Grantee Research Project Results
Publications Details for Grant Number R834798C001
Relative Toxicity of Air Pollution Mixtures
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Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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Abstract | Inhalation of traffic-derived particulates causes arrhythmia and autonomic imbalance and alters ventricular repolarization and hemodynamics in a rat model of high fructose-diet-induced cardiometabolic syndrome. | None | Carll AP, Crespo SM, Zati DH, Papapostolou V, Lawrence J, Diaz EA, Harkema JR, Godleski JJ | Carll AP, Crespo SM, Zati DH, Papapostolou V, Lawrence J, Diaz EA, Harkema JR, Godleski JJ. Inhalation of traffic-derived particulates causes arrhythmia and autonomic imbalance and alters ventricular repolarization and hemodynamics in a rat model of high fructose-diet-induced cardiometabolic syndrome. American Journal of Respiratory and Critical Care Medicine 2015;191(Abstract Issue):A5236. |
R834798 (2015) R834798 (Final) R834798C001 (Final) |
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Abstract | Repeat inhalation exposure to traffic-derived particles exacerbates ischemic, left ventricular hemodynamic, sympathetic, and arrhythmic responses to psychosocial stress and decreases contractility index in conscious rats. | THE TOXICOLOGIST: SUPPLEMENT TO TOXICOLOGICAL SCIENCES | Carll AP, da Silva TD, Crespo SM, Lima BT, Zati DH, Godleski JJ | Carll AP, da Silva TD, Crespo SM, Lima BT, Zati DH, Godleski JJ. Repeat inhalation exposure to traffic-derived particles exacerbates ischemic, left ventricular hemodynamic, sympathetic, and arrhythmic responses to psychosocial stress and decreases contractility index in conscious rats. The Toxicologist: Supplement to Toxicological Sciences 2015;144(1):2551. |
R834798 (2015) R834798 (Final) R834798C001 (Final) |
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Abstract | Toxicological Evaluation of Realistic Emissions Source Aerosols (TERESA): mobile sources-tunnel studies. | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | Diaz EA, Chung Y, Long MS, Lawrence J, Papapostolou V, Lamoureux D, Mazzaro V, Buonfiglio H, Yoo PS, Franco F, Godleski JJ | Diaz EA, Chung Y, Long MS, Lawrence J, Papapostolou V, Lamoureux D, Mazzaro V, Buonfiglio H, Yoo PS, Franco F, Godleski JJ. Toxicological Evaluation of Realistic Emissions Source Aerosols (TERESA): mobile sources-tunnel studies. American Journal of Respiratory and Critical Care Medicine 2011;183:A3231. |
R834798 (2010) R834798 (2011) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2010) R834798C001 (2011) R834798C001 (2014) R834798C001 (Final) |
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Abstract | Effects of traffic-related particles on blood pressure and DNA methylation. | JOURNAL OF CLINICAL HYPERTENSION | Lamoureux DP, Diaz EA, Chung YS, Long MS, Lawrence J, Papapostolou V, Nguyen PS, Godleski JJ | Lamoureux DP, Diaz EA, Chung YS, Long MS, Lawrence J, Papapostolou V, Nguyen PS, Godleski JJ. Effects of traffic-related particles on blood pressure and DNA methylation. Journal of Clinical Hypertension 2011;13(Suppl 1):A131 (Abstract PO-287). |
R834798 (2010) R834798 (2011) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2010) R834798C001 (2011) R834798C001 (2014) R834798C001 (Final) |
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Journal Article | US EPA particulate matter research centers: summary of research results for 2005–2011. | AIR QUALITY, ATMOSPHERE & HEALTH | Breysse PN, Delfino RJ, Dominici F, Elder ACP, Frampton MW, Froines JR, Geyh AS, Godleski JJ, Gold DR, Hopke PK, Koutrakis P, Li N, Oberdorster G, Pinkerton KE, Samet JM, Utell MJ, Wexler AS | Breysse PN, Delfino RJ, Dominici F, Elder ACP, Frampton MW, Froines JR, Geyh AS, Godleski JJ, Gold DR, Hopke PK, Koutrakis P, Li N, Oberdorster G, Pinkerton KE, Samet JM, Utell MJ, Wexler AS. US EPA particulate matter research centers: summary of research results for 2005–2011. Air Quality, Atmosphere & Health 2013;6(2):333-355. |
R832413 (Final) R832414 (Final) R832415 (Final) R832416 (Final) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2013) R834798C001 (2014) |
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Journal Article | Inhaled ambient-level traffic-derived particulates decrease cardiac vagal influence and baroreflexes and increase arrhythmia in a rat model of metabolic syndrome. | None | Carll AP, Crespo SM, Mauricio Filho S, Zati DH, Coull BA, Diaz EA, Raimundo RD, Jaeger TN, Ricci-Vitor AL, Papapostolou V, Lawrence JE, Garner DM, Perry BS, Harkema JR, Godleski JJ | Carll AP, Crespo SM, Mauricio Filho S, Zati DH, Coull BA, Diaz EA, Raimundo RD, Jaeger TN, Ricci-Vitor AL, Papapostolou V, Lawrence JE, Garner DM, Perry BS, Harkema JR, Godleski JJ. Inhaled ambient-level traffic-derived particulates decrease cardiac vagal influence and baroreflexes and increase arrhythmia in a rat model of metabolic syndrome. Particle and Fibre Toxicology 2017;14(1):16 (15 pp.). |
R834798 (2016) R834798 (Final) R834798C001 (Final) |
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Journal Article | Effects of fresh and aged vehicular exhaust emissions on breathing pattern and cellular responses – pilot single vehicle study. | None | Diaz EA, Chung Y, Papapostolou V, Lawrence J, Long MS, HatakeyamaV,Gomes B, Calil Y, Sato R, Koutrakis P, Godleski JJ | Diaz EA, Chung Y, Papapostolou V, Lawrence J, Long MS, Hatakeyama V, Gomes B, Calil Y, Sato R, Koutrakis P, Godleski JJ. Effects of fresh and aged vehicular exhaust emissions on breathing pattern and cellular responses – pilot single vehicle study. Inhalation Toxicology 2012;24(5):288-295. |
R827353 (Final) R832416 (Final) R834798 (2012) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2012) R834798C001 (2014) R834798C001 (Final) |
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Journal Article | Effects of fresh and aged traffic-related particles on breathing pattern, cellular responses, and oxidative stress. | AIR QUALITY, ATMOSPHERE & HEALTH | Diaz EA, Chung Y, Lamoureux DP, Papapostolou V, Lawrence J, Long MS,Mazzaro V, Buonfiglio H, Sato R, Koutrakis P, Godleski JJ | Diaz EA, Chung Y, Lamoureux DP, Papapostolou V, Lawrence J, Long MS, Mazzaro V, Buonfiglio H, Sato R, Koutrakis P, Godleski JJ. Effects of fresh and aged traffic-related particles on breathing pattern, cellular responses, and oxidative stress. Air Quality, Atmosphere & Health 2013;6(2):431-444. |
R832416 (Final) R834798 (2012) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2012) R834798C001 (2013) R834798C001 (2014) R834798C001 (Final) |
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Journal Article | Toxicological Evaluation of Realistic Emission Source Aerosols (TERESA)-power plant studies: assessment of cellular responses. | None | Godleski JJ, Diaz EA, Lemos M, Long M, Ruiz P, Gupta T, Kang CM, Coull B | Godleski JJ, Diaz EA, Lemos M, Long M, Ruiz P, Gupta T, Kang C-M, Coull B. Toxicological Evaluation of Realistic Emission Source Aerosols (TERESA)-power plant studies: assessment of cellular responses. Inhalation Toxicology 2011;23(Suppl 2):60-74. |
R832416C005 (2010) R834798 (2013) R834798 (2014) R834798 (Final) R834798C001 (Final) R834798C005 (Final) |
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Journal Article | Opposing effects of particle pollution, ozone, and ambient temperature on arterial blood pressure. | ENVIRONMENTAL HEALTH PERSPECTIVES | Hoffmann B, Luttmann-Gibson H, Cohen A, Zanobetti A, de Souza C, FoleyC, Suh HH, Coull BA, Schwartz J, Mittleman M, Stone P, Horton E, Gold DR | Hoffmann B, Luttmann-Gibson H, Cohen A, Zanobetti A, de Souza C, Foley C, Suh HH, Coull BA, Schwartz J, Mittleman M, Stone P, Horton E, Gold DR. Opposing effects of particle pollution, ozone, and ambient temperature on arterial blood pressure. Environmental Health Perspectives 2012;120(2):241-246. |
R832416 (Final) R832416C001 (Final) R834798 (2012) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2014) R834798C002 (Final) R834798C004 (2012) R834798C004 (2014) R834798C004 (Final) |
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Journal Article | Effects of fresh and aged vehicular particulate emissions on blood pressure in normal adult male rats. | None | Lamoureux DP, Diaz EA, Chung Y, Coull BA, Papapostolou V, Lawrence J, Sato R, Godleski JJ | Lamoureux DP, Diaz EA, Chung Y, Coull BA, Papapostolou V, Lawrence J, Sato R, Godleski JJ. Effects of fresh and aged vehicular particulate emissions on blood pressure in normal adult male rats. Air Quality, Atmosphere & Health 2013;6(2):407-418. |
R827353 (Final) R832416 (Final) R834798 (2012) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2012) R834798C001 (2013) R834798C001 (2014) R834798C001 (Final) |
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Journal Article | Cardiac and pulmonary oxidative stress in rats exposed to realistic emissions of source aerosols. | INHALATION TOXICOLOGY | Lemos M, Diaz EA, Gupta T, Kang C-M, Ruiz P, Coull BA, Godleski JJ, Gonzalez-Flecha B | Lemos M, Diaz EA, Gupta T, Kang C-M, Ruiz P, Coull BA, Godleski JJ, Gonzalez-Flecha B. Cardiac and pulmonary oxidative stress in rats exposed to realistic emissions of source aerosols. Inhalation Toxicology 2011;23(Suppl 2):75-83. |
R832416 (Final) R832416C005 (2010) R834798 (2013) R834798 (2014) R834798 (Final) R834798C001 (Final) R834798C005 (Final) |
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Journal Article | A meta-analysis and multisite time-series analysis of the differential toxicity of major fine particulate matter constituents. | AMERICAN JOURNAL OF EPIDEMIOLOGY | Levy JI, Diez D, Dou Y, Barr C, Dominici F | Levy JI, Diez D, Dou Y, Barr CD, Dominici F. A meta-analysis and multisite time-series analysis of the differential toxicity of major fine particulate matter constituents. American Journal of Epidemiology 2012;175(11):1091-1099. |
R832416C001 (Final) R832417 (Final) R834798 (2012) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2014) R834798C005 (2012) R834798C005 (Final) R834894 (2012) R834894 (2013) |
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Journal Article | Laboratory evaluation of a prototype photochemical chamber designed to investigate the health effects of fresh and aged vehicular exhaust emissions. | INHALATION TOXICOLOGY | Papapostolou V, Lawrence JE, Diaz EA, Wolfson JM, Ferguson ST, Long MS,Godleski JJ, Koutrakis P | Papapostolou V, Lawrence JE, Diaz EA, Wolfson JM, Ferguson ST, Long MS, Godleski JJ, Koutrakis P. Laboratory evaluation of a prototype photochemical chamber designed to investigate the health effects of fresh and aged vehicular exhaust emissions. Inhalation Toxicology 2011;23(8):495-505. |
R832416 (Final) R832416C005 (Final) R834798 (2010) R834798 (2011) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2010) R834798C001 (2011) R834798C001 (2014) R834798C001 (Final) R834798C005 (Final) |
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Journal Article | Development and characterization of an exposure generation system to investigate the health effects of particles from fresh and aged traffic emissions. | AIR QUALITY, ATMOSPHERE & HEALTH | Papapostolou V, Lawrence JE, Ferguson ST, Wolfson JM, Diaz EA, Godleski JJ, Koutrakis P | Papapostolou V, Lawrence JE, Ferguson ST, Wolfson JM, Diaz EA, Godleski JJ, Koutrakis P. Development and characterization of an exposure generation system to investigate the health effects of particles from fresh and aged traffic emissions. Air Quality, Atmosphere & Health 2013;6(2):419-429. |
R832416 (Final) R834798 (2012) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2012) R834798C001 (2013) R834798C001 (2014) R834798C001 (Final) |
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Journal Article | Childhood and adult socioeconomic position, cumulative lead levels, and pessimism in later life: the VA Normative Aging Study. | AMERICAN JOURNAL OF EPIDEMIOLOGY | Peters JL, Kubzansky LD, Ikeda A, Spiro III A, Wright RO, Weisskopf MG,Kim D, Sparrow D, Nie LH, Hu H, Schwartz J | Peters JL, Kubzansky LD, Ikeda A, Spiro III A, Wright RO, Weisskopf MG, Kim D, Sparrow D, Nie LH, Hu H, Schwartz J. Childhood and adult socioeconomic position, cumulative lead levels, and pessimism in later life: the VA Normative Aging Study. American Journal of Epidemiology 2011;174(12):1345-1353. |
R832416 (Final) R832416C001 (Final) R834798 (2010) R834798 (2011) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2014) R834798C001 (Final) R834798C002 (2010) R834798C002 (2011) R834798C002 (2014) R834798C002 (Final) |
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Journal Article | Ozone and survival in four cohorts with potentially predisposing diseases. | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | Zanobetti A, Schwartz J | Zanobetti A, Schwartz J. Ozone and survival in four cohorts with potentially predisposing diseases. American Journal of Respiratory and Critical Care Medicine 2011;184(7):836-841. |
R832416 (Final) R832416C001 (Final) R834798 (2010) R834798 (2011) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2014) R834798C001 (Final) R834798C002 (2010) R834798C002 (2011) R834798C002 (2014) R834798C002 (Final) R834798C005 (Final) |
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Journal Article | Heart rate variability in metabolic syndrome. | None | Raimundo RD, Godleski JJ | Raimundo RD, Godleski JJ. Heart rate variability in metabolic syndrome. Journal of Human Growth and Development. 2015; 25(1):7-10. |
R834798C001 (Final) |
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Presentation | Effects of fresh and aged traffic-related particles on breathing pattern, cellular responses and oxidative stress. | None | Diaz EA, Chung Y, Long MS, Lawrence J, Papapostolou V, Hatakeyama V, Gomes B, Calil Y, Godleski JJ | Diaz EA, Chung Y, Long MS, Lawrence J, Papapostolou V, Hatakeyama V, Gomes B, Calil Y, Godleski JJ. Effects of fresh and aged traffic-related particles on breathing pattern, cellular responses and oxidative stress. Presented at Experimental Biology 2012, San Diego, CA, April 21-25, 2012. |
R834798 (2012) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2012) R834798C001 (2014) R834798C001 (Final) |
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Presentation | Cellular and respiratory responses to inhalation of traffic derived particles in a rat model of high fructose diet-induced cardio-metabolic syndrome. | None | Diaz EA, Papapostolou V, Harkema JR, Godelski JJ | Diaz EA, Papapostolou V, Harkema JR, Godelski JJ. Cellular and respiratory responses to inhalation of traffic derived particles in a rat model of high fructose diet-induced cardio-metabolic syndrome. Presented at the Experimental Biology Meeting (EB2015), Boston, MA, March 28-April 1, 2015. |
R834798 (2015) R834798 (Final) R834798C001 (Final) |
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Presentation | Pulmonary dysfunction and air pollution. | None | Godleski, JJ | Godleski JJ. Pulmonary dysfunction and air pollution. Presented at Experimental Biology 2012, Symposium on Air Pollution, San Diego, CA, April 21-25, 2012. |
R834798 (2012) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2012) R834798C001 (2014) R834798C001 (Final) |
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Presentation | Cardiovascular effects of air pollution. | None | Godleski JJ | Godleski JJ. Cardiovascular effects of air pollution. Presented at the University of Sao Paulo Air Pollution Symposium, Sao Paulo, Brazil, August 2012 (invited). |
R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2013) R834798C001 (2014) R834798C001 (Final) |
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Presentation | Cardiovascular effects of air pollution. | None | Godleski JJ | Godleski JJ. Cardiovascular effects of air pollution. Presented to the Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health, Pittsburgh, PA, October 2012. |
R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2013) R834798C001 (2014) R834798C001 (Final) |
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Presentation | Air pollution and hypertension: mechanistic studies. | None | Godleski JJ | Godleski JJ. Air pollution and hypertension: mechanistic studies. Presented at the International Occupational and Environmental Health Summit, Philadelphia, PA, September 5-7, 2012 (keynote). |
R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2013) R834798C001 (2014) R834798C001 (Final) |
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Presentation | Cardiovascular health effects of traffic-related ambient particles. | None | Godleski JJ | Godleski JJ. Cardiovascular health effects of traffic-related ambient particles. Presented at the People to People Program, Harvard Law School, Cambridge, MA, August 2013. |
R834798 (2015) R834798 (Final) R834798C001 (2014) R834798C001 (Final) |
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Presentation | Assessing cardiovascular health effects of environmental agents. | None | Godleski JJ | Godleski JJ. Assessing cardiovascular health effects of environmental agents. Presented at the Harvard School of Public Health, Methods in Environmental Health Series, Cambridge, MA, October 2013. |
R834798 (2015) R834798 (Final) R834798C001 (2014) |
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Presentation | Cardiovascular effects of traffic-related air pollution complex mixtures. | None | Godleski JJ | Godleski JJ. Cardiovascular effects of traffic-related air pollution complex mixtures. Presented to the Department of Environmental and Occupational Health, Boston University School of Public Health, Boston, MA, October 2013. |
R834798 (2015) R834798 (Final) R834798C001 (2014) R834798C001 (Final) |
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Presentation | Cardiovascular health effects of traffic-related ambient particles. | None | Godleski JJ | Godleski JJ. Cardiovascular health effects of traffic-related ambient particles. Presented at the University of Sao Paulo Air Pollution Symposium, Sao Paulo, Brazil, September 2013. |
R834798 (2015) R834798 (Final) R834798C001 (2014) R834798C001 (Final) |
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Presentation | Air pollution, cardiovascular health effects and climate change. | None | Godleski JJ | Godleski JJ. Air pollution, cardiovascular health effects and climate change. Presented at Boston College, Sloan School of Business, Program on Sustainability, April 2014 (invited). |
R834798 (2015) R834798 (Final) R834798C001 (2014) |
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Presentation | New approaches to analyses of blood pressure signals for heart rate variability and arythmias in environmental exposure studies. | None | Godleski JJ, Carll A | Godleski JJ, Carll A. New approaches to analyses of blood pressure signals for heart rate variability and arythmias in environmental exposure studies. Presented at the EMKA Users Meeting, Columbus, OH, May 13-14, 2014. |
R834798 (2015) R834798 (Final) R834798C001 (2014) |
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Presentation | Update: health effects of traffic-related air pollution. | None | Godleski JJ | Godleski JJ. Update: health effects of traffic-related air pollution. Presented at the Faculty of Medicine International Symposium, University of Sao Paulo, Sao Paulo, Brazil, June 24, 2015 (invited). |
R834798 (2015) R834798 (Final) R834798C001 (Final) |
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Presentation | Invited Speaker University of Sao Paulo Air Pollution Symposium Sao Paulo Brazil. | None | Godleski, JJ Air Pollution, Cardiovascular Health Effects and Climate Change | Godleski JJ. Air pollution, cardiovascular health effects and climate change. Presented at the University of Sao Paulo Air Pollution Symposium, Sao Paulo, Brazil, June 2014 (invited speaker). |
R834798 (2015) R834798 (Final) R834798C001 (2014) |
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Presentation | Effects of fresh and aged vehicular particulate emissions on blood pressure in normal adult male rats. | None | Lamoureux D, Diaz EA, Chung Y, Long MS, Lawrence J, Papapostolou V, Nguyen PS, Godleski JJ | Lamoureux D, Diaz EA, Chung Y, Long MS, Lawrence J, Papapostolou V, Nguyen PS, Godleski JJ. Effects of fresh and aged vehicular particulate emissions on blood pressure in normal adult male rats. Presented at Experimental Biology 2012, San Diego, CA, April 21-25, 2012. |
R834798 (2012) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2012) R834798C001 (2014) R834798C001 (Final) |
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Presentation | Modeling secondary particle formation in the laboratory for toxicological studies. | None | Lawrence J, Papapostolou V | Lawrence J, Papapostolou V. Modeling secondary particle formation in the laboratory for toxicological studies. Presented via the Harvard-U.S. EPA Webinar, May 1, 2012. |
R834798 (2012) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2012) R834798C001 (2014) R834798C001 (Final) |
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Presentation | . | None | John Godleski, Invited Keynote Speaker, Children Adolescent Health Convocation, Cardiovascular Health Heart Rate Variability Symposium Vitoria Brazil, May 18, 2016 | John Godleski, Invited Keynote Speaker, Children and Adolescent Health Convocation, Cardiovascular Health and Heart Rate Variability Symposium Vitoria Brazil, May 18, 2016. |
R834798C001 (Final) |
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Presentation | Health Effects of Traffic-Related Air Pollution, Sao Paulo Brazil May 16, 2016. | None | John Godleski Invited Speaker, School of Public Health University of Sao Paulo, Symposium on Obesity, Metabolic Syndrome Air Pollution | John Godleski Invited Speaker, School of Public Health University of Sao Paulo, Symposium on Obesity, Metabolic Syndrome and Air Pollution. Health Effects of Traffic-Related Air Pollution, Sao Paulo Brazil May 16, 2016. |
R834798C001 (Final) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.