Grantee Research Project Results
Publications Details for Grant Number R835167
High-Throughput Cellular Assays for Modeling Toxicity in the Fish Reproductive System
Other Views
- All
Publications - Selected
Publication Types - Journal
Articles - Publications Submitted
After Final Report - Redisplay this page with
Reference Title, Journal, and Author Columns - Display this Page
in RIS Format
| Reference Type | Citation | Progress Report Year | Document Sources |
|---|---|---|---|
| Book Chapter | Murphy CA, Nisbet P, Antczak N, Garcia-Reyero A, Gergs KL, Mathews T, Muller EB, Nacci D, Peace A, Remien CH, Schultz IR, Watanabe KH. Linking adverse outcome pathways to dynamic energy budets:a conceptual model. In:Garcia-Reyero N, Murphy C, eds. A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment, Springer International Publishing, 2018, Chapter 14, pp. 281-302. |
R835167 (Final) R835797 (2016) R835798 (2017) |
|
| Book Chapter | Schultz IR, Watanabe KH. The development of quantitative AOPs. In:Garcia-Reyero N, Murphy CA, eds. A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment. Switzerland:Springer International Publishing, 2017, Chapter 13, pp. 263-280. |
R835167 (Final) |
|
| Journal Article | Gillies K, Krone SM, Nagler JJ, Schultz IR. A computational model of the rainbow trout hypothalamus-pituitary-ovary-liver axis. PLoS Computational Biology 2016;20;12(4):e1004874 (27 pp.). |
R835167 (2015) R835167 (2016) R835167 (Final) |
|
| Journal Article | Jia Y, Cavileer TD, Nagler JJ. Acute hyperthermic responses of heat shock protein and estrogen receptor mRNAs in rainbow trout hepatocytes. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 2016;201:156-161. |
R835167 (2015) R835167 (2016) R835167 (Final) |
|
| Journal Article | Robert A, Schultz IR, Hucher N, Monsinjon T, Knigge T. Toxicokinetics, disposition and metabolism of fluoxetine in crabs. Chemosphere 2017;186:958-967. |
R835167 (Final) |
|
| Journal Article | Schultz IR, Nagler JJ, Swanson P, Wunschel D, Skillman AD, Burnett V, Smith D, Barry R. Toxicokinetic, toxicodynamic, and toxicoproteomic aspects of short-term exposure to trenbolone in female fish. Toxicological Sciences 2013;136(2):413-429. |
R835167 (2013) R835167 (2014) R835167 (2015) R835167 (2016) R835167 (Final) |
|
| Presentation | Gillies K, Harding L, Monson C, Cavileer T, Young G, Nagler J, Swanson P, Schultz I. Adverse outcome pathway assessment for a series of model toxicants. Presented at the 36th Annual Society of Environmental Toxicology and Chemistry (SETAC) Meeting, Salt Lake City, UT, November 1-5, 2015. |
R835167 (Final) |
not available |
| Presentation | Gillies K, Cavileer T, Nagler J, Coatney C, Trostle C, Schultz I. Toxicokinetics and development of a physiologically based toxicokinetic model for tamoxifen in rainbow trout. Presented at the 56th Annual Society of Toxicology Meeting, Baltimore, MD, March 13-17, 2016. |
R835167 (2015) R835167 (2016) R835167 (Final) |
not available |
| Presentation | Gillies K, Cavileer T, Nagler J, Coatney C, Trostle C, Schultz I. Toxicokinetics and development of a physiologically based toxicokinetic model for tamoxifen in rainbow trout. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835167 (2015) R835167 (Final) |
not available |
| Presentation | Harding LB, Schultz IR, Young G, Swanson P. The pituitary gland as a target of endocrine disrupting compounds in coho salmon, Oncorhynchus kisutch. Presented at the Salish Sea Ecosystem Conference, Seattle, WA, April 30-May 2, 2014. |
R835167 (2014) R835167 (2015) R835167 (2016) R835167 (Final) |
not available |
| Presentation | Harding LB, Schultz IR, Young G, Swanson P. Pituitary gonadotropins are targets of endocrine disruption in salmon and trout. Poster presented at the 3rd Biennial Conference of the North American Society for Comparative Endocrinology (NASCE), Ottawa, Ontario, Canada, June 21-25, 2015. |
R835167 (2015) R835167 (2016) R835167 (Final) |
|
| Presentation | Harding LB, Monson CA, Young G, Swanson P. Sex steroid regulation of pituitary gonadotropins during primary oocyte growth in coho salmon. Poster presented at the 3rd Biennial Meeting of the North American Society for Comparative Endocrinology, Ottawa, ON, Canada, June 21-25, 2015. |
R835167 (2015) R835167 (2016) R835167 (Final) |
not available |
| Presentation | Harding LB, Schultz IR, Silva DAM, Ylitalo GM, Swanson P. Wastewater treatment plant effluent alters pituitary gonadotropin mRNA levels in juvenile coho salmon. Presented at the Salish Sea Ecosystem Conference, Vancouver, British Columbia, Canada, April 13-15, 2016. |
R835167 (Final) |
not available |
| Presentation | Harding LB, Schultz IR, Young G, Swanson P. Selective serotonin reuptake inhibitors alter pituitary gonadotropin expression in vivo and in vitro in salmon and trout. Poster presented at the 18th International Congress of Comparative Endocrinology, Lake Louise, Alberta, Canada, June 4-9, 2017. |
R835167 (Final) |
not available |
| Presentation | Monson C,Schultz IR, Harding LA, Swanson P, Young G. Development of a high throughput method to assess effects of endocrine disrupting chemicals on ovarian function, using short-term culture of rainbow trout ovarian follicle. Presented at the Society of Environmental Toxicology and Chemistry (SETAC) North America 35th Annual Meeting, Vancouver, British Columbia, Canada, November 9-13, 2014. |
R835167 (2015) R835167 (2016) R835167 (Final) |
not available |
| Presentation | Schultz IR, Woodruff D, Timchalk C, Watanabe K. New insights into the adverse outcome pathway for domoic acid in aquatic and terrestrial organisms. Poster presented at the Society of Environmental Toxicology and Chemistry (SETAC) North America 33rd Annual Meeting, Long Beach, CA, November 11-15, 2012 (invited). |
R835167 (2013) R835167 (2015) R835167 (2016) R835167 (Final) |
not available |
| Presentation | Schultz IR, Swanson P, Young G, Nagler J. Adverse outcome pathways of fish reproduction: integrating cellular assays of trout pituitary, ovary and liver toxicity with contaminant exposures. Presented at the Society of Environmental Toxicology and Chemistry (SETAC) Europe 23rd Annual Meeting, Glasgow, Scotland, United Kingdom, May 12-16, 2013. |
R835167 (2013) R835167 (2015) R835167 (2016) R835167 (Final) |
not available |
| Presentation | Schultz IR. Recent developments in adverse outcome pathway models. Presented at the Society of Environmental Toxicology and Chemistry (SETAC) Workshop, Mechanistic Effect Models for Ecological Risk Assessment: Recent Progress and Future Directions, Nashville, TN, November 17, 2013. |
R835167 (2014) R835167 (2015) R835167 (2016) R835167 (Final) |
not available |
| Presentation | Schultz IR. Biological models linking molecules-to-organisms. Presented at the NIMBioS Investigative Workshop on Predictive Models for Ecological Risk Assessment, Knoxville, TN, April 28-30, 2014. |
R835167 (2014) R835167 (2015) R835167 (2016) R835167 (Final) |
not available |
| Presentation | Schultz IR, Hayton WL. AOPs and reverse toxicokinetics: estimating internal dose metrics from environmental exposures. Presented at the 35rd Annual Society of Environmental Toxicology and Chemistry (SETAC) meeting, November 9-13, 2014. |
R835167 (Final) |
not available |
| Presentation | Schultz IR, Harding MC, Cavileer T, Young G, Nagler J, Swanson P. Incorporating in vitro measurements of rainbow trout pituitary, ovary and liver function with biological modeling of fish reproduction. Presented at the 35th Annual Society of Environmental Toxicology and Chemistry (SETAC) meeting, Vancouver, British Columbia, Canada, November 9-13, 2014. |
R835167 (Final) |
not available |
| Presentation | Schultz IR, Harding MC, Cavileer T, Young G, Nagler J, Swanson P. Incorporating in vitro measurements of rainbow trout pituitary, ovary and liver function with biological modeling of fish reproduction. Presented at the 18th Meeting of Pollutant Responses in Marine Organisms (PRIMO), Trondheim, Norway, May 24-27, 2015. |
R835167 (Final) |
not available |
| Presentation | Schultz IR, Gillies K. Applying PBTK and compartmental models for reverse tociocokinetics: interspecies differences and environmental influences. Presented at the Society of Environmental Toxicology and Chemistry (SETAC) 36th Annual Meeting, Salt Lake City, UT, November 1-5, 2015. |
R835167 (Final) |
not available |
| Presentation | Swanson P, Harding LB, Young G, Schulz IR. Effects of endocrine disrupting chemicals in aquatic ecosystems on fish pituitary function. Presented at the Annual Meeting of the Society for Study of Reproduction, Grand Rapids, MI, July 19-23, 2014 (invited). |
R835167 (2014) R835167 (2015) R835167 (2016) R835167 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.