Grantee Research Project Results
Publications Details for Grant Number R833772
Safety/Toxicity Assessment of Ceria (A Model Engineered NP) to the Brain
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Reference Type | Citation | Progress Report Year | Document Sources |
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Abstract | Huang X, Wang B, Grulke E, Beck M. Toward tuning the surface functionalization of small ceria nanoparticles. THE JOURNAL OF CHEMICAL PHYSICS 2014;140(7):074703. |
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Journal Article | Boyes W, Chen R, Chen C, Yokel R. The neurotoxic potential of engineered nanomaterials. NEUROTOXICOLOGY 2012;33(4):902-910 |
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Journal Article | Carlander U, Moto T, Desalegn A, Yokel R, Johanson G. Physiologically based pharmacokinetic modeling of nanoceria systemic distribution in rats suggests dose- and route-dependent biokinetics. INTERNATIONAL JOURNAL OF NANOMEDICINE 2018;13:2631-2646 |
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Journal Article | Dan M, Wu P, Grulke E, Graham U, Unrine J, Yokel R. Ceria-engineered nanomaterial distribution in, and clearance from, blood: size matters. NANOMEDICINE 2011;7(1):95-110 |
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Journal Article | Graham U, Tseng M, Jasinski J, Yokel R, Unrine J, Davis B, Dozier A, Hardas S, Sultana R, Grulke E, Allan D. Inâ Vivo Processing of Ceria Nanoparticles inside Liver: Impact on Free-Radical Scavenging Activity and Oxidative Stress. CHEMPLUSCHEM 2014;79(8):1083-1088 |
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Journal Article | Graham U, Yokel R, Fernback J, Dozier A, Drummy L, Mahalingam K, Tseng M, Birtch E. Analytical High-resolution Electron Microscopy Reveals Organ-specific Nanoceria Bioprocessing. TOXILOGIC PATHOLOGY 2017;46(1):47-61 |
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Journal Article | Graham U, Dozier A, Oberdorster G, Yokel R, Molina R, Brain J, Pinto J. Tissue Specific Fate of Nanomaterials by Advanced Analytical Imaging Techniques - A Review. CHEMICAL RESEARCH IN TOXICOLOGY 2020;33(5):1145-1162 |
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Journal Article | Hardas S, Butterfield D, Sultana R, Tseng M, Dan M, Florence R, Unrine J, Graham U, Wu P, Grulke E, Yokel R. Brain Distribution and Toxicological Evaluation of a Systemically Delivered Engineered Nanoscale Ceria. TOXICOLOGICAL SCIENCES 2010;116(2):562-576 |
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Journal Article | Hardas S, Sultana R, Warrier G, Dan M, Florence R, Wu P, Grulke E, Tseng M, Unrine J, Graham U, Yokel R, Butterfield D. Rat brain pro-oxidant effects of peripherally administered 5 nm ceria 30 days after exposure. NEUROTOXICITY 2012;33(5):1147-1155 |
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Journal Article | Hardas S, Sultana R, Warrier G, Dan M, Wu P, Grulke E, Tsang M, Unrine J, Graham U, Yokel R, Butterfield D. Rat hippocampal responses up to 90 days after a single nanoceria dose extends a hierarchical oxidative stress model for nanoparticle toxicity. NANOTOXICOLOGY 2014;8(1):155-166 |
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Journal Article | Harris S, Wegner S, Hong SW, Faustman EM. Phthalate metabolism and kinetics in an in vitro model of testis development. Toxicology in Vitro 2016;32:123-131. |
R833772 (2009) R834514 (Final) R834514C003 (Final) R835738 (2016) R835738 (2017) R835738C004 (2015) R835738C004 (2016) R835738C004 (2017) |
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Journal Article | Kanniah V, Wu P, Mandzy N, Grulke E. Fractal analysis as a complimentary technique for characterizing nanoparticle size distributions. POWDER TECHNOLOGY 2012;226:189-198 |
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Journal Article | Laux P, Riebeling C, Booth A, Brain J, Brunner J, Cerrillo C, Creutzenberg O, Estrela-Lopis I, Gebel T, Johanson G, Jungnickel H, Kock H, Tentscert J, Tlili A, Schaffer A, Sips A, Yokel R, Luch A. Biokinetics of nanomaterials: The role of biopersistence. NANOLMPACT 2017;6:69-80 |
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Journal Article | Tseng M, Lu X, Duan X, Hardas S, Sultana R, Wu P, Unrine J, Graham U, Butterfield A, Grulke E, Yokel R. Alteration of hepatic structure and oxidative stress induced by intravenous nanoceria. TOXICOLOGY AND APPLIED PHARMACOLOGY 2012;260(2):173-182 |
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Journal Article | Wang B, Wu P, Yokel R, Grulke E. Influence of surface charge on lysozyme adsorption to ceria nanoparticles. APPLIED SURFACE SCIENCE 2012;258(14):5332-5341 |
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Journal Article | Yokel RA, Florence RL, Unrine JM, Tseng MT, Graham UM, Wu P, Grulke EA, Sultana R, Hardas SS, Butterfield DA. Biodistribution and oxidative stress effects of a systemically-introduced commercial ceria engineered nanomaterial. Nanotoxicology 2009;3(3):234-248. |
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Journal Article | Yokel R, MacPhail R. Engineered nanomaterials: exposures, hazards, and risk prevention. JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY 2011;6(7) |
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Journal Article | Yokel R, Au T, MacPhail R, Hardas S, Butterfield D, Sultana R, Goodman M, Tseng M, Dan M, Haghnazar H, Unrine J, Graham U, Wu P, Grulke E. Distribution, Elimination, and Biopersistence to 90 Days of a Systemically Introduced 30 nm Ceria-Engineered Nanomaterial in Rats. TOXILOGICAL SCIENCES 2012;127(1):256-268 |
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Journal Article | Yokel R, Tseng M, Dan M, Unrine J, Graham U, Wu P, Grulke E. Biodistribution and biopersistence of ceria engineered nanomaterials: size dependence. NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY AND MEDICINE 2013;9(3):398-407 |
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Journal Article | Yokel R, Unrine J, Wu P, Wang B, Grulke E. Nanoceria biodistribution and retention in the rat after its intravenous administration are not greatly influenced by dosing schedule, dose, or particle shape. ENVIRONMENTAL SCIENCE: NANO 2014;1:549-560 |
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Journal Article | Yokel R, Hussain S, Garantziotis S, Demokritou P, Castranova V, Cassee F. The yin: an adverse health perspective of nanoceria: uptake, distribution, accumulation, and mechanisms of its toxicity. ENVIRONMENTAL SCIENCE: NANO 2014;1(5):406-428 |
R833772 (2009) |
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Patent/Patent Application | Mandzy NS, Grulke EA, Druffle TL. Methods of making and using metal oxide nanoparticles. U.S. Patent Application No. 12/083,986, Publication No. 2009/0202714 A1, August 13, 2009. |
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Presentation | Tseng MT, Lu X, Grulke E, Wu P, Florence R, Yokel RA. Removal of systemically-administered ceria nanoparticles by reticuloendothelial cells. Presented at the Symposium on Advances in Nanotechnology and Applications, College of Pharmacy, Sullivan University, Louisville, KY, October 2-4, 2008. |
R833772 (2009) |
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Presentation | Tseng MT, Lu X, Grulke E, Wu P, Florence R, Yokel RA. Pivotal role of reticuloendothelial cells in biodistribution of engineered nanomaterials. Presented at the International Congress of Nano-Bio Clean Tech, San Francisco, CA, October 27-30, 2008. |
R833772 (2009) |
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Presentation | Yokel RA, Florence RL, Tseng MT, Graham UM, Sultana R, Butterfield DA, Wu P, Grulke EA. Biodistribution and toxicity assessment of systemic ceria nanoparticles. Presented at the U.S.-Thai Pharmacy Consortium Meeting, Madison, WI, July 15-18, 2008. |
R833772 (2009) |
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Presentation | Yokel RA, Florence R, Unrine J, Tseng MT, Graham UM, Sultana R, Butterfield DA, Wu P, Grulke EA. Safety/toxicity assessment of ceria (a model engineered NP) to the brain. Presented at EPA's Interagency Environmental Nanotechnology Grantees Workshop, Tampa, FL, November 19-21, 2008. |
R833772 (2009) |
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Presentation | Yokel RA. Nanoscale material environmental and health research at the University of Kentucky. Presented at the Inaugural John P. Wyatt Lecture Award Program in Environmental Health and Disease, University of Kentucky, Lexington, KY, November 5, 2008. |
R833772 (2009) |
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Presentation | Yokel RA, Florence RL, Tseng MT, Graham UM, Sultana R, Butterfield DA, Wu P, Grulke EA. Biodistribution and toxicity of systemically-introduced nanoscale ceria. Presented at the 2nd International Conference on Nanotoxicology, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland, September 7-10, 2008. |
R833772 (2009) |
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Proceedings | Yokel RA, Florence R, Unrine J, Tseng MT, Graham UM, Sultana R, Butterfield DA, Wu P, Grulke EA. Safety/toxicity assessment of ceria (a model engineered NP) to the brain. In: Proceedings of EPA's Interagency Environmental Nanotechnolgoy Grantees Workshop, Tampa, FL, November 19-21, 2008, p. 37. |
R833772 (2009) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.