Science Inventory

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Wetmore, B., K. Paul-Friedman, K. Carstens, J. Harrill, J. Wambaugh, T. Shafer, K. Houck, R. Judson, AND G. Patlewicz. Category-based toxicity and toxicokinetic evaluations of per- and polyfluoroalkyl substances (PFAS) for new approach method (NAM) application. ACS, San Francisco, CA, August 13 - 17, 2023. https://doi.org/10.23645/epacomptox.23845122

Wetmore, B., K. Friedman, K. Carstens, J. Harrill, J. Wambaugh, T. Shafer, K. Houck, R. Judson, AND G. Patlewicz. Category-based toxicity and toxicokinetic evaluations of per- and polyfluoroalkyl substances (PFAS) for new approach method (NAM) application (SERMACS 2023). SERMACS, Durham, NC, October 25 - 28, 2023. https://doi.org/10.23645/epacomptox.24790650

Patlewicz, G., K. Friedman, K. Houck, L. Zhang, R. Huang, M. Xia, J. Brown, AND S. Simmons. Evaluating the utility of a high throughput thiol-containing fluorescent probe to screen for reactivity: A case study with the Tox21 library. Computational Toxicology. Elsevier B.V., Amsterdam, Netherlands, 26:100271, (2023). https://doi.org/10.1016/j.comtox.2023.100271

Houck, K., K. Friedman, M. Feshuk, G. Patlewicz, M. Smeltz, M. Clifton, B. Wetmore, S. Velichko, A. Berenyi, AND E. Berg. Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells. ALTEX. Society ALTEX Edition, Kuesnacht, Switzerland, 40(2):248-270, (2023). https://doi.org/10.14573/altex.2203041

Villeneuve, D., B. Blackwell, J. Cavallin, J. Collins, J. Hoang, R. Hofer, K. Houck, K. Jensen, M. Kahl, R. Kutsi, A. Opseth, K. Santana Rodriguez, C. Schaupp, E. Stacy, AND G. Ankley. In vivo effects of four per- and polyfluoroalkyl substances identified as estrogenic via in vitro screening. Society of Toxicology 62nd Annual Meeting, Nashville, TN, March 19 - 23, 2023. https://doi.org/10.23645/epacomptox.24749445

Villeneuve, D., B. Blackwell, J. Cavallin, J. Collins, J. Hoang, R. Hofer, K. Houck, K. Jensen, M. Kahl, R. Kutsi, A. Opseth, K. Santana Rodriguez, C. Schaupp, E. Stacy, AND G. Ankley. Verification of In Vivo Estrogenic Activity for Four Per- and Polyfluoroalkyl Substances (PFAS) Identified as Estrogen Receptor Agonists via New Approach Methodologies. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 57(9):3794-3803, (2023). https://doi.org/10.1021/acs.est.2c09315

Korunes, K., J. Liu, R. Huang, M. Xia, K. Houck, AND C. Corton. A gene expression biomarker for predictive toxicology to identify chemical modulators of NF-κB. PLOS ONE . Public Library of Science, San Francisco, CA, 17(2):e0261854, (2022). https://doi.org/10.1371/journal.pone.0261854

Kuo, B., M. Beal, J. Wills, P. White, F. Marchetti, A. Nong, T. Barton-Maclaren, K. Houck, AND C. Yauk. Comprehensive interpretation of in vitro micronucleus test results for 292 chemicals: from hazard identification to risk assessment application. Archives of Toxicology. Springer, New York, NY, 96(7):2067-2085, (2022). https://doi.org/10.1007/s00204-022-03286-2

Judson, R., D. Reif, K. Houck, T. Knudsen, J. Harrill, AND K. Paul-Friedman. Principles of Toxicology: Environmental and Industrial Applications, 4th Edition - Chapter 6: Computational Toxicology. Chapter 6, Principles of Toxicology: Environmental and Industrial Applications, 4th Edition. John Wiley & Sons, Inc., Hoboken, NJ, , 143-157, (2022).

Han, J., W. Gu, H. Barrett, D. Yang, S. Tang, J. Sun, J. Liu, H. Krause, K. Houck, AND H. Peng. A Roadmap to the Structure-Related Metabolism Pathways of Per- and Polyfluoroalkyl Substances in the Early Life Stages of Zebrafish (Danio rerio). ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 129(7):077004, (2021). https://doi.org/10.1289/EHP7169

Houck, K., A. Simha, A. Bone, J. Doering, S. Vliet, C. LaLone, A. Medvedev, AND S. Makarov. Evaluation of a Multiplexed, Multispecies Nuclear Receptor Assay for Chemical Hazard Assessment. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 72:105016, (2021). https://doi.org/10.1016/j.tiv.2020.105016

Qu, W., D. Crizer, M. DeVito, S. Waidyanatha, M. Xia, K. Houck, AND S. Ferguson. Exploration of Xenobiotic Metabolism within Cell Lines Used for Tox21 Chemical Screening. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 73:105109, (2021). https://doi.org/10.1016/j.tiv.2021.105109

Franzosa, J., J. Bonzo, J. Jack, Nancy C. Baker, P. Kothiya, R. Witek, P. Hurban, S. Siferd, S. Hester, I. Shah, S. Ferguson, K. Houck, AND J. Wambaugh. High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures. npj Systems Biology and Applications. Springer Nature, New York, NY, 7:Article 7, (2021). https://doi.org/10.1038/s41540-020-00166-2

Borrel, A., R. Rudel, K. Houck, AND N. Kleinstreuer. KC-QSARs: Modeling Key Characteristics of Chemical Carcinogenesis. International Conference on Environmental Mutagens, Ottawa, N/A, CANADA, August 28 - September 02, 2021.

Miller, J., J. Chua, J. Heng, K. Houck, D. Zink, AND L. Loo. Nephrotoxicity Prediction and Structure-Activity Analyses of ToxCast Chemicals Based on High-Throughput Image-Based Phenotypic Profiling. 11th World Congress on Alternatives and Animal Use in the Life Sciences (WC11), Maastricht, N/A, NETHERLANDS, August 23 - September 03, 2021.

Han, J., J. Fu, J. Sun, D. Hall, D. Yang, D. Blatz, K. Houck, C. Ng, J. Doering, C. LaLone, AND H. Peng. Quantitative Chemical Proteomics Reveals Interspecies Variations on Binding Schemes of L-FABP with Perfluorooctanesulfonate. Nature Communications. Nature Publishing Group, London, Uk, 55(13):9012-9023, (2021). https://doi.org/10.1021/acs.est.1c00509

Richard, A., R. Huang, S. Waidyanatha, P. Shinn, B. Collins, I. Thillainadarajah, Chris Grulke, A. Williams, R. Lougee, R. Judson, K. Houck, Mahmoud A. Shobair, C. Yang, J. Rathman, A. Yasgar, S. Fitzpatrick, A. Simeonov, R. Thomas, K. Crofton, R. Paules, J. Bucher, C. Austin, R. Kavlock, AND R. Tice. The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 34(2):189-216, (2021). https://doi.org/10.1021/acs.chemrestox.0c00264

Brown, J., M. Feshuk, K. Houck, R. Judson, AND K. Paul-Friedman. Update on the ToxCast Pipeline and Invitrodb. Society of Toxicology Annual Meeting (Virtual), N/A, N/A, March 12 - 26, 2021. https://doi.org/10.23645/epacomptox.14681241

Cavallin, J., G. Ankley, B. Blackwell, J. Hoang, R. Hofer, K. Houck, K. Jensen, M. Kahl, R. Kutsi, A. Opseth, K. Santana Rodriguez, E. Stacy, AND Dan Villeneuve. Verification of In Vivo Estrogenic Activity for Four Polyfluoroalkyl Substances (PFAS) Identified as Estrogen Receptor Agonists in High-Throughput Screening. SETAC North America 42nd Annual meeting, Portland, OR, November 14 - 18, 2021. https://doi.org/10.23645/epacomptox.17064230

Medvedev, A., L. Medvedeva, E. Martsen, M. Moeser, K. Gorman, B. Lin, B. Blackwell, Dan Villeneuve, K. Houck, K. Crofton, AND S. Makarov. Harmonized Cross-Species Assessment of Endocrine and Metabolic Disruptors by Ecotox FACTORIAL Assay. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 54(19):12142-12153, (2020). https://doi.org/10.1021/acs.est.0c03375

Borrel, A., R. Huang, S. Sakamuru, M. Xia, A. Simeonov, K. Mansouri, K. Houck, R. Judson, AND N. Kleinstreuer. High-Throughput Screening to Predict Chemical-Assay Interference. Scientific Reports. Nature Publishing Group, London, Uk, 10:3986, (2020). https://doi.org/10.1038/s41598-020-60747-3

Lynch, C., S. Sakamuru, R. Huang, K. Houck, S. Ferguson, AND M. Xia. Identification of Compounds from the Tox21 10K Compound Library which Modulate CYP3A4 Gene Expression through Activation of the Pregnane X Receptor. Keystone Symposia: Gene Regulation: From Mechanisms to Disease, Keystone, CO, January 26 - 30, 2020.

Phillips, A., J. McCord, B. Blackwell, K. Houck, AND E. Ulrich. New Approach Methodologies to Prioritize and Identify Key Components of UVCBs. SETAC North America 41st Annual Meeting. Virtual Conference, RTP, NC, November 15 - 19, 2020. https://doi.org/10.23645/epacomptox.13138604

Phillips, A., J. McCord, B. Blackwell, K. Houck, AND E. Ulrich. New Approach Methodologies to Prioritize and Identify Key Components of UVCBs (STEEP Conference). University of Rhode Island. Sources, Transport, Exposure & Effects of PFAS (STEEP) Trainee Conference, RTP, NC, October 13 - 14, 2020. https://doi.org/10.23645/epacomptox.13370192

Yang, D., J. Han, D. Ross Hall, J. Sun, J. Fu, S. Kutarna, K. Houck, C. LaLone, J. Doering, C. Ng, AND H. Peng. Nontarget Screening of Per- and Polyfluoroalkyl Substances Binding to Human Liver Fatty Acid Binding Protein. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 54(9):5676-5686, (2020). https://doi.org/10.1021/acs.est.0c00049