Grantee Research Project Results

2005 Progress Report: Prospective Study of Atherosclerosis, Clinical Cardiovascular Disease, and Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants in a Multi-Ethnic Cohort (MESA Air)

EPA Grant Number: R831697
Title: Prospective Study of Atherosclerosis, Clinical Cardiovascular Disease, and Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants in a Multi-Ethnic Cohort (MESA Air)
Investigators: Kaufman, Joel D. , Sheppard, Lianne (Elizabeth) A. , Barr, R. Graham , Liu, Kiang J. , Avol, Edward L. , Burke, Gregory L. , Kinney, Patrick L. , Diez Roux, Ana V. , Larson, Timothy V. , Folsom, Aaron , Casillas, Adrian , Astor, Brad , OLeary, Daniel , Siscovick, David , Jacobs, David , Daviglus, Martha , Cohen, Martin , Seixas, Noah , Sampson, Paul , Kronmal, Richard , Detrano, Robert , Liu, Sally , Shea, Steven , Lumley, Thomas , Nyerges, Timothy
Current Investigators: Kaufman, Joel D. , Sheppard, Lianne (Elizabeth) A. , Adar, Sara D. , Barr, R. Graham , Liu, Kiang J. , Burke, Gregory L. , Diez Roux, Ana V. , Larson, Timothy V. , Szpiro, Adam , Navas-Acien, Ana , Siscovick, David , Jacobs, David , Goldstein, James , Watson, Karol , Daviglus, Martha , Budoff, Matthew , Sampson, Paul , Kronmal, Richard
Institution: University of Washington , Northwestern University , Tufts University , University of California - Los Angeles , University of Southern California , New England Medical Center , Columbia University in the City of New York , University of Minnesota , University of Vermont , University of Michigan , The Johns Hopkins University , Wake Forest University
Current Institution: University of Washington , Columbia University in the City of New York , Northwestern University , Tellus Institute , The Johns Hopkins University , University of California - Los Angeles , University of Michigan , University of Minnesota
EPA Project Officer: Chung, Serena
Project Period: August 1, 2004 through July 31, 2014
Project Period Covered by this Report: August 1, 2004 through July 31, 2005
Project Amount: $32,999,090
RFA: Epidemiologic Research on Health Effects of Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants (2003) RFA Text | Recipients Lists
Research Category: Air Quality and Air Toxics , Human Health , Particulate Matter , Air

Objective:

The objective of the Multi-Ethnic Study of Atherosclerosis (MESA) Air study is to prospectively examine the relation between an individual-level assessment of long-term ambient air pollution exposures (including fine particulate matter and gaseous co-pollutants) and the progression of subclinical cardiovascular disease in a multicity, multiethnic cohort. The MESA Air study will also prospectively examine the relation between an individual-level assessment of long-term ambient air pollution exposures and the incidence of cardiovascular disease, including myocardial infarction and cardiovascular death.

Progress Summary:

Work efforts in Year 1 of the project concentrated on revising and refining study protocols (to accommodate grant funding timing and amount and advisory comments); establishing key administrative, technical, and scientific infrastructure; and establishing local and regional centers around the country to initiate study activities. These study activities also included:

Written statistical analysis for the optimal number and location of study sites.
Establishment of an External Scientific Advisory Committee (ESAC), including a meeting in January 2005, revision of the study design based on written ESAC comments, and a written response to comments.
Initial recruitment of participants from the main MESA cohort.
Establishment of fixed air sampling sites within most of the Field Center locations.
Identification of areas for recruitment of new MESA Air participants.
Establishment of quality assurance and quality control procedures for air exposure sampling campaigns.

Future Activities:

Exam 4 is scheduled to begin in September 2005 and will last until June 2007. The majority of recruitment for MESA Air will be completed during this exam. Deployment of exposure assessment activities will be launched according to established protocols.

Journal Articles:

No journal articles submitted with this report: View all 300 publications for this project

Supplemental Keywords:

epidemiology, health effects, human health,, RFA, Scientific Discipline, Health, PHYSICAL ASPECTS, Air, particulate matter, Health Risk Assessment, Epidemiology, Risk Assessments, Biochemistry, Physical Processes, ambient aerosol, lung injury, long term exposure, lung disease, airway disease, exposure, airborne particulate matter, atherosclerosis, cardiovascular vulnerability, ambient particle health effects, human exposure, epidemiological studies, aersol particles, cardiovascular disease

Relevant Websites:

http://depts.washington.edu/mesaair/ Exit

Progress and Final Reports:

Original Abstract

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.