Grantee Research Project Results

2019 Progress Report: Using an Exposome Approach to Assess the Effects of PM2.5 on CVD Outcomes

EPA Grant Number: R839275
Title: Using an Exposome Approach to Assess the Effects of PM2.5 on CVD Outcomes
Investigators: Juarez, Paul D , Hood, Darryl
Institution: Meharry Medical College
EPA Project Officer: Hahn, Intaek
Project Period: January 1, 2018 through December 31, 2020 (Extended to December 31, 2021)
Project Period Covered by this Report: January 1, 2019 through December 31,2019
Project Amount: $800,000
RFA: Using a Total Environment Framework (Built, Natural, Social Environments) to Assess Life-long Health Effects of Chemical Exposures (2017) RFA Text | Recipients Lists
Research Category: Human Health

Objective:

To curate and link longitudinal, geo-coded, measures of PM2.5 and heat metrics, chemical and non-chemical exposures from the natural, built, and social environments, and data on inherent personal characteristics, activities/behaviors among participants in the SCCS, with clinical measures of cardiovascular health outcomes, and population measures of CVD disparities.

To use advanced graph-theoretical computational tools, augmented with more conventional biostatistics, to elucidate latent, combined, cumulative and interactive relationships between measures of PM2.5, heat metrics, environmental exposures, personal characteristics and activities/behaviors with cardiovascular health outcomes and disparities among SCCS participants across the southeast.

To model the mechanisms and pathways through which multiple, interactive and cumulative risks for PM2.5 and heat metrics, chemical and non-chemical stressors from the natural, social, and built environments and personal characteristics and behaviors adversely impact the progression of cardiovascular health outcomes among SCCS participants and population-level health disparities by race and gender across 12 southeastern states.

Progress Summary:

1. Outputs
  1. Co-investigators continue to meet via weekly Zoom videoconferences (Thurs at 3:00 – 4:30 pm CST).
  2. Southern Community Cohort Study participants residential addresses were linked to daily 1-km grid cells for heat metrics (min/max temperature, heat index)
  3. Approximately 15,000 additional environmental variables added to the public health exposome data base bringing the total # of variables to over 50,000.
  4. Meta-data dictionary updated
  5. Three (3) Research grants (U54 renewal application, P01, and R01) submitted using an Exposome-wide Association Study approach

1. Outcomes
  1. 1 Annual investigator meeting convened, August 11-13, 2018, Columbus, OH.
  2. 1 Annual EPA STAR grantees conference attended
  3. 7 presentations at national conferences.
  4. 2 articles currently under review
  5. 6 articles published

Future Activities:

Future Research Activities:

Link 24,000 public health exposome, PM2.5, and heat metrics data (daily, 1-km gridded data of minimum/maximum temperature and heat index) to SCCS survey data at enrollment.
Link longitudinal public health exposome, PM2.5, and heat metrics to 4 waves of SCCS survey data. (2002-2019).
Conduct undifferentiated combinatorial analytics to identify paracliques in combined PHE/PM2.5/heat metrics/SCCS survey data
Incorporate Medicaid/Medicare claims data into data base/analyses.
Incorporate Death Index files into data base/analyses.
Engage post-doctoral fellows and graduate students in research activities.
Year one budget carryovers from OSU, UT Knoxville and USRA were completed. All other budget items are in line with the 3-year approved budget. No significant variations from the approved budget are anticipated.

Journal Articles on this Report : 5 Displayed | Download in RIS Format

Publications Views
Other project views:	All 21 publications	11 publications in selected types	All 9 journal articles

Publications
Type	Citation	Project	Document Sources
Journal Article	Cifuentes P, Reichard J, Im W, Smith S, Colen C, Giurgescu C, Williams KP, Gillespie S, Juarez PD, Hood DB. Application of the Public Health Exposome Framework to Estimate Phenotypes of Resilience in a Model Ohio African-American Women’s Cohort. Journal of Urban Health 2019;96:57-71	R839275 (2018) R839275 (2019) R839275 (2020)	Abstract from PubMed Full-text: Springer - Full Text HTML Exit
Journal Article	Felix AS, Lehman A, Nolan TS, Sealy-Jefferson S, Breathett K, Hood DB, Addison D, Anderson CM, Cené CW, Warren BJ, Jackson RD, Williams KP. Stress, Resilience, and Cardiovascular Disease Risk Among Black Women. Circ Cardiovasc Qual Outcomes 2019;12(4):e005284	R839275 (2018) R839275 (2019) R839275 (2020)	Abstract from PubMed Full-text: AHA Journal- Full Text HTML Exit Abstract: AHA Journals - Abstract HTML Exit
Journal Article	Giurgescu C, Nowak A, Gillespie S, Nolan T, Anderson C, Ford J, Hood DB, Williams KP. Neighborhood environment and DNA methylation:Implications for Cardiovascular Disease Risk. Journal of Urban Health 2019;96(Suppl 1):23-34	R839275 (2018) R839275 (2019) R839275 (2020)	Abstract from PubMed Other: Springer - Full Text HTML Exit
Journal Article	Juarez PD, Matthews-Juarez P. Applying an Exposome-Wide (ExWAS) Approach to Cancer Research. Frontiers in Oncology 2018;8(313)	R839275 (2018) R839275 (2019) R839275 (2020) R839275 (Final)	Full-text from PubMed Abstract from PubMed Associated PubMed link Full-text: Frontiers in Oncology - Full Text HTML Exit
Journal Article	Lu Y, Phillips CA, Langston MA. Biclique:an R package for maximal biclique enumeration in bipartite graphs. BMC Research Notes 2020;13(1):1-5.	R839275 (2019) R839275 (2020)	Full-text from PubMed Abstract from PubMed Full-text: BMC - Full Text HTML Exit Other: `BMC - Full Text PDF Exit

Supplemental Keywords:

Heat Metrics, environmental exposure, exposome, Minimum/maximum temperature, heat index, combinatorial analysis, paracliques

Progress and Final Reports:

Original Abstract

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.