic states in diverse developmental processes. Presented at the Cold Spring Harbor Laboratory Meeting on Systems Biology: Global Regulation of Gene Expression, Cold Spring Harbor, NY, February 26-March 2, 2017. |
R835737 (2017) |
not available |
| Presentation | Roy S. Integrative inference of functional transcriptional gene regulatory networks. Presented at the Great Lakes Bioinformatics Conference (GLBIO), Chicago, IL, May 15-17, 2017 (invited). |
R835737 (2017) R835737C004 (2017) R835737C005 (2017) |
not available |
| Presentation | Seirup M. Spatial recovery of the hepatic lobule using single cell RNA sequencing data. Presented at Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835737 (2017) |
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| Presentation | Seirup M, Sengputa S, Thomson J. [title not provided]. Presented at the U.S. Environmental Protection Agency Virtual Tissue Meeting, 2017. |
R835737 (2017) |
not available |
| Presentation | Sheibani N, Falero-Perez J, Sorenson CM. Cytochrome P450 1B1 is a key regulator of ocular oxidative stress and pathogenesis of congenital glaucoma. Poster presented at the Midwest Eye Research Symposium, Iowa City, IA, August 3-4, 2017. |
R835737 (2017) |
not available |
| Presentation | Sheibani N, Zaitoun I, Cengiz P, Cikla U, Zafe D, Udho E, Sorenson CM. Hypoxic-ischemic insult disrupts normal retinal vascular development. Poster presented at the Association for Research in Vision and Ophthalmology Annual Meeting, Baltimore, MD, May 7-11, 2017. |
R835737 (2017) |
not available |
| Presentation | Sheibani N. Metabolic stress and retinal vascular cell dysfunction in diabetes. Preseneted at the Department of Medicine, Endocrinology, Diabetes and Metabolism Grand Rounds, University of Wisconsin, Madison, WI, November 16, 2017. |
R835737 (2017) |
not available |
| Presentation | Sheibani N. Cyp1b1 and congenital glaucoma. Presented at the McPherson Eye Research Institute, University of Wisconsin-Madison, Fall Seminar Series, Madison, WI, September 12, 2017. |
R835737 (2017) |
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| Presentation | Sheibani N. Negative regulators of angiogenesis and ocular vascular homeostasis. Presented at the Meharry Medical College, Department of Microbiology and Immunology, Nashville, TN, January 25, 2018. |
R835737 (2017) |
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| Presentation | Thomson J. [title not provided] Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835737 (2017) R835737C001 (2017) |
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| Presentation | Xiao A, Pidikiti R, Maynard M, Sheibani N, Harrison L. The use of sodium sulfide, a hydrogen sulfide donor, to sensitize glioblastoma multiforme to photon and proton radiotherapy. Poster presented at the American Association for Cancer Research (AACR) Annual Meeting, Washington, DC, April 1-5, 2017. |
R835737 (2017) |
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| Presentation | Xiao A, Maynard M, Pidikiti R, Sheibani N, Couraud P-O, Alexander JS, Harrison L. Sodium sulfide, a hydrogen sulfide donor, sensitizes glioblastoma to photons and protons. Poster presented at the 63rd International Meeting of the Radiation Research Society, Cancun, Mexico, October 15-17, 2017. |
R835737 (2017) |
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| Presentation | Murphy WL. Engineered microphysiological systems for cell-based predictive models of developmental neurotoxicity. Presented at the Teratology Society Annual Meeting: New Horizons in Birth Defects Research, San Antonio, TX, June 25-29, 2016. |
R835737 (2017) |
not available |
| Presentation | Johnson B. A microphysiological approach to elucidating gene-environment interactions in orofacial clefting. Presented at the U.S. Environmental Protection Agency Virtual Tissue Meeting, December 2017. |
R835737 (2017) |
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| Presentation | Zafer Gurel Z, Sorenson CM, Sheibani N. Metabolic stress and O-GlcNAc modification regulate the selective sensitivity of retinal vascular cells to hyperglycemia. Poster presented at the American Diabetes Association (ADA) 77th Scientific Sessions, San Diego CA June 9-13, 2017. |
R835737 (2017) |
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| Presentation | Murphy WL. Bioinspired materials for cell and gene therapies. Presented at the Gordon Research Conference on Signal Transduction in Engineered Extracellular Matrices, Andover, NH, July 22-27, 2018. |
R835737 (2017) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.