Grantee Research Project Results
Publications Details for Grant Number R834514C004
Genetic Susceptibility
RFA:
Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2009)
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Reference Type | Citation | Progress Report Year | Document Sources |
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Book Chapter | Costa LG, Cole TB, Furlong CE. Paraoxonase (PON1) and detoxication of nerve agents. In: Gupta R, ed. Handbook of Toxicology of Chemical Warfare Agents, Second Edition. New York, NY: Elsevier, January 21, 2015, Chapter 73, pp. 1089-1098. |
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Journal Article | Asselbergs, F.W., Y. Guo, E.P. van Iperen, S. Sivapalaratnam, V. et al. Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci. Am J Hum Genet, 2012. 91(5):p. 823-38. |
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Journal Article | Cole TB, Jansen K, Park S, Li W-F, Furlong CE, Costa LG. The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 status. Advances in Experimental Medicine and Biology 2010;660:47-60. |
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Journal Article | Cole TB, Fisher JC, Burbacher TM, Costa LG, Furlong CE. Neurobehavioral assessment of mice following repeated postnatal exposure to chlorpyrifos-oxon. Neurotoxicology and Teratology. 2012;34(3):311-22. |
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Journal Article | Giordano G, Tait L, Furlong CE, Cole TB, Kavanagh TJ, Costa LG. Gender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expression. Free Radical Biology and Medicine 2013;58:98-108. |
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Journal Article | Inoue S, Becker AL, Kim J-H, Shu Z, Soelberg SD, Weigel KM, Hiraiwa M, Cairns A, Lee H-B, Furlong CE, Oh K, Lee K-H, Gao D, Chung J-H, Cangelosi GA. Semi-automated, occupationally safe immunofluorescence microtip sensor for rapid detection of mycobacterium cells in sputum. PLoS One 2014;9(1):e86018. |
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Journal Article | Kim DS, Marsillach J, Furlong CE, Jarvik GP. Pharmacogenetics of paraoxonase activity: elucidating the role of high-density lipoprotein in disease. Pharmacogenomics 2013;14(12):1495-1515. |
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Journal Article | Kim DS, Burt AA, Rosenthal EA, Ranchalis JE, Eintracht JF, Hatsukami TS, Furlong CE, Marcovina S, Albers JJ, Jarvik GP. HDL-3 is a superior predictor of carotid artery disease in a case-control cohort of 1725 participants. Journal of the American Heart Association 2014;3(3):e000902. |
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Journal Article | Kim DS, Crosslin DR, Auer PL, Suzuki SM, Marsillach J, Burt AA, Gordon AS, Meschia JF, Nalls MA, Worrall BB, Longstreth Jr. WT, Gottesman RF, Furlong CE, Peters U, Rich SS, Nickerson DA, Jarvik GP. Rare coding variation in paraoxonase-1 is associated with ischemic stroke in the NHLBI Exome Sequencing Project. Journal of Lipid Research 2014;55(6):1173-1178. |
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Journal Article | Kim DS, Burt AA, Ranchalis JE, Jarvik LE, Eintracht JF, Furlong CE, Jarvik GP. Effects of dietary components on high-density lipoprotein measures in a cohort of 1,566 participants. Nutrition & Metabolism 2014;11(1):44 (9 pp.). |
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Journal Article | Kim DS, Burt AA, Ranchalis JE, Vuletic S, Vaisar T, Li WF, Rosenthal EA, Dong W, Eintracht JF, Motulsky AG, Brunzell JD, Albers JJ, Furlong CE, Jarvik GP. PLTP activity inversely correlates with CAAD: effects of PON1 enzyme activity and genetic variants on PLTP activity. Journal of Lipid Research 2015;56(7):1351-1362. |
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Journal Article | Marsillach J, Costa LG, Furlong CE. Protein adducts as biomarkers of exposure to organophosphorus compounds. Toxicology 2013;307:46-54. |
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Journal Article | Marsillach J, Suzuki SM, Richter RJ, McDonald MG, Rademacher PM, MacCoss MJ, Hsieh EJ, Rettie AE, Furlong CE. Human valacyclovir hydrolase/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase. PLoS One 2014;9(10):e110054. |
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Journal Article | Marsillach J, Becker JO, Vaisar T, Hahn BH, Brunzell JD, Furlong CE, deBoer IH, McMahon MA, Hoofnagle AN, DCCT/EDIC Research Group. Paraoxonase-3 is depleted from the high-density lipoproteins of autoimmune disease patients with subclinical atherosclerosis. Journal of Proteome Research 2015;14(5):2046-2054. |
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Journal Article | Mehta AJ, Zanobetti A, Bind MA, Kloog I, Koutrakis P, Sparrow D, Vokonas PS, Schwartz JD. Long-term exposure to ambient fine particulate matter and renal function in older men: the Veterans Administration Normative Aging Study. Environmental Health Perspectives 2016;124(9):1353-1360. |
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Journal Article | Marsillach, J., E.J. Hsieh, R.J. Richter, M.J. Maccoss, and C.E. Furlong, Proteomic analysis of adducted butyrylcholinesterase for biomonitoring organophosphorus exposures. Chem Biol Interact, 2012. |
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Journal Article | Kim, DS, Crosslin, DR, Auer, PL, Suzuki, SM, Marsillach, J, Burt, AA, Gordon, AS, Meschia, JF, Nalls, MA, Worrall, BB, Longstreth, WT, Jr., Gottesman, RF, Furlong, CE, Peters, U, Rich, SS, Nickerson, DA and Jarvik, GP. 2014. Rare coding variation in paraoxonase-1 is associated with ischemic stroke in the NHLBI Exome Sequencing Project. J Lipid Res. 55(6):1173-1178. 4031948. |
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Journal Article | Guizzetti, M., N.H. Moore, G. Giordano, K.L. VanDeMark, and L.G. Costa, Ethanol inhibits neuritogenesis induced by astrocyte muscarinic receptors. Glia, 2010. 58(12):p. 1395-406. PMCID2925144. |
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Journal Article | Richter RJ, Jarvik GP, Furlong CE. 2010. Paraoxonase 1 (PON1) Status as a Risk Factor for Disease or Exposure. Adv Exp Med Biol 660:29-35. PMID 20221868. DOI 10.1007/978-1-60761-350-3_. NIHMSID #193805. |
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Journal Article | Kim, DS, Burt, AA, Ranchalis, JE, Richter, RJ, Marshall, JK, Nakayama, KS, Jarvik, ER, Eintracht, JF, Rosenthal, EA, Furlong, CE and Jarvik, GP. 2012. Dietary cholesterol increases paraoxonase 1 enzyme activity. J Lipid Res. 53(11):2450-8. PMCID:PMC3466014. |
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Journal Article | Kim, DS, Burt, A, Ranchalis, J, Richter, RJ, Marshall, E, Rosenthal, E, Furlong, C and Jarvik, GP. 2012. Additional common polymorphisms in the PON gene cluster predict PON1 activity but not vascular disease. J Lipids 2012:476316. PMCID:PMC3364586. |
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Journal Article | Costa, LG, de Laat, R, Dao, K, Pellacani, C, Cole, TB and Furlong, CE. 2013. Paraoxonase-2 (PON2) in brain and its potential role in neuroprotection. Neurotoxicology. 3942372. |
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Journal Article | Kim, DS, Burt, AA, Crosslin, DR, Robertson, PD, Ranchalis, JE, Boyko, EJ, Nickerson, DA, Furlong, CE and Jarvik, GP. 2013. Novel common and rare genetic determinants of paraoxonase activity:FTO, SERPINA12, and ITGAL. J Lipid Res. 54(2):552-60. PMCID:PMC3588879. |
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Journal Article | Costa, LG, Giordano, G, Cole, TB, Marsillach, J and Furlong, CE. 2013. Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity. Toxicology. 307(10):115-122. PMCID:PMC3516631. |
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Journal Article | Costa, LG, Tait, L, de Laat, R, Dao, K, Giordano, G, Pellacani, C, Cole, TB and Furlong, CE. 2013. Modulation of paraoxonase 2 (PON2) in mouse brain by the polyphenol quercetin:a mechanism of neuroprotection? Neurochem Res. 38(9):1809-18. 3735620. |
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Journal Article | Marsillach, J, Hsieh, EJ, Richter, RJ, MacCoss, MJ, Furlong, CE. 2013. Proteomic analysis of adducted butyrylcholinesterase for biomonitoring organophosphorus exposures. Chem Biol Interact 203(1):85-90. |
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Journal Article | Cole, TB, Li, WF, Co, AL, Hay, AM, MacDonald, JW, Bammler, TK, Farin, FM, Costa, LG and Furlong, CE. 2014. Repeated Gestational Exposure of Mice to Chlorpyrifos Oxon is Associated with Paraoxonase 1 (PON1)-Modulated Effects in Maternal and Fetal Tissues. Toxicol Sci. |
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Journal Article | Garrick JM, Dao K, de Laat R, Elsworth J, Cole TB, Marsillach J, Furlong CE, Costa LG. 2016. Developmental expression of paraoxonase 2. Chem Biol Interact. pii:S0009-2797(16)30116-8. doi:10.1016/j.cbi.2016.04.001. PMID:27062895. |
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Journal Article | Furlong CE, Marsillach J, Jarvik GP, Costa LG. 2016. Paraoxonases-1,-2 and-3:What are their functions? Chem Biol Interact. doi:10.1016/j.cbi.2016.05.036. PMID:27238723. |
R834513C003 (2016) R834514C004 (Final) |
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Journal Article | Marsillach J, Costa LG, Furlong CE. 2016. Paraoxonase-1 and Early-Life Environmental Exposures. Ann Glob Health. 82(1):100-10. PMID:27325068; PMCID:PMC4916371. |
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Journal Article | Cole, T.B., J.C. Fisher, T.M. Burbacher, L.G. Costa, and C.E. Furlong, Neurobehavioral assessment of mice following repeated postnatal exposure to chlorpyrifos-oxon. Neurotoxicol Teratol, 2012. 34(3):p. 311-322. |
R834514C004 (Final) R834798C003 (Final) |
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Journal Article | Burton C, Marsillach J, Zhang YS, Zhao W, Zheng X. Bioanalysis. 2015;7(13):1667-73. doi:10.4155/bio.15.90. Epub 2015 Jul 7** Judit Marsillach selected as a finalist for the Young Investigator Award to identify and reward promising early career researchers in the community. |
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Journal Article | Furlong, C.E., R.J. Richter, L.G. Costa, and G.P. Jarvik, Paraoxonase 1 (PON1) Status in Risk Assessment for Organophosphate Exposure and Pharmacokinetics, in Chapter 9:Parameters for Pesticide QSAR and PBPK/PD Models for Human Risk Assessment. 2012, American Chemical Society:Available at:http://pubs.acs.org/doi/abs/10.1021/bk-2012-1099.ch009. p. 133-147. |
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Journal Article | Costa, L.G., G. Giordano, and C.E. Furlong, Pharmacological and dietary modulators of paraxonase 1 (PON1) activity and expression:the hunt goes on. Biochem Pharmacol, 2011. 81(3):p. 337-344. PMCID3077125. |
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Journal Article | Kim, D.S., A. Burt, J. Ranchalis, R.J. Richter, E. Marshall, E. Rosenthal, C. Furlong, and G.P. Jarvik, Additional common polymorphisms in the PON gene cluster predict PON1 activity but not vascular disease. J Lipids, 2012. 2012(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364586/pdf/JL2012-476316.pdf). |
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Journal Article | Kim, D.S., A.A. Burt, J.E. Ranchalis, R.J. Richter, J.K. Marshall, K.S. Nakayama, E.R. Jarvik, J.F. Eintracht, E.A. Rosenthal, C.E. Furlong, and G.P. Jarvik, Dietary cholesterol increases paraoxonase 1 enzyme activity. J Lipid Res, 2012. 53(11):p. 2450-8. |
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Presentation | Furlong CE, Li W-F, Cole TB, Beyer RP, Bammler TK, Park SS, Farin FM, Costa LG. Effects of paraoxonase-1 (PON1) status on pre-and postnatal exposures to chlorpyrifos oxon and diazoxon. Presented at the 38th Annual Meeting of the Neurobehavioral Teratology Society, Bellevue, WA, June 28-July 2, 2014 (invited). |
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Presentation | Furlong CE, Marsillach J. Biomarkers of organophosphate exposure. Presented at the Global Cabin Air Quality Executive Meeting, London, United Kingdom, February 25, 2015 (invited). |
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Presentation | Furlong CE. Your genome and its ability to modulate toxic exposures--some examples. Presented at the Bainbridge Island Women’s Club, Bainbridge Island, WA, January 15, 2015 (invited). |
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Presentation | Furlong, C. Presentation:The Many Facets of Gene/Environment Interactions of the Paraoxonases. in NIEHS Keystone Lecture Series. 2012 September. Triangle Park, NC. |
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Presentation | Marsillach J, Hsieh EJ, Richter RJ, MacCoss MJ, Hoofnagle AN, Rettie AE, MacDonald MG, Furlong CE. Biomonitoring human organophosphorus exposures by mass spectrometry. Presented at the Association of Analytical Chemistry Accurate Mass Spectrometry Workshop, Tacoma, WA, June 18, 2014 (invited). |
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Presentation | Marsillach J, Hsieh EJ, Richter RJ, MacCoss MJ, Hoofnagle AN, Furlong CE. Use of dried blood spots and mass spectrometry for biomonitoring organophosphorus exposures. Poster presented at the 38th Annual Meeting of the Neurobehavioral Teratology Society, Bellevue, WA, June 28-July 2, 2014. |
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Presentation | Marsillach J, Hsieh EJ, Richter RJ, Suzuki SM, Bukowski TR, MacCoss MJ, Hoofnagle AN, Furlong CE. Biomarkers of organophosphorus exposures in humans--detection of insecticide exposures in humans. Poster presented at the Superfund Research Program Annual Meeting, San Jose, CA, November 12-14, 2014. |
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Presentation | Marsillach J, Furlong CE. Biomarkers of organophosphate exposure and cytochromes P450S. Presented at the Global Cabin Air Quality Executive Meeting, London, United Kingdom, February 25, 2015 (invited). |
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Presentation | Marsillach J. Adductomics and human exposome: monitoring exposures to organophosphates. Presented at Summer Talks in Neurotoxicology and Psychopharmacology, Reus, Spain, June 15-16, 2015 (invited). |
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Presentation | Marsillach J, Hsieh EJ, Richter RJ, Paulsen MH, Simpson CD, MacCoss MJ, Hoofnagle AN, Furlong CE. Adductomics and organophosphorus exposures in communities. Poster presented at the Superfund Research Program Annual Meeting, San Juan, Puerto Rico, November 18-20, 2015. |
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Presentation | Marsillach J, Hsieh EJ, Richter RJ, Suzuki SM, Bukowski TR, MacCoss MJ, Hoofnagle AN, Furlong CE. Proteomics characterization of biomarkers of organophosphorus exposure. Presented at the 12th International Meeting on Cholinesterases and 6th International Conference on Paraoxonases, Elche, Spain, September 27-30, 2015 (invited). |
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Presentation | Marsillach, J., E. Hsieh, R.J. Richter, M.J. MacCoss, D. Tomazela, M.H. Paulsen, C.D. Simpson, and C. Furlong. Poster:Mass spectrometric-based biomarker analysis of organophosphorus exposure in agricultural workers in Society of Toxicology Annual Meeting. 2012 March. San Francisco, CA. |
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Presentation | Furlong, C., R.J. Richter, W.F. Li, T.B. Cole, J. Marsillach, S.M. Suzuki, E.R. Jarvik, and L.G. Costa. Presentation:Plenary Lecture 1:Paraoxonase (PON1) Status and Modulation of the Toxicity of Specific Organophosphorus Compounds. in 5th International Conference on Paraoxonases. 2012 July. Columbus, OH. |
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Presentation | Marsillach, J, Hsieh, EJ, Richter, RJ, MacCoss, MJ, Hoofnagle, AN and Furlong, CE. 2013. Poster:Proteomics analysis of biomarkers of organophosphorus exposures. Scientific Session 3:Risks of Pollutants during Early Life Exposures. 2013 Superfund Research Annual Meeting, Baton Rouge, Louisiana(October 2013). |
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Presentation | Marsillach, J, Hsieh, EJ, Richter, RJ, MacCoss, MJ, Hoofnagle, AN and Furlong, CE. 2014. Poster:Proteomic analysis of dried blood spots for biomonitoring organophosphorus exposures. Society of Toxicology Annual Meeting. Phoenix, AZ. |
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Presentation | Engineering recombinant PON1s for increased catalytic efficiency of OP hydrolysis. Furlong CE, Bukowski TR, Suzuki SM, Marsillach J, Richter RJ, Costa LG. 12th International Meeting on Cholinesterases and 6th International Conference on Paraoxonases, September 27-30, 2015, Elche (Spain). INVITED SPEAKER. |
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Presentation | Giordano, G, Furlong, CE, Cole, TB and Costa, LG (2013:March). Poster:Estradiol Modulates Paraoxonase-2 Expression in Mouse Brain. Society of Toxicology Annual Meeting. San Antonio, TX. |
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Presentation | Cole, TB, Li, WF, Co, AL, Marsillach, J, Hay, AM, Richter, RJ, Costa, LG and Furlong, CE (2013:March). Presentation:Maternal Paraoxonase (PON1) Status Modulates Fetal Effects Associated with Gestational Exposure of Mice to Chlorpyrifos Oxon. Society of Toxicology Annual Meeting. San Antonio, TX. |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.