Grantee Research Project Results

2004 Progress Report: Long-term Exposure to Ambient Particulate Matter and Subclinical Atherosclerosis

EPA Grant Number: CR830543
Title: Long-term Exposure to Ambient Particulate Matter and Subclinical Atherosclerosis
Investigators: Diez Roux, Ana V. , Keeler, Gerald J. , Samson, Perry , Lin, Xihong
Current Investigators: Diez Roux, Ana V. , Auchincloss, Amy H , Keeler, Gerald J. , Dvonch, J. Timothy , O'Neill, Marie , Samson, Perry , Raghunathan, Trivellore
Institution: University of Michigan
Current Institution: University of Michigan , Drexel University
EPA Project Officer: Chung, Serena
Project Period: April 1, 2003 through March 31, 2006 (Extended to March 31, 2008)
Project Period Covered by this Report: April 1, 2004 through March 31, 2005
Project Amount: $768,990
RFA: Epidemiologic Research on Health Effects of Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants (2002) RFA Text | Recipients Lists
Research Category: Human Health , Particulate Matter , Air

Objective:

The general objective of the research project is to determine if long-term exposure to airborne particles is related to the development of atherosclerosis. The specific objectives of the research project are to:

examine the relationship between long-term exposure to air particles and the prevalence of subclinical atherosclerotic disease after controlling for established cardiovascular risk factors and key co-pollutants;
examine if established cardiovascular risk factors modify the relation between long-term exposure to airborne particles and prevalence of subclinical disease;
examine if associations between long-term exposure and atherosclerosis are similar in different race/ethnic groups;
and examine associations between current and recent exposure to air particles and inflammatory markers (a potential biologic mechanism linking air particle exposure to atherosclerosis).

Progress Summary:

Year 2 of the project was focused on data collection, database construction, and acute effects analyses. We performed the following specific tasks:

Continued residential history data collection.
Cleaned and geocoded residential history data.
Completed creation of historical exposure dataset.
Completed analyses relating recent PM_2.5 exposures to inflammatory markers.
Developed space-time models for historical data.
Developed models to predict PM_2.5 data from historical PM₁₀.

Future Activities:

We plan to:

finalize and submit for publication a manuscript on short-term exposure and inflammatory markers;
complete space-time modeling of historical data and draft manuscript;
and prepare a draft manuscript relating long-term exposures to prevalence of subclinical disease.

Journal Articles:

No journal articles submitted with this report: View all 11 publications for this project

Supplemental Keywords:

exposure, ambient air, health effects, sensitive populations, epidemiology, health risk assessment, physical processes, risk assessments, particulate matter, acute health effects, aerosol particles, air pollution, airborne particulate matter, ambient particle health effects, atherosclerosis, biomarker, exposure, human exposure, human health effects, human health risk, long term exposure,, RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, Air, particulate matter, Health Risk Assessment, Risk Assessments, Physical Processes, Environmental Monitoring, long term exposure, human health effects, exposure, atherosclerosis, airborne particulate matter, air pollution, particle exposure, human exposure, ambient particle health effects, Acute health effects, aersol particles, biomarker

Progress and Final Reports:

Original Abstract

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.