Grantee Research Project Results
Publications Details for Grant Number R835167
High-Throughput Cellular Assays for Modeling Toxicity in the Fish Reproductive System
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Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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Book Chapter | Linking adverse outcome pathways to dynamic energy budgets: a conceptual model | None | Murphy CA, Nisbet P, Antczak N, Garcia-Reyero A, Gergs KL, Mathews T, Muller EB, Nacci D, Peace A, Remien CH, Schultz IR, Watanabe KH | Murphy CA, Nisbet P, Antczak N, Garcia-Reyero A, Gergs KL, Mathews T, Muller EB, Nacci D, Peace A, Remien CH, Schultz IR, Watanabe KH. Linking adverse outcome pathways to dynamic energy budets:a conceptual model. In:Garcia-Reyero N, Murphy C, eds. A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment, Springer International Publishing, 2018, Chapter 14, pp. 281-302. |
R835167 (Final) R835797 (2016) R835798 (2017) R835798 (Final) |
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Book Chapter | The development of quantitative AOPs. | None | Schultz IR, Watanabe KH | Schultz IR, Watanabe KH. The development of quantitative AOPs. In:Garcia-Reyero N, Murphy CA, eds. A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment. Switzerland:Springer International Publishing, 2017, Chapter 13, pp. 263-280. |
R835167 (Final) |
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Journal Article | A computational model of the rainbow trout hypothalamus-pituitary-ovary-liver axis. | PLOS COMPUTATIONAL BIOLOGY | Gillies K, Krone SM, Nagler JJ, Schultz IR | Gillies K, Krone SM, Nagler JJ, Schultz IR. A computational model of the rainbow trout hypothalamus-pituitary-ovary-liver axis. PLoS Computational Biology 2016;20;12(4):e1004874 (27 pp.). |
R835167 (2015) R835167 (2016) R835167 (Final) |
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Journal Article | Acute hyperthermic responses of heat shock protein and estrogen receptor mRNAs in rainbow trout hepatocytes. | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A: MOLECULAR & INTEGRATIVE PHYSIOLOGY | Jia Y, Cavileer TD, Nagler JJ | Jia Y, Cavileer TD, Nagler JJ. Acute hyperthermic responses of heat shock protein and estrogen receptor mRNAs in rainbow trout hepatocytes. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 2016;201:156-161. |
R835167 (2015) R835167 (2016) R835167 (Final) |
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Journal Article | Toxicokinetics, disposition and metabolism of fluoxetine in crabs. | None | Robert A, Schultz IR, Hucher N, Monsinjon T, Knigge T | Robert A, Schultz IR, Hucher N, Monsinjon T, Knigge T. Toxicokinetics, disposition and metabolism of fluoxetine in crabs. Chemosphere 2017;186:958-967. |
R835167 (Final) |
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Journal Article | Toxicokinetic, toxicodynamic and toxicoproteomic aspects of short-term exposure to trenbolone in female fish. | TOXICOLOGICAL SCIENCES | Schultz IR, Nagler JJ, Swanson P, Wunschel D, Skillman AD, Burnett V, Smith D, Barry R | Schultz IR, Nagler JJ, Swanson P, Wunschel D, Skillman AD, Burnett V, Smith D, Barry R. Toxicokinetic, toxicodynamic, and toxicoproteomic aspects of short-term exposure to trenbolone in female fish. Toxicological Sciences 2013;136(2):413-429. |
R835167 (2013) R835167 (2014) R835167 (2015) R835167 (2016) R835167 (Final) |
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Presentation | Adverse outcome pathway assessment for a series of model toxicants. | None | Gillies K, Harding L, Monson C, Cavileer T, Young G, Nagler J, Swanson P, Schultz I | Gillies K, Harding L, Monson C, Cavileer T, Young G, Nagler J, Swanson P, Schultz I. Adverse outcome pathway assessment for a series of model toxicants. Presented at the 36th Annual Society of Environmental Toxicology and Chemistry (SETAC) Meeting, Salt Lake City, UT, November 1-5, 2015. |
R835167 (Final) |
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Presentation | . | None | Gillies K, Cavileer T, Nagler J, Coatney C, Trostle C, Schultz I | Gillies K, Cavileer T, Nagler J, Coatney C, Trostle C, Schultz I. Toxicokinetics and development of a physiologically based toxicokinetic model for tamoxifen in rainbow trout. Presented at the 56th Annual Society of Toxicology Meeting, Baltimore, MD, March 13-17, 2016. |
R835167 (2015) R835167 (2016) R835167 (Final) |
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Presentation | Toxicokinetics and development of a physiologically based toxicokinetic model for tamoxifen in rainbow trout. | None | Gillies K, Cavileer T, Nagler J, Coatney C, Trostle C, Schultz I | Gillies K, Cavileer T, Nagler J, Coatney C, Trostle C, Schultz I. Toxicokinetics and development of a physiologically based toxicokinetic model for tamoxifen in rainbow trout. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835167 (2015) R835167 (Final) |
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Presentation | The pituitary gland as a target of endocrine disrupting compounds in coho salmon, Oncorhynchus kisutch. | None | Harding LB, Schultz IR, Young G, Swanson P | Harding LB, Schultz IR, Young G, Swanson P. The pituitary gland as a target of endocrine disrupting compounds in coho salmon, Oncorhynchus kisutch. Presented at the Salish Sea Ecosystem Conference, Seattle, WA, April 30-May 2, 2014. |
R835167 (2014) R835167 (2015) R835167 (2016) R835167 (Final) |
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Presentation | Pituitary gonadotropins are targets of endocrine disruption in salmon and trout. | None | Harding LB, Schultz IR, Young G, Swanson P | Harding LB, Schultz IR, Young G, Swanson P. Pituitary gonadotropins are targets of endocrine disruption in salmon and trout. Poster presented at the 3rd Biennial Conference of the North American Society for Comparative Endocrinology (NASCE), Ottawa, Ontario, Canada, June 21-25, 2015. |
R835167 (2015) R835167 (2016) R835167 (Final) |
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Presentation | Sex steroid regulation of pituitary gonadotropins during primary oocyte growth in coho salmon. | None | Harding LB, Monson CA, Young G, Swanson P | Harding LB, Monson CA, Young G, Swanson P. Sex steroid regulation of pituitary gonadotropins during primary oocyte growth in coho salmon. Poster presented at the 3rd Biennial Meeting of the North American Society for Comparative Endocrinology, Ottawa, ON, Canada, June 21-25, 2015. |
R835167 (2015) R835167 (2016) R835167 (Final) |
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Presentation | Wastewater treatment plant effluent alters pituitary gonadotropin mRNA levels in juvenile coho salmon. | None | Harding LB, Schultz IR, Silva DAM, Ylitalo GM, Swanson P | Harding LB, Schultz IR, Silva DAM, Ylitalo GM, Swanson P. Wastewater treatment plant effluent alters pituitary gonadotropin mRNA levels in juvenile coho salmon. Presented at the Salish Sea Ecosystem Conference, Vancouver, British Columbia, Canada, April 13-15, 2016. |
R835167 (Final) |
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Presentation | Selective serotonin reuptake inhibitors alter pituitary gonadotropin expression in vivo and in vitro in salmon and trout. | None | Harding LB, Schultz IR, Young G, Swanson P | Harding LB, Schultz IR, Young G, Swanson P. Selective serotonin reuptake inhibitors alter pituitary gonadotropin expression in vivo and in vitro in salmon and trout. Poster presented at the 18th International Congress of Comparative Endocrinology, Lake Louise, Alberta, Canada, June 4-9, 2017. |
R835167 (Final) |
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Presentation | Development of a high throughput method to assess effects of endocrine disrupting chemicals on ovarian function, using short-term culture of rainbow trout ovarian follicle. | None | Monson C,Schultz IR, Harding LA, Swanson P, Young G | Monson C,Schultz IR, Harding LA, Swanson P, Young G. Development of a high throughput method to assess effects of endocrine disrupting chemicals on ovarian function, using short-term culture of rainbow trout ovarian follicle. Presented at the Society of Environmental Toxicology and Chemistry (SETAC) North America 35th Annual Meeting, Vancouver, British Columbia, Canada, November 9-13, 2014. |
R835167 (2015) R835167 (2016) R835167 (Final) |
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Presentation | New insights into the adverse outcome pathway for domoic acid in aquatic and terrestrial organisms. | None | Schultz IR, Woodruff D, Timchalk C, Watanabe K | Schultz IR, Woodruff D, Timchalk C, Watanabe K. New insights into the adverse outcome pathway for domoic acid in aquatic and terrestrial organisms. Poster presented at the Society of Environmental Toxicology and Chemistry (SETAC) North America 33rd Annual Meeting, Long Beach, CA, November 11-15, 2012 (invited). |
R835167 (2013) R835167 (2015) R835167 (2016) R835167 (Final) |
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Presentation | Adverse outcome pathways of fish reproduction: integrating cellular assays of trout pituitary, ovary and liver toxicity with contaminant exposures. | None | Schultz IR, Swanson P, Young G, Nagler J | Schultz IR, Swanson P, Young G, Nagler J. Adverse outcome pathways of fish reproduction: integrating cellular assays of trout pituitary, ovary and liver toxicity with contaminant exposures. Presented at the Society of Environmental Toxicology and Chemistry (SETAC) Europe 23rd Annual Meeting, Glasgow, Scotland, United Kingdom, May 12-16, 2013. |
R835167 (2013) R835167 (2015) R835167 (2016) R835167 (Final) |
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Presentation | Recent developments in adverse outcome pathway models. | None | Schultz IR | Schultz IR. Recent developments in adverse outcome pathway models. Presented at the Society of Environmental Toxicology and Chemistry (SETAC) Workshop, Mechanistic Effect Models for Ecological Risk Assessment: Recent Progress and Future Directions, Nashville, TN, November 17, 2013. |
R835167 (2014) R835167 (2015) R835167 (2016) R835167 (Final) |
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Presentation | Biological models linking molecules-to-organisms. | None | Schultz IR | Schultz IR. Biological models linking molecules-to-organisms. Presented at the NIMBioS Investigative Workshop on Predictive Models for Ecological Risk Assessment, Knoxville, TN, April 28-30, 2014. |
R835167 (2014) R835167 (2015) R835167 (2016) R835167 (Final) |
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Presentation | AOPs and reverse toxicokinetics: estimating internal dose metrics from environmental exposures. | None | Schultz IR, Hayton WL | Schultz IR, Hayton WL. AOPs and reverse toxicokinetics: estimating internal dose metrics from environmental exposures. Presented at the 35rd Annual Society of Environmental Toxicology and Chemistry (SETAC) meeting, November 9-13, 2014. |
R835167 (Final) |
not available |
Presentation | Incorporating in vitro measurements of rainbow trout pituitary, ovary and liver function with biological modeling of fish reproduction. | None | Schultz IR, Harding MC, Cavileer T, Young G, Nagler J, Swanson P | Schultz IR, Harding MC, Cavileer T, Young G, Nagler J, Swanson P. Incorporating in vitro measurements of rainbow trout pituitary, ovary and liver function with biological modeling of fish reproduction. Presented at the 35th Annual Society of Environmental Toxicology and Chemistry (SETAC) meeting, Vancouver, British Columbia, Canada, November 9-13, 2014. |
R835167 (Final) |
not available |
Presentation | Incorporating in vitro measurements of rainbow trout pituitary, ovary and liver function with biological modeling of fish reproduction. | None | Schultz IR, Harding MC, Cavileer T, Young G, Nagler J, Swanson P. | Schultz IR, Harding MC, Cavileer T, Young G, Nagler J, Swanson P. Incorporating in vitro measurements of rainbow trout pituitary, ovary and liver function with biological modeling of fish reproduction. Presented at the 18th Meeting of Pollutant Responses in Marine Organisms (PRIMO), Trondheim, Norway, May 24-27, 2015. |
R835167 (Final) |
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Presentation | Applying PBTK and compartmental models for reverse tociocokinetics: interspecies differences and environmental influences. | None | Schultz IR, Gillies K | Schultz IR, Gillies K. Applying PBTK and compartmental models for reverse tociocokinetics: interspecies differences and environmental influences. Presented at the Society of Environmental Toxicology and Chemistry (SETAC) 36th Annual Meeting, Salt Lake City, UT, November 1-5, 2015. |
R835167 (Final) |
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Presentation | Effects of endocrine disrupting chemicals in aquatic ecosystems on fish pituitary function. | None | Swanson P, Harding LB, Young G, Schulz IR | Swanson P, Harding LB, Young G, Schulz IR. Effects of endocrine disrupting chemicals in aquatic ecosystems on fish pituitary function. Presented at the Annual Meeting of the Society for Study of Reproduction, Grand Rapids, MI, July 19-23, 2014 (invited). |
R835167 (2014) R835167 (2015) R835167 (2016) R835167 (Final) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.