Grantee Research Project Results
Final Report: Using an Exposome Approach to Assess the Effects of PM2.5 on CVD Outcomes
EPA Grant Number: R839275Title: Using an Exposome Approach to Assess the Effects of PM2.5 on CVD Outcomes
Investigators: Juarez, Paul D , Hood, Darryl
Institution: Meharry Medical College
EPA Project Officer: Hahn, Intaek
Project Period: January 1, 2018 through December 31, 2020 (Extended to December 31, 2021)
Project Amount: $800,000
RFA: Using a Total Environment Framework (Built, Natural, Social Environments) to Assess Life-long Health Effects of Chemical Exposures (2017) RFA Text | Recipients Lists
Research Category: Human Health
Objective:
1. To curate and link longitudinal, geo-coded measures of PM2.5 and heat metrics, chemical and non-chemical exposures from the natural, built, and social environments, data on inherent personal characteristics, and activities/behaviors among participants in the Southern Community Cohort Study (SCCS) with clinical measures of cardiovascular health outcomes and population measures of cardiovascular disease (CVD) disparities.
2. Use advanced graph-theoretical computational tools, augmented with more conventional biostatistics, to elucidate latent, combined, cumulative, and interactive relationships between measures of PM2.5, heat metrics, environmental exposures, personal characteristics, and activities/behaviors with cardiovascular health outcomes and racial disparities among SCCS participants.
3. To model the mechanisms and pathways through which multiple, interactive, and cumulative risks for PM2.5 and heat metrics, chemical and non-chemical stressors from the natural, social, and built environments and personal characteristics and behaviors adversely impact the progression of cardiovascular health outcomes among SCCS participants and population-level health disparities by race and gender.
Summary/Accomplishments (Outputs/Outcomes):
-
-
- Co-investigators continue to meet via weekly Zoom videoconferences (Thurs at 3:00 – 4:30 pm CST).
- Crosswalks created between PM5, heat metrics, and census tracts for 12 southeastern states created
- PHE database expanded to 62,000 variables
- PHE database updated to 2018 – 2021
- Six (6) publications submitted/under review
- Invited, Standing Member, Clinical Trials Review Study Section (CLTR), Heart, Lung, and Blood Initial Review Group (HLB), NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (NHLBI), 07/01/2022 - 06/30/202
- Met with SCCS leadership to discuss application of Artificial Intelligence/Machine Learning tools to SCCS data
- PD Juarez participated on two study sections
- M. A. Langston participated in two NIH study sections, two NSF scientific panels, and three DOD CDMRP review panels
- A. Ramesh participated in four NIH study sections, two NIOSH review panels, and 1DOD CDMRP review panel
-
Journal Articles on this Report : 3 Displayed | Download in RIS Format
| Other project views: | All 21 publications | 11 publications in selected types | All 9 journal articles |
|---|
| Type | Citation | ||
|---|---|---|---|
|
|
Grady S, Dojcsak L, Harvile E, Wallace M, Vilda D, Donneyong M, Hood D, Valdez R, Ramesh A, Im W, Matthews-Juarez P, Juarez P, Langston M. Seminar:Scalable Preprocessing Tools for Exposomic Data Analysis. ENVIRONMENTAL HEALTH PERSPECTIVES 2023;131(12):124201. |
R839275 (Final) |
|
|
|
Juarez PD, Matthews-Juarez P. Applying an Exposome-Wide (ExWAS) Approach to Cancer Research. Frontiers in Oncology 2018;8(313) |
R839275 (2018) R839275 (2019) R839275 (2020) R839275 (Final) |
Exit |
|
|
Juarez PD, Hood DB, Song MA, Ramesh A. Use of an exposome approach to understand the effects of exposures from the natural, built, and social environments on cardio-vascular disease onset, progression, and outcomes. Frontiers in public health 2020;8. |
R839275 (2020) R839275 (Final) |
Exit |
Supplemental Keywords:
Heat Metrics, environmental exposure, exposome, Minimum/maximum temperature, heat index, combinatorial analysis, paracliques
Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.