Grantee Research Project Results
2020 Progress Report: Using an Exposome Approach to Assess the Effects of PM2.5 on CVD Outcomes
EPA Grant Number: R839275Title: Using an Exposome Approach to Assess the Effects of PM2.5 on CVD Outcomes
Investigators: Juarez, Paul D , Hood, Darryl
Institution: Meharry Medical College
EPA Project Officer: Hahn, Intaek
Project Period: January 1, 2018 through December 31, 2020 (Extended to December 31, 2021)
Project Period Covered by this Report: January 1, 2020 through December 31,2020
Project Amount: $800,000
RFA: Using a Total Environment Framework (Built, Natural, Social Environments) to Assess Life-long Health Effects of Chemical Exposures (2017) RFA Text | Recipients Lists
Research Category: Human Health
Objective:
To curate and link longitudinal, geo-coded, measures of PM2.5 and heat metrics, chemical and non-chemical exposures from the natural, built, and social environments, and data on inherent personal characteristics, activities/behaviors among participants in the SCCS, with clinical measures of cardiovascular health outcomes, and population measures of CVD disparities.
To use advanced graph-theoretical computational tools, augmented with more conventional biostatistics, to elucidate latent, combined, cumulative and interactive relationships between measures of PM2.5, heat metrics, environmental exposures, personal characteristics and activities/behaviors with cardiovascular health outcomes and disparities among SCCS participants across the southeast.
To model the mechanisms and pathways through which multiple, interactive and cumulative risks for PM2.5 and heat metrics, chemical and non-chemical stressors from the natural, social, and built environments and personal characteristics and behaviors adversely impact the progression of cardiovascular health outcomes among SCCS participants and population-level health disparities by race and gender across 12 southeastern states.
Progress Summary:
Co-investigators continue to meet via weekly Zoom videoconferences (Thurs at 3:00 – 4:30 pm CST). PHE database updated to 2018 – 2021. PHE database expanded to 62,000 variables. Cross walks between PM5, heat metrics and census tracts for 12 southeastern states created.
Southern Community Cohort Study participants residential addresses were linked to daily 1-km grid cells for heat metrics (min/max temperature, heat index). Approximately 15,000 additional environmental variables added to the public health exposome data base bringing the total # of variables to over 50,000. Meta-data dictionary updated.
- 8 articles published
- 4 articles in preparation
- 2 presentations at national conferences
Future Activities:
- Request submitted to SCCS for data on respiratory disease.
- Publications in proccess
Journal Articles on this Report : 8 Displayed | Download in RIS Format
| Other project views: | All 21 publications | 11 publications in selected types | All 9 journal articles |
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Cifuentes P, Reichard J, Im W, Smith S, Colen C, Giurgescu C, Williams KP, Gillespie S, Juarez PD, Hood DB. Application of the Public Health Exposome Framework to Estimate Phenotypes of Resilience in a Model Ohio African-American Women’s Cohort. Journal of Urban Health 2019;96:57-71 |
R839275 (2018) R839275 (2019) R839275 (2020) |
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Felix AS, Lehman A, Nolan TS, Sealy-Jefferson S, Breathett K, Hood DB, Addison D, Anderson CM, Cené CW, Warren BJ, Jackson RD, Williams KP. Stress, Resilience, and Cardiovascular Disease Risk Among Black Women. Circ Cardiovasc Qual Outcomes 2019;12(4):e005284 |
R839275 (2018) R839275 (2019) R839275 (2020) |
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Giurgescu C, Nowak A, Gillespie S, Nolan T, Anderson C, Ford J, Hood DB, Williams KP. Neighborhood environment and DNA methylation:Implications for Cardiovascular Disease Risk. Journal of Urban Health 2019;96(Suppl 1):23-34 |
R839275 (2018) R839275 (2019) R839275 (2020) |
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Juarez PD, Matthews-Juarez P. Applying an Exposome-Wide (ExWAS) Approach to Cancer Research. Frontiers in Oncology 2018;8(313) |
R839275 (2018) R839275 (2019) R839275 (2020) R839275 (Final) |
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Juarez PD, Hood DB, Song MA, Ramesh A. Use of an exposome approach to understand the effects of exposures from the natural, built, and social environments on cardio-vascular disease onset, progression, and outcomes. Frontiers in public health 2020;8. |
R839275 (2020) R839275 (Final) |
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Lu Y, Phillips CA, Langston MA. Biclique:an R package for maximal biclique enumeration in bipartite graphs. BMC Research Notes 2020;13(1):1-5. |
R839275 (2019) R839275 (2020) |
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Donneyong MM, Chang TJ, Jackson JW, Langston MA, Juarez PD, Sealy-Jefferson S, Lu B, Im W, Valdez RB, Way BM, Colen C. Structural and Social Determinants of Health Factors Associated with County-Level Variation in Non-Adherence to Antihypertensive Medication Treatment. International journal of environmental research and public health 2020;17(18):6684. |
R839275 (2020) |
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Juarez PD, Tabatabai M, Burciaga Valdez R, Hood DB, Im W, Mouton C, Colen C, Al-Hamdan MZ, Matthews-Juarez P, Lichtveld MY, Sarpong D. The Effects of Social, Personal, and Behavioral Risk Factors and PM2. 5 on Cardio-Metabolic Disparities in a Cohort of Community Health Center Patients. International Journal of Environmental Research and Public Health 2020;17(10):3561. |
R839275 (2020) |
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Supplemental Keywords:
Heat Metrics, environmental exposure, exposome, Minimum/maximum temperature, heat index, combinatorial analysis, paracliquesProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.