Grantee Research Project Results
Journal Publications Details for Grant Number R832413C003
The Chemical Properties of PM and their Toxicological Implications
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Journal Article | Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. | CIRCULATION RESEARCH | Araujo JA, Barajas B, Kleinman M, Wang X, Bennett BJ, Gong KW, Navab M, Harkema J, Sioutas C, Lusis AJ, Nel AE | Araujo JA, Barajas B, Kleinman M, Wang X, Bennett BJ, Gong KW, Navab M, Harkema J, Sioutas C, Lusis AJ, Nel AE. Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circulation Research 2008;102(5):589-596. |
R832413 (2008) R832413 (2009) R832413 (2010) R832413 (Final) R832413C001 (2008) R832413C001 (Final) R832413C002 (2007) R832413C002 (2008) R832413C002 (2009) R832413C002 (Final) R832413C003 (Final) |
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| Journal Article | Evaluating the toxicity of airborne particulate matter and nanoparticles by measuring oxidative stress potential—a workshop report and consensus statement. | INHALATION TOXICOLOGY | Ayres JG, Borm P, Cassee FR, Castranova V, Donaldson K, Ghio A, Harrison RM, Hider R, Kelly F, Kooter IM, Marano F, Maynard RL, Mudway I, Nel A, Sioutas C, Smith S, Baeza-Squiban A, Cho A, Duggan S, Froines J | Ayres JG, Borm P, Cassee FR, Castranova V, Donaldson K, Ghio A, Harrison RM, Hider R, Kelly F, Kooter IM, Marano F, Maynard RL, Mudway I, Nel A, Sioutas C, Smith S, Baeza-Squiban A, Cho A, Duggan S, Froines J. Evaluating the toxicity of airborne particulate matter and nanoparticles by measuring oxidative stress potential—a workshop report and consensus statement. Inhalation Toxicology 2008;20(1):75-99. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) R832413C002 (2008) R832413C003 (2008) R832413C003 (2009) |
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| Journal Article | Oxidative potential of semi-volatile and non volatile particulate matter (PM) from heavy-duty vehicles retrofitted with emission control technologies. | ENVIRONMENTAL SCIENCE & TECHNOLOGY | Biswas S, Verma V, Schauer JJ, Cassee FR, Cho AK, Sioutas C | Biswas S, Verma V, Schauer JJ, Cassee FR, Cho AK, Sioutas C. Oxidative potential of semi-volatile and non volatile particulate matter (PM) from heavy-duty vehicles retrofitted with emission control technologies. Environmental Science & Technology 2009;43(10):3905-3912. |
R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (Final) R832413C003 (2009) R832413C003 (2010) R832413C003 (Final) |
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| Journal Article | Redox activity of airborne particulate matter at different sites in the Los Angeles Basin. | ENVIRONMENTAL RESEARCH | Cho AK, Sioutas C, Miguel AH, Kumagai Y, Schmitz DA, Singh M, Eiguren-Fernandez A, Froines JR | Cho AK, Sioutas C, Miguel AH, Kumagai Y, Schmitz DA, Singh M, Eiguren-Fernandez A, Froines JR. Redox activity of airborne particulate matter at different sites in the Los Angeles Basin. Environmental Research 2005;99(1):40-47. |
R827352 (Final) R827352C001 (Final) R827352C013 (Final) R827352C014 (Final) R832413C003 (2010) R832413C003 (Final) |
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| Journal Article | Comparison of the chemical and oxidative characteristics of particulate matter (PM) collected by different methods: filters, impactors, and biosamplers. | None | Daher N, Ning Z, Cho AK, Shafer M, Schauer JJ, Sioutas C | Daher N, Ning Z, Cho AK, Shafer M, Schauer JJ, Sioutas C. Comparison of the chemical and oxidative characteristics of particulate matter (PM) collected by different methods:filters, impactors, and biosamplers. Aerosol Science and Technology 2011;45(11):1294-1304. |
R832413 (Final) R832413C001 (Final) R832413C003 (Final) |
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| Journal Article | Determination of metal-based hydroxyl radical generating capacity of ambient and diesel exhaust particles. | INHALATION TOXICOLOGY | DiStefano E, Eiguren-Fernandez A, Delfino RJ, Sioutas C, Froines J, Cho AK | DiStefano E, Eiguren-Fernandez A, Delfino RJ, Sioutas C, Froines JR, Cho AK. Determination of metal-based hydroxyl radical generating capacity of ambient and diesel exhaust particles. Inhalation Toxicology 2009;21(9):731-738. |
R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (Final) R832413C003 (2009) R832413C003 (2010) R832413C004 (2010) |
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| Journal Article | Seasonal influence on vapor- and particle-phase polycyclic aromatic hydrocarbon concentrations in school communities located in Southern California. | AEROSOL SCIENCE AND TECHNOLOGY | Eiguren-Fernandez A, Avol EL, Thurairatnam S, Hakami M, Froines JR, Miguel AH | Eiguren-Fernandez A, Avol EL, Thurairatnam S, Hakami M, Froines JR, Miguel AH. Seasonal influence on vapor-and particle-phase polycyclic aromatic hydrocarbon concentrations in school communities located in Southern California. Aerosol Science & Technology 2007;41(4):438-446. |
R827352 (Final) R827352C009 (Final) R827352C013 (Final) R832413 (2008) R832413 (Final) R832413C003 (2007) R832413C003 (2008) R832413C003 (Final) |
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| Journal Article | Atmospheric formation of 9,10-phenanthraquinone in the Los Angeles air basin. | ATMOSPHERIC ENVIRONMENT | Eiguren-Fernandez A, Miguel AH, Lu R, Purvis K, Grant B, Mayo P, Di Stefano E, Cho AK, Froines J | Eiguren-Fernandez A, Miguel AH, Lu R, Purvis K, Grant B, Mayo P, Di Stefano E, Cho AK, Froines J. Atmospheric formation of 9,10-phenanthraquinone in the Los Angeles air basin. Atmospheric Environment 2008;42(10):2312-2319. |
R827352 (Final) R832413 (2007) R832413 (2008) R832413 (Final) R832413C003 (2007) R832413C003 (2008) R832413C003 (2009) R832413C003 (2010) R832413C003 (Final) |
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| Journal Article | Atmospheric distribution of gas- and particle-phase quinones in Southern California. | AEROSOL SCIENCE AND TECHNOLOGY | Eiguren-Fernandez A, Miguel AH, Di Stefano E, Schmitz DA, Cho AK, Thurairatnam S, Avol EL, Froines JR | Eiguren-Fernandez A, Miguel AH, Di Stefano E, Schmitz DA, Cho AK, Thurairatnam S, Avol EL, Froines JR. Atmospheric distribution of gas-and particle-phase quinones in Southern California. Aerosol Science and Technology 2008;42(10):854-861. |
R827352 (Final) R832413 (2008) R832413 (Final) R832413C003 (2009) R832413C003 (2010) R832413C003 (Final) |
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| Journal Article | Redox and electrophilic properties of vapor- and particle-phase components of ambient aerosols. | None | Eiguren-Fernandez A, Shinyashiki M, Schmitz DA, DiStefano E, Hinds W, Kumagai Y, Cho AK, Froines JR | Eiguren-Fernandez A, Shinyashiki M, Schmitz DA, DiStefano E, Hinds W, Kumagai Y, Cho AK, Froines JR. Redox and electrophilic properties of vapor-and particle-phase components of ambient aerosols. Environmental Research 2010;110(3):207-212. |
R832413 (Final) R832413C003 (2010) R832413C003 (Final) R832413C005 (2010) R832413C005 (Final) |
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| Journal Article | Effects of a single intratracheal administration of phenanthraquinone on murine lung. | JOURNAL OF APPLIED TOXICOLOGY | Hiyoshi K, Takano H, Inoue K, Ichinose T, Yanagisawa R, Tomura S, Cho AK, Froines JR, Kumagai Y | Hiyoshi K, Takano H, Inoue K, Ichinose T, Yanagisawa R, Tomura S, Cho AK, Froines JR, Kumagai Y. Effects of a single intratracheal administration of phenanthraquinone on murine lung. Journal of Applied Toxicology 2005;25(1):47-51. |
R827352 (2004) R827352 (Final) R827352C001 (Final) R832413C003 (2010) |
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| Journal Article | Redox activity and chemical speciation of size fractioned PM in the communities of the Los Angeles-Long Beach harbor. | ATMOSPHERIC CHEMISTRY AND PHYSICS | Hu S, Polidori A, Arhami M, Shafer MM, Cho A, Schauer JJ, Sioutas C | Hu S, Polidori A, Arhami M, Shafer MM, Schauer JJ, Cho A, Sioutas C. Redox activity and chemical speciation of size fractioned PM in the communities of the Los Angeles-Long Beach harbor. Atmospheric Chemistry and Physics 2008;8(21):6439-6451. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (Final) R832413C003 (2010) R832413C003 (Final) |
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| Journal Article | Effects of naphthoquinone on airway responsiveness in the presence or absence of antigen in mice. | ARCHIVES OF TOXICOLOGY | Inoue KI, Takano H, Ichinose T, Tomura S, Yanagisawa R, Sakurai M, Sumi D, Cho AK, Hiyoshi K, Kumagai Y | Inoue K-I, Takano H, Ichinose T, Tomura S, Yanagisawa R, Sakurai M, Sumi D, Cho AK, Hiyoshi K, Kumagai Y. Effects of naphthoquinone on airway responsiveness in the presence or absence of antigen in mice. Archives of Toxicology 2007;81(8):575-581. |
R832413 (2007) R832413 (2008) R832413 (Final) R832413C003 (2007) R832413C003 (2008) R832413C003 (2010) |
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| Journal Article | Chemical knockdown of protein-tyrosine phosphatase 1B by 1,2-naphthoquinone through covalent modification causes persistent transactivation of epidermal growth factor receptor. | JOURNAL OF BIOLOGICAL CHEMISTRY | Iwamoto N, Sumi D, Ishii T, Uchida K, Cho AK, Froines JR, Kumagai Y | Iwamoto N, Sumi D, Ishii T, Uchida K, Cho AK, Froines JR, Kumagai Y. Chemical knockdown of protein-tyrosine phosphatase 1B by 1,2-naphthoquinone through covalent modification causes persistent transactivation of epidermal growth factor receptor. Journal of Biological Chemistry 2007;282(46):33396-33404. |
R832413 (2008) R832413 (Final) R832413C003 (2007) R832413C003 (2008) R832413C003 (2010) R832413C003 (Final) |
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| Journal Article | Biochemical and cellular effects of electrophiles present in ambient air samples. | None | Iwamoto N, Nishiyama A, Eiguren-Fernandez A, Hinds W, Kumagai Y, Froines JR, Cho AK, Shinyashiki M | Iwamoto N, Nishiyama A, Eiguren-Fernandez A, Hinds W, Kumagai Y, Froines JR, Cho AK, Shinyashiki M. Biochemical and cellular effects of electrophiles present in ambient air samples. Atmospheric Environment 2010;44(12):1483-1489. |
R832413 (Final) R832413C003 (2010) R832413C003 (Final) R832413C005 (2010) R832413C005 (Final) |
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| Journal Article | 1,2-Naphthoquinone activates vanilloid receptor 1 through increased protein tyrosine phosphorylation, leading to contraction of guinea pig trachea. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Kikuno S, Taguchi K, Iwamoto N, Yamano S, Cho AK, Froines JR, Kumagai Y | Kikuno S, Taguchi K, Iwamoto N, Yamano S, Cho AK, Froines JR, Kumagai Y. 1,2-Naphthoquinone activates vanilloid receptor 1 through increased protein tyrosine phosphorylation, leading to contraction of guinea pig trachea. Toxicology and Applied Pharmacology 2006;210(1-2):47-54. |
R827352 (Final) R827352C001 (Final) R832413C003 (2010) |
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| Journal Article | Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice. | JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION | Kleinman MT, Hamade A, Meacher D, Oldham M, Sioutas C, Chakrabarti B, Stram D, Froines JR, Cho AK | Kleinman MT, Hamade A, Meacher D, Oldham M, Sioutas C, Chakrabarti B, Stram D, Froines JR, Cho AK. Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice. Journal of the Air & Waste Management Association 2005;55(9):1277-1288. |
R827352 (2004) R827352 (Final) R827352C001 (Final) R827352C005 (Final) R827352C014 (Final) R832413C003 (2010) |
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| Journal Article | Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice. | INHALATION TOXICOLOGY | Kleinman MT, Sioutas C, Froines JR, Fanning E, Hamade A, Mendez L, Meacher D, Oldham M | Kleinman MT, Sioutas C, Froines JR, Fanning E, Hamade A, Mendez L, Meacher D, Oldham M. Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice. Inhalation Toxicology 2007;19(Suppl 1):117-126. |
R827352 (Final) R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) R832413C003 (2007) |
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| Journal Article | Intra-community spatial variation of size-fractionated PM mass, OC, EC, and trace elements in the Long Beach, CA area. | ATMOSPHERIC ENVIRONMENT | Krudysz MA, Froines JR, Fine PM, Sioutas C | Krudysz MA, Froines JR, Fine PM, Sioutas C. Intra-community spatial variation of size-fractionated PM mass, OC, EC, and trace elements in the Long Beach, CA area. Atmospheric Environment 2008;42(21):5374-5389. |
R832157 (2007) R832157 (Final) R832413 (2007) R832413 (2008) R832413 (Final) R832413C001 (2007) R832413C001 (Final) R832413C003 (2007) |
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| Journal Article | Generation of reactive oxygen species mediated by humic-like substances in atmospheric aerosols. | ENVIRONMENTAL SCIENCE & TECHNOLOGY | Lin P, Yu JZ | Lin P, Yu JZ. Generation of reactive oxygen species mediated by humic-like substances in atmospheric aerosols. Environmental Science & Technology 2011;45(24):10362-10368. |
R832413C003 (Final) |
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| Journal Article | Relationship between redox activity and chemical speciation of size-fractionated particulate matter. | PARTICLE & FIBRE TOXICOLOGY | Ntziachristos L, Froines JR, Cho AK, Sioutas C | Ntziachristos L, Froines JR, Cho AK, Sioutas C. Relationship between redox activity and chemical speciation of size-fractionated particulate matter. Particle and Fibre Toxicology 2007;4:5 (12 pp.). |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) R832413C003 (2008) R832413C003 (2010) |
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| Journal Article | The interactions of 9,10-phenanthrenequinone with glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a potential site for toxic actions. | CHEMICO-BIOLOGICAL INTERACTIONS | Rodriguez CE, Fukuto JM, Taguchi K, Froines J, Cho AK | Rodriguez CE, Fukuto JM, Taguchi K, Froines J, Cho AK. The interactions of 9,10-phenanthrenequinone with glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a potential site for toxic actions. Chemico-Biological Interactions 2005;155(1-2):97-110. |
R827352 (Final) R827352C001 (Final) R832413C003 (2010) |
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| Journal Article | On the interaction between glyceraldehyde-3-phosphate dehydrogenase and airborne particles: evidence for electrophilic species. | ATMOSPHERIC ENVIRONMENT | Shinyashiki M, Rodriguez CE, Di Stefano EW, Sioutas C, Delfino RJ, Kumagai Y, Froines JR, Cho AK | Shinyashiki M, Rodriguez CE, Di Stefano EW, Sioutas C, Delfino RJ, Kumagai Y, Froines JR, Cho AK. On the interaction between glyceraldehyde-3-phosphate dehydrogenase and airborne particles:evidence for electrophilic species. Atmospheric Environment 2008;42(3):517-529. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2008) R832413C001 (Final) R832413C003 (2007) R832413C003 (2008) R832413C003 (2010) R832413C003 (Final) R832413C004 (2009) R832413C004 (2010) |
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| Journal Article | Electrophilic and redox properties of diesel exhaust particles. | ENVIRONMENTAL RESEARCH | Shinyashiki M, Eiguren-Fernandez A, Schmitz DA, Di Stefano E, Li N, Linak WP, Cho SH, Froines JR, Cho AK | Shinyashiki M, Eiguren-Fernandez A, Schmitz DA, Di Stefano E, Li N, Linak WP, Cho S-H, Froines JR, Cho AK. Electrophilic and redox properties of diesel exhaust particles. Environmental Research 2009;109(3):239-244. |
R832413 (2008) R832413 (Final) R832413C003 (2009) R832413C003 (2010) R832413C003 (Final) R832413C004 (2010) |
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| Journal Article | An approach to evaluate two-electron reduction of 9,10-phenanthraquinone and redox activity of the hydroquinone associated with oxidative stress. | FREE RADICAL BIOLOGY AND MEDICINE | Taguchi K, Fujii S, Yamano S, Cho AK, Kamisuki S, Nakai Y, Sugawara F, Froines JR, Kumagai Y | Taguchi K, Fujii S, Yamano S, Cho AK, Kamisuki S, Nakai Y, Sugawara F, Froines JR, Kumagai Y. An approach to evaluate two-electron reduction of 9,10-phenanthraquinone and redox activity of the hydroquinone associated with oxidative stress. Free Radical Biology and Medicine 2007;43(5):789-799. |
R827352 (Final) R832413C003 (2010) |
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| Journal Article | Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells. | FREE RADICAL BIOLOGY & MEDICINE | Taguchi K, Shimada M, Fujii S, Sumi D, Pan X, Yamano S, Nishiyama T, Hiratsuka A, Yamamoto M, Cho AK, Froines JR, Kumagai Y | Taguchi K, Shimada M, Fujii S, Sumi D, Pan X, Yamano S, Nishiyama T, Hiratsuka A, Yamamoto M, Cho AK, Froines JR, Kumagai Y. Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells. Free Radical Biology and Medicine 2008;44(8):1645-1655. |
R827352 (Final) R832413 (2007) R832413 (2008) R832413C003 (2007) R832413C003 (2008) R832413C003 (2009) R832413C003 (2010) |
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| Journal Article | Redox activity of urban quasi-ultrafine particles from primary and secondary sources. | None | Verma V, Ning Z, Cho AK, Schauer JJ, Shafer MM, Sioutas C | Verma V, Ning Z, Cho AK, Schauer JJ, Shafer MM, Sioutas C. Redox activity of urban quasi-ultrafine particles from primary and secondary sources. Atmospheric Environment 2009;43(40):6360-6368. |
R832413 (Final) R832413C001 (2010) R832413C001 (Final) R832413C003 (Final) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.