Grantee Research Project Results
Journal Publications Details for Grant Number R835737
Human Models for Analysis of Pathways (H MAPs) Center
RFA:
Organotypic Culture Models for Predictive Toxicology Center (2013)
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Journal Article | Retinal oxidative stress at the onset of diabetes determined by synchrotron FTIR widefield imaging: towards diabetes pathogenesis. | ANALYST | Aboualizadeh E, Ranji M, Sorenson CM, Sepehr R, Sheibani N, Hirschmugl CJ | Aboualizadeh E, Ranji M, Sorenson CM, Sepehr R, Sheibani N, Hirschmugl CJ. Retinal oxidative stress at the onset of diabetes determined by synchrotron FTIR widefield imaging:towards diabetes pathogenesis. Analyst 2017;142(7):1061-1072. |
R835737 (2017) |
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| Journal Article | Temporal diabetes-induced biochemical changes in distinctive layers of mouse retina. | None | Aboualizadeh E, Sorenson CM, Schofield AJ, Unger M, Sheibani N,Hirschmugl CJ | Aboualizadeh E, Sorenson CM, Schofield AJ, Unger M, Sheibani N, Hirschmugl CJ. Temporal diabetes-induced biochemical changes in distinctive layers of mouse retina. Scientific Reports 2018;8(1):1096. |
R835737 (2017) |
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| Journal Article | Synthetic alternatives to Matrigel | NATURE REVIEWS MATERIALS | Aisenbrey E, Murphy W | Aisenbrey E, Murphy W. Synthetic alternatives to Matrigel. Nature Reviews Materials 2020 |
R835737 (Final) |
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| Journal Article | A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction | DEVELOPMENTAL BIOLOGHY, STEM CELLS AND REGENERATIVE MEDICINE | Bakooshli M, Lippmann E, Mulcahy B, Iyer N, Nguyen C, Tung K, Stewart B, van den Dorpel H, Fuehrmann T, Gilbert P, Shoichet M, Bigot A, Pegoraro E, Ahn H, Ginsberg H, Zhen M, Ashton R, Gilbert P | Bakooshli M, Lippmann E, Mulcahy B, Iyer N, Nguyen C, Tung K, Stewart B, van den Dorpel H, Fuehrmann T, Gilbert P, Shoichet M, Bigot A, Pegoraro E, Ahn H, Ginsberg H, Zhen M, Ashton R, Gilbert P. A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction. DEVELOPMENTAL BIOLOGHY, STEM CELLS AND REGENERATIVE MEDICINE 2019;8(e44530) |
R835737 (Final) |
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| Journal Article | Uniform neural tissue models produced on synthetic hydrogels using standard culture techniques. | EXPERIMENT BIOLOGY MEDICINE | Barry C, Schmitz MT, Propson NE, Hou Z, Zhang J, Nguyen BK, Bolin JM,Jiang P, McIntosh BE, Probasco MD, Swanson S, Stewart R, Thomson JA,Schwartz MP, Murphy WL | Barry C, Schmitz MT, Propson NE, Hou Z, Zhang J, Nguyen BK, Bolin JM, Jiang P, McIntosh BE, Probasco MD, Swanson S, Stewart R, Thomson JA, Schwartz MP, Murphy WL. Uniform neural tissue models produced on synthetic hydrogels using standard culture techniques. Experimental Biology and Medicine 2017;242(17):1679-1689. |
R835737 (2017) R835737C001 (2017) |
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| Journal Article | Human iPSC-derived endothelial cell sprouting assay in synthetic hydogel arrays. | ACTA BIOMATERIALIA | Belair DG, Schwartz MP, Knudsen T, Murphy WL | Belair DG, Schwartz MP, Knudsen T, Murphy WL. Human iPSC-derived endothelial cell sprouting assay in synthetic hydogel arrays. Acta Biomaterialia 2016;39:12-24. |
R835737 (2016) R835737 (2017) R835737C004 (2015) |
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| Journal Article | Differential regulation of angiogenesis using degradable VEGF-binding microspheres. | BIOMATERIALS | Belair DG, Miller MJ, Wang S, Darjatmoko SR, Binder BYK, Sheibani N,Murphy WL | Belair DG, Miller MJ, Wang S, Darjatmoko SR, Binder BYK, Sheibani N, Murphy WL. Differential regulation of angiogenesis using degradable VEGF-binding microspheres. Biomaterials 2016;93:27-37. |
R835737 (2015) R835737 (2016) R835737 (2017) R835737C004 (2015) R835737C004 (2016) |
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| Journal Article | Regulating VEGF signaling in platelet concentrates via specific VEGF sequestering. | BIOMATERIALS SCIENCE | Belair DG, Le NN, Murphy WL | Belair DG, Le NN, Murphy WL. Regulating VEGF signaling in platelet concentrates via specific VEGF sequestering. Biomaterials Science 2016;4(5):819-825. |
R835737 (2015) R835737 (2016) R835737 (2017) R835737C004 (2015) |
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| Journal Article | Integrating transcriptomic and proteomic data using predictive regulatory network models of host response to pathogens. | PLOS COMPUTATIONAL BIOLOGY | Chasman D, Walters KB, Lopes TJ, Eisfeld AJ, Kawaoka Y, Roy S | Chasman D, Walters KB, Lopes TJ, Eisfeld AJ, Kawaoka Y, Roy S. Integrating transcriptomic and proteomic data using predictive regulatory network models of host response to pathogens. PLoS Computational Biology2016;12(7):e1005013. |
R835737 (2015) R835737 (2016) R835737 (2017) R835737C005 (2015) |
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| Journal Article | Network-based approaches for analysis of complex biological systems. | CURRENT OPINION IN BIOTECHNOLOGY | Chasman D, Fotuhi Siahpirani A, Roy S | Chasman D, Fotuhi Siahpirani A, Roy S. Network-based approaches for analysis of complex biological systems. Current Opinion in Biotechnology 2016;39:157-166. |
R835737 (2015) R835737 (2016) R835737 (2017) R835737C005 (2015) |
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| Journal Article | Inference of cell type specific regulatory networks on mammalian lineages. | CURRENT OPINION IN SYSTEMS BIOLOGY | Chasman D, Roy S | Chasman D, Roy S. Inference of cell type specific regulatory networks on mammalian lineages. Current Opinion in Systems Biology 2017;2:130-139. |
R835737 (2017) R835737C004 (2017) R835737C005 (2016) R835737C005 (2017) |
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| Journal Article | Microparticles locally deliver active interleukin-1 receptor antagonist in vivo. | None | Clements AE, Groves ER, Chamberlain CS, Vanderby R, Murphy WL | Clements AE, Groves ER, Chamberlain CS, Vanderby R, Murphy WL. Microparticles locally deliver active interleukin-1 receptor antagonist in vivo. Advanced Healthcare Materials 2018;7(16):1800263. |
R835737 (Final) |
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| Journal Article | Mechanistic role of cytochrome P450 (CYP)1B1 in oxygen-mediated toxicity in pulmonary cells: a novel target for prevention of hyperoxic lung injury. | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | Dinu D, Chu C, Veith A, Lingappan K, Couroucli X, Jefcoate CR, SheibaniN, Moorthy B | Dinu D, Chu C, Veith A, Lingappan K, Couroucli X, Jefcoate CR, Sheibani N, Moorthy B. Mechanistic role of cytochrome P450 (CYP)1B1 in oxygen-mediated toxicity in pulmonary cells:a novel target for prevention of hyperoxic lung injury. Biochemical and Biophysical Research Communications 2016;476(4):346-351. |
R835737 (2016) R835737 (2017) R835737C004 (2016) |
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| Journal Article | Single-injection ex ovo transplantation method for broad spinal cord engraftment of human pluripotent stem cell-derived motor neurons | JOURNAL OF NEUROSCIENCE METHODS | Estevez-Silva M, Sreeram A, Cuskey S, Fedorchak N, Layer N, Ashton R | Estevez-Silva M, Sreeram A, Cuskey S, Fedorchak N, Layer N, Ashton R. Single-injection ex ovo transplantation method for broad spinal cord engraftment of human pluripotent stem cell-derived motor neurons. JOURNAL OF NEUROSCIENCE METHODS 2018;298:16-23 |
R835737 (Final) |
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| Journal Article | PEDF expression affects retinal endothelial cell proangiogenic properties through alterations in cell adhesive mechanisms. | None | Falero-Perez J, Park S, Sorenson CM, Sheibani N | Falero-Perez J, Park S, Sorenson CM, Sheibani N. PEDF expression affects retinal endothelial cell proangiogenic properties through alterations in cell adhesive mechanisms. American Journal of Physiology-Cell Physiology 2017;313(4):C405-C420. |
R835737 (2017) |
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| Journal Article | Cyp1b1-deficient retinal astrocytes are more proliferative and migratory and are protected from oxidative stress and inflammation. | AMERICAN JOURNAL OF PHYSIOLOGY | Falero-Perez J, Sorenson C, Sheibani N | Falero-Perez J, Sorenson C, Sheibani N. Cyp1b1-deficient retinal astrocytes are more proliferative and migratory and are protected from oxidative stress and inflammation. AMERICAN JOURNAL OF PHYSIOLOGY 2019;306(6):C767-C781 |
R835737 (Final) |
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| Journal Article | High glucose promotes the migration of retinal pigment epithelial cells through increased oxidative stress and PEDF expression. | AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | Farnoodian M, Halbach C, Slinger C, Pattnaik BR, Sorenson CM, Sheibani N | Farnoodian M, Halbach C, Slinger C, Pattnaik BR, Sorenson CM, Sheibani N. High glucose promotes the migration of retinal pigment epithelial cells through increased oxidative stress and PEDF expression. American Journal of Physiology-Cell Physiology 2016;311(3):C418-C436. |
R835737 (2016) R835737 (2017) R835737C004 (2016) |
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| Journal Article | Negative regulators of angiogenesis: important targets for treatment of exudative AMD. | None | Farnoodian M, Wang S, Dietz J, Nickells RW, Sorenson CM, Sheibani N | Farnoodian M, Wang S, Dietz J, Nickells RW, Sorenson CM, Sheibani N. Negative regulators of angiogenesis: important targets for treatment of exudative AMD. Clinical Science 2017;131(15):1763-1780. |
R835737 (2017) |
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| Journal Article | PEDF expression affects the oxidative and inflammatory state of choroidal endothelial cells. | None | Farnoodian M, Sorenson CM, Sheibani N | Farnoodian M, Sorenson CM, Sheibani N. PEDF expression affects the oxidative and inflammatory state of choroidal endothelial cells. American Journal of Physiology-Cell Physiology 2018;314(4):C456-C472. |
R835737 (2017) |
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| Journal Article | Biofunctionalized plants as diverse biomaterials for human cell culture. | ADVANCED HEALTHCARE MATERIALS | Fontana G, Gershlak J, Adamski M, Lee J-S, Matsumoto S, Le HD, Binder B,Wirth J, Gaudette G, Murphy WL | Fontana G, Gershlak J, Adamski M, Lee J-S, Matsumoto S, Le HD, Binder B, Wirth J, Gaudette G, Murphy WL. Biofunctionalized plants as diverse biomaterials for human cell culture. Advanced Healthcare Materials 2017;6(8):1601225. |
R835737 (2016) R835737 (2017) |
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| Journal Article | Physiological responses and gene co-expression network of mycorrhizal roots under K+ deprivation. | PLANT PHYSIOLOGY | Garcia K, Chasman D, Roy S, Ane J-M | Garcia K, Chasman D, Roy S, Ane J-M. Physiological responses and gene co-expression network of mycorrhizal roots under K+ deprivation. Plant Physiology 2017;173(3):1811-1823. |
R835737 (2017) R835737C004 (2017) R835737C005 (2017) |
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| Journal Article | Quantitative assessment of retinopathy using multi-parameter image analysis. | JOURNAL OF MEDICAL SIGNALS AND SENSORS | Ghanian Z, Staniszewski K, Jamali N, Sepehr R, Wang S, Sorenson CM,Sheibani N, Ranji M | Ghanian Z, Staniszewski K, Jamali N, Sepehr R, Wang S, Sorenson CM, Sheibani N, Ranji M. Quantitative assessment of retinopathy using multi-parameter image analysis. Journal of Medical Signals and Sensors 2016;6(2):71-80. |
R835737 (2016) R835737 (2017) R835737C004 (2016) |
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| Journal Article | O-Linked β-N -acetylglucosamine (O-GlcNAc) modification:a new pathway to decode pathogenesis of diabetic retinopathy. | None | Gurel Z, Sheibani N | Gurel Z, Sheibani N. O-Linked β-N -acetylglucosamine (O-GlcNAc) modification: a new pathway to decode pathogenesis of diabetic retinopathy. Clinical Science 2018;132(2):185-198. |
R835737 (2017) |
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| Journal Article | Targeting of 12/15-Lipoxygenase in retinal endothelial cells, but not in monocytes/macrophages, attenuates high glucose-induced retinal leukostasis. | BIOCHIMICA ET BIOPHYSICA ACTA (BBA)-MOLECULAR BASIS OF DISEASE | Ibrahim AS, Saleh H, El-Shafey M, Hussein KA, El-Masry K, Baban B,Sheibani N, Wang MH, Tawfik A, Al-Shabrawey M | Ibrahim AS, Saleh H, El-Shafey M, Hussein KA, El-Masry K, Baban B, Sheibani N, Wang MH, Tawfik A, Al-Shabrawey M. Targeting of 12/15-lipoxygenase in retinal endothelial cells, but not in monocytes/macrophages, attenuates high glucose-induced retinal leukostasis. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids 2017;1862(6):636-645. |
R835737 (2017) |
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| Journal Article | Modular derivation of diverse, regionally discrete human posterior CNS neurons enables discovery of transcriptomic patterns | SCIENCE ADVANCES | Iyer N, Shin J, Cuskey S, Tian Y, Nicol N, Doersch T, Seipel F, McCalla S, Roy S, Ashton R | Iyer N, Shin J, Cuskey S, Tian Y, Nicol N, Doersch T, Seipel F, McCalla S, Roy S, Ashton R. Modular derivation of diverse, regionally discrete human posterior CNS neurons enables discovery of transcriptomic patterns. SCIENCE ADVANCES 2022;8(39):eabn7430 |
R835737 (Final) |
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| Journal Article | Vitamin D receptor expression is essential during retinal vascular development and attenuation of neovascularization by 1, 25(OH)2 D3 . | PLOS ONE | Jamali N, Wang S, Darjatmoko SR, Sorenson CM, Sheibani N | Jamali N, Wang S, Darjatmoko SR, Sorenson CM, Sheibani N. Vitamin D receptor expression is essential during retinal vascular development and attenuation of neovascularization by 1, 25(OH)2 D3 . PLoS One 2017;12(12):e0190131. |
R835737 (2017) |
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| Journal Article | Vitamin D and regulation of vascular cell function. | None | Jamali N, Sorenson CM, Sheibani N | Jamali N, Sorenson CM, Sheibani N. Vitamin D and regulation of vascular cell function. American Journal of Physiology-Heart and Circulatory Physiology 2017;314(4):H753-H765. |
R835737 (2017) |
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| Journal Article | A Microphysiological Approach to Evaluate Effectors of Intercellular Hedgehog Signaling in Development | FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | Johnson B, VItek R, Morgan M, Fink D, Beames T, Geiger P, Beebe D, Lipinski R | Johnson B, VItek R, Morgan M, Fink D, Beames T, Geiger P, Beebe D, Lipinski R. A Microphysiological Approach to Evaluate Effectors of Intercellular Hedgehog Signaling in Development. Frontiers in Cell and Developmental Biology 2021;9:71. |
R835737 (Final) |
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| Journal Article | Engineered Perineural Vascular Plexus for Modeling Developmental Toxicity | ADVANCED HEALCARE MATERIALS | Kauschik G, Gupta K, Harms V, Torr E, Evans J, Johnson H, Soref C, Acevedo-Acevedo S, Antosiewicz-Bourget J, Mamott D | Kauschik G, Gupta K, Harms V, Torr E, Evans J, Johnson H, Soref C, Acevedo-Acevedo S, Antosiewicz-Bourget J, Mamott D. Engineered Perineural Vascular Plexus for Modeling Developmental Toxicity. Advanced Healcare Materials 2020;(2000825). |
R835737 (Final) |
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| Journal Article | Functionalization of microparticles with mineral coatings enhances non-viral transfection of primary human cells. | SCIENTIFIC REPORTS | Khalil AS, Yu X, Xie AW, Fontana G, Umhoefer JM, Johnson HJ, Hookway TA,McDevitt TC, Murphy WL | Khalil AS, Yu X, Xie AW, Fontana G, Umhoefer JM, Johnson HJ, Hookway TA, McDevitt TC, Murphy WL. Functionalization of microparticles with mineral coatings enhances non-viral transfection of primary human cells. Scientific Reports 2017;7(1):14211. |
R835737 (2017) |
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| Journal Article | Single-dose mRNA therapy via biomaterial-mediated sequestration of overexpressed proteins | SCIENCE ADVANCES | Khalil A, Yu X, Umhoefer J, Chamberlain C, COnnie S, Wildenauer L, Diarra G, Hacker T, Murphy W | Khalil A, Yu X, Umhoefer J, Chamberlain C, COnnie S, Wildenauer L, Diarra G, Hacker T, Murphy W. Single-dose mRNA therapy via biomaterial-mediated sequestration of overexpressed proteins. Science Advances 2020;6(27):eaba2422. |
R835737 (Final) |
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| Journal Article | Micropatterned, clickable culture substrates enable in situ spatiotemporal control of human PSC-derived neural tissue morphology. | CHEMICAL COMMUNICATIONS | Knight GT, Sha J, Ashton RS | Knight GT, Sha J, Ashton RS. Micropatterned, clickable culture substrates enable in situ spatiotemporal control of human PSC-derived neural tissue morphology. Chemical Communications 2015;51(25):5238-5241. |
R835737 (2015) R835737 (2016) R835737C002 (2015) R835737C002 (2016) |
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| Journal Article | Engineering induction of singular neural rosette emergence within jPSC-derived tissues. | None | Knight GT, Lundin BF, Iyer N, Ashton LMT, Sethares WA, Willett RM, Ashton RS | Knight GT, Lundin BF, Iyer N, Ashton LMT, Sethares WA, Willett RM, Ashton RS. Engineering induction of singular neural rosette emergence within jPSC-derived tissues. eLIFE 2018;7:e37549 (23 pp.). |
R835737 (2017) R835737 (Final) R835737C002 (2017) |
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| Journal Article | Surface functionalization and dynamics of polymeric cell culture substrates. | CURRENT OPINION IN BIOTECHNOLOGY | Krutty JD, Schmitt SK, Gopalan P, Murphy WL | Krutty JD, Schmitt SK, Gopalan P, Murphy WL. Surface functionalization and dynamics of polymeric cell culture substrates. Current Opinion in Biotechnology 2016;40:164-169. |
R835737 (2017) |
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| Journal Article | β2-adrenergic receptor antagonism attenuates CNV through inhibition of VEGF and IL-6 expression. | None | Lavine JA, Farnoodian M, Wang S, Darjatmoko SR, Wright LS, Gamm DM, Ip MS, Sorenson CM, Sheibani N | Lavine JA, Farnoodian M, Wang S, Darjatmoko SR, Wright LS, Gamm DM, Ip MS, Sorenson CM, Sheibani N. β2-adrenergic receptor antagonism attenuates CNV through inhibition of VEGF and IL-6 expression. Investigative Ophthalmology & Visual Science 2017;58(1):299-308. |
R835737 (2017) R835737 (Final) |
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| Journal Article | Combination of Heparin Binding Peptide and Heparin Cell Surface Coatings for Mesenchymal Stem Cell Spheroid Assembly. | BIOCONJUGATE CHEMISTRY | Lei J, Murphy W, Temenoff J | Lei J, Murphy W, Temenoff J. Combination of Heparin Binding Peptide and Heparin Cell Surface Coatings for Mesenchymal Stem Cell Spheroid Assembly. BIOCONJUGATE CHEMISTRY 2018;29(4):878-884 |
R835737 (Final) |
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| Journal Article | Deriving, regenerating, and engineering CNS tissues using human pluripotent stem cells. | None | Lemke KA, Aghayee A, Ashton RS | Lemke KA, Aghayee A, Ashton RS. Deriving, regenerating, and engineering CNS tissues using human pluripotent stem cells. Current Opinion in Biotechnology 2017;47:36-42. |
R835737 (2017) R835737C002 (2017) |
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| Journal Article | The effect of Tmem135 overexpression on the mouse heart. | PLOS ONE | Lewis S, Takimoto T, Mehrvar S, Higuchi H, Doebley A, Stokes G, Sheibani N, Ideda S, Ranji M, Ikeda A | Lewis S, Takimoto T, Mehrvar S, Higuchi H, Doebley A, Stokes G, Sheibani N, Ideda S, Ranji M, Ikeda A. The effect of Tmem135 overexpression on the mouse heart. PLOS ONE 2018;13(8):e0201986 |
R835737 (Final) |
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| Journal Article | Social motility of biofilm-like microcolonies in a gliding bacterium | NATURE COMMUNICATIONS | Li C, Hurley A, Hu W, Warrick J, Lozano G, Ayuso J, Pan W, Handlesman J, Beebe D | Li C, Hurley A, Hu W, Warrick J, Lozano G, Ayuso J, Pan W, Handlesman J, Beebe D. Social motility of biofilm-like microcolonies in a gliding bacterium. Nature Communications 2021;12(1). |
R835737 (Final) |
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| Journal Article | Sustaining intravitreal residence with L-arginine peptide-conjugated nanocarriers. | INVESTIGATIVE OPHTHALMOLOLOGY VISUAL SCIENCE< | Li H, Liu W, Sorenson CM, Sheibani N, Albert DM, Senanayake T,Vinogradov S, Henkin J, Zhang HF | Li H, Liu W, Sorenson CM, Sheibani N, Albert DM, Senanayake T, Vinogradov S, Henkin J, Zhang HF. Sustaining intravitreal residence with L-arginine peptide-conjugated nanocarriers. Investigative Ophthalmolology & Visual Science 2017;58(12):5142-5150. |
R835737 (2017) |
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| Journal Article | Chemically defined differentiation of human pluripotent stem cells to hindbrain and spinal cord neural stem cells with defined regional identities. | PROTOCOL EXCHANGE | Lippmann E, Estevez-Silva M, Ashton R | Lippmann E, Estevez-Silva M, Ashton R. Chemically defined differentiation of human pluripotent stem cells to hindbrain and spinal cord neural stem cells with defined regional identities. Protocol Exchange 2015; 27 pp. |
R835737 (2015) R835737 (2016) |
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| Journal Article | Evaluation of PEG-Based Hydrogel Influence on Estrogen-Receptor-Driven Responses in MCF7 Breast Cancer Cells | ACS PUBLICATIONS | Livingston M, Morgan M, Daly W, Murphy W, Johnson B, Virumbrales-Munoz M | LIvingston M, Morgan M, Daly W, Murphy W, Johnson B, Virumbrales-Munoz M. Evaluation of PEG-Based Hydrogel Influence on Estrogen-Receptor-Driven Responses in MCF7 Breast Cancer Cells. ACS Publications 2019;5(11):6089-6098. |
R835737 (2018) R835737C003 (Final) |
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| Journal Article | New ideas for non-animal approaches to predict repeated-dose systemic toxicity: Report from an EPAA Blue Sky Workshop | REGULATORY TOXICOLOGY AND PHARMACOLOGY | Mahony C, Ashton R, Birk B, Boobis A, Cull T, Datson G, Ewart L, Knudsen T, Manou I, Maurer-Stroh S | Mahony C, Ashton R, Birk B, Boobis A, Cull T, Datson G, Ewart L, Knudsen T, Manou I, Maurer-Stroh S. New ideas for non-animal approaches to predict repeated-dose systemic toxicity:Report from an EPAA Blue Sky Workshop. Regulatory Toxicology and Pharmacology 2020;114(UNSP 104668). |
R835737 (Final) |
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| Journal Article | Human induced pluripotent stem cell-derived planar neural organoids assembled on synthetic hydrogels | None | Majumder J, Torr E, Aisenbrey E, Lebakken C, Favreau P, Richards W, Yin Y, Chang Q, Murphy W | Majumder J, Torr E, Aisenbrey E, Lebakken C, Favreau P, Richards W, Yin Y, Chang Q, Murphy W. Human induced pluripotent stem cell-derived planar neural organoids assembled on synthetic hydrogels. JOURNAL OF TISSUE ENGINEERING 2024;15(20417314241230633) |
R835737 (Final) |
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| Journal Article | The case for applying tissue engineering methodologies to instruct human organoid morphogenesis. | None | Marti-Figueroa CR, Ashton RS | Marti-Figueroa CR, Ashton RS. The case for applying tissue engineering methodologies to instruct human organoid morphogenesis. Acta Biomaterialia 2017;54:35-44. |
R835737 (2017) R835737C002 (2017) |
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| Journal Article | Intravitreal Delivery of VEGF-A(165)-loaded PLGA Microparticles Reduces Retinal Vaso-Obliteration in an In Vivo Mouse Model of Retinopathy of Prematurity. | CURRENT EYE RESEARCH | Mezu-Ndubuisi O, Wang Y, Schoephoerster J, Falero_Perez J, Zaitoun I, Sheibani, Gong S | Mezu-Ndubuisi O, Wang Y, Schoephoerster J, Falero_Perez J, Zaitoun I, Sheibani, Gong S. Intravitreal Delivery of VEGF-A(165)-loaded PLGA Microparticles Reduces Retinal Vaso-Obliteration in an In Vivo Mouse Model of Retinopathy of Prematurity. CURRENT EYE RESEARCH 2018;44(Full Text HTML):275-286 |
R835737 (Final) |
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| Journal Article | Destructive effect of non-enzymatic glycation on catalase and remediation via curcumin. | None | Mofidi Najjar F, Taghavi F, Ghadari R, Sheibani N, Moosavi-Movahedi AA | Mofidi Najjar F, Taghavi F, Ghadari R, Sheibani N, Moosavi-Movahedi AA. Destructive effect of non-enzymatic glycation on catalase and remediation via curcumin. Archives of Biochemistry and Biophysics 2017;630:81-90. |
R835737 (2017) |
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| Journal Article | Tracking and Predicting Human Somatic Cell Reprogramming Using Nuclear Characteristics | BIOPHYSICAL JOURNAL | Molugy K, Harkness T, Carlson-Tevermer J, Prestil R, Piscopo N, Seymour S, Knight G, Ashton R, Saha K | Molugy K, Harkness T, Carlson-Tevermer J, Prestil R, Piscopo N, Seymour S, Knight G, Ashton R, Saha K. Tracking and Predicting Human Somatic Cell Reprogramming Using Nuclear Characteristics. BIOPHYSICAL JOURNAL 2020;118(9):2086-2102. |
R835737 (Final) |
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| Journal Article | Personalized in vitro cancer models to predict therapeutic response: challenges and a framework for improvement. | PHARMACOLOGY & THERAPEUTICS | Morgan MM, Johnson BP, Livingston MK, Schuler LA, Alarid ET, Sung KE,Beebe DJ | Morgan MM, Johnson BP, Livingston MK, Schuler LA, Alarid ET, Sung KE, Beebe DJ. Personalized in vitro cancer models to predict therapeutic response:challenges and a framework for improvement. Pharmacology & Therapeutics 2016;165:79-92. |
R835737 (2016) R835737 (2017) R835737C003 (2015) R835737C003 (2016) |
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| Journal Article | Mammary fibroblasts reduce apoptosis and speed estrogen-induced hyperplasia in an organotypic MCF7-derived duct model. | None | Morgan MM, Livingston MK, Warrick JW, Stanek EM, Alarid ET, Beebe DJ,Johnson BP | Morgan MM, Livingston MK, Warrick JW, Stanek EM, Alarid ET, Beebe DJ, Johnson BP. Mammary fibroblasts reduce apoptosis and speed estrogen-induced hyperplasia in an organotypic MCF7-derived duct model. Scientific Reports 2018;8(1):7139. |
R835737 (2017) R835737C003 (2017) R835737C003 (Final) |
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| Journal Article | Mammary adipose stromal cells derived from obese women reduce sensitivity to the aromatase inhibitor anastrazole in an organotypic breast model | FASEB JOURNAL | Morgan M, Arendt L, Alarid E, Beebe D, Johnson B | Morgan M, Arendt L, Alarid E, Beebe D, Johnson B. Mammary adipose stromal cells derived from obese women reduce sensitivity to the aromatase inhibitor anastrazole in an organotypic breast model. FASEB Journal 2019;33(7):8623-8633. |
R835737 (2018) R835737C003 (Final) |
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| Journal Article | Modeling chemical effects on breast cancer: the importance of the microenvironment in vitro | INTEGRATIVE BIOLOGY | Morgan M, Schuler L, Ciciliano J, Johnson B, Alarid E, Beebe D | Morgan M, Schuler L, Ciciliano J, Johnson B, Alarid E, Beebe D. Modeling chemical effects on breast cancer: the importance of the microenvironment in vitro. Integrative Biology 2020;12(2):21-33 |
R835737 (Final) |
not available |
| Journal Article | Versatile synthetic alternatives to Matrigel for vascular toxicity screening and stem cell expansion. | NATURE BIOMEDICAL ENGINEERING | Nguyen EH, Daly WT, Le NNT, Farnoodian M, Belair DG, Schwartz MP,Lebakken CS, Ananiev GE, Saghiri MA, Knudsen TB, Sheibani N, Murphy WL | Nguyen EH, Daly WT, Le NNT, Farnoodian M, Belair DG, Schwartz MP, Lebakken CS, Ananiev GE, Saghiri MA, Knudsen TB, Sheibani N, Murphy WL. Versatile synthetic alternatives to Matrigel for vascular toxicity screening and stem cell expansion. Nature Biomedical Engineering 2017;1(7):0096. |
R835737 (2016) R835737 (2017) |
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| Journal Article | Bioengineering solutions for manufacturing challenges in CAR T cells. | None | Piscopo NJ, Mueller KP, Das A, Hematti P, Murphy WL, Palecek SP,Capitini CM, Saha K | Piscopo NJ, Mueller KP, Das A, Hematti P, Murphy WL, Palecek SP, Capitini CM, Saha K. Bioengineering solutions for manufacturing challenges in CAR T cells. Biotechnology Journal 2018;13(2):1700095. |
R835737 (2017) |
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| Journal Article | Regulation of high glucose-induced apoptosis of brain pericytes by mitochondrial CA VA: a specific target for prevention of diabetic cerebrovascular pathology. | BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - MOLECULAR BASIS OF DISEASE | Price TO, Sheibani N, Shah GN | Price TO, Sheibani N, Shah GN. Regulation of high glucose-induced apoptosis of brain pericytes by mitochondrial CA VA:a specific target for prevention of diabetic cerebrovascular pathology. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 2017;1863(4):929-935. |
R835737 (2017) |
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| Journal Article | The influence of biomaterials on cytokine production in 3D cultures. | BIOMACROMOLECULES | Regier MC, Montanez-Sauri SI, Schwartz MP, Murphy WL, Beebe DJ, Sung KE | Regier MC, Montanez-Sauri SI, Schwartz MP, Murphy WL, Beebe DJ, Sung KE. The influence of biomaterials on cytokine production in 3D cultures. Biomacromolecules 2017;18(3):709-718. |
R835737 (2016) R835737 (2017) |
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| Journal Article | Andrographolide ameliorates abdominal aortic aneurysm progression by inhibiting inflammatory cell infiltration through downregulation of cytokine and integrin expression. | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS | Ren J, Liu Z, Wang Q, Giles J, Greenberg J, Sheibani N, Kent KC, Liu B | Ren J, Liu Z, Wang Q, Giles J, Greenberg J, Sheibani N, Kent KC, Liu B. Andrographolide ameliorates abdominal aortic aneurysm progression by inhibiting inflammatory cell infiltration through downregulation of cytokine and integrin expression. Journal of Pharmacology and Experimental Therapeutics 2016;356(1):137-147. |
R835737 (2016) R835737 (2017) R835737C004 (2016) |
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| Journal Article | Functional role of inorganic trace elements in angiogenesis part III: (Ti, Li, Ce, As, Hg, Va, Nb and Pb). | CRITICAL REVIEWS IN ONCOLOGY/HEMATOLOGY | Saghiri MA, Orangi J, Asatourian A, Sorenson CM, Sheibani N | Saghiri MA, Orangi J, Asatourian A, Sorenson CM, Sheibani N. Functional role of inorganic trace elements in angiogenesis part III: (Ti, Li, Ce, As, Hg, Va, Nb and Pb). Critical Reviews in Oncology/Hematology 2016;98:290-301. |
R835737 (2016) R835737 (2017) R835737C004 (2016) |
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| Journal Article | The role of angiogenesis in implant dentistry part I: review of titanium alloys, surface characteristics and treatments. | MEDICINA ORAL, PATOLOGÍA ORAL Y CIRUGÍA BUCAL | Saghiri MA, Asatourian A, Garcia-Godoy F, Sheibani N | Saghiri MA, Asatourian A, Garcia-Godoy F, Sheibani N. The role of angiogenesis in implant dentistry part I: review of titanium alloys, surface characteristics and treatments. Medicina Oral, Patología Oral y Cirugía Bucal 2016;21(4):e514-e525. |
R835737 (2016) R835737 (2017) R835737C004 (2016) |
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| Journal Article | The role of angiogenesis in implant dentistry part II: the effect of bone-grafting and barrier membrane materials on angiogenesis. | MEDICINA ORAL, PATOLOGÍA ORAL Y CIRUGÍA BUCAL | Saghiri MA, Asatourian A, Garcia-Godoy F, Sheibani N | Saghiri MA, Asatourian A, Garcia-Godoy F, Sheibani N. The role of angiogenesis in implant dentistry part II: the effect of bone-grafting and barrier membrane materials on angiogenesis. Medicina Oral, Patología Oral y Cirugía Bucal 2016;21(4):e526-e537. |
R835737 (2016) R835737 (2017) R835737C004 (2016) |
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| Journal Article | Effect of biomaterials on angiogenesis during vital pulp therapy. | DENTAL MATERIALS JOURNAL | Saghiri MA, Asatourian A, Garcia-Godoy F, Sheibani N | Saghiri MA, Asatourian A, Garcia-Godoy F, Sheibani N. Effect of biomaterials on angiogenesis during vital pulp therapy. Dental Materials Journal 2016;35(5):701-709. |
R835737 (2016) R835737 (2017) R835737C004 (2016) |
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| Journal Article | Calcium silicate-based cements and functional impacts of various constituents. | DENTAL MATERIALS JOURNAL | Saghiri MA, Orangi J, Asatourian A, Gutmann JL, Garcia-Godoy F, Lotfi M,Sheibani N | Saghiri MA, Orangi J, Asatourian A, Gutmann JL, Garcia-Godoy F, Lotfi M, Sheibani N. Calcium silicate-based cements and functional impacts of various constituents. Dental Materials Journal 2017;36(1):8-18. |
R835737 (2016) R835737 (2017) R835737C004 (2016) |
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| Journal Article | Bcl-2 expression is essential for development and normal physiological properties of tooth hard tissue and saliva production. | None | Saghiri MA, Asatourian A, Gurel Z, Sorenson CM, Sheibani N | Saghiri MA, Asatourian A, Gurel Z, Sorenson CM, Sheibani N. Bcl-2 expression is essential for development and normal physiological properties of tooth hard tissue and saliva production. Experimental Cell Research 2017;358(2):94-100. |
R835737 (2017) |
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| Journal Article | Reproducibility across single-cell RNA-seq protocols for spatial ordering analysis | PLOS ONE | Seirup M, Chu L, Sengupta S, Leng N, Browder H, Kapadia K, Shafer C, Duffin B, Elwell A, Bolin J | Seirup M, Chu L, Sengupta S, Leng N, Browder H, Kapadia K, Shafer C, Duffin B, Elwell A, Bolin J. Reproducibility across single-cell RNA-seq protocols for spatial ordering analysis. PLOS One 2020;15(9). |
R835737 (Final) |
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| Journal Article | Rapid changes in chromatin structure during dedifferentiation of primary hepatocytes in vitro | GENOMICS | Seirup M, Sengupta S, Swanson S, McIntosh B, Collins M, Cu L, Cheng Z, Gorkin D, Duffin B, Bolin J, Argus C, Stewart R, Thompson J | Seirup M, Sengupta S, Swanson S, McIntosh B, Collins M, Cu L, Cheng Z, Gorkin D, Duffin B, Bolin J, Argus C, Stewart R, Thompson J. Rapid changes in chromatin structure during dedifferentiation of primary hepatocytes in vitro. GENOMICS 2022;114(3):110330. |
R835737 (Final) |
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| Journal Article | Razor-printed sticker microdevices for cell-based applications. | None | Stallcop LE, Alvarez-García YR, Reyes-Ramos AM, Ramos-Cruz KP, MorganMM, Shi Y, Li L, Beebe DJ, Domenech M, Warrick JW | Stallcop LE, Alvarez-Garcia YR, Reyes-Ramos AM, Ramos-Cruz KP, Morgan MM, Shi Y, Li L, Beebe DJ, Domenech M, Warrick JW. Razor-printed sticker microdevices for cell-based applications. Lab on a Chip 2018;18(3):451-462. |
R835737 (2017) R835737C003 (2017) R835737C003 (Final) |
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| Journal Article | Enabling cell recovery from 3D cell culture microfluidic devices for tumour microenvironment biomarker profiling | SCIENTIFIC REPORTS | Virumbrales-Munoz M, Ayuso J, Lacueva A, Randelovic T, Livingston M, Beebe D, Olivan S, Pereboom D, Doblare M, Fernandez L | Virumbrales-Munoz M, Ayuso J, Lacueva A, Randelovic T, Livingston M, Beebe D, Olivan S, Pereboom D, Doblare M, Fernandez L. Enabling cell recovery from 3D cell culture microfluidic devices for tumour microenvironment biomarker profiling. Scientific Reports 2020;10(1):757. |
R835737 (Final) |
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| Journal Article | Controlled self-assembly of stem cell aggregates instructs pluripotency and lineage bias. | SCIENTIFIC REPORTS | Xie AW, Binder BY, Khalil AS, Schmitt SK, Johnson HJ, Zacharias NA,Murphy WL | Xie AW, Binder BYK, Khalil AS, Schmitt SK, Johnson HJ, Zacharias NA, Murphy WL. Controlled self-assembly of stem cell aggregates instructs pluripotency and lineage bias. Scientific Reports 2017;7(1):14070. |
R835737 (2017) |
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| Journal Article | Controlled aggregation enhances immunomodulatory potential of mesenchymal stromal cell aggregates | STEM CELLS TRANSLATIONAL MEDICINE | Xie A, Zacharias N, Binder B, Murphy W | Xie A, Zacharias N, Binder B, Murphy W. Controlled aggregation enhances immunomodulatory potential of mesenchymal stromal cell aggregates. Stem Cells Translational Medicine 2021;1(18). |
R835737 (Final) |
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| Journal Article | Cone-specific promoters for gene therapy of achromatopsia and other retinal diseases. | HUMAN GENE THERAPY | Ye G-J, Budzynski E, Sonnentag P, Nork TM, Sheibani N, Gurel Z, Boye SL, Peterson JJ, Boye SE, Hauswirth WW, Chulay JD | Ye G-J, Budzynski E, Sonnentag P, Nork TM, Sheibani N, Gurel Z, Boye SL, Peterson JJ, Boye SE, Hauswirth WW, Chulay JD. Cone-specific promoters for gene therapy of achromatopsia and other retinal diseases. Human Gene Therapy 2016;27(1):72-82. |
R835737 (2016) R835737 (2017) R835737C004 (2016) |
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| Journal Article | Nanostructured mineral coatings stabilize proteins for therapeutic delivery. | ADVANCED MATERIALS | Yu X, Biedrzycki AH, Khalil AS, Hess D, Umhoefer JM, Markel MD, Murphy WL | Yu X, Biedrzycki AH, Khalil AS, Hess D, Umhoefer JM, Markel MD, Murphy WL. Nanostructured mineral coatings stabilize proteins for therapeutic delivery. Advanced Materials 2017;29(33):1701255. |
R835737 (2017) |
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| Journal Article | Stable engineered vascular networks from human induced pluripotent stem cell-derived endothelial cells cultured in synthetic hydrogels. | ACTA BIOMATERIALIA | Zanotelli MR, Ardalani H, Zhang J, Hou Z, Nguyen EH, Swanson S, NguyenBK, Bolin J, Elwell A, Bischel LL, Xie AW, Stewart R, Beebe DJ, ThomsonJA, Schwartz MP, Murphy WL. | Zanotelli MR, Ardalani H, Zhang J, Hou Z, Nguyen EH, Swanson S, Nguyen BK, Bolin J, Elwell A, Bischel LL, Xie AW, Stewart R, Beebe DJ, Thomson JA, Schwartz MP, Murphy WL. Stable engineered vascular networks from human induced pluripotent stem cell-derived endothelial cells cultured in synthetic hydrogels. Acta Biomaterialia 2016;35:32-41. |
R835737 (2015) R835737 (2016) R835737 (2017) R835737C001 (2017) R835737C004 (2015) |
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| Journal Article | A genome-wide analysis of vascular morphogenesis for human pluripotent stem cell-derived endothelial cells cultured in synthetic hydrogels compared to standard 2D or 3D culture platforms. | STEM CELL REPORTS | Zhang J, Schwartz MP, Hou Z, Bai Y, Ardalani H, Swanson S, Steill J,Ruotti V, Elwell A, Nguyen BK, Bolin J, Stewart R, Thomson JA, Murphy WL | Zhang J, Schwartz MP, Hou Z, Bai Y, Ardalani H, Swanson S, Steill J, Ruotti V, Elwell A, Nguyen BK, Bolin J, Stewart R, Thomson JA, Murphy WL. A genome-wide analysis of human pluripotent stem cell-derived endothelial cells in 2D or 3D culture. Stem Cell Reports 2017;8(4):907-918. |
R835737 (2016) R835737 (2017) R835737C001 (2017) |
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| Journal Article | Functional characterization of human pluripotent stem cell-derived arterial endothelial cells. | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES | Zhang J, Chu LF, Hou Z, Schwartz MP, Hacker T, Vickerman V, Swanson S,Leng N, Nguyen BK, Elwell A, Bolin J, Brown ME, Stewart R, BurlinghamWJ, Murphy WL, Thomson JA | Zhang J, Chu LF, Hou Z, Schwartz MP, Hacker T, Vickerman V, Swanson S, Leng N, Nguyen BK, Elwell A, Bolin J, Brown ME, Stewart R, Burlingham WJ, Murphy WL, Thomson JA. Functional characterization of human pluripotent stem cell-derived arterial endothelial cells. Proceedings of the National Academy of Sciences of the United States of America 2017;114(30):E6072-E6078. |
R835737 (2017) R835737C001 (2017) |
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| Journal Article | Chromatin module inference on cellular trajectories identifies key transition points and poised epigenetic states in diverse developmental processes. | None | Roy S, Sridharan R | Roy S, Sridharan R. Chromatin module inference on cellular trajectories identifies key transition points and poised epigenetic states in diverse developmental processes. Genome Research 2017;27(7):1250-1262. |
R835737 (2017) R835737C005 (2016) |
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| Journal Article | Addition of mineral coated microparticles to soluble interleukin-1 receptor antagonist injected subcutaneously improves and extends systemic interleukin-1 inhibition. | None | Clements AE, Leiferman EM, Chamberlain CS, Vanderby R, Murphy WL | Clements AE, Leiferman EM, Chamberlain CS, Vanderby R, Murphy WL. Addition of mineral coated microparticles to soluble interleukin-1 receptor antagonist injected subcutaneously improves and extends systemic interleukin-1 inhibition. Advanced Therapeutics 2018;1(7):1800048. |
R835737 (Final) |
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| Journal Article | Sustained release and protein stabilization reduce the growth factor dosage required for human pluripotent stem cell expansion. | None | Khalil AS, Xie AW, Johnson HJ, Murphy WL | Khalil AS, Xie AW, Johnson HJ, Murphy WL. Sustained release and protein stabilization reduce the growth factor dosage required for human pluripotent stem cell expansion. Biomaterials 2020:120007. |
R835737 (Final) |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.