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Chemical Prioritization Methods for Nuclear Receptor Modulators at the U.S. EPA
Citation:
Houck, K. Chemical Prioritization Methods for Nuclear Receptor Modulators at the U.S. EPA. Presented at EDTA International Symposium, Seoul, N/A, SOUTH KOREA, November 09, 2018. https://doi.org/10.23645/epacomptox.7388282
Impact/Purpose:
Invited presentation to the Endocrine Disrupting Chemicals International Symposium at Dongguk University in Seoul South Korea.
Description:
In vitro/alternative and computational approaches are valuable for chemical prioritization, especially where we understand the targets and toxicity pathways. Nuclear receptors are an inherently important target of environmental chemicals. Endocrine disruption is one important mode of action mediated by NR’s but there are many more receptors with varied, important physiology. Using high-throughput approaches will require systematically addressing key technical and data analysis challenges like assay interferences, selective receptor modulators, and cytotoxicity.
URLs/Downloads:
DOI: Chemical Prioritization Methods for Nuclear Receptor Modulators at the U.S. EPA
HOUCK_DONGGUK_V2_M.PDF (PDF, NA pp, 9787.063 KB, about PDF)