Grantee Research Project Results
2005 Progress Report: Long-term Exposure to Ambient Particulate Matter and Subclinical Atherosclerosis
EPA Grant Number: CR830543Title: Long-term Exposure to Ambient Particulate Matter and Subclinical Atherosclerosis
Investigators: Diez Roux, Ana V. , Keeler, Gerald J. , Samson, Perry , Raghunathan, Trivellore
Current Investigators: Diez Roux, Ana V. , Auchincloss, Amy H , Keeler, Gerald J. , Dvonch, J. Timothy , O'Neill, Marie , Samson, Perry , Raghunathan, Trivellore
Institution: University of Michigan
Current Institution: University of Michigan , Drexel University
EPA Project Officer: Chung, Serena
Project Period: April 1, 2003 through March 31, 2006 (Extended to March 31, 2008)
Project Period Covered by this Report: April 1, 2005 through March 31,2006
Project Amount: $768,990
RFA: Epidemiologic Research on Health Effects of Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants (2002) RFA Text | Recipients Lists
Research Category: Particulate Matter , Human Health , Air
Objective:
The general aim of the project is to determine if long-term exposure to airborne particles is related to the development of atherosclerosis. The objectives are to examine: (1) the relationship between long-term exposure to air particles and the prevalence of subclinical atherosclerotic disease after controlling for established cardiovascular risk factors and key copollutants; (2) if established cardiovascular risk factors modify the relation between long-term exposure to airborne particles and prevalence of subclinical disease; (3) if associations between long-term exposure and atherosclerosis are similar in different race/ethnic groups; and (4) associations between current and recent exposure to air particles and inflammatory markers (a potential biologic mechanism linking air particle exposure to atherosclerosis).
Progress Summary:
The third year of the project has focused on the development of the multiple imputation models for historical PM10 and PM2.5 exposures and the construction of cumulative exposure measures for study participants. We have initiated analyses of long-term exposures in relation to subclinical atherosclerosis. We also have completed two manuscripts: one on acute exposures and inflammatory markers (published in the American Journal of Epidemiology) and a second manuscript on PM exposures and microalbuminuria, which currently is being reviewed by Multi-Ethnic Study of Atherosclerosis (MESA) co-authors.
Future Activities:
- Finalize and submit for publication manuscript on space-time modeling of historical data.
- Finalize and submit for publication manuscript on long-term exposures and subclinical atherosclerosis.
- Complete data analyses with blood pressure and vascular stiffness as outcomes.
Journal Articles on this Report : 4 Displayed | Download in RIS Format
| Other project views: | All 11 publications | 6 publications in selected types | All 6 journal articles |
|---|
| Type | Citation | ||
|---|---|---|---|
|
|
Auchincloss AH, Diez Roux AV, Dvonch JT, Brown PL, Barr RG, Daviglus ML, Goff Jr. DC, Kaufman JD, O'Neill MS. Associations between recent exposure to ambient fine particulate matter and blood pressure in the Multi-Ethnic Study of Atherosclerosis (MESA). Environmental Health Perspectives 2008;116(4):486-491. |
CR830543 (2005) CR830543 (Final) R831697 (2009) R831697 (2010) R831697 (2011) R831697 (2012) R831697 (2013) R831697 (Final) |
Exit Exit |
|
|
Diez Roux AV, Auchincloss AH, Astor B, Barr RG, Cushman M, Dvonch T, Jacobs Jr. DR, Kaufman J, Lin X, Samson P. Recent exposure to particulate matter and C-reactive protein concentration in the Multi-Ethnic Study of Atherosclerosis. American Journal of Epidemiology 2006;164(5):437-448. |
CR830543 (2005) CR830543 (Final) |
Exit Exit |
|
|
Diez Roux AV, Auchincloss AH, Franklin TG, Raghunathan T, Barr RG, Kaufman J, Astor B, Keeler J. Long-term exposure to ambient particulate matter and prevalence of subclinical atherosclerosis in the Multi-Ethnic Study of Atherosclerosis. American Journal of Epidemiology 2008;167(6):667-675. |
CR830543 (2005) CR830543 (Final) R831697 (2009) R831697 (2010) |
Exit Exit |
|
|
O'Neill MS, Diez-Roux AV, Auchincloss AH, Franklin TG, Jacobs Jr DR, Astor BC, Dvonch JT, Kaufman J. Airborne particulate matter exposure and urinary albumin excretion: the Multi-Ethnic Study of Atherosclerosis. Occupational and Environmental Medicine 2008;65(8):534-540. |
CR830543 (2005) CR830543 (Final) R827353 (Final) R831697 (2009) R831697 (2010) |
Exit |
Supplemental Keywords:
exposure, ambient air, health effects, sensitive populations, epidemiology,, Health, RFA, Scientific Discipline, Air, PHYSICAL ASPECTS, Health Risk Assessment, Physical Processes, Risk Assessments, particulate matter, Environmental Monitoring, human exposure, long term exposure, aersol particles, airborne particulate matter, exposure, Acute health effects, atherosclerosis, ambient particle health effects, air pollution, biomarker, human health risk, human health effectsProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.