Grantee Research Project Results
2013 Progress Report: Multi-Scale Assessment of Health Effects of Air Pollution Mixtures Using Novel Measurements and Models
EPA Grant Number: R834799Center: The Southeastern Center for Air Pollution and Epidemiology: Multiscale Measurements and Modeling of Mixtures
Center Director: Tolbert, Paige
Title: Multi-Scale Assessment of Health Effects of Air Pollution Mixtures Using Novel Measurements and Models
Investigators: Tolbert, Paige , Russell, Armistead G.
Current Investigators: Tolbert, Paige , Sarnat, Stefanie Ebelt , Strickland, Matthew J , Weber, Rodney J. , Odman, Mehmet Talat , Winquist, Andrea , Russell, Armistead G. , Nenes, Athanasios , Flanders, Dana , Diaz-Sanchez, David , Talbott, Evelynn , Chang, Howard , Mulholland, James , Sarnat, Jeremy , Waller, Lance , Darrow, Lyndsey , Bergin, Michael , Klein, Mitchel , Guensler, Randy , Bilonick, Richard , Greenwald, Roby , Barry, Vaughn , Liu, Yang , Hu, Yongtao
Institution: Emory University , Georgia Institute of Technology
Current Institution: Emory University , Duke University , Georgia Institute of Technology
EPA Project Officer: Chung, Serena
Project Period: January 1, 2011 through December 31, 2016
Project Period Covered by this Report: August 1, 2012 through July 31,2013
Project Amount: $7,999,779
RFA: Clean Air Research Centers (2009) RFA Text | Recipients Lists
Research Category: Climate Change , Air Quality and Air Toxics , Air
Objective:
Project 1: Development and Deployment of an Instrumentation Suite for Comprehensive Air Quality Characterization, Including Aerosol ROS
Objective: Develop method(s) for measuring reactive oxygen species (ROS) online and semi-continuously, acquire instrumentation, and organize measurement program. Undertake an extensive measurement campaign that will characterize spatial distributions of key air quality parameters to inform the SCAPE modeling and health studies.
Project 2: Examining In-Vehicle Pollution and Oxidative Stress in a Cohort of Daily Commuters
Objective: Examine the effects of exposure to particulate mixtures occurring during automobile commuting and within indoor, non-commuting microenvironments and corresponding measures of oxidative stress-mediated response.
Project 3: Novel Estimates of Pollutant Mixtures and Pediatric Health in Two Birth Cohorts
Objective: Explore the interplay between certain early life events, characterizations of air pollutant mixtures developed as part of the Center’s Mixtures Characterization Toolkit, and a range of pediatric health outcomes using two large, population-based birth cohorts.
Project 4: A Multi-City Time-Series Study of Pollutant Mixtures and Acute Morbidity
Objective: Conduct a multi-city time-series study to clarify the impacts of air quality on acute cardiorespiratory morbidity in five U.S. cities using novel mixture characterization metrics.
Air Quality Core
Objective: Provide Center researchers the information and methods to comprehensively characterize air pollutant mixtures relevant to their projects and to support project activities by collecting and managing data, developing a “Mixture Characterization Toolkit” (MC Toolkit) for further analyses specific to the projects, and providing the expertise and resources to facilitate the application of MC Toolkit components.
Biostatistics Core
Objective: Provide statistical support to the Center and to the associated Projects.
Progress Summary:
Project 1: Development and Deployment of an Instrumentation Suite for Comprehensive Air Quality Characterization, Including Aerosol ROS
Research Conducted and Results Generated:
- Deployed dichlorofluorescein (DCFH)-ROS online instrument based on a mist chamber collector for measuring ROS (total), ROS (gas) and particle-bound ROS by difference. Ambient data were analyzed, and a paper was published describing the new instrument and ambient results (King, et al., 2013).
- Conducted Project 1 ambient sampling program with a suite of instrumentation at paired sites: Jefferson Street (JST) and a mobile site (trailer) rotated between rural, near road and roadside sites. Each paired measurement was for nominally 1 month sampling periods. Data are archived for use by other SCAPE investigators.
- Developed two automated ROS analytical systems for high throughput analysis of extracts from high volume and EPA CAPs filters via dithiothreitol (DTT) assay. Analysis protocol included water and methanol extracts for investigating secondary and primary species, followed by each solvent extract being further divided into hydrophilic and hydrophobic (HULIS) fractions for DTT analysis.
- Extracted and analyzed DTT activity of over 170 Project 1 high volume filters following the protocol of (3).
- Analyzed DTT activity of EPA CAPS filters from two CAPS experiments as part of a collaborative study with Bob Devlin to investigate possible links between DTT activity and health endpoints.
- Analyzed DTT activity of Project 2 in-vehicle filters.
- Developed GC-MS method and began analysis of high volume filters for PAHs and quinones.
- Contributed to preliminary work on developing a cyto-toxicity assay in collaboration with Emory researchers (Jeremy Sarnat and Michael Caudle) for comparison of DTT activity to a cellular assay.
Project 2: Examining In-Vehicle Pollution and Oxidative Stress in a Cohort of Daily Commuters
Research Conducted and Results Generated:
- As of July 5, 2013, 100 (of 120 total) sampling sessions were completed. Review of the health and pollutant measurements indicate satisfactory data capture and completeness.
- Several manuscripts from the pilot Atlanta Commuters Exposure Study (ACE-1) are currently in preparation.
Project 3: Novel Estimates of Pollutant Mixtures and Pediatric Health in Two Birth Cohorts
Research Conducted and Results Generated:
- Kaiser Permanente historical birth cohort construction is ongoing and will be finalized later in 2013. Based on preliminary descriptive statistics, there appears to be high sensitivity to correctly identify children with asthma.
- Characterized air quality throughout Georgia, including through: development of a method for fusing Community Multiscale Air Quality (CMAQ) model output with measurements from stationary monitors, estimates of biomass burning events using high resolution remote sensing data from multiple NASA satellites, and development of methods to calculate downscaled CMAQ estimates at 250 meter grids over longer time-periods using land use information in support of the Kaiser Permanente birth cohort study.
- Continued work on measurement error with a publication on the effects of error on health effect estimates in time-series studies (Strickland, et al., 2013).
- Worked on manuscripts and analyses of the substantive associations between air pollutants and pediatric morbidity (including potential effect measure modification by gestational age), which are at various points of development; selected results of this work were shared during the May 2013 Clean Air Research Center (CLARC) webinar and the July 2013 CLARC annual meeting.
Project 4: A Multi-City Time-Series Study of Pollutant Mixtures and Acute Morbidity
Research Conducted and Results Generated:
- Conducted database development, including: calculation of daily population-weighted averages of multiple pollutants by fusion of monitoring and CMAQ modeled data, health outcome data processing for Birmingham and Pittsburg, and a geodatabase for the project.
- Evaluated metrics for characterizing socioeconomic status at the ZIP code level among the five study areas.
- Examined study design issues for comparing epidemiologic results among the five cities (e.g., temporal and spatial extent of available data) and progression of analyses.
- Conducted single-city epidemiological analyses for Atlanta, Dallas, and St. Louis. Methodological work resulted in two publications (Winquist, et al., 2012a; Winquist, et al., 2012b).
- Continued efforts on application of spatially refined modeled estimates of ambient concentrations and population exposures in Atlanta epidemiologic analyses, with several articles in press (Sarnat S et al., 2013; Sarnat J et al., 2013) and in review (Dionisio, et al., submitted; Baxter, et al., submitted); several conference presentations were made (Dionisio, et al., ISES 2012; Chang, et al., ENAR 2013) and are planned (Ozkaynak, et al., ISEE 2013; Sarnat J, et al., ISEE 2013; Klein, et al., ISEE 2013; Chang, et al., JSM 2013).
- Continued work on applying PM2.5 components data (Winquist, et al., ISEE 2013) and PM2.5 source apportionment outputs (Sarnat, et al., ISEE 2013) to epidemiologic analyses in St. Louis, comparing results among multiple source apportionment approaches (Maier, et al., 2013).
- Continued work on methods for detecting and analyzing air pollution mixtures using multi-pollutant monitoring data, including mobile source indicators (Pachon, et al., 2012), self-organizing maps, classification and regression trees (C&RT) (Gass, et al., ISEE 2013), and multi-pollutant joint effects (Winquist, et al., ISEE 2013). C&RT analyses currently are being extended to the multi-city context (Atlanta, Dallas, and St. Louis).
- Developed a statistical modeling approach to quantifying projection uncertainties in future ambient ozone levels and its health impact due to climate change (manuscript in preparation).
Air Quality Core
Research Conducted and Results Generated:
- Applied various receptor modeling approaches (CMB-based, PMF, ensemble) to Atlanta, Dallas, and St. Louis (Maier, et al., 2013).
- The ensemble approach was used to characterize uncertainty in the various methods used in source apportionment analyses using Atlanta SEARCH site data (Balachandran, et al., 2013).
- A new Bayesian receptor modeling approach was developed that extends the ensemble modeling approach, and was applied to the Atlanta data sets (Balachandran, et al., submitted).
- Results from the various source apportionment methods were analyzed to better understand their temporal variability and how the application of the receptor methods can alter temporal variability as compared to the base air quality data.
- In support of Project 3, a significant amount of work has focused on developing spatiotemporal fields of air quality and source impact metrics.
- In support of Project 3, a new aerosol product with 1 km spatial resolution derived by the Multi-Angle Implementation of Atmospheric Correction (MAIAC) algorithm was examined using a two-stage spatial statistical model with meteorological fields and land use parameters as ancillary variables to estimate daily mean PM2.5 concentrations. Both model fitting and cross validation indicate a good fit between the dependent variable and predictor variables.
Biostatistics Core
Research Conducted and Results Generated:
- Began analysis of state-wide association between gestational exposure to PM2.5 and preterm birth. An approach to identify susceptible windows of exposure for preterm birth has been developed, and a manuscript is currently under review (Chang, et al., submitted 2013b).
- Evaluated the use of satellite-derived PM2.5 estimates in a time-series analysis of emergency department visits in Atlanta (Chang, et al., ENAR 2013).
- Explored the self-organizing map (SOM) and classification and regression tree (C&RT) methods for assessing the health effect of air pollution mixtures observed in Atlanta, St. Louis, and Dallas (Gass, et al., submitted; Pearce, et al., submitted).
- Continued work on methods for the identification of model mis-specification, particularly due to confounding.
Future Activities:
- Complete field measurement phase.
- Finish DTT analysis on high volume filters.
- Develop method for analysis of water soluble metals from high volume filter extracts.
- Develop acellular method based on ascorbate depletion for analysis of a select fraction of high volume filters.
- Continue collaborations with EPA (Bob Devlin) for analysis of CAPS and possibly to provide filter extracts for EPA ROS analysis with various probes.
- Continue collaborations with Emory University in development of a cellular assay and analysis of Project 1 filters.
- Quantify quinones, PAHs and organic tracers in a subset of Project 1 filters.
- Analyze data and publish results.
- Expect seven ACE-1 manuscripts to be submitted during the upcoming reporting period.
- Field data collection will continue through fall 2013 for ACE-2, with a target end date for sampling of September 30, 2013.
- Many of the data parameters have been processed and will be ready for data analysis shortly after sampling ends. Chemical analyses of PM organic and elemental species, blood biomarker analyses and heart rate variability data processing will likely continue through December 2013.
- Finalize epidemiologic model specification, with initial exposure and health effects modeling commencing in 2014.
- Continue to construct the Kaiser Permanente birth cohort and start epidemiological analyses in early 2014.
- Develop manuscripts on analyses of associations between air pollution and pediatric respiratory morbidity in Atlanta, and air pollution and preterm delivery in the state-wide cohort.
- Begin epidemiologic analyses using the source apportionment estimates.
- Complete database management activities.
- Submit five manuscripts currently in preparation.
- Continue multi-city C&RT analysis.
- Initiate analyses focused on effect modification in single- and multi-city context.
- Continue collection of relevant air quality-related data (e.g., emissions data).
- Continue application of the various source apportionment approaches.
- Further application of the spatiotemporal extension of the hybrid CTM-CMB approach.
- Develop spatial PM fields using high resolution AOD data fused with CTM model fields.
- Continue to support the Air Quality Core on developing and evaluating air quality products for use in health analyses.
- Continue collaborations on the design and analysis of exposure measurements (Projects 1 and 2) and health effect studies (Projects 3 and 4).
- Extend classification and regression tree (C&RT) and self-organizing map (SOM) techniques for characterizing air pollution mixtures.
Journal Articles: 136 Displayed | Download in RIS Format
Other center views: | All 338 publications | 139 publications in selected types | All 135 journal articles |
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Abrams JY, Weber RJ, Klein M, Samat SE, Chang HH, Strickland MJ, Verma V, Fang T, Bates JT, Mulholland JA, Russell AG, Tolbert PE. Associations between ambient fine particulate oxidative potential and cardiorespiratory emergency department visits. Environmental Health Perspectives 2017;125(10):107008. |
R834799 (Final) |
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Alhanti BA, Chang HH, Winquist A, Mulholland JA, Darrow LA, Sarnat SE. Ambient air pollution and emergency department visits for asthma: a multi-city assessment of effect modification by age. Journal of Exposure Science & Environmental Epidemiology 2016;26(2):180-188. |
R834799 (2015) R834799 (2016) R834799 (Final) R834799C004 (2015) R834799C004 (Final) R829213 (Final) |
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Balachandran S, Pachon JE, Hu Y, Lee D, Mulholland JA, Russell AG. Ensemble-trained source apportionment of fine particulate matter and method uncertainty analysis. Atmospheric Environment 2012;61:387-394. |
R834799 (2012) R834799 (2013) R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2013) R834799C003 (2014) R834799C003 (2015) R834799C003 (Final) R834799C004 (2013) R834799C004 (2014) R834799C004 (2015) R834799C004 (Final) R833866 (2012) R833866 (Final) |
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Balachandran S, Chang HH, Pachon JE, Holmes HA, Mulholland JA, Russell AG. Bayesian-based ensemble source apportionment of PM2.5. Environmental Science & Technology 2013;47(23):13511-13518. |
R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2013) R834799C003 (2014) R833866 (Final) |
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Balachandran S, Pachon JE, Lee S, Oakes MM, Rastogi N, Shi W, Tagaris E, Yan B, Davis A, Zhang X, Weber RJ, Mulholland JA, Bergin MH, Zheng M, Russell AG. Particulate and gas sampling of prescribed fires in South Georgia, USA. Atmospheric Environment 2013;81:125-135. |
R834799 (2015) R834799 (2016) R834799 (Final) R833866 (Final) |
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Bates JT, Weber RJ, Abrams J, Verma V, Fang T, Klein M, Strickland MJ, Sarnat SE, Chang HH, Mulholland JA, Tolbert PE, Russell AG. Reactive oxygen species generation linked to sources of atmospheric particulate matter and cardiorespiratory effects. Environmental Science & Technology 2015;49(22):13605-13612. |
R834799 (2015) R834799 (2016) R834799 (Final) R834799C001 (Final) R834799C003 (Final) R834799C004 (2015) R834799C004 (Final) |
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Baxter LK, Dionisio KL, Burke J, Sarnat SE, Sarnat JA, Hodas N, Rich DQ, Turpin BJ, Jones RR, Mannshardt E, Kumar N, Beevers SD, Ozkaynak H. Exposure prediction approaches used in air pollution epidemiology studies: key findings and future recommendations. Journal of Exposure Science & Environmental Epidemiology 2013;23(6):654-659. |
R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C004 (2013) R834799C004 (2014) R834799C004 (2015) R834799C004 (Final) R833865 (Final) |
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Bergin MH, Tripathi SN, Jai Devi J, Gupta T, Mckenzie M, Rana KS, Shafer MM, Villalobos AM, Schauer JJ. The discoloration of the Taj Mahal due to particulate carbon and dust deposition. Environmental Science & Technology 2015;49(2):808-812. |
R834799 (2015) R834799 (2016) R834799 (Final) R834799C002 (2015) R834799C002 (Final) R835039 (Final) |
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Boyd CM, Sanchez J, Xu L, Eugene AJ, Nah T, Tuet WY, Guzman MI, Ng NL. Secondary organic aerosol formation from the β-pinene+NO3 system: effect of humidity and peroxy radical fate. Atmospheric Chemistry and Physics 2015;15(13):7497-7522. |
R834799 (Final) R835403 (2014) R835403 (2015) R835403 (Final) |
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Brock CA, Wagner NL, Anderson BE, Attwood AR, Beyersdorf A, Campuzano-Jost P, Carlton AG, Day DA, Diskin GS, Gordon TD, Jimenez JL, Lack DA, Liao J, Markovic MZ, Middlebrook AM, Ng NL, Perring AE, Richardson MS, Schwarz JP, Washenfelder RA, Welti A, Xu L, Ziemba LD, Murphy DM. Aerosol optical properties in the southeastern United States in summer--Part 1: Hygroscopic growth. Atmospheric Chemistry and Physics 2016;16(8):4987-5007. |
R834799 (Final) |
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Brown MS, Sarnat SE, DeMuth KA, Brown LAS, Whitlock DR, Brown SW, Tolbert PE, Fitzpatrick AM. Residential proximity to a major roadway is associated with features of asthma control in children. PLoS ONE 2012;7(5):e37044 ( pp.). |
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Budisulistiorini SH, Canagaratna MR, Croteau PL, Baumann K, Edgerton ES, Kollman MS, Ng NL, Verma V, Shaw SL, Knipping EM, Worsnop DR, Jayne JT, Weber RJ, Surratt JD. Intercomparison of an Aerosol Chemical Speciation Monitor (ACSM) with ambient fine aerosol measurements in downtown Atlanta, Georgia. Atmospheric Measurement Techniques 2014;7(7):1929-1941. |
R834799 (2015) R834799 (2016) R834799 (Final) R834799C001 (2015) R834799C001 (Final) |
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Chang HH, Reich BJ, Miranda ML. A spatial time-to-event approach for estimating associations between air pollution and preterm birth. Journal of the Royal Statistical Society--Series C (Applied Statistics) 2013;62(2):167-179. |
R834799 (2014) R834799 (2016) R834799 (Final) R834799C002 (2014) R834799C003 (2013) R834799C003 (2014) R833293 (2011) R833293 (2012) R833293 (Final) R833293C001 (2011) R833293C001 (Final) R833293C002 (2011) R833293C002 (Final) |
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Chang HH, Hu X, Liu Y. Calibrating MODIS aerosol optical depth for predicting daily PM2.5 concentrations via statistical downscaling. Journal of Exposure Science & Environmental Epidemiology 2014;24(4):398-404. |
R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2013) R834799C003 (2014) R834799C003 (2015) R834799C003 (Final) |
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Chang HH, Hao H, Sarnat SE. A statistical modeling framework for projecting future ambient ozone and its health impact due to climate change. Atmospheric Environment 2014;89:290-297. |
R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C004 (2014) R834799C004 (2015) R834799C004 (Final) |
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Chang HH, Warren JL, Darrow LA, Reich BJ, Waller LA. Assessment of critical exposure and outcome windows in time-to-event analysis with application to air pollution and preterm birth study. Biostatistics 2015;16(3):509-521. |
R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2015) R834799C003 (Final) |
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Chen T, Sarnat SE, Grundstein AJ, Winquist A, Chang HH. Time-series analysis of heat waves and emergency department visits in Atlanta, 1993 to 2012. Environmental Health Perspectives 2017;125(5):057009 (9 pp.). |
R834799 (2016) R834799 (Final) R834799C004 (Final) R829213 (Final) |
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Darrow LA, Hess J, Rogers CA, Tolbert PE, Klein M, Sarnat SE. Ambient pollen concentrations and emergency department visits for asthma and wheeze. Journal of Allergy and Clinical Immunology 2012;130(3):630-638. |
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Darrow LA, Klein M, Flanders WD, Mulholland JA, Tolbert PE, Strickland MJ. Air pollution and acute respiratory infections among children 0-4 years: an 18-year time-series study. American Journal of Epidemiology 2014;180(10):968-977. |
R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2015) R834799C003 (Final) |
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Dionisio KL, Isakov V, Baxter LK, Sarnat JA, Sarnat SE, Burke J, Rosenbaum A, Graham SE, Cook R, Mulholland J, Ozkaynak H. Development and evaluation of alternative approaches for exposure assessment of multiple air pollutants in Atlanta, Georgia. Journal of Exposure Science & Environmental Epidemiology 2013;23(6):581-592. |
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Dionisio KL, Baxter LK, Chang HH. An empirical assessment of exposure measurement error and effect attenuation in bipollutant epidemiologic models. Environmental Health Perspectives 2014;122(11):1216-1224. |
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Dionisio KL, Chang HH, Baxter LK. A simulation study to quantify the impacts of exposure measurement error on air pollution health risk estimates in copollutant time-series models. Environmental Health 2016;15(1):114 (10 pp.). |
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Fang T, Verma V, Guo H, King LE, Edgerton ES, Weber RJ. A semi-automated system for quantifying the oxidative potential of ambient particles in aqueous extracts using the dithiothreitol (DTT) assay: results from the Southeastern Center for Air Pollution and Epidemiology (SCAPE). Atmospheric Measurement Techniques 2015;8(1):471-482. |
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Fang T, Guo H, Verma V, Peltier RE, Weber RJ. PM2.5 water-soluble elements in the southeastern United States: automated analytical method development, spatiotemporal distributions, source apportionment, and implications for heath studies. Atmospheric Chemistry and Physics 2015;15(20):11667-11682. |
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Fang T, Verma V, Bates JT, Abrams J, Klein M, Strickland MJ, Sarnat SE, Chang HH, Mulholland JA, Tolbert PE, Russell AG, Weber RJ. Oxidative potential of ambient water-soluble PM2.5 in the southeastern United States: contrasts in sources and health associations between ascorbic acid (AA) and dithiothreitol (DTT) assays. Atmospheric Chemistry and Physics 2016;16(6):3865-3879. |
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Fang T, Zeng L, Gao D, Verma V, Stefaniak AB, Weber RJ. Ambient size distributions and lung deposition of aerosol dithiothreitol-measured oxidative potential: Contrast between soluble and insoluble particles. Environmental Science & Technology 2017;51(12):6802-6811. |
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Fang T, Guo H, Zeng L, Verma V, Nenes A, Weber RJ. Highly acidic ambient particles, soluble metals, and oxidative potential: A link between sulfate and aerosol toxicity. Environmental Science & Technology 2017;51(5):2611-2620. |
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Flanders WD, Klein M, Darrow LA, Strickland MJ, Sarnat SE, Sarnat JA, Waller LA, Winquist A, Tolbert PE. A method for detection of residual confounding in time-series and other observational studies. Epidemiology 2011;22(1):59-67. |
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Flanders WD, Klein M, Darrow LA, Strickland MJ, Sarnat SE, Sarnat JA, Waller LA, Winquist A, Tolbert PE. A method to detect residual confounding in spatial and other observational studies. Epidemiology 2011;22(6):823-826. |
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Flanders WD, Klein M. A general, multivariate definition of causal effects in epidemiology. Epidemiology 2015;26(4):481-489. |
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Flanders WD, Klein M. Rejoinder. Epidemiology 2015;26(4):496-497. |
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Flanders WD, Klein M, Mirabelli MC. Conditions for valid estimation of causal effects on prevalence in cross-sectional and other studies. Annals of Epidemiology 2016;26(6):389-394.e2. |
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Flanders WD, Strickland MJ, Klein M. A new method for partial correction of residual confounding in time-series and other observational studies. American Journal of Epidemiology 2017;185(10):941-949. |
R834799 (2016) R834799 (Final) R834799C003 (Final) |
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Friberg MD, Zhai X, Holmes HA, Chang HH, Strickland MJ, Sarnat SE, Tolbert PE, Russell AG, Mulholland JA. Method for fusing observational data and chemical transport model simulations to estimate spatiotemporally resolved ambient air pollution. Environmental Science & Technology 2016;50(7):3695-3705. |
R834799 (2016) R834799 (Final) R834799C003 (Final) R834799C004 (2015) R834799C004 (Final) |
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Friberg MD, Kahn RA, Holmes HA, Chang HH, Sarnat SE, Tolbert PE, Russell AG, Mulholland JA. Daily ambient air pollution metrics for five cities: evaluation of data-fusion-based estimates and uncertainties. Atmospheric Environment 2017;158:36-50. |
R834799 (2016) R834799 (Final) R834799C004 (Final) |
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Gao D, Fang T, Verma V, Zeng L, Weber RJ. A method for measuring total aerosol oxidative potential (OP) with the dithiothreitol (DTT) assay and comparisons between an urban and roadside site of water-soluble and total OP. Atmospheric Measurement Techniques 2017;10(8):2821-2835. |
R834799 (Final) |
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Gass K, Klein M, Chang HH, Flanders WD, Strickland MJ. Classification and regression trees for epidemiologic research: an air pollution example. Environmental Health 2014;13(1):17 (10 pp.). |
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Gass K, Balachandran S, Chang HH, Russell AG, Strickland MJ. Ensemble-based source apportionment of fine particulate matter and emergency department visits for pediatric asthma. American Journal of Epidemiology 2015;181(7):504-512. |
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Gass K, Klein M, Sarnat SE, Winquist A, Darrow LA, Flanders WD, Chang HH, Mulholland JA, Tolbert PE, Strickland MJ. Associations between ambient air pollutant mixtures and pediatric asthma emergency department visits in three cities: a classification and regression tree approach. Environmental Health 2015;14:58 (14 pp.). |
R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2015) R834799C003 (Final) R834799C004 (2014) R834799C004 (2015) R834799C004 (Final) |
Exit Exit Exit |
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Golan R, Ladva C, Greenwald R, Krall JR, Raysoni AU, Kewada P, Winquist A, Flanders WD, Liang D-H, Sarnat JA. Acute pulmonary and inflammatory response in young adults following a scripted car commute. Air Quality, Atmosphere & Health 2018;11(2):123-136. |
R834799 (Final) |
Exit |
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Goldman GT, Mulholland JA, Russell AG, Strickland MJ, Klein M, Waller LA, Tolbert PE. Impact of exposure measurement error in air pollution epidemiology: effect of error type in time-series studies. Environmental Health 2011;10:61 (11 pp.). |
R834799 (2011) R834799 (2013) R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2011) R834799C003 (2013) R834799C003 (2014) R834799C003 (2015) R834799C003 (Final) R834799C004 (2013) R834799C004 (2014) R834799C004 (2015) R834799C004 (Final) R829213 (Final) R833866 (Final) |
Exit Exit |
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Goldman GT, Mulholland JA, Russell AG, Gass K, Strickland MJ, Tolbert PE. Characterization of ambient air pollution measurement error in a time-series health study using a geostatistical simulation approach. Atmospheric Environment 2012;57:101-108. |
R834799 (2012) R834799 (2013) R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2012) R834799C003 (2013) R834799C003 (2014) R834799C003 (2015) R834799C003 (Final) R834799C004 (2013) R834799C004 (2014) R834799C004 (2015) R834799C004 (Final) R829213 (Final) R833626 (Final) R833866 (Final) |
Exit Exit Exit |
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Greenwald R, Bergin MH, Yip F, Boehmer T, Kewada P, Shafer MM, Schauer JJ, Sarnat JA. On-roadway in-cabin exposure to particulate matter: measurement results using both continuous and time-integrated sampling approaches. Aerosol Science and Technology 2014;48(6):664-675. |
R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C002 (2014) R834799C002 (2015) R834799C002 (Final) |
Exit Exit Exit |
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Guo H, Xu L, Bougiatioti A, Cerully KM, Capps SL, Hite Jr. JR, Carlton AG, Lee S-H, Bergin MH, Ng NL, Nenes A, Weber RJ. Fine-particle water and pH in the southeastern United States. Atmospheric Chemistry and Physics 2015;15(9):5211-5228. |
R834799 (2015) R834799 (2016) R834799 (Final) R834799C001 (2015) R834799C001 (Final) R835041 (2015) R835041 (Final) R835410 (2013) R835410 (2014) R835410 (2015) R835410 (Final) |
Exit Exit Exit |
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Hao H, Chang HH, Holmes HA, Mulholland JA, Klein M, Darrow LA, Strickland MJ. Air pollution and preterm birth in the U.S. state of Georgia (2002-2006): associations with concentrations of 11 ambient air pollutants estimated by combining Community Multiscale Air Quality Model (CMAQ) simulations with stationary monitor measurements. Environmental Health Perspectives 2016;124(6):875-880. |
R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2015) R834799C003 (Final) |
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Heidari L, Winquist A, Klein M, O’Lenick CR, Grundstein A, Sarnat SE. Susceptibility to heat-related fluid and electrolyte imbalance emergency department visits in Atlanta, Georgia, USA. International Journal of Environmental Research and Public Health 2016;13(10):982 (17 pp.). |
R834799 (2016) R834799 (Final) R834799C004 (Final) R829213 (Final) |
Exit Exit Exit |
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Henneman LRF, Holmes HA, Mulholland JA, Russell AG. Meteorological detrending of primary and secondary pollutant concentrations: Method application and evaluation using long-term (2000–2012) data in Atlanta. Atmospheric Environment 2015;119(Suppl C):201-210. |
R834799 (Final) |
Exit Exit |
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Hu X, Waller LA, Al-Hamdan MZ, Crosson WL, Estes Jr. MG, Estes SM, Quattrochi DA, Sarnat JA, Liu Y. Estimating ground-level PM2.5 concentrations in the southeastern U.S. using geographically weighted regression. Environmental Research 2013;121:1-10. |
R834799 (2013) R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2013) R834799C003 (2014) R834799C003 (2015) R834799C003 (Final) |
Exit Exit Exit |
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Hu X, Waller LA, Lyapustin A, Wang Y, Al-Hamdan MZ, Crosson WL, Estes Jr. MG, Estes SM, Quattrochi DA, Puttaswamy SJ, Liu Y. Estimating ground-level PM2.5 concentrations in the Southeastern United States using MAIAC AOD retrievals and a two-stage model. Remote Sensing of Environment 2014;140:220-232. |
R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2013) R834799C003 (2014) R834799C003 (2015) R834799C003 (Final) |
Exit Exit Exit |
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Hu X, Waller LA, Lyapustin A, Wang Y, Liu Y. 10-year spatial and temporal trends of PM2.5 concentrations in the southeastern US estimated using high-resolution satellite data. Atmospheric Chemistry and Physics 2014;14(12):6301-6314. |
R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2014) R834799C003 (2015) R834799C003 (Final) |
Exit Exit |
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Hu X, Waller LA, Lyapustin A, Wang Y, Liu Y. Improving satellite-driven PM2.5 models with Moderate Resolution Imaging Spectroradiometer fire counts in the southeastern U.S. Journal of Geophysical Research: Atmospheres 2014;119(19):11375-11386. |
R834799 (2015) R834799 (2016) R834799 (Final) |
Exit Exit |
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Hu Y, Balachandran S, Pachon JE, Baek J, Ivey C, Holmes H, Odman MT, Mulholland JA, Russell AG. Fine particulate matter source apportionment using a hybrid chemical transport and receptor model approach. Atmospheric Chemistry and Physics 2014;14(11):5415-5431. |
R834799 (2015) R834799 (2016) R834799 (Final) |
Exit Exit |
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Hu Y, Odman MT, Chang ME, Russell AG. Operational forecasting of source impacts for dynamic air quality management. Atmospheric Environment 2015;116:320-322. |
R834799 (2015) R834799 (2016) R834799 (Final) R833866 (Final) R835217 (2014) R835217 (Final) |
Exit Exit Exit |
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Huang R, Zhai X, Ivey CE, Friberg MD, Hu X, Liu Y, Qian Di, Schwartz J, Mulholland JA, Russel AG. Air pollutant exposure field modeling using air quality model-data fusion methods and comparison with satellite AOD-derived fields: application over North Carolina, USA. Air Quality, Atmosphere & Health 2018;11(1):11-22. |
R834799 (Final) |
Exit |
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Ivey CE, Holmes HA, Hu YT, Mulholland JA, Russell AG. Development of PM2.5 source impact spatial fields using a hybrid source apportionment air quality model. Geoscientific Model Development 2015;8(7):2153-2165. |
R834799 (2015) R834799 (2016) R834799 (Final) |
Exit Exit |
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Ivey CE, Holmes HA, Hu Y, Mulholland JA, Russell AG. A method for quantifying bias in modeled concentrations and source impacts for secondary particulate matter. Frontiers of Environmental Science & Engineering 2016;10:14. |
R834799 (2016) R834799 (Final) |
Exit Exit |
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Ivey C, Holmes H, Shi G, Balachandran S, Hu Y, Russell AG. Development of PM2.5 source profiles using a hybrid chemical transport-receptor modeling approach. Environmental Science & Technology 2017;51(23):13788-13796. |
R834799 (Final) R833626 (Final) R833866 (Final) |
Exit Exit Exit |
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Keller JP, Chang HH, Strickland MJ, Szpiro AA. Measurement error correction for predicted spatiotemporal air pollution exposures. Epidemiology 2017;28(3):338-345. |
R834799 (2016) R834799 (Final) R834799C003 (Final) R834796 (2016) R834796 (Final) |
Exit Exit |
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Keller JP, Chang HH, Strickland MJ, Szpiro AA. Measurement error correction for predicted spatiotemporal air pollution exposures. Epidemiology 2017;28(3):338-345. |
R834799 (Final) R834796 (Final) |
Exit Exit |
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Keller JP, Chang HH, Strickland MJ, Szpiro AA. Measurement error correction for predicted spatiotemporal air pollution exposures. Epidemiology 2017;28(3):338-345. |
R834799 (2016) R834799 (Final) R834799C003 (Final) R834796 (2016) R834796 (Final) |
Exit Exit |
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King LE, Weber RJ. Development and testing of an online method to measure ambient fine particulate Reactive Oxygen Species (ROS) based on the 2’,7’-dichlorofluorescin (DCFH) assay. Atmospheric Measurement Techniques 2013;6(7):1647-1658. |
R834799 (2013) R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C001 (2013) R834799C001 (2014) R834799C001 (2015) R834799C001 (Final) |
Exit Exit |
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Krall JR, Chang HH, Sarnat SE, Peng RD, Waller LA. Current methods and challenges for epidemiological studies of the associations between chemical constituents of particulate matter and health. Current Environmental Health Reports 2015;2(4):388-398. |
R834799 (2016) R834799 (Final) R834799C004 (2015) R834799C004 (Final) |
Exit Exit Exit |
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Krall JR, Mulholland JA, Russell AG, Balachandran S, Winquist A, Tolbert PE, Waller LA, Sarnat SE. Associations between source-specific fine particulate matter and emergency department visits for respiratory disease in four U.S. cities. Environmental Health Perspectives 2017;125(1):97-103. |
R834799 (2016) R834799 (Final) R834799C004 (2015) R834799C004 (Final) R829213 (Final) R833866 (Final) |
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Krall Jenna R, Chandresh N, Ladva Armistead G, Russell Rachel Golan, Xing Peng, Guoliang Shi, Roby Greenwald, Amit U. Raysoni, Lance A. Waller, and Jeremy A. Sarnat. “Source-Specific Pollution Exposure and Associations with Pulmonary Response in the Atlanta Commuters Exposure Studies.” Journal of Exposure Science & Environmental Epidemiology 28, no. 4 (June 2018):337–47. |
R834799 (Final) |
Exit Exit |
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Ladva CN, Golan R, Greenwald R, Yu T, Sarnat SE, Flanders WD, Uppal K, Walker DI, Tran V, Liang D, Jones DP, Sarnat JA. Metabolomic profiles of plasma, exhaled breath condensate, and saliva are correlated with potential for air toxics detection. Journal of Breath Research 2017;12(1):016008. |
R834799 (Final) |
Exit |
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Lawson AB. Commentary: Assessment of chance should be central in investigation of cancer clusters. International Journal of Epidemiology 2013;42(2):448-449. |
R834799 (Final) |
Exit Exit |
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Li W, Xu L, Liu X, Zhang J, Lin Y, Yao X, Gao H, Zhang D, Chen J, Wang W, Harrison RM, Zhang X, Shao L, Fu P, Nenes A, Shi Z. Air pollution–aerosol interactions produce more bioavailable iron for ocean ecosystems. Science Advances 2017;3(3):e1601749 (7 pp.). |
R834799 (Final) |
Exit Exit |
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Liang, Donghai, Rachel Golan, Jennifer L. Moutinho, Howard H. Chang, Roby Greenwald, Stefanie E. Sarnat, Armistead G. Russell, and Jeremy A. Sarnat. “Errors Associated with the Use of Roadside Monitoring in the Estimation of Acute Traffic Pollutant-Related Health Effects.” Environmental Research 165 (August 1, 2018):210–19. |
R834799 (Final) |
Exit Exit Exit |
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Liu J, Bergin M, Guo H, King L, Kotra N, Edgerton E, Weber RJ. Size-resolved measurements of brown carbon in water and methanol extracts and estimates of their contribution to ambient fine-particle light absorption. Atmospheric Chemistry and Physics 2013;13(24):12389-12404. |
R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C001 (2013) R834799C001 (2014) R834799C001 (2015) R834799C001 (Final) |
Exit Exit Exit |
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Liu J, Scheuer E, Dibb J, Ziemba LD, Thornhill KL, Anderson BE, Wisthaler A, Mikoviny T, Devi JJ, Bergin M, Weber RJ. Brown carbon in the continental troposphere. Geophysical Research Letters 2014;41(6):2191-2195. |
R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C001 (2014) R834799C001 (2015) R834799C001 (Final) R835039 (Final) |
Exit Exit Exit |
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Lv B, Hu Y, Chang HH, Russell AG, Bai Y. Improving the accuracy of daily PM2.5 distributions derived from the fusion of ground-level measurements with aerosol optical depth observations, a case study in North China. Environmental Science & Technology 2016;50(9):4752-4759. |
R834799 (Final) R833866 (Final) R835217 (Final) |
Exit Exit Exit |
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Ma Z, Hu X, Huang L, Bi J, Liu Y. Estimating ground-level PM2.5 in China using satellite remote sensing. Environmental Science & Technology 2014;48(13):7436-7444. |
R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2014) R834799C003 (2015) R834799C003 (Final) |
Exit Exit Exit |
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Ma Z, Hu X, Sayer AM, Levy R, Zhang Q, Xue Y, Tong S, Bi J, Huang L, Liu Y. Satellite-based spatiotemporal trends in PM2.5 concentrations: China, 2004-2013. Environmental Health Perspectives 2016;124(2):184-192. |
R834799 (2015) R834799 (2016) R834799 (Final) |
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Maier ML, Balachandran S, Sarnat SE, Turner JR, Mulholland JA, Russell AG. Application of an ensemble-trained source apportionment approach at a site impacted by multiple point sources. Environmental Science & Technology 2013;47(8):3743-3751. |
R834799 (2013) R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C004 (2013) R834799C004 (2014) R834799C004 (2015) R834799C004 (Final) R833626 (Final) R833866 (Final) |
Exit Exit Exit |
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McGuinn LA, Ward-Caviness C, Neas LM, Schneider A, Di Q, Chudnovsky A, Schwartz J, Koutrakis P, Russell AG, Garcia V, Kraus WE, Hauser ER, Cascio W, Diaz-Sanchez D, Devlin RB. Fine particulate matter and cardiovascular disease: comparison of assessment methods for long-term exposure. Environmental Research 2017;159:16-23. |
R834799 (Final) R835872 (2016) |
Exit Exit Exit |
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Mirabelli MC, Golan R, Greenwald R, Raysoni AU, Holguin F, Kewada P, Winquist A, Flanders WD, Sarnat JA. Modification of traffic-related respiratory response by asthma control in a population of car commuters. Epidemiology 2015;26(4):546-555. |
R834799 (2015) R834799 (2016) R834799 (Final) R834799C002 (2015) R834799C002 (Final) |
Exit |
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Neelon B, Chang HH, Ling Q, Hastings NS. Spatiotemporal hurdle models for zero-inflated count data: exploring trends in emergency department visits. Statistical Methods in Medical Research 2014 [Epub ahead of print]. |
R834799 (2014) R834799 (2015) R834799 (2016) |
Exit |
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Neelon B, Chang HH, Ling Q, Hastings NS. Spatiotemporal hurdle models for zero-inflated count data: Exploring trends in emergency department visits. Statistical Methods in Medical Research 2016;25(6):2558-2576. |
R834799 (Final) |
Exit |
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O'Lenick CR, Winquist A, Mulholland JA, Friberg MD, Chang HH, Kramer MR, Darrow LA, Sarnat SE. Assessment of neighbourhood-level socioeconomic status as a modifier of air pollution-asthma associations among children in Atlanta. Journal of Epidemiology and Community Health 2017;71(2):129-136. |
R834799 (2016) R834799 (Final) R834799C004 (Final) R829213 (Final) |
Exit |
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O'Lenick CR, Winquist A, Chang HH, Kramer MR, Mulholland JA, Grundstein A, Sarnat SE. Evaluation of individual and area-level factors as modifiers of the association between warm-season temperature and pediatric asthma morbidity in Atlanta, GA. Environmental Research 2017;156:132-144. |
R834799 (2016) R834799 (Final) R834799C004 (Final) |
Exit Exit Exit |
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O’Lenick CR, Chang HH, Kramer MR, Winquist A, Mulholland JA, Friberg MD, Sarnat SE. Ozone and childhood respiratory disease in three US cities: evaluation of effect measure modification by neighborhood socioeconomic status using a Bayesian hierarchical approach. Environmental Health 2017;16(1):36 (15 pp.). |
R834799 (2016) R834799 (Final) R834799C004 (Final) R829213 (Final) |
Exit Exit Exit |
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Pachon JE, Balachandran S, Hu Y, Mulholland JA, Darrow LA, Sarnat JA, Tolbert PE, Russell AG. Development of outcome-based, multipollutant mobile source indicators. Journal of the Air & Waste Management Association 2012;62(4):431-442. |
R834799 (2012) R834799 (2013) R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2013) R834799C003 (2014) R834799C003 (2015) R834799C003 (Final) R834799C004 (2013) R834799C004 (2014) R834799C004 (2015) R834799C004 (Final) R833626 (Final) R833866 (Final) |
Exit Exit Exit |
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Pachon JE, Weber RJ, Zhang X, Mulholland JA, Russell AG. Revising the use of potassium (K) in the source apportionment of PM2.5. Atmospheric Pollution Research 2013;4(1):14-21. |
R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C004 (2013) R834799C004 (2014) R834799C004 (2015) R833626 (Final) R833866 (Final) |
Exit Exit Exit |
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Park S-K, Russell AG. Regional adjustment of emission strengths via four dimensional data assimilation. Asia-Pacific Journal of Atmospheric Sciences 2013;49(3):361-374. |
R834799 (2015) R834799 (2016) R834799 (Final) R831076 (Final) |
Exit |
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Park S-K, Marmur A, Russell AG. Environmental risk assessment: comparison of receptor and air quality models for source apportionment. Human and Ecological Risk Assessment 2013;19(5):1385-1403. |
R834799 (2015) R834799 (2016) R834799 (Final) R831076 (Final) |
Exit |
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Pearce JL, Waller LA, Chang HH, Klein M, Mulholland JA, Sarnat JA, Sarnat SE, Strickland MJ, Tolbert PE. Using self-organizing maps to develop ambient air quality classifications: a time series example. Environmental Health 2014;13:56. |
R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2015) R834799C003 (Final) R834799C004 (2014) R834799C004 (2015) R834799C004 (Final) |
Exit Exit Exit |
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Pearce JL, Waller LA, Mulholland JA, Sarnat SE, Strickland MJ, Chang HH, Tolbert PE. Exploring associations between multipollutant day types and asthma morbidity: epidemiologic applications of self-organizing map ambient air quality classifications. Environmental Health 2015;14:55 (12 pp.). |
R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2013) R834799C003 (2015) R834799C003 (Final) R834799C004 (2013) R834799C004 (2015) R834799C004 (Final) |
Exit Exit Exit |
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Pearce JL, Waller LA, Sarnat SE, Chang HH, Klein M, Mulholland JA, Tolbert PE. Characterizing the spatial distribution of multiple pollutants and populations at risk in Atlanta, Georgia. Spatial and Spatio-temporal Epidemiology 2016;18:13-23. |
R834799 (2016) R834799 (Final) R834799C004 (Final) |
Exit Exit Exit |
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Pennington AF, Strickland MJ, Freedle KA, Klein M, Drews-Botsch C, Hansen C, Darrow LA. Evaluating early-life asthma definitions as a marker for subsequent asthma in an electronic medical record setting. Pediatric Allergy and Immunology 2016;27(6):591-596. |
R834799 (2016) R834799 (Final) |
Exit |
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Pennington AF, Strickland MJ, Klein M, Zhai X, Russell AG, Hansen C, Darrow LA. Measurement error in mobile source air pollution exposure estimates due to residential mobility during pregnancy. Journal of Exposure Science and Environmental Epidemiology 2017;27(5):513-520. |
R834799 (2016) R834799 (Final) R834799C003 (Final) |
Exit |
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Pennington AF, Strickland MJ, Klein M, Zhai X, Bates JT, Drews-Botsch C, Hansen C, Russell AG, Tolbert PE, Darrow LA. Exposure to mobile source air pollution in early-life and childhood asthma incidence: the Kaiser Air Pollution and Pediatric Asthma Study. Epidemiology 2018;29(1):22-30. |
R834799 (Final) |
Exit |
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Pennington A, Strickland M, Gass K, Klein M, Sarnat S, Tolbert P, Balachandran S, Change H, Russel A, Mulholland J, Darrow L. Source-Apportioned PM2.5 and Cardiorespiratory Emergency Department Visits Accounting for Source Contribution Uncertainty. EPIDEMIOLOGY 2019;30(6):789-798. |
R834799 (Final) R833866 (Final) |
Exit |
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Qin M, Hu Y, Wang X, Vasilakos P, Boyd CM, Xu L, Song Y, Ng NL, Nenes A, Russell AG. Modeling biogenic secondary organic aerosol (BSOA) formation from monoterpene reactions with NO3:a case study of the SOAS campaign using CMAQ. Atmospheric Environment 2018;184:146-155. |
R834799 (Final) R835403 (Final) |
Exit Exit Exit |
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Redman JD, Holmes HA, Balachandran S, Maier ML, Zhai X, Ivey C, Digby K, Mulholland JA, Russell AG. Development and evaluation of a daily temporal interpolation model for fine particulate matter species concentrations and source apportionment. Atmospheric Environment 2016;140:529-538. |
R834799 (2016) R834799 (Final) R833626 (Final) R833866 (Final) |
Exit Exit Exit |
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Reich BJ, Chang HH, Strickland MJ. Spatial health effects analysis with uncertain residential locations. Statistical Methods in Medical Research 2014;23(2):156-168. |
R834799 (2012) R834799 (2013) R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2012) R834799C003 (2013) R834799C003 (2014) R834799C003 (2015) R834799C003 (Final) R833863 (2011) |
Exit Exit Exit |
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Reich BJ, Chang HH, Foley KM. A spectral method for spatial downscaling. Biometrics 2014;70(4):932-942. |
R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R835228 (2013) R835228 (2014) R835228 (Final) |
Exit Exit Exit |
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Sarnat JA, Sarnat SE, Flanders WD, Chang HH, Mulholland J, Baxter L, Isakov V, Ozkaynak H. Spatiotemporally resolved air exchange rate as a modifier of acute air pollution-related morbidity in Atlanta. Journal of Exposure Science & Environmental Epidemiology 2013;23(6):606-615. |
R834799 (2013) R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C002 (2013) R834799C002 (2014) R834799C002 (2015) R834799C002 (Final) R834799C004 (2013) R834799C004 (2014) R834799C004 (2015) R834799C004 (Final) |
Exit Exit |
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Sarnat JA, Golan R, Greenwald R, Raysoni AU, Kewada P, Winquist A, Sarnat SE, Flanders WD, Mirabelli MC, Zora JE, Bergin MH, Yip F. Exposure to traffic pollution, acute inflammation and autonomic response in a panel of car commuters. Environmental Research 2014;133:66-76. |
R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C002 (2014) R834799C002 (2015) R834799C002 (Final) |
Exit Exit Exit |
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Sarnat SE, Sarnat JA, Mulholland J, Isakov V, Ozkaynak H, Chang HH, Klein M, Tolbert PE. Application of alternative spatiotemporal metrics of ambient air pollution exposure in a time-series epidemiological study in Atlanta. Journal of Exposure Science & Environmental Epidemiology 2013;23(6):593-605. |
R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C004 (2013) R834799C004 (2014) R834799C004 (2015) R834799C004 (Final) |
Exit |
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Sarnat SE, Winquist A, Schauer JJ, Turner JR, Sarnat JA. Fine particulate matter components and emergency department visits for cardiovascular and respiratory diseases in the St. Louis, Missouri-Illinois, metropolitan area. Environmental Health Perspectives 2015;123(5):437-444. |
R834799 (2015) R834799 (2016) R834799 (Final) R834799C004 (2014) R834799C004 (2015) R834799C004 (Final) |
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Sarnat SE, Chang HH, Weber RJ. Ambient PM2.5 and health: does PM2.5 oxidative potential play a role? American Journal of Respiratory and Critical Care Medicine 2016;194(5):530-531. |
R834799 (2016) R834799 (Final) R834799C001 (Final) R834799C004 (Final) |
Exit |
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Shi G, Xu J, Peng X, Xiao Z, Chen K, Tian Y, Guan X, Feng Y, Yu H, Nenes A, Russell AG. pH of aerosols in a polluted atmosphere:source contributions to highly acidic Aerosol. Environmental Science & Technology 2017;51(8):4289-4296. |
R834799 (Final) |
Exit |
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Shi G, Peng X, Huangfu Y, Wang W, Xu J, Tian Y, Feng Y, Ivey CE, Russell AG. Quantification of source impact to PM using three-dimensional weighted factor model analysis on multi-site data. Atmospheric Environment 2017;160:89-96. |
R834799 (Final) |
Exit Exit |
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Strickland MJ, Darrow LA, Mulholland JA, Klein M, Flanders WD, Winquist A, Tolbert PE. Implications of different approaches for characterizing ambient air pollutant concentrations within the urban airshed for time-series studies and health benefits analyses. Environmental Health 2011;10:36 (9 pp.). |
R834799 (2011) R834799 (2013) R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2011) R834799C003 (2013) R834799C003 (2014) R834799C003 (2015) R834799C003 (Final) R834799C004 (2013) R834799C004 (2014) R834799C004 (2015) R834799C004 (Final) R829213 (Final) |
Exit Exit |
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Strickland MJ, Marsh CA, Darrow LA. Gestational age-specific associations between infantile acute bronchiolitis and asthma after age five. Pediatric and Perinatal Epidemiology 2014;28(6):521-526. |
R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2015) R834799C003 (Final) |
Exit |
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Strickland MJ, Klein M, Flanders WD, Chang HH, Mulholland JA, Tolbert PE, Darrow LA. Modification of the effect of ambient air pollution on pediatric asthma emergency visits: susceptible subpopulations. Epidemiology 2014;25(6):843-850. |
R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2014) R834799C003 (2015) R834799C003 (Final) |
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Strickland MJ, Gass KM, Goldman GT, Mulholland JA. Effects of ambient air pollution measurement error on health effect estimates in time-series studies: a simulation-based analysis. Journal of Exposure Science & Environmental Epidemiology 2015;25(2):160-166. |
R834799 (2013) R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2013) R834799C003 (2014) R834799C003 (2015) R834799C003 (Final) |
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Strickland MJ, Hao H, Hu X, Chang HH, Darrow LA, Liu Y. Pediatric emergency visits and short-term changes in PM2.5 concentrations in the U.S. state of Georgia. Environmental Health Perspectives 2016;124(5):690-696. |
R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2015) R834799C003 (Final) |
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Strickland MJ, Lin Y, Darrow LA, Warren JL, Mulholland JA, Chang HH. Associations between ambient air pollutant concentrations and birth weight:A quantile regression analysis.Epidemiology 2019;30:624. |
R834799 (Final) |
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Tuet WY, Fok S, Verma V, Tagle Rodriguez MS, Grosberg A, Champion JA, Ng NL. Dose-dependent intracellular reactive oxygen and nitrogen species (ROS/RNS) production from particulate matter exposure: comparison to oxidative potential and chemical composition. Atmospheric Environment 2016;144:335-344. |
R834799 (Final) |
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Verma V, Rico-Martinez R, Kotra N, King L, Liu J, Snell TW, Weber RJ. Contribution of water-soluble and insoluble components and their hydrophobic/hydrophilic subfractions to the reactive oxygen species-generating potential of fine ambient aerosols. Environmental Science & Technology 2012;46(20):11384-11392. |
R834799 (2012) R834799 (2013) R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C001 (2012) R834799C001 (2013) R834799C001 (2014) R834799C001 (2015) R834799C001 (Final) |
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Verma V, Rico-Martinez R, Kotra N, Rennolds C, Liu J, Snell TW, Weber RJ. Estimating the toxicity of ambient fine aerosols using freshwater rotifer Brachionus calyciflorus (Rotifera: Monogononta). Environmental Pollution 2013;182:379-384. |
R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C001 (2013) R834799C001 (2014) R834799C001 (2015) R834799C001 (Final) |
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Verma V, Fang T, Guo H, King L, Bates JT, Peltier RE, Edgerton E, Russell AG, Weber RJ. Reactive oxygen species associated with water-soluble PM2.5 in the southeastern United States: spatiotemporal trends and source apportionment. Atmospheric Chemistry and Physics 2014;14(23):12915-12930. |
R834799 (2015) R834799 (2016) R834799 (Final) R834799C001 (2015) R834799C001 (Final) |
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Verma V, Fang T, Xu L, Peltier RE, Russell AG, Ng NL, Weber RJ. Organic aerosols associated with the generation of reactive oxygen species (ROS) by water-soluble PM2.5. Environmental Science & Technology 2015;49(7):4646-4656. |
R834799 (2015) R834799 (2016) R834799 (Final) R834799C001 (2015) R834799C001 (Final) |
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Verma V, Wang Y, El-Afifi R, Fang T, Rowland J, Russell AG, Weber RJ. Fractionating ambient humic-like substances (HULIS) for their reactive oxygen species activity—assessing the importance of quinones and atmospheric aging. Atmospheric Environment 2015;120:351-359. |
R834799 (2015) R834799 (2016) R834799 (Final) R834799C001 (Final) |
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Vreeland H, Weber R, Bergin M, Greenwald R, Golan R, Russell AG, Verma V, Sarnat JA. Oxidative potential of PM2.5 during Atlanta rush hour: Measurements of in-vehicle dithiothreitol (DTT) activity. Atmospheric Environment 2017;165:169-178. |
R834799 (Final) |
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Waller LA. Commentary: regarding assessments of chance in investigations of ‘cluster series.’ International Journal of Epidemiology 2013;42(2):449-452. |
R834799 (2013) R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2013) R834799C003 (2014) R834799C003 (2015) R834799C003 (Final) |
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Weber RJ, Guo H, Russell AG, Nenes A. High aerosol acidity despite declining atmospheric sulfate concentrations over the past 15 years. Nature Geoscience 2016;9:282-285. |
R834799 (2016) R834799 (Final) R834799C001 (Final) R835410 (2013) R835410 (2014) R835410 (2015) R835410 (Final) |
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Winquist A, Klein M, Tolbert P, Sarnat SE. Power estimation using simulations for air pollution time-series studies. Environmental Health 2012;11:68 (12 pp.). |
R834799 (2012) R834799 (2013) R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C004 (2012) R834799C004 (2013) R834799C004 (2014) R834799C004 (2015) R834799C004 (Final) |
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Winquist A, Klein M, Tolbert P, Flanders WD, Hess J, Sarnat SE. Comparison of emergency department and hospital admissions data for air pollution time-series studies. Environmental Health 2012;11:70 (14 pp.). |
R834799 (2012) R834799 (2013) R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C004 (2012) R834799C004 (2013) R834799C004 (2014) R834799C004 (2015) R834799C004 (Final) |
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Winquist A, Kirrane E, Klein M, Strickland M, Darrow LA, Sarnat SE, Gass K, Mulholland J, Russell A, Tolbert P. Joint effects of ambient air pollutants on pediatric asthma emergency department visits in Atlanta, 1998-2004. Epidemiology 2014;25(5):666-673. |
R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2014) R834799C003 (2015) R834799C003 (Final) R834799C004 (2014) R834799C004 (2015) R834799C004 (Final) |
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Winquist A, Schauer JJ, Turner JR, Klein M, Sarnat SE. Impact of ambient fine particulate matter carbon measurement methods on observed associations with acute cardiorespiratory morbidity. Journal of Exposure Science & Environmental Epidemiology 2015;25(2):215-221. |
R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C004 (2014) R834799C004 (2015) R834799C004 (Final) |
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Winquist A, Grundstein A, Chang HH, Hess J, Sarnat SE. Warm season temperature and emergency department visits in Atlanta, Georgia. Environmental Research 2016;147:314-323. |
R834799 (2016) R834799 (Final) R834799C004 (Final) |
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Xiao Q, Ma Z, Li S, Liu Y. The impact of winter heating on air pollution in China. PLoS One 2015;10(1):e0117311 (11 pp.). |
R834799 (Final) |
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Xiao Q, Liu Y, Mulholland JA, Russell AG, Darrow LA, Tolbert PE, Strickland MJ. Pediatric emergency department visits and ambient air pollution in the U.S. state of Georgia: a case-crossover study. Environmental Health 2016;15(1):115. |
R834799 (2016) R834799 (Final) R834799C003 (Final) |
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Xu L, Guo H, Boyd CM, Klein M, Bougiatioti A, Cerully KM, Hite JR, Isaacman-VanWertz G, Kreisberg NM, Knote C, Olson K, Koss A, Goldstein AH, Hering SV, de Gouw JA, Baumann K, Lee S-H, Nenes A, Weber RJ, Ng NL. Effects of anthropogenic emissions on aerosol formation from isoprene and monoterpenes in the southeastern United States. Proceedings of the National Academy of Sciences of the United States of America 2015;112(1):37-42. |
R834799 (2015) R834799 (2016) R834799 (Final) R834799C001 (2015) R834799C001 (Final) R835403 (2014) R835403 (2015) R835403 (Final) R835410 (2013) R835410 (2014) R835410 (2015) R835410 (Final) |
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Xu L, Suresh S, Guo H, Weber RJ, Ng NL. Aerosol characterization over the southeastern United States using high resolution aerosol mass spectrometry: spatial and seasonal variation of aerosol composition, sources, and organic nitrates. Atmospheric Chemistry and Physics 2015;15(15):7307-7336. |
R834799 (2015) R834799 (2016) R834799 (Final) |
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Ye D, Klein M, Chang HH, Sarnat JA, Mulholland JA, Edgerton ES, Winquist A, Tolbert PE, Sarnat SE. Estimating acute cardiorespiratory effects of ambient volatile organic compounds. Epidemiology 2017;28(2):197-206. |
R834799 (2016) R834799 (Final) R834799C004 (Final) |
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Ye D, Klein M, Mulholland JA, Russell AG, Weber R, Edgerton ES, Chang HH, Sarnat JA, Tolbert PE, Sarnat SE. Estimating acute cardiovascular effects of ambient PM2.5 metals. Environmental Health Perspectives 2018;126:027007 (10 pp.). |
R834799 (Final) R829213 (Final) |
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Yu C, Di Girolamo L, Chen L, Zhang X, Liu Y. Statistical evaluation of the feasibility of satellite-retrieved cloud parameters as indicators of PM2.5 levels. Journal of Exposure Science & Environmental Epidemiology 2015;25(5):457-466. |
R834799 (2014) R834799 (2015) R834799 (2016) R834799 (Final) R834799C003 (2014) R834799C003 (2015) R834799C003 (Final) |
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Yu W, Liu Y, Ma Z, Bi J. Improving satellite-based PM2.5 estimates in China using Gaussian processes modeling in a Bayesian hierarchical setting. Scientific Reports 2017;7(1):7048 (9 pp.). |
R834799 (Final) |
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Zhai X, Russell AG, Sampath P, Mulholland JA, Kim B-U, Kim Y, D'Onofrio D. Calibrating R-LINE model results with observational data to develop annual mobile source air pollutant fields at fine spatial resolution: Application in Atlanta. Atmospheric Environment 2016;147:446-457. |
R834799 (Final) |
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Zhai X, Mulholland JA, Russell AG, Holmes HA. Spatial and temporal source apportionment of PM2.5 in Georgia, 2002 to 2013. Atmospheric Environment 2017;161:112-121. |
R834799 (Final) |
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Zhang T, Gong W, Wang W, Ji Y, Zhu Z, Huang Y. Ground level PM(2.5) estimates over China using satellite-based geographically weighted regression (GWR) models are improved by including NO(2) and enhanced vegetation index (EVI). International Journal of Environmental Research and Public Health 2016;13(12):E1215 (12 pp). |
R834799 (Final) |
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Zhang W, Trail MA, Hu Y, Nenes A, Russell AG. Use of high-order sensitivity analysis and reduced-form modeling to quantify uncertainty in particulate matter simulations in the presence of uncertain emissions rates: A case study in Houston. Atmospheric Environment 2015;122:103-113. |
R834799 (Final) |
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Zhang Z, Manjourides J, Cohen T, Hu Y, Jiang Q. Spatial measurement errors in the field of spatial epidemiology. International Journal of Health Geographics 2016;15(1):21 (12 pp.). |
R834799 (Final) |
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Supplemental Keywords:
scientific discipline, health, risk assessments, health risk assessment, biochemistry, airshed modeling, climate change, children's health, human health risk, oxidative stress, ambient particle health effects, air pollution, particulate matter, Health, Scientific Discipline, Health Risk Assessment, Risk Assessments, Biochemistry, children's health, particulate matter, ambient air monitoring, climate change, air pollution, airshed modeling, ambient particle health effects, human health riskProgress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834799C001 Development and Deployment of an Instrumentation Suite for Comprehensive Air Quality Characterization Including Aerosol ROS
R834799C002 Examining In-Vehicle Pollution and Oxidative Stress in a Cohort of Daily Commuters
R834799C003 Novel Estimates of Pollutant Mixtures and Pediatric Health in Two Birth Cohorts
R834799C004 A Multi-City Time-Series Study of Pollutant Mixtures and Acute Morbidity
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2016 Progress Report
- 2015 Progress Report
- 2014 Progress Report
- 2012 Progress Report
- 2011 Progress Report
- Original Abstract
135 journal articles for this center