Grantee Research Project Results
Using an Exposome Approach to Assess the Effects of PM2.5 on CVD Outcomes
EPA Grant Number: R839275Title: Using an Exposome Approach to Assess the Effects of PM2.5 on CVD Outcomes
Investigators: Juarez, Paul D , Hood, Darryl
Institution: Meharry Medical College
EPA Project Officer: Hahn, Intaek
Project Period: January 1, 2018 through December 31, 2020 (Extended to December 31, 2021)
Project Amount: $800,000
RFA: Using a Total Environment Framework (Built, Natural, Social Environments) to Assess Life-long Health Effects of Chemical Exposures (2017) RFA Text | Recipients Lists
Research Category: Human Health
Description:
The overall aim of this proposal is to assess the latent, combined, cumulative and interactive effects of PM2.5 and heat metrics, together with other chemical and non-chemical stressors from the natural, built, and social environments, and inherent personal characteristics, activities, and behaviors, on the progression of cardiovascular health and population-level, disparities, over time and space.
Objective:
Study objectives are: 1. To curate and link longitudinal, geocoded, measures of PM2.5 and heat metrics, chemical and non-chemical exposures from the natural, built, and social environments, and data on inherent personal characteristics, activities/behaviors among participants in the SCCS, with clinical measures of cardiovascular health outcomes, and population measures of CVD disparities; 2. To use advanced graphtheoretical computational tools, augmented with more conventional biostatistics, to elucidate latent, combined, cumulative and interactive relationships between measures of PM2.5, heat metrics, environmental exposures, personal characteristics and activities/behaviors with cardiovascular health outcomes and disparities among SCCS participants across the southeast; and 3. To model the mechanisms and pathways through which multiple, interactive and cumulative risks for PM2.5 and heat metrics, chemical and non-chemical stressors from the natural, social, and built environments and personal characteristics and behaviors adversely impact the progression of cardiovascular health outcomes among SCCS participants and population-level health disparities by race and gender across 12 southeastern states.
Approach:
To do so, we will link four categories of existing data that cover the years 2002- 2016 for 12-southeastern states: 1) spatially and temporally continuous, daily measures of PM2.5 (3 km grid) and heat metrics (1 km grid); 2) annual county measures from over 30,000 chemical and non-chemical exposures from the natural, built, and social environments; 3) four waves of survey data on inherent personal characteristics, activities/behaviors among 85,000 adult participants in the Southern Community Cohort Study (SCCS), and 4) linked measures of CVD health from Medicaid, Medicare, and Death Index files.
Expected Results:
The results of this study are expected to demonstrate the effectiveness of using a total environment framework (natural, built and social environments) in assessing life-long effects of chemical and non-chemical environmental exposures on cardio-vascular disease.
Publications and Presentations:
Publications have been submitted on this project: View all 21 publications for this projectJournal Articles:
Journal Articles have been submitted on this project: View all 9 journal articles for this projectSupplemental Keywords:
Exposome, cohort, PM2.5, natural, built, social and policy environments, cardiovascular disease (CVD), graph-theoretical algorithms, survival analysis.Progress and Final Reports:
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.