Publications for Center:

Vanderbilt Pittsburgh Resource for Organotypic Models for Predictive Toxicology

Grant Number R835736

Abstract (4)
Journal Article (39)
Patent/Patent Application (4)
Presentation (101)
Video (1)
Reference Type Citation Progress Report Year Document Sources
Abstract Auner A, Tasneem K, McCawley L, Markov D, Hutson S. Sorption of potential toxicants by PDMS in microfluidic devices. Bulletin of the American Physical Society 2017;62(13):BAPS.2017.SES.B2.6. R835736 (2018)
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Abstract Markov DA, Fryman P, McCawley LJ. Toxicant bioavailability when using low volume polymer based organ-on-a-chip bioreactors to study exposures to chemical contaminants. The Toxicologist, Supplement to Toxicological Sciences 2016;150(1):596 (Abstract No. 3541). R835736 (2018)
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Abstract Gnecco JS, Pensabene V, Li D, Ding T, Hui E, Bruner-Tran KL, Osteen KG (2017). R835736 (2018)
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Abstract “Compartmentalized culture of perivascular stroma and endothelial cells in a microfluidic. R835736 (2018)
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Journal Article Alexander PG, Clark KL, Tuan RS. Prenatal exposure to environmental factors and congenital limb defects. Birth Defects Research, Part C, Embryo Today: Reviews 2016;108(3):243-273. R835736 (2015)
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Journal Article Anders AP, Gaddy JA, Doster RS, Aronoff DM. Current concepts in maternal-fetal immunology: recognition and response to microbial pathogens by decidual stromal cells. American Journal of Reproductive Immunology 2017;77(3):e12623 (14 pp.). R835736 (2016)
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Journal Article Auner AW, Tasneem KM, Markov DA, McCawley LJ, Hutson MS. Chemical-PDMS Binding Kinetics and Implications for Bioavailability in microfluidic Devices. Lab on a Chip 2019;19(5):864-874 R835736 (2018)
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Journal Article Auner AW, Kazi M. Tasneem KM, Markov DA, McCawley LJ, Hutson MS. Chemical-PDMS binding kinetics and implications for bioavailability in microfluidic devices. Lab on a Chip 2019;19(5):864-874 R835736 (2018)
Journal Article Bruner-Tran KL, Duleba AJ, Taylor HS, Osteen KG. Developmental toxicant exposure is associated with transgenerational adenomyosis in a murine model. Biology of Reproduction 2016;95(4):73 (10 pp.). R835736 (2015)
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Journal Article Bruner-Tran KL, Gnecco J, Ding T, Glore DR, Pensabene V, Osteen KG. Exposure to the environmental endocrine disruptor TCDD and human reproductive dysfunction: translating lessons from murine models. Reproductive Toxicology 2017;68:59-71. R826300 (Final)
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Journal Article Bruner-Tran KL, Mokshagundam S, Herington JL, Osteen KG. Rodent Models of Experimental Endometriosis: Identifying Mechanisms of Disease and Therapeutic Targets. Current Women's Health Reviews 2018;14(2):173–188 R835736C003 (2018)
Journal Article Cyr KJ, Avaldi OM, Wikswo JP. Circadian hormone control in a human-on-a-chip:in vitro biology’s ignored component? Experimental Biology and Medicine 2017;242(17):1714-1731. R835736 (2017)
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Journal Article Ding T, Lambert LA, Aronoff DM, Osteen KG, Bruner-Tran KL. Sex-dependent influence of developmental toxicant exposure on group B Streptococcus -mediated preterm birth in a murine model. Reproductive Sciences 2018;25(5):662-673. R835736 (2017)
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Journal Article Dodds JN, May JC, McLean JA. Investigation of the complete suite of the leucine and isoleucine isomers: toward prediction of ion mobility separation capabilities. Analytical Chemistry 2017;89(1):952-959. R835736 (2015)
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Journal Article Gnecco JS, Anders AP, Cliffel D, Pensabene V, Rogers LM, Osteen K, Aronoff DM. Instrumenting a fetal membrane on a chip as emerging technology for preterm birth research. Current Pharmaceutical Design 2017;23(40):6115-6124. R835736 (2016)
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Journal Article Gnecco JS, Pensabene V, Li DJ, Ding T, Hui EE, Bruner-Tran KL, Osteen KG. Compartmentalized culture of perivascular stroma and endothelial cells in a microfluidic model of the human endometrium. Annals of Biomedical Engineering 2017;45(7):1758-1769. R835736 (2017)
Journal Article Gnecco JS, Pensabene V, Li DJ, Ding T, Hui EE, Bruner-Tran KL, Osteen KG. Compartmentalized culture of perivascular stroma and endothelial cells in a microfluidic model of the human endometrium. Annals of Biomedical Engineering 2017;45(7):1758-1769. R835736 (2015)
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Journal Article Gnecco JS, Ding T, Smith C, Lu J, Bruner-Tran KL, Osteen KG. Hemodynamic forces enhance decidualization via endothelial-derived prostaglandin E2 and prostacyclin in a microfluidic model of the human endometrium. Human Reproduction 2019;43(4):702-714 R835736C003 (2018)
Journal Article Gough A, Vernetti L, Bergenthal L, Shun TY, Taylor DL. The MicroPhysiology Systems Database for analyzing and modeling compound interactions with human and animal organ models. Applied In Vitro Toxicology 2016;2(2):103-117. R835736 (2015)
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Journal Article Gough A, Vernetti L, Bergenthal L, Shun TY, Taylor DL. The MicroPhysiology Systems Database for analyzing and modeling compound interactions with human and animal organ models. Applied In Vitro Toxicology 2016;2(2):103-117. R835736 (2017)
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Journal Article Hutson MS, Alexander PG, Allwardt V, Aronoff DM, Bruner-Tran KL, Cliffel DE, Davidson JM, Gough A, Markov DA, McCawley LJ, McKenzie JR, McLean JA, Osteen KG, Pensabene V, Samson PC, Senutovitch NK, Sherrod SD, Shotwell MS, Taylor DL, Tetz LM, Tuan RS, Vernetti LA, Wikswo JP. Organs-on-chips as bridges for predictive toxicology. Applied In Vitro Toxicology 2016;2(2):97-102. R835736 (2015)
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Journal Article Hutson MS, Leung MCK, Baker NC, Spencer RM, Knudsen TB. Computational model of secondary palate fusion and disruption. Chemical Research in Toxicology 2017;30(4):965-979. R835736 (2015)
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Journal Article Iannetti L, D'Urso G, Conoscenti G, Cutri E, Tuan RS, Raimondi MT, Gottardi R, Zunino P. Distributed and Lumped Parameter Models for the Characterization of High Throughput Bioreactors. PLoS One 2016;11(9):e0162774 (25 pp.). R835736 (2016)
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Journal Article Karolak A, Markov DA, McCawley LJ, Rejniak KA. Towards personalized computational oncology: from spatial models of tumour spheroids, to organoids, to tissues. Journal of the Royal Society Interface 2018;15(138):20170703. R835736 (2018)
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Journal Article Kimmel DW, Rogers LM, Aronoff DM, Cliffel DE. Prostaglandin E2 regulation of macrophage innate immunity. Chemical Research in Toxicology 2016;29(1):19-25. R835736 (2016)
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Journal Article Lee-Montiel FT, George SM, Gough AH, Sharma AD, Wu J, DeBiasio R, Vernetti LA, Taylor DL. “Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems. Exp Biol Med 2017;242(16):1617-1632. R835736C004 (2018)
Journal Article Leung MC, Hutson MS, Seifert AW, Spencer RM, Knudsen TB. Computational modeling and simulation of genital tubercle development. Reproductive Toxicology 2016;64:151-161. R835736 (2015)
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Journal Article Leung MCK, Hutson MS, Seifert AW, Spencer RM, Knudsen TB. Computational modeling and simulation of genital tubercle development. Reproductive Toxicology 2016;64:151-161. R835736 (2017)
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Journal Article Li X, George SM, Vernetti L, Gough AH, Taylor DL. A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX. Lab on a Chip 2018;21;18(17):2614-2631 R835736 (2018)
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Journal Article May JC, Morris CB, McLean JA. Ion mobility collision cross section compendium. Analytical Chemistry 2017;89(2):1032-1044. R835736 (2016)
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Journal Article Rogers JM, Anders AP, Doster RS, Gill EA, Gnecco JS, Holley JM, Randis TM, Ratner AJ, Gaddy JA, Osteen K, Arnoff DM. Decidual stromal cell-derived PGE(2) regulates macrophage responses to microbial threat. American Journal of Reproductive Immunology 2018;80(4). R835736C003 (2018)
Journal Article Senutovitch N, Vernetti L, Boltz R, DeBiasio R, Gough A, Taylor DL. Fluorescent protein biosensors applied to microphysiological systems. Experimental Biology and Medicine 2015;240(6):795-808. R835736 (2015)
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Journal Article Soto-Gutierrez A, Gough A, Vernetti LA, Taylor DL, Monga SP. Pre-clinical and clinical investigations of metabolic zonation in liver diseases: the potential of microphysiology systems. Experimental Biology and Medicine 2017;242(16):1605-1616. R835736 (2017)
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Journal Article Stocks MM, Crispens MA, Ding T, Mokshagundam S, Bruner-Tran KL, Osteen KG. Therapeutically targeting the inflammasome product in a chimeric model of endometriosis-related surgical adhesions. Reproductive Sciences 2017;24(8):1121-1128. R835736 (2015)
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Journal Article Vernetti LA, Senutovitch N, Boltz R, DeBiasio R, Shun TY, Gough A, Taylor DL. A human liver microphysiology platform for investigating physiology, drug safety, and disease models. Experimental Biology and Medicine 2016;241(1):101-114. R835736 (2015)
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Journal Article Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. Scientific Reports 2017;7:42296 (14 pp.). R835736 (2017)
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Journal Article Vernetti LA, Vogt A, Gough A, Taylor DL. Evolution of experimental models of the liver to predict human drug hepatotoxicity and efficacy. Clinics in Liver Disease 2017;21(1):197-214. R835736 (2015)
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Journal Article Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. Scientific Reports 2017;7:42296 (15 pp.). R835736 (2015)
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Journal Article Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. Scientific Reports 2017;7:42296 (14 pp.). R835736 (2018)
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Journal Article Watson DE, Hunziker R, Wikswo JP. Fitting tissue chips and microphysiological systems into the grand scheme of medicine, biology, pharmacology, and toxicology. Experimental Biology and Medicine 2017;242(16):1559-1572. R835736 (2017)
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Journal Article Wikswo JP. Looking to the future of organs-on-chips: interview with Professor John Wikswo. Future science OA 2017;3(2):FSO163. R835736 (2018)
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Journal Article Miller DR, McClain ES, Cliffel DE. Electrochemical Microphysiometry Detects Cellular Glutamate Up-take. Journal of The Electrochemical Society 2018;165(12):G3120-G3124. R835736C005 (2018)
Journal Article Ding T et al, 2018. Reproductive Sciences 25(5):662-673 Bruner-Tran KL et al, 2018. Current Women’s Health Rev Jun;14(2):173-188 Rogers et al, 2018. American Journal of Reproductive Immunology Oct;80(4):e13032. R835736 (2018)
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Patent/Patent Application Wilkso, John P. Integrated Organ-on-Chip Systems and Applications of the Same, US Patent, 10,078,075 B2, 2018. R835736C005 (2018)
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Patent/Patent Application Wilkso JP, Interconnections of Multiple Perfused Engineered Tissue Constructs and Microbioreactors, Multi-Microformulators and Applications of the Same. US Patent 10,023,832 B2, 2018 R835736C005 (2018)
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Patent/Patent Application Wikswo et Multicompartment Microfluidic Bioreactors, Cylindrical Rotary Valves and Applications of Same. Patent Pending Serial No. 62/677,468. 2018 R835736C005 (2018)
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Patent/Patent Application System for Extensible Cell Culture, Microdialysis Imaging, and Regional Chemical Delivery and Control. Patent Pending. 2018 R835736 (2018)
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Presentation Alexander PG. VPROMPT: technological innovations. Poster presented at the Society of Toxicology 2016 Satellite Meeting: 3D or Not 3D: That is the [Predictive Toxicology] Question, New Orleans, LA, March 17, 2016. R835736 (2016)
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Presentation Alexander P, Pirosa A, Yang Y, Tan J, Clark K, Tuan R. Stage-specific OCMs to analyze teratogen-induced limb defects. Presented at the 56th Annual Meeting and ToxExpo, Society of Toxicology, Baltimore, MD, March 12-16 2017. R835736 (2018)
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Presentation Alexander P. Organotypic culture model to analyze developmental limb malformations resulting from toxicant/teratogen exposure. Presented at the 56th Annual Meeting and ToxExpo, Society of Toxicology, Baltimore, MD, March 12-16 2017. R835736 (2018)
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Presentation Arosh JA, Lee J, Meagher M, Bruner-Tran KL, Osteen KG, Banu SK. Prostaglandin E2 signaling and peripheral and central pain mechanisms in endometriosis. Poster presented at the 13th World Congress on Endometriosis, Vancouver, British Columbia, Canada, May 17-20, 2017. R835736 (2017)
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Presentation Basu N, Head J, Mittal K, Dornbos P, Arini A, Armstrong B, Murphy C. Development and application of in vitro cell-free neurochemical screening assays to predict adverse effects in fish, birds, and mammals. Presented at the 41st Annual Aquatic Toxicity Workshop (ATW), Ottawa, Ontario, Canada, September 28-October 1, 2014. R835170 (2015)
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Presentation Bruner-Tran KL, Gnecco JS, Osteen KG. Exposure to an environmental endocrine disrupting chemical promotes transgenerational reproductive dysfunction. Presented at PPTOX V, 5th Conference on Prenatal Programming and Toxicity, Kitakyushu, Fukuoka, Japan, November 13-16, 2016. R835736 (2016)
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Presentation Bruner-Tran KL, Stocks M, Arosh JA, Osteen KG. Therapeutically targeting the inflammasome product in a chimeric model of post-surgical adhesions. Poster presented at the 13th World Congress on Endometriosis, Vancouver, British Columbia, Canada, May 17-20, 2017. R835736 (2017)
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Presentation Clark K, Tuan R, Pirosa A, Yu Y, Alexander P. Human mesenchymal stem cell cultures to model teratogen-induced limb malformations. Presented at the 56th Annual Meeting and ToxExpo, Society of Toxicology, Baltimore, MD, March 12-16 2017. R835736 (2018)
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Presentation Daly WT. [title not provided]. Presented at the NIH Tissue Chip Meeting, Washington DC, May 2017. R835736 (2018)
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Presentation Ding T, Archibong A, Osteen KG, Bruner-Tran KL. Paternal developmental exposure to TCDD alters the adult sperm and placental epigenome and negatively effects pregnancy outcomes in control partners. Presented at PPTOX V, 5th Conference on Prenatal Programming and Toxicity, Kitakyushu, Fukuoka, Japan, November 13-16, 2016. R835736 (2016)
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Presentation Gnecco JS, Ding TB, Pensabene V, Arosh J, Bruner-Tran KL, Osteen KG. TCDD exposure alters monocyte and macrophage behavior: a combined murine and microfluidic human cell approach to understanding the immune/endocrine microenvironment of endometriosis. Poster presented at the Annual Meeting of the Society for the Study of Reproduction, San Juan, Puerto Rico, June 18-22, 2015. R835736 (2016)
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Presentation Gnecco JS, Ding TB, Pensabene V, Arosh J, Bruner-Tran KL, Osteen KG. TCDD exposure alters monocyte and macrophage behavior: a combined murine and microfluidic human cell approach to understanding the immune/endocrine microenvironment of endometriosis. Presented at the Annual Meeting of the Society for the Study of Reproduction, San Juan, Puerto Rico, June 18-22, 2015. R835736 (2015)
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Presentation Gnecco JS, Cook C, Hill A, Pensabene V, Ding T, Aronoff D, Griffith L, Osteen KG. Implementation of PEG hydrogels for microfluidic models of the human female reproductive tract. Presented at the Infection and Immunology Symposium, Vanderbilt University Medical Center, Nashville, TN, April 8, 2016. R835736 (2016)
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Presentation Gnecco JS, Ding T, Pensabene V, Aronoff D, Bruner-Tran KL, Osteen KG. A novel microfluidic model of the human endometrial perivascular stroma crosstalk. Poster presented at the Society for Reproductive Investigation (SRI) 63rd Annual Scientific Meeting, Montreal, Quebec, Canada, March 16-19, 2016. R835736 (2016)
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Presentation Gnecco JS, Ding T, Aronoff D, Bruner-Tran KL, Osteen KG. Exposure of human fetal membranes to dioxin ex vivo is associated with a hyperinflammatory response: potential relevance to preterm birth. Poster presented at PPTOX V, 5th Conference on Prenatal Programming and Toxicity, Kitakyushu, Fukuoka, Japan, November 13-16, 2016. R835736 (2016)
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Presentation Gnecco JS, Ding T, Smith C, Bruner-Tran KL, Osteen KG. Shear stress-induced prostaglandins enhance progesterone action in the perivascular stroma of the human endometrium. Poster presented at the Vanderbilt Translational Research Forum, Nashville, TN, October 13, 2017. R835736 (2017)
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Presentation Gough AH. A human liver microphysiology platform for investigating physiology, drug safety and disease models. Presented at the 2nd Tissue Models & Phenotypic Screening Conference, Berlin, Germany, May 5-6, 2015. R835736 (2016)
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Presentation Gough A. Mining cellular heterogeneity for mechanistic insights in phenotypic profiling and drug discovery. Presented at the ThermoFisher Regional User Group Symposium, Cambridge, MA, October 29, 2015. R835736 (2016)
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Presentation Gough A. Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery. Presented at the New England Cytometry User Group Meeting, Cambridge, MA, October 6, 2015. R835736 (2016)
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Presentation Lambert LA, Ding T, Aronoff D, Osteen KG, Bruner-Tran KL. Influence of developmental toxicant exposure on infection-mediated preterm birth. Poster presented at the Vanderbilt Symposium on Infection and Immunology, Nashville, TN, April 13, 2017. R835736 (2017)
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Presentation Markov DA, Block III FE, Brown JA, McCawley LJ, Wikswo JP. Compact mechanatronic system for the perfusion, control, analysis, and maintenance of organ-on-chip microbioreactors. Presented at SLAS2016, the 5th Annual Society for Laboratory Automation and Screening International Conference & Exhibition, San Diego, CA, January 23-27, 2016. R835736 (2016)
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Presentation Markov DA. Advances in the development of organ-on-chip microbioreactors. Presented at the Aalborg University Medical Center, Aalborg, Denmark, June 2016. R835736 (2016)
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Presentation Markov DA, Fryman P, McCawley LJ. Toxicant bioavailability when using low volume polymer based organ-on-a-chip bioreactors to study exposures to chemical contaminants. Poster presented at the Society of Toxicology 55th Annual Meeting & ToxExpo, New Orleans, LA, March 13-17, 2016. R835736 (2016)
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Presentation Markov DA, Auner A, Schafer E, Fryman P, Hutson HS, McCawley LJ. Mammosphere vioreactor for life-stage specific toxicology: considerations for toxicant bioavailability in organ-on-chip bioreactors. Presented at the Society of Toxicology Satellite Meeting "Horizons and Challenges in Organotypic Culture Models for Predictive Toxicology," Baltimore, MD, March 11, 2017. R835736 (2018)
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Presentation Markov DA. Advanced Systems For Perfusion, Control, Analysis, and Maintenance of Organ-on-chip Microbioreactors.Presented at: 3rd Annual STAR Organotypic Culture Models (OCM) for Predictive Toxicology Research Centers Progress Review: Implementation of Microphysiological Systems in Toxicological Assessments; May 2018, Durhan, NC R835736C001 (2018)
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Presentation McCawley LJ. Physical dynamics of cancer response to chemotherapy in 3D microenvironments: a platform to examine complex physical and chemical microenvironments. Presented at the 7th Annual Symposium: Annual Physics of Cancer, Leipzig, Germany, October 4-6, 2016. R835736 (2016)
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Presentation McCawley LJ. Mammary Gland-Organotypic Culture Module (MG-OCM) as a microfluidic platform for assessment of toxicant exposures on organoid development. Presented at:FutureTox IV Progress to Maturity:Predictive Developmental and Reproductive Toxicology for Healthy Children November 2018, Arlington, VA. R835736C001 (2018)
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Presentation McCawley, LJ. Mammary Gland-Organotypic Culture Module (MG-OCM) as a microfluidic platform for assessment of toxicant exposures on organoid development. Presented at: 3rd Annual STAR Organotypic Culture Models (OCM) for Predictive Toxicology Research Centers Progress Review:Implementation of Microphysiological Systems in Toxicological Assessments; May 2018. R835736C001 (2018)
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Presentation Mokshagundam S, Ding T, Lambert LA, Rinaudo P, Osteen KG, Bruner-Tran KL. Paternal developmental toxicant exposure induces transgenerational placental dysfunction. Poster presented at the Vanderbilt Translational Research Forum, Nashville, TN, October 13, 2017. R835736 (2017)
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Presentation Osteen, KG and Bruner-Tran KL. Is it in your genes or the environment? Envisioning a modifiable "endometriosis phenotype." Presented at the American Society for Reproductive Medicine Annual Meeting, International Endometriosis Association Sponsored Forum, Baltimore, MD, October 17-21, 2015. R835736 (2015)
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Presentation Osteen KG, Gnecco JS, Bruner-Tran KL. Envisioning a modifiable systemic endometriosis phenotype: the future of endometriosis. Presented at the Massachusetts Institute of Technology, Cambridge, MA, July 2016. R835736 (2016)
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Presentation Osteen KG. Building an organ-on-a-chip model of the human menstrual cycle. Presented at Rutgers University, NJ, April 2017. R835736 (2017)
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Presentation Osteen K. Inflammatory triggers of the systemic endometriosis/pre-term birth phenotype. Presented at the University of California, San Diego, CA, February 2017. R835736 (2017)
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Presentation Schwab AP, Alleman J, Banks MK, Switzenbaum M. Development of an integrated biotoxicity protocol for biosolids. Presented at the Water and Environment Federation Conference, Baltimore, MD, February 19-22, 2003. R828770 (2003)
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Presentation Taylor DL. Human microphysiology platform for liver safety and efficacy testing. Presented at the AAPS/ITC Joint Workshop on Drug Transporters in ADME: From the Bench to the Bedside, Baltimore, MD, April 15-16, 2015. R835736 (2016)
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Presentation Taylor DL. Potential and challenges in developing and applying 3D microtissues. Presented at SLAS2015, the 4th Annual Society for Laboratory Automation and Screening Conference & Exhibition, Washington, DC, February 7-11, 2015. R835736 (2016)
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Presentation Taylor DL. Technology and market developments drive biotechnology company formation: a personal view. Presented at the Biotechnology Entrepreneurship Boot Camp 2015, Philadelphia, PA, June 15-18, 2015. R835736 (2016)
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Presentation Taylor DL. Human microphysiology platform for liver safety and efficacy testing. Presented at the Annual Symposium for the Johns Hopkins Digestive Diseases Basic and Translational Research Core Center, Baltimore, MD, June 2015. R835736 (2016)
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Presentation Taylor DL. Intellectual property and patents. Presented at the Scientific Ethics and the Responsible Conduct of Research Course, Pittsburgh, PA, June 2015. R835736 (2016)
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Presentation Taylor DL. Human microphysiology platform for liver efficacy and safety testing and linkage to other organ systems. Presented at the McGowan Institute for Regenerative Medicine Retreat, Nemacolin Woodlands Resort, Farmington, PA, March 8-10, 2015. R835736 (2016)
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Presentation Taylor DL. A quantitative systems biology platform for drug discovery. Presented at the Quantitative Systems Pharmacology (QSP) Congress, Boston, MA, October 20, 2015. R835736 (2016)
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Presentation Taylor DL. Implementing a quantitative systems pharmacology platform. Presented at Novartis, Pittsburgh, PA, October 2015. R835736 (2016)
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Presentation Taylor DL. Innovations in cellular imaging. Presented at Carnegie Mellon University, Pittsburgh, PA, October 2015. R835736 (2016)
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Presentation Taylor DL. Liver microphysiology system and integration with intestine and kidney MPS. Presented at GlaxoSmithKline, Collegeville, PA, October 2015. R835736 (2016)
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Presentation Taylor DL. Implementing a quantitative systems pharmacology platform for drug discovery in academia. Presented at Discovery on Target, Boston, MA, September 21-24, 2015. R835736 (2016)
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Presentation Taylor DL. [title not provided]. Presented at the University of Pittsburgh School of Medicine, Board of Visitors Meeting, Pittsburgh, PA, September 2015. R835736 (2016)
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Presentation Taylor DL. Using systems pharmacology to identify predictive responses within 3D tissue models to enhance the drug discovery process. Presented at the 3D Tissue Models Conference, San Diego, CA, August 29-31, 2016. R835736 (2016)
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Presentation Taylor DL. Evolution of a human liver MPS platform. Presented at the Society for Experimental Biology and Medicine (SEBM) Annual Meeting, Chicago, IL, April 24, 2017. R835736 (2017)
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Presentation Taylor DL. Spatial tumor biology for phenotyping, immunotyping and recapitulating tumor microenvironments. Presented at the Melanoma Specialized Programs of Research Excellence (SPORE) Meeting at the University of Pittsburgh, Pittsburgh, PA, August 2017. R835736 (2017)
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Presentation Taylor DL, Vernetti LA. Functional application of liver organotypic culture models. Presented via the EPA Virtual Tissue Models Meeting Webinar, February 22, 2017. R835736 (2017)
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Presentation Taylor DL. Role of human liver microphysiology systems as part of a quantitative systems pharmacology platform for investigating ADMET and liver disease progression. Presented at the Eli Lilly meeting, Indianapolis, IN, July 24, 2017. R835736 (2017)
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Presentation Taylor DL. The evolution, challenges and recent application of high content screening. Presented at the Servier Pharmaceutical Company Presentation, Paris, France, June 9, 2017. R835736 (2017)
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Presentation Taylor DL. The next technology wave: biosensors, extreme computing, and organ chips for predicting cardiovascular toxicity. Presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. R835736 (2017)
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Presentation Taylor DL. Quantitative systems pharmacology of liver diseases: human liver microphysiology system (MPS). Presented at the Astra-Zeneca Review of AZ MPS Program, Boston, MA, March 23, 2017. R835736 (2017)
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Presentation Taylor DL. Evolution of a human liver microphysiology system. Presented at the National Center for Advancing Translational Sciences (NCATS), The National Institues of Health, Bethesda, MD, May 5, 2017. R835736 (2017)
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Presentation Taylor DL. The application of quantitative systems pharmacology to investigate liver diseases and toxicology. Presented at the Tsinghua Seminar, Pittsburgh, PA, May 8, 2017. R835736 (2017)
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Presentation Taylor DL. Investigating human liver disease progression with 3D microfluidic models. Presented at the High-Content Analysis and Phenotypic Screening Conference, Boston, MA, November 6, 2017. R835736 (2017)
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Presentation Taylor DL. [title not provided]. Presented at the National Academy of Sciences Roundtable, Washington, DC, October 5, 2017. R835736 (2017)
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Presentation Taylor DL, Gough A. A human liver-on-a-chip as a key experimental component of the application of quantitative systems pharmacology. Presented at the Roche Seminar, Basel, Switzerland, October 6, 2017. R835736 (2017)
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Presentation Taylor DL. Quantitative systems pharmacology (QSP) in drug discovery. Presented at the NCI Online Principles of Clinical Pharmacology Course, Pittsburgh, PA, September 18, 2017. R835736 (2017)
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Presentation Taylor DL. Metastatic breast cancer explored in a human, 3D, microfluidic liver chip. Presented at the Charles River Conference, Boston, MA, September 26, 2017. R835736 (2017)
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Presentation Taylor DL. Role of human liver microphysiology systems as part of a quantitative systems pharmacology platform for investigating ADMET and liver disease progression. Presented via the Health and Environmental Sciences Institute Webinar, September 5, 2017. R835736 (2017)
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Presentation Taylor, DL. A Human Liver Microphysiology System for Drug Discovery and development. Presented at North American meeting of the International Society for the Study of Xenobiotics, Montreal, Canada. July 16th-18, 2018. R835736C004 (2018)
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Presentation Taylor, DL. Application of quantitative systems pharmacology (QSP) and human microphysiology systems (MPS) to develop therapeutic strategies for liver diseases, Lawrenceville, New Jersey. October 26, 2018. R835736C004 (2018)
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Presentation Taylor, DL. Human Microphysiology Systems as a Critical Component of Quantitative Systems Pharmacology Applied to Drug Discovery and Development. Presented at DILI Sym Meeting, Chapel Hill, North Carolina. September 11, 2018. R835736C004 (2018)
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Presentation Taylor DL. The Evolution of Human Experimental Models for Drug Discovery/Development and Precision medicine:Different Model Types, Reproducibility, Applications and Future Impact. Presented at NIH workshop, Pittsburgh, Pennsylvania. September 13th-14th, 2018. R835736C004 (2018)
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Presentation Taylor DL. Development and application of a human, 3D, 4 cell type, microfluidic, liver model for toxicity and efficacy testing. Presented at the Drug-Induced Liver Injury (DILI) Conference XVI, East Hyattsville, MD, March 23-24, 2016. R835736 (2016)
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Presentation Thomson J. [title not provided] Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. R835736 (2018)
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Presentation Tuan R. Adult stem cells and biomimetic materials for tissue engineering and modeling: repair, restore, and create. Presented at the 13th Annual Meeting of the International Federation for Adipose Therapeutics and Science (IFATS), New Orleans, LA, November 5-8, 2015 (keynote). R835736 (2016)
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Presentation Tuan R. Adult stem cells and biomimetic materials for tissue engineering and modeling: repair, restore, and re-create. Presented at the American Society for Investigative Pathology PISA 2015 - Pathways to Translational Medicine: Recent Advances in Cell Injury, Inflammation, and Neoplasia, Baltimore, MD, October 8-10, 2015 (keynote). R835736 (2015)
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Presentation Vernetti LA. Development of an integrated liver microphysiological system. Presented at the 20th North American International Society for the Study of Xenobiotics (ISSX) Meeting, Orlando, FL, October 18-22, 2015. R835736 (2016)
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Presentation Vernetti LA. Predicting human toxicity from MOA based high content imaging in 2D and 3D microphysiology systems. Presented at Thermo Fisher, Princeton, NJ, October 13, 2016. R835736 (2016)
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Presentation Vernetti LA, Gough A, Bergenthal L, Karcher S, Shun T, Wolter Q, Gavlock D, Reese C, Schurdak M, Taylor DL. Poster Presentation:The Human Liver Acinus MicroPhysiology System (LAMPS) for Analyzing and Ranking the Hepatotoxicity Potential of Compounds and as a Metabolic Component for Integration with other OCM. Presented at 3rd Annual STAR Organotypic Culture Models (OCM) for Predictive Toxicology Research Centers Progress Reviews. May 22 and 23, 2018. R835736C004 (2018)
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Presentation Vernetti L. Application and challenges to constructing a competent human liver on a chip. Presented at the Society of Toxicology 2016 Satellite Meeting 3D or Not 3D: That is the [Predictive Toxicology] Question, New Orleans, LA, March 17, 2016 (invited). R835736 (2016)
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Presentation Wikswo JP. Nanoscience and biology: connecting nano to micro and milli for in vitro interrogation and control. Presented at the NSF-sponsored Annual Nanoscale Science and Engineering Grantees Conference, Arlington, VA, December 9-10, 2015 (invited). R835736 (2015)
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Presentation Wikswo JP. Organs on chips: bioreactors, sensors, controls and interconnects to support constructionist biology. Presented to the Department of Biomedical Engineering, Northwestern University, Evanston, IL, April 27-28, 2016 (invited). R835736 (2016)
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Presentation Wikswo JP. Hands on with organ-on-a-chip workshop. Presented at the 3D Tissue Models Conference, San Diego, CA, August 29-31, 2016 (invited). R835736 (2016)
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Presentation Wikswo JP. In vitro modeling of the blood brain barrier using complex 3D models. Presented at the 3D Tissue Models Conference, San Diego, CA, August 29-31, 2016 (invited). R835736 (2016)
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Presentation Wikswo JP. Organs-on-chips, metabolomics, systems biology, and closing the hermeneutic circle of biology. Presented at the University of Tennessee Health Science Center, Memphis, TN, December 15, 2016 (invited). R835736 (2017)
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Presentation Wikswo JP. Organs on chips for drug development, toxicology, and systems biology: a distributed yet interconnected modular approach. Presented at the Organ-on-a-Chip World Congress 2016 & 3D-Culture, Boston, MA, July 7-8, 2016 (invited). R835736 (2016)
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Presentation Wikswo JP. Human neurovascular unit on-a-chip: microscale systems for tissue-level response. Presented at the 56th Annual Meeting of the Teratology Society, San Antonio, TX, June 25-29, 2016 (invited). R835736 (2016)
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Presentation Wikswo JP. Cutting-edge safety—preclinical in vitro models. Presented at American Society of Tropical Medicine & Hygiene (ASTMH), Atlanta, GA, November 13, 2016 (invited). R835736 (2018)
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Presentation Wikswo JP. Probing the complexities of biology and medicine: closing the hermeneutic circle with in vitro and in silico models. Presented at the Eighth Scientific Meeting of the TMJ Association, Bethesda, MD, September 11-13, 2016 (invited). R835736 (2016)
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Presentation Wikswo JP. Hormonal modulation of organs-on-chips to recapitulate in vivo ADME tox profiles in vitro. Presented at the 3D Tissue Models Summit, Boston, MA, August 29-30, 2017 (invited). R835736 (2017)
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Presentation Wikswo JP. Organs-on-chips: a developer's masterclass. Presented at the 3D Tissue Models Summit, Boston, MA, August 29-30, 2017 (invited). R835736 (2017)
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Presentation Wikswo JP. Modular architectures and control strategies for coupled microphysiological systems. Presented at Eli Lilly, Indianapolis, IN, January 4, 2017 (invited). R835736 (2016)
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Presentation Wikswo JP. Fitting iPSCs, 3D cell culture, tissue chips and microphysiological systems into the grand scheme of biology, medicine, pharmacology, and toxicology. Presented at the Select Biosciences Organ-on-a-Chip World Congress & 3D-Culture Conference, Boston. MA, July 10, 2017 (invited). R835736 (2017)
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Presentation Wikswo JP. Scientific and technical strengths and limitations of MPS for drug toxicity testing. Presented at The Toxicology Forum 43rd Annual Summer Meeting, Annapolis, MD, July 12, 2017 (invited). R835736 (2017)
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Presentation Wikswo JP. Analytical chemistry for understanding the physiology and pathology of 3D cellular models. Presented at the World Preclinical Congress, Boston, MA, June 13-15, 2017 (invited). R835736 (2017)
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Presentation Wikswo JP. Multichannel microformulators suitable for massively parallel automated design of biological experiments. Presented at the American Physical Society Meeting, New Orleans, LA, March 13-17, 2017 (invited). R835736 (2017)
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Presentation Wikswo JP. Organs on chips for drug discovery and development. Preseneted at the Eli Lilly Grand Rounds, Indianapolis, IN, March 22, 2017 (invited). R835736 (2018)
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Presentation Wikswo JP. Topologies, analytics, and automation for microphysiological systems. Presented at the Select Biosciences Organ-on-a-Chip Europe Conference, Munich, Germany, May 10-11, 2017 (invited). R835736 (2017)
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Presentation Wikswo JP. Organs on chips for oncology research: neurovascular unit, support hardware, and analytics. Presented at the Physical Sciences Oncology Network Annual Meeting, Koch Institute, MIT, Boston, MA, October 17-19, 2017. R835736 (2017)
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Presentation Wikswo JP. The opportunities and challenges of engineered models of cancer: cells, hardware, analytics, and interpretation. Presented at the Physical Sciences-Oncology Network Annual Investigators Meeting, Cambridge, MA, October 17-19, 2017 (invited). R835736 (2018)
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Presentation Wikswo JP. Strengths, limitations and applications of microphysiological systems for drug development. Presented at the FDA Toxicology Working Group Meeting, Washington, DC, October 26, 2017 (invited). R835736 (2017)
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Presentation Wikswo JP. Functional coupling of human microphysiological systems. Presented at the Roundtable on Science and Welfare in Laboratory Animal Use, Institute for Laboratory Animal Research, Washington, DC, October 5-6, 2017 (invited). R835736 (2018)
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Presentation Yu S, Tan J, Clark K, Alexander PG, Tuan R. High density human stem cell micromass to model teratogen-induced limb malformations. Poster presented at the Society of Toxicology 55th Annual Meeting & ToxExpo, New Orleans, LA, March 13-17, 2016. R835736 (2016)
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Presentation Zeisler R, Oflaz RD, Ondov JM. Advances in the development of standard reference materials for air particulate matter. Presented at the American Nuclear Society Winter Meeting, Washington, DC, November 17-22, 2002. R828771 (Final)
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Presentation Pirosa A, Alexander PG, Clark K, Lin H, Yang Y, and Tuan R “Development of human organotypic culture models for teratogenesis assessment on limb development” McGowan Institute for Regenerative Medicine Scientific Retreat March 5-6, 2018 Pittsburgh PA Pirosa A, Alexander PG, Clark K, Lin H, Yang Y, and Tuan R “Development of human organotypic culture models for teratogenesis assessment on limb development” Organs-and Tissues-on-Chips Keystone Symposia, Montana, April 8-12, 2018. R835736 (2018)
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Presentation D.A. Markov, E. Shafer, L.J. McCawley “Examining PDMS – Compound Interactions as a Function of PDMS Treatments in Organ-On-Chip Systems” BMES 2018, Atlanta GA, 2018 ". R835736C001 (2018)
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Presentation Taylor, DL, Gordon Research Conference on Toxicology, “Functional Coupling of Liver Microphysiological Systems,” Easton, Massachusetts. June 10th-15, 2018. ". R835736C004 (2018)
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Video Cohn S. Endo what? Educational documentary video, 55 minutes, 2016. R835736 (2016)
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