Grantee Research Project Results
San Joaquin Valley Aerosol Health Effects Research Center (SAHERC)
EPA Grant Number: R832414Center: UC Davis Center for Children's Environmental Health and Disease Prevention
Center Director: Van de Water, Judith
Title: San Joaquin Valley Aerosol Health Effects Research Center (SAHERC)
Investigators: Wexler, Anthony S. , Pinkerton, Kent E.
Institution: University of California - Davis
EPA Project Officer: Chung, Serena
Project Period: October 1, 2005 through September 30, 2010 (Extended to September 30, 2011)
Project Amount: $7,999,767
RFA: Particulate Matter Research Centers (2004) RFA Text | Recipients Lists
Research Category: Human Health , Particulate Matter , Air
Objective:
This proposal will investigate the mechanistic links between ambient particles and the health effects that they elicit. This objective entails two goals:
- Understanding the metabolic response of tissue and organs when they are exposed to particulate pollutants,
- and understanding the characteristics of the particulate pollutants and their gaseous co-pollutants that elicit these responses.
Approach:
The proposed center is composed of five projects supported by five cores. The projects will investigate the metabolic response to pollutant exposure in pulmonary and cardiovascular tissues, whole animal effects of exposure, transport of particles from the airways to other tissues, and the effects of particles and gases on lung development in juveniles. The projects will take both top down approaches, identifying the characteristics of particles that elicit health responses, and bottom up approaches, examining the metabolic responses that these particles elicit. We will perform both field and laboratory studies. The field studies will take place in the San Joaquin Valley of California, one of the worst violators of the National Ambient Air Quality Standards for particulate matter. The laboratory studies will examine the effects of particles from sources or laboratory-generated particles with carefully controlled properties that model ambient ones or those from dominant sources. The research team, composed of physiologists, toxicologists, chemists, and engineers who already collaborate on air pollution studies in the UC Davis Air Quality Research Center, will use their complementary skills to address the center’s objectives.
Expected Results:
Epidemiological studies show a correlation between elevated particulate matter concentrations and increased rates of morbidity and mortality, but these studies do not suggest the mechanisms or the particle properties that cause this correlation. The center’s scientists will investigate the properties of the particles that are responsible for these health effects, the metabolism that underlies these effects, and the consequences of chronic exposures, especially during childhood, that make individuals more susceptible to adverse effects.
Journal Articles: 64 Displayed | Download in RIS Format
Other center views: | All 128 publications | 71 publications in selected types | All 64 journal articles |
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Aung HH, Lame MW, Gohil K, He G, Denison MS, Rutledge JC, Wilson DW. Comparative gene responses to collected ambient particles in vitro:endothelial responses. Physiological Genomics 2011;43(15):917-929. |
R832414 (Final) R832414C002 (Final) |
Exit Exit Exit |
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Bein KJ, Zhao Y, Wexler AS. Conditional sampling for source-oriented toxicological studies using a single particle mass spectrometer. Environmental Science & Technology 2009;43(24):9445-9452. |
R832414 (Final) R832414C005 (Final) |
Exit Exit Exit |
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Bein KJ, Wexler AS. A high-efficiency, low-bias method for extracting particulate matter from filter and impactor substrates. Atmospheric Environment 2014;90:87-95. |
R832414 (Final) |
Exit Exit Exit |
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Bein KJ, Zhao Y, Wexler AS. Retrospective source attribution for source-oriented sampling. Atmospheric Environment 2015;119:228-239. |
R832414 (Final) |
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Breysse PN, Delfino RJ, Dominici F, Elder ACP, Frampton MW, Froines JR, Geyh AS, Godleski JJ, Gold DR, Hopke PK, Koutrakis P, Li N, Oberdorster G, Pinkerton KE, Samet JM, Utell MJ, Wexler AS. US EPA particulate matter research centers: summary of research results for 2005–2011. Air Quality, Atmosphere & Health 2013;6(2):333-355. |
R832414 (Final) R832413 (Final) R832415 (Final) R832416 (Final) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2013) R834798C001 (2014) |
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Chan JKW, Fanucchi MV, Anderson DS, Abid AD, Wallis CD, Dickinson DA, Kumfer BM, Kennedy IM, Wexler AS, Van Winkle LS. Susceptibility to inhaled flame-generated ultrafine soot in neonatal and adult rat lungs. Toxicological Sciences 2011;124(2):472-486. |
R832414 (Final) R832414C001 (Final) |
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Chan JKW, Charrier JG, Kodani SD, Vogel CF, Kado SY, Anderson DS, Anastasio C, Van Winkle LS. Combustion-derived flame generated ultrafine soot generates reactive oxygen species and activates Nrf2 antioxidants differently in neonatal and adult rat lungs. Particle and Fibre Toxicology 2013;10:34. |
R832414 (Final) |
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Chan JKW, Kodani SD, Charrier JG, Morin D, Edwards PC, Anderson DS, Anastasio C, Van Winkle LS. Age-specific effects on rat lung glutathione and antioxidant enzymes after inhaling ultrafine soot. American Journal of Respiratory Cell and Molecular Biology 2013;48(1):114-124. |
R832414 (Final) |
Exit Exit |
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Chen C-Y, Chow D, Chiamvimonvat N, Glatter KA, Li N, He Y, Pinkerton KE, Bonham AC. Short-term secondhand smoke exposure decreases heart rate variability and increases arrhythmia susceptibility in mice. American Journal of Physiology-Heart and Circulatory Physiology 2008;295(2):H632-H639. |
R832414 (Final) R831918 (Final) |
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Day KC, Plopper CG, Fanucchi MV. Age-specific pulmonary cytochrome P-450 3A1 expression in postnatal and adult rats. American Journal of Physiology-Lung Cellular and Molecular Physiology 2006;291(1):L75-L83. |
R832414 (2009) R832414C001 (2007) R832414C001 (2008) R832414C001 (Final) |
Exit Exit Exit |
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den Hartigh LJ, Lame MW, Ham W, Kleeman MJ, Tablin F, Wilson DW. Endotoxin and polycyclic aromatic hydrocarbons in ambient fine particulate matter from Fresno, California initiate human monocyte inflammatory responses mediated by reactive oxygen species.Toxicology In Vitro 2010;24(7):1993-2002. |
R832414 (2010) R832414 (Final) R832414C002 (2010) R832414C002 (Final) |
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Donaldson K, Borm PJA, Oberdorster G, Pinkerton KE, Stone V, Tran CL. Concordance between in vitro and in vivo dosimetry in the proinflammatory effects of low-toxicity, low-solubility particles: the key role of the proximal alveolar region. Inhalation Toxicology 2008;20(1):53-62. |
R832414 (Final) R832414C003 (2008) R832414C003 (2009) R832414C003 (Final) R829215 (Final) |
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Enright HA, Bratt JM, Bluhm AP, Kenyon NJ, Louie AY. Tracking retention and transport of ultrafine polystyrene in an asthmatic mouse model using positron emission tomography. Experimental Lung Research 2013;39(7):304-313. |
R832414 (Final) R832414C004 (Final) |
Exit |
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Ge X, Zhang Q, Sun Y, Ruehl CR, Setyan A. Effect of aqueous-phase processing on aerosol chemistry and size distributions in Fresno, California, during wintertime. Environmental Chemistry 2012;9(3):221-235. |
R832414 (Final) |
Exit Exit |
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Ge X, Setyan A, Sun Y, Zhang Q. Primary and secondary organic aerosols in Fresno, California during wintertime: results from high resolution aerosol mass spectrometry. Journal of Geophysical Research-Atmospheres 2012;117:15. |
R832414 (Final) |
Exit Exit |
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Gojova A, Lee JT, Jung HS, Guo B, Barakat AI, Kennedy IM. Effect of cerium oxide nanoparticles on inflammation in vascular endothelial cells. Inhalation Toxicology 2009;21(Suppl 1):123-130. |
R832414 (Final) |
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Greeley MA, Van Winkle LS, Edwards PC, Plopper CG. Airway trefoil factor expression during naphthalene injury and repair. Toxicological Sciences 2010;113(2):453-467. |
R832414 (Final) R832414C001 (2010) R832414C001 (Final) |
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Ham WA, Herner JD, Green PG, Kleeman MJ. Size distribution of health-relevant trace elements in airborne particulate matter during a severe winter stagnation event: implications for epidemiology and inhalation exposure studies. Aerosol Science and Technology 2010;44(9):753-765. |
R832414 (2010) R832414C003 (2010) R832414C003 (Final) |
Exit Exit Exit |
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Ham WA, Kleeman MJ. Size-resolved source apportionment of carbonaceous particulate matter in urban and rural sites in central California. Atmospheric Environment 2011;45(24):3988-3995. |
R832414 (Final) |
Exit Exit Exit |
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Ham WA, Ruehl CR, Kleeman MJ. Seasonal variation of airborne particle deposition efficiency in the human respiratory system. Aerosol Science and Technology 2011;45(7):795-804. |
R832414 (Final) |
Exit Exit Exit |
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Kennedy IM. The health effects of combustion-generated aerosols. Proceedings of the Combustion Institute 2007;31(2):2757-2770. |
R832414 (2009) R832414C001 (2008) R832414C001 (Final) |
Exit |
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Kleeman MJ, Riddle SG, Jakober CA. Size distribution of particle-phase molecular markers during a severe winter pollution episode. Environmental Science & Technology 2008;42(17):6469-6475. |
R832414 (2009) R832414C003 (2008) R832414C003 (2009) R832414C003 (Final) |
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Kleeman MJ, Riddle SG, Robert MA, Jakober CA, Fine PM, Hays MD, Schauer JJ, Hannigan MP. Source apportionment of fine (PM1.8) and ultrafine (PM0.1) airborne particulate matter during a severe winter pollution episode. Environmental Science & Technology 2009;43(2):272-279. |
R832414 (2010) R832414C003 (2009) R832414C003 (2010) R832414C003 (Final) |
Exit |
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Lee DY, Wexler AS, Fanucchi MV, Plopper CG. Expiration rate drives human airway design. Journal of Theoretical Biology 2008;253(2):381-387. |
R832414 (2009) R832414C005 (2008) R832414C005 (Final) |
Exit Exit Exit |
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Lee DY, Wallis C, Wexler AS, Schelegle ES, Van Winkle LS, Plopper CG, Fanucchi MV, Kumfer B, Kennedy IM, Chan JKW. Small particles disrupt postnatal airway development. Journal of Applied Physiology 2010;109(4):1115-1124. |
R832414 (Final) R832414C001 (2010) R832414C005 (2010) R832414C005 (Final) |
Exit Exit Exit |
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Lee DY, Wallis CD, Van Winkle LS, Wexler AS. Disruption of tracheobronchial airway growth following postnatal exposure to ozone and ultrafine particles. Inhalation Toxicology 2011;23(9):520-531. |
R832414 (Final) R832414C005 (Final) |
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Lee DY, Wexler AS. Simulated annealing implementation with shorter Markov chain length to reduce computational burden and its application to the analysis of pulmonary airway architecture. Computers in Biology and Medicine 2011;41(8):707-715. |
R832414 (Final) R832414C005 (Final) |
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Lee DY, Willits N, Wexler AS. Detecting alterations in pulmonary airway development with airway-by-airway comparison. Annals of Biomedical Engineering 2011;39(6):1805-1814. |
R832414 (Final) R832414C005 (Final) |
Exit Exit |
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Lee DY, Srirama PK, Wallis C, Wexler AS. Postnatal growth of tracheobronchial airways of Sprague-Dawley rats. Journal of Anatomy 2011;218(6):717-725. |
R832414 (Final) R832414C005 (Final) |
Exit Exit Exit |
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Lee DY, Wexler AS. Particle deposition in juvenile rat lungs: a model study. Journal of Aerosol Science 2011;42(9):567-579. |
R832414 (Final) R832414C005 (Final) |
Exit Exit Exit |
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Lee D, Park SS, Ban-Weiss GA, Fanucchi MV, Plopper CG, Wexler AS. Bifurcation model for characterization of pulmonary architecture. Anatomical Record 2008;291(4):379-389. |
R832414 (2009) R832414C005 (2007) R832414C005 (2008) R832414C005 (Final) |
Exit Exit Exit |
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Lee D, Fanucchi MV, Plopper CG, Fung J, Wexler AS. Pulmonary architecture in the conducting regions of six rats. Anatomical Record 2008;291(8):916-926. |
R832414 (2009) R832414C005 (2008) R832414C005 (Final) |
Exit Exit Exit |
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Madl AK, Pinkerton KE. Health effects of inhaled engineered and incidental nanoparticles. Critical Reviews in Toxicology 2009;39(8):629-658. |
R832414 (2010) R832414C003 (2009) R832414C003 (2010) R832414C003 (Final) R829215 (Final) R831714 (2005) |
Exit |
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Madl AK, Teague SV, Qu Y, Masiel D, Evans JE, Guo T, Pinkerton KE. Aerosolization system for experimental inhalation studies of carbon-based nanomaterials. Aerosol Science and Technology 2012;46(1):94-107. |
R832414C003 (Final) R829215 (Final) |
Exit Exit Exit |
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Nakayama Wong LS, Lame MW, Jones AD, Wilson DW. Differential cellular responses to protein adducts of naphthoquinone and monocrotaline pyrrole. Chemical Research in Toxicology 2010;23(9):1504-1513. |
R832414 (2010) R832414 (Final) R832414C002 (2010) R832414C002 (Final) |
Exit Exit Exit |
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Nakayama Wong LS, Aung HH, Lame MW, Wegesser TC, Wilson DW. Fine particulate matter from urban ambient and wildfire sources from California's San Joaquin Valley initiate differential inflammatory, oxidative stress, and xenobiotic responses in human bronchial epithelial cells. Toxicology In Vitro 2011;25(8):1895-1905. |
R832414 (Final) R832414C002 (Final) |
Exit Exit Exit |
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Ngo MA, Pinkerton KE, Freeland S, Geller M, Ham W, Cliff S, Hopkins LE, Kleeman MJ, Kodavanti UP, Meharg E, Plummer L, Recendez JJ, Schenker MB, Sioutas C, Smiley-Jewell S, Haas C, Gutstein J, Wexler AS. Airborne particles in the San Joaquin Valley may affect human health. California Agriculture 2010;64(1):12-16. |
R832414 (2010) R832414C003 (2010) R832414C003 (Final) R826246 (Final) R832413 (Final) R832413C001 (2010) R832413C001 (Final) |
Exit Exit |
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Palko HA, Fung JY, Louie AY. Positron emission tomography:a novel technique for investigating the biodistribution and transport of nanoparticles. Inhalation Toxicology 2010;22(8):657-688. |
R832414 (Final) R832414C004 (Final) |
Exit |
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Pham H, Bonham AC, Pinkerton KE, Chen CY. Central neuroplasticity and decreased heart rate variability after particulate matter exposure in mice. Environmental Health Perspectives 2009;117(9):1448-1453. |
R832414 (2010) R832414C003 (2009) R832414C003 (2010) R832414C003 (Final) R831918 (Final) |
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Pinkerton KE, Joad JP. Influence of air pollution on respiratory health during perinatal development. Clinical and Experimental Pharmacology and Physiology 2006;33(3):269-272. |
R832414 (2009) R829215 (Final) |
Exit |
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Plummer LE, Smiley-Jewell S, Pinkerton KE. Impact of air pollution on lung inflammation and the role of Toll-like receptors. International Journal of Interferon, Cytokine and Mediator Research 2012;4:43-57. |
R832414 (Final) R829215 (Final) |
Exit Exit |
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Plummer LE, Ham W, Kleeman MJ, Wexler A, Pinkerton KE. Influence of season and location on pulmonary response to California's San Joaquin Valley airborne particulate matter. Journal of Toxicology and Environmental Health-Part A 2012;75(5):253-271. |
R832414 (Final) R832414C003 (Final) |
Exit |
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Riddle SG, Robert MA, Jakober CA, Hannigan MP, Kleeman MJ. Size-resolved source apportionment of airborne particle mass in a roadside environment. Environmental Science & Technology 2008;42(17):6580-6586. |
R832414 (2009) R832414 (Final) R832414C003 (2008) R832414C003 (2009) R832414C003 (Final) |
Exit Exit Exit |
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Ruehl CR, Ham WA, Kleeman MJ. Temperature-induced volatility of molecular markers in ambient airborne particulate matter. Atmospheric Chemistry and Physics 2011;11(1):67-76. |
R832414 (2010) R832414C003 (2010) |
Exit Exit |
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Schenker MB, Pinkerton KE, Mitchell D, Vallyathan V, Elvine-Kreis B, Green FHY. Pneumoconiosis from agricultural dust exposure among young California farmworkers. Environmental Health Perspectives 2009;117(6):988-994. |
R832414 (2010) R832414C003 (2009) R832414C003 (2010) R832414C003 (Final) R826246 (Final) |
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Sekizawa Si, Joad JP, Pinkerton KE, Bonham AC. Distinct tachykinin NK1 receptor function in primate nucleus tractus solitarius neurons is dysregulated after second-hand tobacco smoke exposure. British Journal of Pharmacology 2011;163(4):782-791. |
R832414 (Final) |
Exit Exit Exit |
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Sekizawa S-i, Joad JP, Pinkerton KE, Bonham AC. Secondhand tobacco smoke exposure differentially alters nucleus tractus solitarius neurons at two different ages in developing non-human primates. Toxicology and Applied Pharmacology 2010;242(2):199-208. |
R832414 (2010) R832414C003 (2010) R832414C003 (Final) |
Exit Exit Exit |
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Shen H, Barakat AI, Anastasio C. Generation of hydrogen peroxide from San Joaquin Valley particles in a cell-free solution. Atmospheric Chemistry and Physics 2011;11(2):753-765. |
R832414 (2010) R832414 (Final) R832414C002 (2010) R832414C002 (Final) |
Exit Exit |
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Shen H, Anastasio C. Formation of hydroxyl radical from San Joaquin Valley particles extracted in a cell-free surrogate lung fluid. Atmospheric Chemistry and Physics 2011;11(18):9671-9682. |
R832414 (Final) R832414C002 (Final) |
Exit Exit |
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Shen H, Anastasio C. A comparison of hydroxyl radical and hydrogen peroxide generation in ambient particle extracts and laboratory metal solutions. Atmospheric Environment 2012;46:665-668. |
R832414 (Final) R832414C002 (Final) |
Exit Exit Exit |
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Smith KR, Veranth JM, Kodavanti UP, Aust AE, Pinkerton KE. Acute pulmonary and systemic effects of inhaled coal fly ash in rats: comparison to ambient environmental particles. Toxicological Sciences 2006;93(2):390-399. |
R832414 (Final) R832414C003 (2006) R832414C003 (2007) R832414C003 (2008) R832414C003 (Final) R829215 (Final) |
Exit Exit Exit |
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Srirama PK, Wallis CD, Lee DY, Wexler AS. Imaging extra-thoracic airways and deposited particles in laboratory animals. Journal of Aerosol Science 2012;45:40-49. |
R832414 (Final) R832414C005 (Final) |
Exit Exit Exit |
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Sutherland KM, Combs TJ, Edwards PC, Van Winkle LS. Site-specific differences in gene expression of secreted proteins in the mouse lung: comparison of methods to show differences by location. Journal of Histochemistry and Cytochemistry 2010;58(12):1107-1119. |
R832414 (Final) R832414C001 (2010) R832414C001 (Final) |
Exit Exit Exit |
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Sutherland KM, Edwards PC, Combs TJ, Van Winkle LS. Sex differences in the development of airway epithelial tolerance to naphthalene. American Journal of Physiology-Lung Cellular and Molecular Physiology 2012;302(1):L68-L81. |
R832414 (Final) R832414C001 (Final) |
Exit Exit Exit |
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Tablin F, den Hartigh LJ, Aung HH, Lame MW, Kleeman MJ, Ham W, Norris JW, Pombo M, Wilson DW. Seasonal influences on CAPs exposures:differential responses in platelet activation, serum cytokines and xenobiotic gene expression. Inhalation Toxicology 2012;24(8):506-517. |
R832414 (Final) R832414C002 (Final) |
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Tebockhorst S, Lee D, Wexler AS, Oldham MJ. Interaction of epithelium with mesenchyme affects global features of lung architecture: a computer model of development. Journal of Applied Physiology 2007;102(1):294-305. |
R832414 (2009) R832414C005 (2007) R832414C005 (2008) R832414C005 (Final) |
Exit Exit Exit |
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Van Winkle LS, Chan JK, Anderson DS, Kumfer BM, Kennedy IM, Wexler AS, Wallis C, Abid AD, Sutherland KM, Fanucchi MV. Age specific responses to acute inhalation of diffusion flame soot particles:cellular injury and the airway antioxidant response. Inhalation Toxicology 2010;22(Suppl 2):70-83. |
R832414 (Final) R832414C001 (2010) R832414C001 (Final) |
Exit |
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Wang L, Green FHY, Smiley-Jewell SM, Pinkerton KE. Susceptibility of the aging lung to environmental injury. Seminars in Respiratory and Critical Care Medicine 2010;31(5):539-553. |
R832414 (Final) R829215 (Final) |
Exit |
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Wegesser TC, Pinkerton KE, Last JA. California wildfires of 2008: coarse and fine particulate matter toxicity. Environmental Health Perspectives 2009;117(6):893-897. |
R832414 (2010) R832414C003 (2009) R832414C003 (2010) R832414C003 (Final) |
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Wegesser TC, Franzi LM, Mitloehner FM, Eiguren-Fernandez A, Last JA. Lung antioxidant and cytokine responses to coarse and fine particulate matter from the great California wildfires of 2008. Inhalation Toxicology 2010;22(7):561-570. |
R832414 (Final) R832439 (Final) |
Exit Exit |
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Wells MA, Abid A, Kennedy IM, Barakat AI. Serum proteins prevent aggregation of Fe2O3 and ZnO nanoparticles. Nanotoxicology 2012;6(8):837-846. |
R832414 (Final) |
Exit Exit |
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Wexler AS, Johnston MV. What have we learned from highly time-resolved measurements during EPA's Supersites Program and related studies? Journal of the Air & Waste Management Association 2008;58(2):303-319. |
R832414 (Final) R832414C005 (Final) |
Exit Exit |
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Wilson DW, Aung HH, Lame MW, Plummer L, Pinkerton KE, Ham W, Kleeman M, Norris JW, Tablin F. Exposure of mice to concentrated ambient particulate matter results in platelet and systemic cytokine activation. Inhalation Toxicology 2010;22(4):267-276. |
R832414 (2010) R832414 (Final) R832414C002 (Final) R832414C003 (2010) R832414C003 (Final) |
Exit |
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Zhong C-Y, Zhou Y-M, Smith KR, Kennedy IM, Chen C-Y, Aust AE, Pinkerton KE. Oxidative injury in the lungs of neonatal rats following short-term exposure to ultrafine iron and soot particles. Journal of Toxicology and Environmental Health, Part A-Current Issues 2010;73(12):837-847. |
R832414 (2010) R832414C003 (2010) R832414C003 (Final) R829215 (Final) |
Exit Exit |
Supplemental Keywords:
ambient air, ozone, exposure, health effects, human health, metabolism, sensitive populations, infants, children, PAH, metals, oxidants, agriculture, transportation,Progress and Final Reports:
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832414C001 Project 1 -- Pulmonary Metabolic Response
R832414C002 Endothelial Cell Responses to PM—In Vitro and In Vivo
R832414C003 Project 3 -- Inhalation Exposure Assessment of San Joaquin Valley Aerosol
R832414C004 Project 4 -- Transport and Fate Particles
R832414C005 Project 5 -- Architecture Development and Particle Deposition
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2010 Progress Report
- 2009 Progress Report
- 2008 Progress Report
- 2007 Progress Report
- 2006 Progress Report
64 journal articles for this center