Grantee Research Project Results
Journal Publications Details for Grant Number R835738C004
Organotypic Model of Testis as a Platform for Adverse Outcomes Pathway Assessment of Engineered Nanomaterials
RFA:
Organotypic Culture Models for Predictive Toxicology Center (2013)
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Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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Journal Article | Comparison of toxicogenomic responses to phthalate ester exposure in an organotypic testis co-culture model and responses observed in vivo. | REPRODUCTIVE TOXICOLOGY | Harris S, Hermsen SA, Yu X, Hong SW, Faustman EM | Harris S, Hermsen SA, Yu X, Hong SW, Faustman EM. Comparison of toxicogenomic responses to phthalate ester exposure in an organotypic testis co-culture model and responses observed in vivo. Reproductive Toxicology 2015;58:149-159. |
R834514 (Final) R834514C003 (2015) R834514C003 (Final) R835738 (2016) R835738 (2017) R835738C004 (2015) R835738C004 (2017) |
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Journal Article | Phthalate metabolism and kinetics in an in vitro model of testis development. | None | Harris S, Wegner S, Hong SW, Faustman EM | Harris S, Wegner S, Hong SW, Faustman EM. Phthalate metabolism and kinetics in an in vitro model of testis development. Toxicology in Vitro 2016;32:123-131. |
R833772 (2009) R834514 (Final) R834514C003 (Final) R835738 (2016) R835738 (2017) R835738C004 (2015) R835738C004 (2016) R835738C004 (2017) |
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Journal Article | The presence of macrophages and inflammatory responses in an in vitro testicular co-culture model of male reproductive development enhance relevance to in vivo conditions. | None | Harris S, Shubin SP, Wegner S, Van Ness K, Green F, Hong SW, Faustman EM | Harris S, Shubin SP, Wegner S, Van Ness K, Green F, Hong SW, Faustman EM. The presence of macrophages and inflammatory responses in an in vitro testicular co-culture model of male reproductive development enhance relevance to in vivo conditions. Toxicology In Vitro 2016;36:210-215. |
R834514 (Final) R834514C003 (Final) R835738 (2016) R835738 (2017) R835738C004 (2016) R835738C004 (2017) |
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Journal Article | Short-term inhalation study of graphene oxide nanoplates. | None | Kim YH, Jo MS, Kim JK, Shin JH, Baek JE, Park HS, An HJ, Lee JS, Kim BW, KH Kim, Ahn KH, Jeon KS, Oh SM, Lee JH, Workman T, Faustman EM, Yu IJ | Kim YH, Jo MS, Kim JK, Shin JH, Baek JE, Park HS, An HJ, Lee JS, Kim BW, Kim HP, Ahn KH, Jeon KS, Oh SM, Lee JH, Workman T, Faustman EM, Yu IJ. Short-term inhalation study of graphene oxide nanoplates. Nanotoxicology 2018;12(3):224-238. |
R835738 (2017) R835738C001 (2018) R835738C004 (2018) R835738C005 (2018) |
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Journal Article | Tissue distribution of gold and silver after subacute intravenous injection of co-administered gold and silver nanoparticles of similar sizes. | ARCHIVES OF TOXICOLOGY | Lee JH, Sung JH, Ryu HR, Song KS, Song NW, Park HM, Shin BS, Ahn K, Gulumian M, Faustman EM, Yu IJ | Lee JH, Sung JH, Ryu HR, Song KS, Song NW, Park HM, Shin BS, Ahn K, Gulumian M, Faustman EM, Yu IJ. Tissue distribution of gold and silver after subacute intravenous injection of co-administered gold and silver nanoparticles of similar sizes. Archives of Toxicology 2018;92(4):1393-1405. |
R835738 (2017) R835738C004 (2018) |
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Journal Article | Kinetics of Glutathione Depletion and Antioxidant Gene Expression as Indicators of Chemical Modes of Action Assessed in vitro in Mouse Hepatocytes with Enhanced Glutathione Synthesis. | CHEMICAL RESEARCH IN TOXICOLOGY | Melnikov F, Botta D, White CC, Schmuck SC, Schaupp CM, Gallagher EP,Brooks BW, Williams ES, Coish P, Anastas PT, Voutchkova-Kostal A, KostalJ Kavanagh TJ (2018) | Melnikov F, Botta D, White CC, Schmuck SC, Schaupp CM, Gallagher EP, Brooks BW, Williams ES, Coish P, Anastas PT, Voutchkova-Kostal A, Kostal J and Kavanagh TJ. Kinetics of Glutathione Depletion and Antioxidant Gene Expression as Indicators of Chemical Modes of Action Assessed in vitro in Mouse Hepatocytes with Enhanced Glutathione Synthesis. Chemical Research in Toxicology2019:32(3);421-436 |
R835738C001 (2018) R835738C003 (2018) R835738C004 (2018) |
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Journal Article | Characterization of 3D embryonic C57BL/6 and A/J mouse midbrain micromass in vitro culture systems for developmental neurotoxicity testing. | None | Park JJ, Weldon BA, Hong S, Workman T, Griffith WC, Park JH, Faustman EM | Park JJ, Weldon BA, Hong S, Workman T, Griffith WC, Park JH, Faustman EM. Characterization of 3D embryonic C57BL/6 and A/J mouse midbrain micromass in vitro culture systems for developmental neurotoxicity testing. Toxicology In Vitro 2018;48:33-44. |
R835738 (2017) R835738C001 (2018) R835738C004 (2018) R835738C005 (2018) |
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Journal Article | Developing the regulatory utility of the exposome: mapping exposures for risk assessment through lifestage exposome snapshots (LEnS). | ENVIRONMENTAL HEALTH PERSPECTIVES | Shaffer R, Smith MN, Faustman EM | Shaffer R, Smith MN, Faustman EM. Developing the regulatory utility of the exposome: mapping exposures for risk assessment through Lifestage Exposome Snapshots (LEnS). Environmental Health Perspectives 2017;123(8):085003 (8 pp.). |
R835738 (2017) R835738C004 (2018) R835738C005 (2017) |
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Journal Article | Microphysiological systems to assess nonclinical toxicity. | None | Van Ness KP, Chang SY, Weber EJ, Zumpano D, Eaton DL, Kelly EJ | Van Ness KP, Chang SY, Weber EJ, Zumpano D, Eaton DL, Kelly EJ. Microphysiological systems to assess nonclinical toxicity. Current Protocols in Toxicology 2017;73(1):14.18.1-14.18.28. |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) R835738C002 (2018) R835738C004 (2018) R835738C005 (2017) |
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Journal Article | Stage-specific signaling pathways during murine testis development and spermatogenesis: a pathway-based analysis to quantify developmental dynamics. | REPRODUCTIVE TOXICOLOGY | Wegner SH, Yu X, Pacheco Shubin S, Griffith WC, Faustman EM | Wegner SH, Yu X, Pacheco Shubin S, Griffith WC, Faustman EM. Stage-specific signaling pathways during murine testis development and spermatogenesis: a pathway-based analysis to quantify developmental dynamics. Reproductive Toxicology 2015;51:31-39. |
R834514 (2015) R834514 (Final) R834514C003 (2015) R834514C003 (Final) R835738 (2016) R835738 (2017) R835738C004 (2015) R835738C004 (2017) |
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Journal Article | Using primary organotypic mouse midbrain cultures to examine developmental neurotoxicity of silver nanoparticles across two genetic strains. | None | Weldon BA, Park JJ, Hong S, Workman T, Dills R, Lee JH, Griffith WC, Kavanagh TJ, Faustman EM | Weldon BA, Park JJ, Hong S, Workman T, Dills R, Lee JH, Griffith WC, Kavanagh TJ, Faustman EM. Using primary organotypic mouse midbrain cultures to examine developmental neurotoxicity of silver nanoparticles across two genetic strains. Toxicology and Applied Pharmacology 2018:354;215-224 |
R835738 (2017) R835738C004 (2017) R835738C004 (2018) R835738C005 (2017) R835738C005 (2018) |
|
Journal Article | Tissue Distribution of Gold and Silver after Subacute Intravenous Injection of Co-administered Gold and Silver Nanoparticles of similar sizes. | None | Lee JH, Sung JH, Ryu HR, Song KS, Song NW, Park HM, Shin BS, Ahn K, Gulumian M, Faustman EM, Yu IJ | Lee JH, Sung JH, Ryu HR, Song KS, Song NW, Park HM, Shin BS, Ahn K, Gulumian M, Faustman EM, Yu IJ. Tissue Distribution of Gold and Silver after Subacute Intravenous Injection of Co-administered Gold and Silver Nanoparticles of similar sizes. Archives of Toxicology 2018:92(4);1393-1405 |
R835738C004 (2018) R835738C005 (2018) |
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Journal Article | In vitro to in vivo benchmark dose comparisons to inform risk assessment of quantum dot nanomaterials. | None | Weldon BA, Griffith WC, Workman T, Scoville DK, Kavanagh TJ, Faustman EM | Weldon BA, Griffith WC, Workman T, Scoville DK, Kavanagh TJ, Faustman EM. 2018. In vitro to in vivo benchmark dose comparisons to inform risk assessment of quantum dot nanomaterials. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology 2018;10(4):e1507. |
R835738 (2017) R835738C001 (2018) R835738C004 (2017) R835738C004 (2018) R835738C005 (2017) R835738C005 (2018) |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.