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Records 1 to 25 of 206 records from [ORD-NCCT] from author Keith Houck

2020
Borrel, A., R. Huang, S. Sakamuru, M. Xia, A. Simeonov, K. Mansouri, K. Houck, R. Judson, AND N. Kleinstreuer. High-Throughput Screening to Predict Chemical-Assay Interference. Scientific Reports. Nature Publishing Group, London, Uk, 10:3986, (2020). https://doi.org/10.1038/s41598-020-60747-3
Zurlinden, T., K. Saili, N. Rush, P. Kothiya, R. Judson, K. Houck, E. Hunter, N. Baker, J. Palmer, R. Thomas, AND T. Knudsen. Profiling the ToxCast Library With a Pluripotent Human (H9) Stem Cell Line-Based Biomarker Assay for Developmental Toxicity. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 174(2):189-209, (2020). https://doi.org/10.1093/toxsci/kfaa014
Judson, R., K. Houck, K. Friedman, J. Brown, P. Browne, P. Johnston, D. Close, K. Mansouri, AND N. Kleinstreuer. Selecting a Minimal set of Androgen Receptor Assays for Screening Chemicals. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 117(November 2020):104764, (2020). https://doi.org/10.1016/j.yrtph.2020.104764
2019
Grulke, C., A. Williams, J. Wambaugh, R. Judson, K. Houck, AND K. Friedman. 20190825 - High-throughput experimental and computational technologies at the National Center for Computational Toxicology (ACS Fall 2019). American Chemical Society Fall Meeting, San Diego, CA, August 25 - 29, 2019. https://doi.org/10.23645/epacomptox.9902693
Wetmore, B., R. Clewell, B. Cholewa, B. Parks, S. Pendse, M. Black, K. Mansouri, S. Haider, E. Berg, R. Judson, K. Houck, M. Martin, H. Clewell III, M. Andersen, R. Thomas, AND P. McMullen. Assessing Bioactivity-Exposure Profiles of Fruits and Vegetables in the BioMAP Profiling System. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 54:41-57, (2019). https://doi.org/10.1016/j.tiv.2018.09.006
Li, S., J. Zhao, R. Huang, M. Santillo, K. Houck, AND M. Xia. Characterization of Organophosphorous Pesticides on Acetylcholinesterase Inhibition Using In Vitro Assays with Xenobiotic Metabolic Capability. Presented at Society of Toxicology 58th Annual Meeting & ToxExpo, Baltimore, MD, March 10 - 14, 2019. https://doi.org/10.1016/j.tiv.2019.01.002
Paul-Friedman, K., M. Martin, K. Crofton, C. Hsu, S. Sakamuru, J. Zhao, M. Xia, R. Huang, D. Stevreva, V. Soni, L. Varticovski, R. Raziuddin, G. Hager, AND K. Houck. Limited chemical structural diversity found to modulate thyroid hormone receptor in the Tox21 chemical library. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 127(9):1-16, (2019). https://doi.org/10.1289/EHP5314
Simha, A., K. Houck, C. Lalone, A. Bone, R. Judson, M. Martin, D. Villeneuve, G. Ankley, A. Medvedev, AND S. Makarov. Novel In Vitro Approach to Assess Multiple Species’ Susceptibility to Potential Endocrine Disruptors. Presented at Endocrine Disruption conference at NIEHS, RTP, NC, April 05, 2019. https://doi.org/10.23645/epacomptox.8023451
Borrel, A., R. Huang, M. Xia, A. Simeonov, R. Judson, K. Houck, AND N. Kleinstreuer. Predicting Chemical-Assay Interference Using Tox21 HTS Data. Presented at Society of Toxicology annual meeting, Baltimore, MD, March 10 - 14, 2019.
Judson, R., R. Thomas, N. Baker, A. Simha, X. Howey, C. Marable, N. Kleinstreuer, AND K. Houck. Workflow for Defining Reference Chemicals for Assessing Performance of In Vitro Assays. ALTEX. Society ALTEX Edition, Kuesnacht, Switzerland, 36(2):261-276, (2019). https://doi.org/10.14573/altex.1809281
Simha, A., R. Judson, R. Thomas, N. Baker, X. Howey, C. Marable, N. Kleinstreuer, AND K. Houck. Workflow for Defining Reference Chemicals to Assess Performance of In Vitro Assays. Presented at Society of Toxicology Annual Meeting, Baltimore, MD, March 10 - 14, 2019. https://doi.org/10.23645/epacomptox.7874000
2018
Kuo, B., J. Wills, P. White, F. Marchetti, A. Nong, A. Williams, K. Houck, R. Tice, AND C. Yauk. A High-throughput Analytical Framework for Efficient Analysis of In Vitro Micronucleus (MN) Dose-response Data. Health Canada Science Forum, OttawaC, March 08 - 09, 2018. https://doi.org/10.23645/epacomptox.6947897
Houck, K. Chemical Prioritization Methods for Nuclear Receptor Modulators at the U.S. EPA. Presented at EDTA International Symposium, Seoul, N/A, SOUTH KOREA, November 09, 2018. https://doi.org/10.23645/epacomptox.7388282
Xia, M., R. Huang, Q. Shi, W. Boyd, J. Zhao, N. Sun, J. Rice, P. Dunlap, A. Hackstadt, M. Bridge, M. Smith, S. Dai, W. Zheng, P. Chu, D. Gerhold, K. Witt, M. DeVito, J. Freeman, C. Austin, K. Houck, R. Thomas, R. Paules, R. Tice, AND A. Simeonov. Comprehensive analyses and prioritization of Tox21 10K chemicals affecting mitochondrial function by in-depth mechanistic studies. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 126(7):1-16, (2018). https://doi.org/10.1289/EHP2589
Sipes, N., R. Huang, K. Shockley, M. Martin, R. Judson, K. Houck, A. Shapiro, J. Addington, S. Auerbach, H. Hong, R. Paules, AND J. Hsieh. Concordance in Modeling Concentration-Response Data: Tox21 10k Library Pipeline Comparison. Presented at OpenTox USA, RTP, NC, July 11 - 12, 2018.
Sipes, N., R. Huang, K. Shockley, M. Martin, A. Shapiro, J. Addington, S. Auerbach, R. Paules, R. Judson, K. Houck, H. Hong, AND J. Hsieh. Confidence in Fitting and Hitting Concentration-Response Data: Tox21 10k Library Pipeline Comparison. Presented at Society of Toxicology Annual Meeting, San Antonio, TX, March 11 - 15, 2018. https://doi.org/10.23645/epacomptox.6945911
Mahapatra, D., Jill A. Franzosa, K. Roell, M. Kuenemann, Keith A. Houck, D. Reif, D. Fourches, AND S. Kullman. Confirmation of High-Throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays. Scientific Reports. Nature Publishing Group, London, Uk, 8(8883):1-16, (2018). https://doi.org/10.1038/s41598-018-27055-3
Flood, S. AND K. Houck. Development and Distribution of Test Method Documentation for ToxCast HTT Assays. Presented at SETAC North America Focused Topic Meeting : High-Throughput Screening, Durham, NC, April 16 - 18, 2018. https://doi.org/10.23645/epacomptox.6948023
Flood, S. AND K. Houck. Development and Distribution of ToxCast and Tox21 HTS Assay Method Descriptions. CompTox Communities of Practice, RTP,NC, January 25, 2018.
Medvedev, A., M. Moeser, L. Medvedeva, E. Martsen, A. Granick, L. Raines, M. Zeng, S. Makarov Jr., K. Houck, AND S. Makarov. Evaluating biological activity of compounds by transcription factor activity profiling. Science Advances. American Association for the Advancement of Science (AAAS), Washington, DC, 4(9):eaar4666, (2018).
Houck, K. AND A. Bone. Filling in the Gaps: The Role Functional Genomics Can Play in 21st Century Toxicology. Presented at Society of Toxicology Meeting, San Antonio, TX, March 11 - 15, 2018. https://doi.org/10.23645/epacomptox.6946166
Judson, R., K. Paul-Friedman, K. Houck, K. Mansouri, P. Browne, AND N. Kleinstreuer. New Approach Methods for Testing Chemicals for Endocrine Disruption Potential. Current Opinion in Toxicology. Elsevier BV, AMSTERDAM, Netherlands, 9:40-47, (2018). https://doi.org/10.1016/j.cotox.2018.10.002
Houck, K., A. Bone, K. Paul-Friedman, C. Hsu, S. Sakamuru, M. Xia, R. Huang, V. Soni, D. Stavreva, AND K. Crofton. Screening the 10K Tox21 chemical library for thyroid hormone receptor modulators. Society of Toxicology, San Antonio, TX, March 11 - 15, 2018.