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Grantee Research Project Results

2010 Progress Report: Prospective Study of Atherosclerosis, Clinical Cardiovascular Disease, and Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants in a Multi-Ethnic Cohort (MESA Air)

EPA Grant Number: R831697
Title: Prospective Study of Atherosclerosis, Clinical Cardiovascular Disease, and Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants in a Multi-Ethnic Cohort (MESA Air)
Investigators: Kaufman, Joel D. , Sheppard, Lianne (Elizabeth) A. , Barr, R. Graham , Liu, Kiang J. , Burke, Gregory L. , Kinney, Patrick L. , Diez Roux, Ana V. , Larson, Timothy V. , Folsom, Aaron , Astor, Brad , OLeary, Daniel , Siscovick, David , Jacobs, David , Daviglus, Martha , Saad, Mohammed , Gross, Myron , Seixas, Noah , Sampson, Paul , Kronmal, Richard , Detrano, Robert , Liu, Sally , Shea, Steven , Lumley, Thomas , Nyerges, Timothy , Wang, Yinhai
Current Investigators: Kaufman, Joel D. , Sheppard, Lianne (Elizabeth) A. , Adar, Sara D. , Barr, R. Graham , Liu, Kiang J. , Burke, Gregory L. , Diez Roux, Ana V. , Larson, Timothy V. , Szpiro, Adam , Navas-Acien, Ana , Siscovick, David , Jacobs, David , Goldstein, James , Watson, Karol , Daviglus, Martha , Budoff, Matthew , Sampson, Paul , Kronmal, Richard
Institution: University of Washington , Northwestern University , Tufts University , University of California - Los Angeles , The Johns Hopkins University , Columbia University in the City of New York , University of Minnesota , University of Vermont , University of Michigan , Wake Forest University
Current Institution: University of Washington , Columbia University in the City of New York , Northwestern University , Tellus Institute , The Johns Hopkins University , University of California - Los Angeles , University of Michigan , University of Minnesota
EPA Project Officer: Chung, Serena
Project Period: August 1, 2004 through July 31, 2014
Project Period Covered by this Report: August 1, 2009 through July 31,2010
Project Amount: $32,999,090
RFA: Epidemiologic Research on Health Effects of Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants (2003) RFA Text |  Recipients Lists
Research Category: Air Quality and Air Toxics , Human Health , Particulate Matter , Air

Objective:

The goal of the Multi-Ethnic Study of Atherosclerosis and Air Pollution Study (MESA Air) is to prospectively examine the relation between an individual level assessment of long-term ambient air pollution exposure (including PM2.5 and gaseous co-pollutants) and the progression of subclinical cardiovascular disease in a multi-city, multi-ethnic cohort.  MESA Air also will prospectively examine the relation between an individual level assessment of long-term ambient air pollution exposures and the incidence of cardiovascular disease, including myocardial infarction and cardiovascular death.

Progress Summary:

During the sixth year of MESA Air, the research team has:

  • Completed sample analysis from the exposure monitoring component of the project, and followed rigorous quality control procedures for data cleaning.  Resulting datasets met data quality objectives specified in the QAPP.
  • Developed (and published) a pragmatic spatio-temporal approach to modeling ambient PM2.5 concentrations across the MESA Air study regions from 2000-2009 using combined regulatory and MESA Air monitoring data.
  • Developed initial predictions of long-term average concentrations of NOx during a 10-year period in Los Angeles and Baltimore, using a likelihood-based spatio-temporal model incorporating dispersion model outputs. An output of this work was the development of an R-code package to produce these estimates.
  • Developed a customized and automated process for the production of CALINE dispersion model estimates, eliminating manual entry, reducing run times and improving output. 
  • Finalized all questionnaires and protocols for Exam 5, including the CT and ultrasound scanning protocols and revisions to the Air Questionnaire.
  • Conducted in-person trainings for the sonographers and for the MESA interviewers who administer the Air Questionnaire. 
  • Finalized selection criteria for the high-tech tests and put into place electronic data capture systems.
  • Began Exam 5 in April, 2010, and to date, 1338 MESA Air participants have had their clinic visit. 97% of these have completed the Air Questionnaire.  Of the 1338 who have come into the clinic, 808 were selected for the subclinical cohort, and of these, 75% have undergone the carotid ultrasound and 59% have undergone the cardiac CT scan.

Future Activities:

During the next project period, we will continue to work closely with the Field Centers and the Coordinating Center on Exam 5 activities, which will continue through the year.  By the end of the next year, we expect to have completed nearly 90% of the Exam 5 visits, and to have acquired approximately 3,200 ultrasounds and CT scans.  We also will focus significant attention on exposure modeling, and are planning to finalize likelihood-based spatio-temporal model predictions for ambient concentrations of PM2.5, NO/NO2/NOx, and LAC/EC/OC. We will finalize our infiltration models for PM2.5, allowing us to utilize the time-location data that have been collected to produce individual-level exposure estimates, one of the primary aims of this project.  Finally, we will continue to conduct early health analyses, to develop plans for ultimate health modeling strategies, and to emphasize publications.

 


Journal Articles on this Report : 18 Displayed | Download in RIS Format

Publications Views
Other project views: All 300 publications 176 publications in selected types All 175 journal articles
Publications
Type Citation Project Document Sources
Journal Article Adar SD, Kaufman JD. Cardiovascular disease and air pollutants: evaluating and improving epidemiological data implicating traffic exposure. Inhalation Toxicology 2007;19(Suppl 1):135-149. R831697 (2008)
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    • Journal Article Adar SD, Klein R, Klein BE, Szpiro AA, Cotch MF, Wong TY, O'Neill MS, Shrager S, Barr RG, Siscovick DS, Daviglus ML, Sampson PD, Kaufman JD. Air pollution and the microvasculature: a cross-sectional assessment of in vivo retinal images in the population-based Multi-Ethnic Study of Atherosclerosis (MESA). PLoS Medicine 2010;7(11):e1000372 (11 pp.). R831697 (2010)
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    • Journal Article Allen RW, Davies H, Cohen MA, Mallach G, Kaufman JD, Adar SD. The spatial relationship between traffic-generated air pollution and noise in 2 US cities. Environmental Research 2009;109(3):334-342. R831697 (2010)
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    • Journal Article Allen RW, Criqui MH, Diez Roux AV, Allison M, Shea S, Detrano R, Sheppard L, Wong ND, Stukovsky KH, Kaufman JD. Fine particulate matter air pollution, proximity to traffic, and aortic atherosclerosis. Epidemiology 2009;20(2):254-264. R831697 (2009)
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  • Abstract: Epidemiology - Abstract
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    • Journal Article Auchincloss AH, Diez Roux AV, Dvonch JT, Brown PL, Barr RG, Daviglus ML, Goff Jr. DC, Kaufman JD, O'Neill MS. Associations between recent exposure to ambient fine particulate matter and blood pressure in the Multi-Ethnic Study of Atherosclerosis (MESA). Environmental Health Perspectives 2008;116(4):486-491. R831697 (2009)
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    • Journal Article Cohen MA, Adar SD, Allen RW, Avol E, Curl CL, Gould T, Hardie D, Ho A, Kinney P, Larson TV, Sampson P, Sheppard L, Stukovsky KD, Swan SS, Liu L-J, Kaufman JD. Approach to estimating participant pollutant exposures in the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). Environmental Science & Technology 2009;43(13):4687-4693. R831697 (2009)
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  • Abstract: ES&T-Abstract
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    • Journal Article Diez Roux AV, Auchincloss AH, Franklin TG, Raghunathan T, Barr RG, Kaufman J, Astor B, Keeler J. Long-term exposure to ambient particulate matter and prevalence of subclinical atherosclerosis in the Multi-Ethnic Study of Atherosclerosis. American Journal of Epidemiology 2008;167(6):667-675. R831697 (2009)
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    • Journal Article Jensen SS, Larson T, Deepti KC, Kaufman JD. Modeling traffic air pollution in street canyons in New York City for intra-urban exposure assessment in the US Multi-Ethnic Study of atherosclerosis and air pollution. Atmospheric Environment 2009;43(30):4544-4556. R831697 (2009)
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    • Journal Article Kim S-Y, Sheppard L, Kim H. Health effects of long-term air pollution:influence of exposure prediction methods. Epidemiology 2009;20(3):442-450. R831697 (2010)
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    • Journal Article Lovasi GS, Diez Roux AV, Hoffman EA, Kawut SM, Jacobs Jr. DR, Barr RG. Association of environmental tobacco smoke exposure in childhood with early emphysema in adulthood among nonsmokers: the MESA-Lung Study. American Journal of Epidemiology 2010;171(1):54-62. R831697 (2010)
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    • Journal Article O'Neill MS, Diez-Roux AV, Auchincloss AH, Franklin TG, Jacobs Jr DR, Astor BC, Dvonch JT, Kaufman J. Airborne particulate matter exposure and urinary albumin excretion: the Multi-Ethnic Study of Atherosclerosis. Occupational and Environmental Medicine 2008;65(8):534-540. R831697 (2009)
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    • Journal Article Park SK, Auchincloss AH, O'Neill MS, Prineas R, Correa JC, Keeler J, Barr RG, Kaufman JD, Diez Roux AV. Particulate air pollution, metabolic syndrome, and heart rate variability: the Multi-Ethnic Study of Atherosclerosis (MESA). Environmental Health Perspectives 2010;118(10):1406-1411. R831697 (2010)
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    • Journal Article Poplawski K, Gould T, Setton E, Allen R, Su J, Larson T, Henderson S, Brauer M, Hystad P, Lightowlers C, Keller P, Cohen M, Silva C, Buzzelli M. Intercity transferability of land use regression models for estimating ambient concentrations of nitrogen dioxide. Journal of Exposure Science & Environmental Epidemiology 2009;19(1):107-117. R831697 (2009)
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    • Journal Article Su JG, Larson T, Gould T, Cohen M, Buzzelli M. Transboundary air pollution and environmental justice:Vancouver and Seattle compared. GeoJournal 2010;75(6):595-608. R831697 (2010)
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    • Journal Article Szpiro AA, Sampson PD, Sheppard L, Lumley T, Adar SD, Kaufman JD. Predicting intra-urban variation in air pollution concentrations with complex spatio-temporal dependencies. Environmetrics 2010;21(6):606-631. R831697 (2010)
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    • Journal Article Van Hee VC, Adar SD, Szpiro AA, Barr RG, Diez Roux A, Bluemke DA, Sheppard L, Gill EA, Bahrami H, Wassel C, Sale MM, Siscovick DS, Rotter JI, Rich SS, Kaufman JD. Common genetic variation, residential proximity to traffic exposure, and left ventricular mass:the Multi-Ethnic Study of Atherosclerosis (MESA). Environmental Health Perspectives 2010;118(7):962-969. R831697 (2010)
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    • Journal Article Van Hee VC, Adar SD, Szpiro AA, Barr RG, Bluemke DA, Diez Roux AV, Gill EA, Sheppard L, Kaufman JD. Exposure to traffic and left ventricular mass and function:the Multi-Ethnic Study of Atherosclerosis. American Journal of Respiratory and Critical Care Medicine 2009;179(9):827-834. R831697 (2009)
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    • Journal Article Wilton D, Szpiro A, Gould T, Larson T. Improving spatial concentration estimates for nitrogen oxides using a hybrid meteorological dispersion/land use regression model in Los Angeles, CA and Seattle, WA. Science of the Total Environment 2010;408(5):1120-1130. R831697 (2010)
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    • Supplemental Keywords:

      Epidemiology, health effects, human health., RFA, Scientific Discipline, Health, PHYSICAL ASPECTS, Air, particulate matter, Health Risk Assessment, Epidemiology, Risk Assessments, Biochemistry, Physical Processes, ambient aerosol, lung injury, long term exposure, lung disease, airway disease, cardiovascular vulnerability, exposure, airborne particulate matter, atherosclerosis, human exposure, ambient particle health effects, epidemiological studies, aersol particles, cardiovascular disease

    Relevant Websites:

    http://depts.washington.edu/mesaair Exit

    Progress and Final Reports:

    Original Abstract
  • 2005 Progress Report
  • 2006 Progress Report
  • 2007 Progress Report
  • 2008 Progress Report
  • 2009 Progress Report
  • 2011 Progress Report
  • 2012 Progress Report
  • 2013 Progress Report
  • Final Report

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    The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

    Project Research Results

    300 publications for this project
    175 journal articles for this project

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