Grantee Research Project Results
Publications Details for Grant Number R832413C002
Project 2: The Role of Oxidative Stress in PM-induced Adverse Health Effects
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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| Journal Article | Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. | CIRCULATION RESEARCH | Araujo JA, Barajas B, Kleinman M, Wang X, Bennett BJ, Gong KW, Navab M, Harkema J, Sioutas C, Lusis AJ, Nel AE | Araujo JA, Barajas B, Kleinman M, Wang X, Bennett BJ, Gong KW, Navab M, Harkema J, Sioutas C, Lusis AJ, Nel AE. Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circulation Research 2008;102(5):589-596. |
R832413 (2008) R832413 (2009) R832413 (2010) R832413 (Final) R832413C001 (2008) R832413C001 (Final) R832413C002 (2007) R832413C002 (2008) R832413C002 (2009) R832413C002 (Final) R832413C003 (Final) |
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| Journal Article | Particulate matter and atherosclerosis:role of particle size, composition and oxidative stress. | None | Araujo JA, Nel AE | Araujo JA, Nel AE. Particulate matter and atherosclerosis:role of particle size, composition and oxidative stress. Particle and Fibre Toxicology 2009;6:24. |
R832413 (Final) R832413C002 (2010) R832413C002 (Final) |
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| Journal Article | Evaluating the toxicity of airborne particulate matter and nanoparticles by measuring oxidative stress potential—a workshop report and consensus statement. | INHALATION TOXICOLOGY | Ayres JG, Borm P, Cassee FR, Castranova V, Donaldson K, Ghio A, Harrison RM, Hider R, Kelly F, Kooter IM, Marano F, Maynard RL, Mudway I, Nel A, Sioutas C, Smith S, Baeza-Squiban A, Cho A, Duggan S, Froines J | Ayres JG, Borm P, Cassee FR, Castranova V, Donaldson K, Ghio A, Harrison RM, Hider R, Kelly F, Kooter IM, Marano F, Maynard RL, Mudway I, Nel A, Sioutas C, Smith S, Baeza-Squiban A, Cho A, Duggan S, Froines J. Evaluating the toxicity of airborne particulate matter and nanoparticles by measuring oxidative stress potential—a workshop report and consensus statement. Inhalation Toxicology 2008;20(1):75-99. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) R832413C002 (2008) R832413C003 (2008) R832413C003 (2009) |
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| Journal Article | Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation. | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | Chan RC-F, Wang M, Li N, Yanagawa Y, Onoe K, Lee JJ, Nel AE | Chan RC-F, Wang M, Li N, Yanagawa Y, Onoe K, Lee JJ, Nel AE. Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation. Journal of Allergy and Clinical Immunology 2006;118(2):455-465. |
R827352 (Final) R827352C002 (Final) R832413 (2008) R832413C002 (2007) R832413C002 (2008) R832413C002 (Final) |
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| Journal Article | T-cell effector pathways in allergic diseases: transcriptional mechanisms and therapeutic targets. | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | Chatila TA, Li N, Garcia-Lloret M, Kim HJ, Nel AE | Chatila TA, Li N, Garcia-Lloret M, Kim H-J, Nel AE. T-cell effector pathways in allergic diseases:transcriptional mechanisms and therapeutic targets. Journal of Allergy and Clinical Immunology 2008;121(4):812-823. |
R832413 (2007) R832413 (2008) R832413 (2010) R832413 (Final) R832413C002 (2007) R832413C002 (2008) R832413C002 (2009) |
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| Journal Article | Use of a rapid cytotoxicity screening approach to engineer a safer zinc oxide nanoparticle through iron doping. | None | George S, Pokhrel S, Xia T, Gilbert B, Ji Z, Schowalter M, Rosenauer A, Damoiseaux R, Bradley KA, Madler L, Nel AE | George S, Pokhrel S, Xia T, Gilbert B, Ji Z, Schowalter M, Rosenauer A, Damoiseaux R, Bradley KA, Madler L, Nel AE. Use of a rapid cytotoxicity screening approach to engineer a safer zinc oxide nanoparticle through iron doping. ACS Nano 2010;4(1):15-29. |
R832413 (Final) R832413C002 (2010) |
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| Journal Article | Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells. | GENOME BIOLOGY | Gong KW, Zhao W, Li N, Barajas B, Kleinman M, Sioutas C, Horvath S, Lusis AJ, Nel A, Araujo JA | Gong KW, Zhao W, Li N, Barajas B, Kleinman M, Sioutas C, Horvath S, Lusis AJ, Nel A, Araujo JA. Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells. Genome Biology 2007;8(7):R149 (13 pp.). |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2008) R832413C001 (Final) R832413C002 (2007) R832413C002 (2008) R832413C002 (Final) |
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| Journal Article | Pro-oxidative DEP chemicals induce heat shock proteins and an unfolding protein response in a bronchial epithelial cell line as determined by DIGE analysis. | None | Jung EJ, Avliyakulov NK, Boontheung P, Loo JA, Nel AE | Jung EJ, Avliyakulov NK, Boontheung P, Loo JA, Nel AE. Pro-oxidative DEP chemicals induce heat shock proteins and an unfolding protein response in a bronchial epithelial cell line as determined by DIGE analysis. Proteomics 2007;7(21):3906-3918. |
R832413 (Final) R832413C002 (Final) |
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| Journal Article | Adjuvant effects of ambient particulate matter monitored by proteomics of bronchoalveolar lavage fluid. | None | Kang X, Li N, Wang M, Boontheung P, Sioutas C, Harkema JR, Bramble LA, Nel AE, Loo JA | Kang X, Li N, Wang M, Boontheung P, Sioutas C, Harkema JR, Bramble LA, Nel AE, Loo JA. Adjuvant effects of ambient particulate matter monitored by proteomics of bronchoalveolar lavage fluid. Proteomics 2010;10(3):520-531. |
R832413 (Final) R832413C002 (2010) R832413C002 (Final) |
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| Journal Article | The cellular impacts of diesel exhaust particles: beyond inflammation and death. | EUROPEAN RESPIRATORY JOURNAL | Li N, Nel AE | Li N, Nel AE. The cellular impacts of diesel exhaust particles:beyond inflammation and death. European Respiratory Journal 2006;27(4):667-668. |
R832413 (2008) R832413 (Final) R832413C002 (2006) R832413C002 (2008) |
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| Journal Article | The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles. | FREE RADICAL BIOLOGY AND MEDICINE | Li N, Xia T, Nel AE | Li N, Xia T, Nel AE. The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles. Free Radical Biology and Medicine 2008;44(9):1689-1699. |
R832413 (2007) R832413 (2008) R832413 (2010) R832413 (Final) R832413C002 (2007) R832413C002 (2008) R832413C002 (2009) |
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| Journal Article | The adjuvant effect of ambient particulate matter is closely reflected by the particulate oxidant potential. | ENVIRONMENTAL HEALTH PERSPECTIVES | Li N, Wang M, Bramble LA, Schmitz DA, Schauer JJ, Sioutas C, Harkema JR, Nel AE | Li N, Wang M, Bramble LA, Schmitz DA, Schauer JJ, Sioutas C, Harkema JR, Nel AE. The adjuvant effect of ambient particulate matter is closely reflected by the particulate oxidant potential. Environmental Health Perspectives 2009;117(7):1116-1123. |
R832413 (2009) R832413 (2010) R832413 (Final) R832413C001 (2009) R832413C001 (Final) R832413C002 (2009) R832413C002 (Final) |
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| Journal Article | Ambient ultrafine particles provide a strong adjuvant effect in the secondary immune response: implication for traffic-related asthma flares. | None | Li N, Harkema JR, Lewandowski RP, Wang M, Bramble LA, Gookin GR, Ning Z, Kleinman MT, Sioutas C, Nel AE | Li N, Harkema JR, Lewandowski RP, Wang M, Bramble LA, Gookin GR, Ning Z, Kleinman MT, Sioutas C, Nel AE. Ambient ultrafine particles provide a strong adjuvant effect in the secondary immune response:implication for traffic-related asthma flares. American Journal of Physiology 2010;299(3):L374-L383. |
R832413 (Final) R832413C001 (2010) R832413C001 (Final) R832413C002 (2010) R832413C002 (Final) |
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| Journal Article | Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery. | None | Liong M, Lu J, Kovochich M, Xia T, Ruehm SG, Nel AE, Tamanoi F, Zink JI | Liong M, Lu J, Kovochich M, Xia T, Ruehm SG, Nel AE, Tamanoi F, Zink JI. Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery. ACS Nano 2008;2(5):889-896. |
R832413 (2010) R832413 (Final) R832413C002 (2009) |
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| Journal Article | Understanding biophysicochemical interactions at the nano-bio interface. | None | Nel AE, Madler L, Velegol D, Xia T, Hoek EM, Somasundaran P, Klaessig F, Castranova V, Thompson M | Nel AE, Madler L, Velegol D, Xia T, Hoek EM, Somasundaran P, Klaessig F, Castranova V, Thompson M. Understanding biophysicochemical interactions at the nano-bio interface. Nature Materials 2009;8(7):543-557. |
R832413 (Final) R832413C002 (2010) |
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| Journal Article | Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. | NANO LETTERS | Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh JI, Wiesner MR, Nel AE | Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh JI, Wiesner MR, Nel AE. Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Letters 2006;6(8):1794-1807. |
R827352 (Final) R827352C002 (Final) R827352C014 (Final) R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) R832413C002 (2006) R832413C002 (2008) |
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| Journal Article | The role of reactive oxygen species and oxidative stress in mediating particulate matter injury. | CLINICS IN OCCUPATIONAL AND ENVIRONMENTAL MEDICINE | Xia T, Kovochich M, Nel A | Xia T, Kovochich M, Nel A. The role of reactive oxygen species and oxidative stress in mediating particulate matter injury. Clinics in Occupational and Environmental Medicine 2006;5(4):817-836. |
R832413 (2008) R832413 (Final) R832413C002 (2007) R832413C002 (2008) |
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| Journal Article | Impairment of mitochondrial function by particulate matter (PM) and their toxic components: implications for PM-induced cardiovascular and lung disease. | FRONTIERS IN BIOSCIENCE | Xia T, Kovochich M, Nel AE | Xia T, Kovochich M, Nel AE. Impairment of mitochondrial function by particulate matter (PM) and their toxic components: implications for PM-induced cardiovascular and lung disease. Frontiers in Bioscience 2007;12(4):1238-1246. |
R832413 (2008) R832413 (Final) R832413C002 (2007) R832413C002 (2008) |
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| Journal Article | Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways. | None | Xia T, Kovochich M, Liong M, Zink JI, Nel AE | Xia T, Kovochich M, Liong M, Zink JI, Nel AE. Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways. ACS Nano 2008;2(1):85-96. |
R832413 (2010) R832413 (Final) R832413C002 (2009) |
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| Journal Article | Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. | None | Xia T, Kovochich M, Liong M, Mädler L, Gilbert B, Shi H, Yeh JI, Zink JI, Nel AE | Xia T, Kovochich M, Liong M, Madler L, Gilbert B, Shi H, Yeh JI, Zink JI, Nel AE. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano 2008;2(10):2121-2134. |
R832413 (2010) R832413 (Final) R832413C002 (2009) |
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| Journal Article | Potential health impact of nanoparticles. | None | Xia T, Li N, Nel AE | Xia T, Li N, Nel AE. Potential health impact of nanoparticles. Annual Review of Public Health 2009;30:137-150. |
R832413 (2008) R832413 (2010) R832413 (Final) R832413C002 (2009) |
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| Journal Article | Use of proteomics to demonstrate a heirarchical oxidative stress response to diesel exhaust particle chemicals in a macrophage cell line. | JOURNAL OF BIOLOGICAL CHEMISTRY | Xiao GG, Wang M, Li N, Loo JA, Nel AE | Xiao GG, Wang M, Li N, Loo JHA, Nel AE. Use of proteomics to demonstrate a heirarchical oxidative stress response to diesel exhaust particle chemicals in a macrophage cell line. Journal of Biological Chemistry 2003;278(50):50781-50790. |
R832413C002 (Final) |
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| Journal Article | Oxidative stress and asthma: proteome analysis of chitinase-like proteins and FIZZ1 in lung tissue and bronchoalveolar lavage fluid. | None | Zhang L, Wang M, Kang X, Boontheung P, Li N, Nel AE, Loo JA | Zhang L, Wang M, Kang X, Boontheung P, Li N, Nel AE, Loo JA. Oxidative stress and asthma:proteome analysis of chitinase-like proteins and FIZZ1 in lung tissue and bronchoalveolar lavage fluid. Journal of Proteome Research 2009;8(4):1631-1638. |
R832413 (2008) R832413 (Final) R832413C002 (Final) |
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| Presentation | Presented at the Feinberg School of Medicine, Northwestern University, Chicago, IL, June 2007 (Invited Speaker/Visiting Professor). | None | Air pollution health effects:an understanding of the role of oxidative in heart and lung disease | Air pollution health effects: an understanding of the role of oxidative in heart and lung disease. Presented at the Feinberg School of Medicine, Northwestern University, Chicago, IL, June 2007 (Invited Speaker/Visiting Professor). |
R832413C002 (2008) |
not available |
| Presentation | Presented at the Keck School of Medicine, University of Southern California, Los Angeles, CA, June 2007 (Invited Speaker/Visiting Professor). | None | Air pollution health effects: an understanding of the role of oxidative in heart and lung disease | Air pollution health effects: an understanding of the role of oxidative in heart and lung disease. Presented at the Keck School of Medicine, University of Southern California, Los Angeles, CA, June 2007 (Invited Speaker/Visiting Professor). |
R832413C002 (2008) |
not available |
| Presentation | " "Gene, Environment, and Disease Panels", for the US-Japan 6. | None | Invited Speaker, AAAAI International Convention, March 2008, Philadelphia, PA, Symposium, " How do Air Pollutants Promote Airways Inflammation and Contribute to Asthma Morbidity?" Title:"How Does Composition of Air Particulates Cause Airways Injury and Promote Allergic Sensitization? | How does composition of air particulates cause airways injury and promote allergic sensitization? Presented at the AAAAI International Convention Symposium, How do Air Pollutants Promote Airways Inflammation and Contribute to Asthma Morbidity? Philadelphia, PA, March 2008 (Invited Speaker). |
R832413C002 (2008) |
not available |
| Presentation | Feasibility of biomarker studies:What can be learned from ambient nanoparticles? | None | Li N | Li N. Feasibility of biomarker studies:What can be learned from ambient nanoparticles? Presented at the Nanomaterials and Worker Health: Medical Surveillance, Exposure Registries, and Epidemiological Research Conference, Keystone Resort and Conference Center, Keystone, CO, July 21-23, 2010. |
R832413C002 (2010) |
not available |
| Presentation | Ambient ultrafine particles promote allergic airway inflammation by increasing T-helper 2 (Th2) and T-helper 17 (Th17) gene expression during the recall immune response. | None | Li N, Harkema JR, Lewandowski RP, Wang M, Bramble LA, Gookin G, Kleinman M, Sioutas C, Nel AE | Li N, Harkema JR, Lewandowski RP, Wang M, Bramble LA, Gookin G, Kleinman M, Sioutas C, Nel AE. Ambient ultrafine particles promote allergic airway inflammation by increasing T-helper 2 (Th2) and T-helper 17 (Th17) gene expression during the recall immune response. Presented at the American Association for Aerosol Research (AAAR) Conference, San Diego, CA, March 22-26, 2010. |
R832413C002 (2010) |
not available |
| Presentation | Pulmonary health effects I: inside the lungs. | None | Li N | Li N. Pulmonary health effects I: inside the lungs. Presented at the San Joaquin Valley Air Pollution Control District Particulate Conference, Fresno, CA, 2010. |
R832413C002 (2010) |
not available |
| Presentation | Presented at the American Thoracic Society International Convention, Proteomic Approaches to Particulate Matter Induced Toxicity, San Francisco, CA, May 2007 (Invited Symposium Speaker). | None | Mechanisms of particulate matter induced mortality | Mechanisms of particulate matter induced mortality. Presented at the American Thoracic Society International Convention, Proteomic Approaches to Particulate Matter Induced Toxicity, San Francisco, CA, May 2007 (Invited Symposium Speaker). |
R832413C002 (2008) |
not available |
| Presentation | Presented at the 11th International Inhalation Symposium (INIS), Fraunhofer ITEM, Hanover, Germany, 2008 (Invited speaker and Session Chair). | None | Nanoparticle-bio-interactions: controlled design and cellular response | Nanoparticle-bio-interactions: controlled design and cellular response. Presented at the 11th International Inhalation Symposium (INIS), Fraunhofer ITEM, Hanover, Germany, 2008 (Invited speaker and Session Chair). |
R832413C002 (2008) |
not available |
| Presentation | EORD Interest Section Forum: the relevance of air pollution in and out of the workplace to the AAAAI community. The interaction between air pollution and allergens. | None | Nel AE | Nel AE. EORD Interest Section Forum: the relevance of air pollution in and out of the workplace to the AAAAI community. The interaction between air pollution and allergens. Presented at the American Academy of Allergy, Asthma and Immunology (AAAAI) International Convention, New Orleans, LA, February 26-March 2, 2010. |
R832413C002 (2010) |
not available |
| Presentation | The implications of the hierachical oxidative stress hypothesis for cardiorespiratory disease. | None | NIH, San Francisco, CA, March 27-28, 2008 | The implications of the hierachical oxidative stress hypothesis for cardiorespiratory disease. Presented at the session, Oxidative Stress and Human Disease, NIH, San Francisco, CA, March 27-28, 2008. |
R832413C002 (2008) |
not available |
| Presentation | Presented at the AAAAI International Convention, Plenary Session, Immunopathogenesis of Asthma, San Diego, CA, February 2007 (Invited Plenary Speaker). | None | Role of oxidative stress by particulate air pollution in asthma exacerbations | Role of oxidative stress by particulate air pollution in asthma exacerbations. Presented at the AAAAI International Convention, Plenary Session, Immunopathogenesis of Asthma, San Diego, CA, February 2007 (Invited Plenary Speaker). |
R832413C002 (2008) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.