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Filling in the Gaps: The Role Functional Genomics Can Play in 21st Century Toxicology
Citation:
Houck, K. AND A. Bone. Filling in the Gaps: The Role Functional Genomics Can Play in 21st Century Toxicology. Presented at Society of Toxicology Meeting, San Antonio, TX, March 11 - 15, 2018. https://doi.org/10.23645/epacomptox.6946166
Impact/Purpose:
Presentation at Society of Toxicology Meeting Mar 2018
Description:
Chemical screening programs such as Tox21 and ToxCast have demonstrated the value of using quantitative, high-throughput assays to produce data for regulatory decisions. While these efforts have covered an impressive amount of biological space, with over 1000 endpoints analyzed in ToxCast, these approaches are limited by our incomplete knowledge of toxicity pathways and gene targets. Addressing these data gaps using high-throughput transcriptomics is an increasingly affordable option; however, observed gene transcription changes do not provide direct data on functional impacts of chemical exposure. Functional genomics and proteomics techniques cover a comprehensive biological space and provide a functional endpoint to support involvement of genes and pathways in toxicological effects. With the advent of CRISPR-Cas9 technology, functional genomic approaches in human cells are well positioned to increase the scope and applicability of high-throughput screening efforts. The first presentation will be an overview of the history of functional genomic technologies with a look forward into the role they could play in toxicology as an introduction to this session. This abstract does not necessarily reflect US EPA policy.
URLs/Downloads:
DOI: Filling in the Gaps: The Role Functional Genomics Can Play in 21st Century Toxicology
SOT_FXNGEN_2018_HOUCK_FINAL.PDF (PDF, NA pp, 1894.516 KB, about PDF)