Grantee Research Project Results

2008 Progress Report: Prospective Study of Atherosclerosis, Clinical Cardiovascular Disease, and Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants in a Multi-Ethnic Cohort (MESA Air)

EPA Grant Number: R831697
Title: Prospective Study of Atherosclerosis, Clinical Cardiovascular Disease, and Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants in a Multi-Ethnic Cohort (MESA Air)
Investigators: Kaufman, Joel D. , Sheppard, Lianne (Elizabeth) A. , Adar, Sara D. , Barr, R. Graham , Liu, Kiang J. , Burke, Gregory L. , Kinney, Patrick L. , Diez Roux, Ana V. , Larson, Timothy V. , Folsom, Aaron , Astor, Brad , OLeary, Daniel , Siscovick, David , Jacobs, David , Watson, Karol , Daviglus, Martha , Budoff, Matthew , Sampson, Paul , Kronmal, Richard , Detrano, Robert , Shea, Steven , Lumley, Thomas , Nyerges, Timothy , Wang, Yinhai
Current Investigators: Kaufman, Joel D. , Sheppard, Lianne (Elizabeth) A. , Adar, Sara D. , Barr, R. Graham , Liu, Kiang J. , Burke, Gregory L. , Diez Roux, Ana V. , Larson, Timothy V. , Szpiro, Adam , Navas-Acien, Ana , Siscovick, David , Jacobs, David , Goldstein, James , Watson, Karol , Daviglus, Martha , Budoff, Matthew , Sampson, Paul , Kronmal, Richard
Institution: University of Washington , Northwestern University , Tufts University , University of California - Los Angeles , University of Southern California , Columbia University in the City of New York , Wake Forest University , University of Minnesota , University of Vermont , University of Michigan , The Johns Hopkins University
Current Institution: University of Washington , Columbia University in the City of New York , Northwestern University , Tellus Institute , The Johns Hopkins University , University of California - Los Angeles , University of Michigan , University of Minnesota
EPA Project Officer: Chung, Serena
Project Period: August 1, 2004 through July 31, 2014
Project Period Covered by this Report: August 1, 2007 through July 31,2008
Project Amount: $32,999,090
RFA: Epidemiologic Research on Health Effects of Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants (2003) RFA Text | Recipients Lists
Research Category: Air Quality and Air Toxics , Human Health , Particulate Matter , Air

Objective:

The goal of the Multi-Ethnic Study of Atherosclerosis and Air Pollution Study (MESA Air) is to prospectively examine the relation between an individual level assessment of long-term ambient air pollution exposure (including PM_2.5 and gaseous co-pollutants) and the progression of subclinical cardiovascular disease in a multi-city, multi-ethnic cohort. MESA Air will also prospectively examine the relation between an individual level assessment of long-term ambient air pollution exposures and the incidence of cardiovascular disease, including myocardial infarction and cardiovascular death.

Progress Summary:

Work efforts in the fourth year of MESA Air concentrated on completing the residential and personal air monitoring campaigns, cleaning and conducting quality assurance procedures on all exposure data, developing individual level interim exposure estimates, and conducting follow-up phone calls to all participants. Specifically:

86% of all MESA Air participants have been contacted for the first MESA Air follow up call (MESA Follow-Up 8). Of these participants, 12.4% have had life changes that have triggered readministration of the Air Questionnaire. To date, Air Questionnaires have been completed for 74% of those triggered.
Clinical events data is available for all MESA Air participants recruited through the main MESA study.
Biweekly fixed site air monitoring continues at between 3 and 7 MESA Air sites per city, for a total of 26 locations. To date, we have collected over 1,900 samples from these sites.
Infiltration monitoring is complete. More than 1000 outdoor and 800 indoor residential samples were collected. Complete infiltration sampling, including two two-week paired indoor and outdoor samples from two distinct seasons, were collected at 383 unique residential locations.
Personal monitoring is complete. A total of 174 personal monitoring samples were collected, and 85 participants provided two two-week samples during each of two distinct seasons.
We have developed individual-level interim exposure estimates for all MESA Air participants. These estimates demonstrate a range of concentrations from 9.6 – 26.3 μg/m³, and demonstrate both between- and within-city variability.
We discussed project status and existing issues with our External Scientific Advisory Committee (ESAC) at our annual meeting in February 2008.

Future Activities:

Throughout the next year, we will complete the majority of the second MESA Air follow-up questionnaire (MESA Follow-Up 9). We will continue to work closely with MESA Air ancillary studies that will expand the scope of MESA Air—including those on PM components and sources and on coarse PM. We will continue fixed site monitoring throughout the year, and conclude that effort in July 2009. We will use our newly developed interim exposure estimates to examine the relationship between progression of atherosclerosis and air pollution, and will continue to publish manuscripts describing our findings. We will also continue to support the submission of ancillary study proposals and the use of MESA Air as a platform for such research.

Journal Articles on this Report : 1 Displayed | Download in RIS Format

Publications Views
Other project views:	All 300 publications	176 publications in selected types	All 175 journal articles

Publications
Type	Citation	Project	Document Sources
Journal Article	Adar SD, Kaufman JD. Cardiovascular disease and air pollutants: evaluating and improving epidemiological data implicating traffic exposure. Inhalation Toxicology 2007;19(Suppl 1):135-149.	R831697 (2008) R831697 (2009) R831697 (2010) R831697 (2011) R831697 (2012) R831697 (2013) R831697 (Final)	Abstract from PubMed Abstract: Taylor & Francis-Abstract Exit

Supplemental Keywords:

epidemiology, health effects, human health, RFA, Scientific Discipline, Health, PHYSICAL ASPECTS, Air, particulate matter, Health Risk Assessment, Epidemiology, Risk Assessments, Biochemistry, Physical Processes, ambient aerosol, lung injury, long term exposure, lung disease, airway disease, exposure, airborne particulate matter, atherosclerosis, cardiovascular vulnerability, ambient particle health effects, human exposure, epidemiological studies, aersol particles, cardiovascular disease

Relevant Websites:

http://depts.washington.edu/mesaair Exit

Progress and Final Reports:

Original Abstract

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.