Grantee Research Project Results
Final Report: Health Effects Institute (2015-2020): A Partnership for Credible and Relevant Science on the Health Effects of Air Pollution
EPA Grant Number: R835902Center: Health Effects Institute (Prior to 2000)
Center Director: Greenbaum, Daniel S.
Title: Health Effects Institute (2015-2020): A Partnership for Credible and Relevant Science on the Health Effects of Air Pollution
Investigators: Greenbaum, Daniel S. , O’Keefe, Robert , Shaikh, Rashid
Institution: Health Effects Institute
EPA Project Officer: Keating, Terry
Project Period: April 1, 2015 through March 31, 2020
Project Amount: $25,000,000
RFA: Health Effects Institute (2015) RFA Text | Recipients Lists
Research Category: Air
Objective:
To support research on the health effects of emissions from motor vehicles, fuels, and other sources of environmental pollution. Themes guiding the research program are
- Continuing Challenges of Multipollutant Science;
- Accountability and Transparency;
- Assessing Emerging Fuels and Technologies; and
- Global Health Science.
Summary/Accomplishments (Outputs/Outcomes):
HEI made significant progress under this Assistance Agreement for the period 2015–2020. In implementing the Agreement, we have initiated, conducted, and/or completed over 60 scientific studies and reports, including major studies on health effects of exposure to very low levels of air pollution and new accountability and traffic-related air pollution studies, to name just a few areas. We have communicated our results throughout the United States, and in capitals of Europe and Asia. Each of our published reports — and their accompanying journal articles — have been cited in the scientific literature an average of 129 times by other scientists, and our work was cited extensively in key decision documents from the U.S. Environmental Protection Agency, the World Health Organization (WHO), the International Agency for Research on Cancer (IARC), and many more organizations.
The specific scientific accomplishments include:
ADDRESSING MULTIPOLLUTANT CHALLENGES, including
- Estimating the Health Effects of Exposures to Low Levels of Air Pollution
- Initiating three new Multipollutant Studies in Large Populations the US, Canada, and Europe to Estimate the Health Effects of Exposure at Low Concentration and
- Completing studies of the Effects of Low Levels of Ozone on the Cardiovascular System (the Multicenter Ozone Study in OldEr Subjects (MOSES), the largest and most rigorous study ever conducted to investigate whether short-term exposure of older, healthy volunteers to near-ambient levels of ozone in a controlled exposure setting induces acute cardiovascular responses.
- Examining Exposures and Health Effects from Traffic and Port Source Mixtures
- Completing a series of traffic-related air pollution exposure studies
- Launching a New Research Program Placing Transport in the Broader Urban Context,
- Communicating comprehensive new results on Diesel Emissions and Health Effects, and
- Initiating a systematic review of the State of Knowledge Regarding Health Effects of Traffic-Related Air Pollution
ACCOUNTABILITY AND TRANSPARENCY including:
- Completing key studies assessing Air Quality Actions nationwide and in Southern California and Atlanta
- Launching a Next Generation of Accountability Studies of bus replacement programs, transportation interventions, and air quality actions in China
- Continuing HEI’s leading efforts on Data Access and Transparency
EMERGING FUELS AND TECHNOLOGIES:
- HEI organized a workshop in 2016, with the goal to present the latest information on the impact of ethanol and aromatics in fuel and the use of gasoline direct injection.
- Ultrafine particle (UFP) emissions and their potential impact continue to be an area of interest and measurements and effects of ultrafine are a part of several HEI studies. HEI has recently issued RFA 19-1, Applying Novel Approaches to Improve Long-Term Exposure Assessment of Outdoor Air Pollution for Health Studies. The RFA is focused, among other pollutants, on ultrafine particles.
- Non-Tail Pipe Emissions As the use of diesel particulate filters, and other technologies, decreases the overall emissions of PM from the tailpipe, non-combustion emissions of PM are receiving more attention, for example, dust from brake and tire wear and resuspended road dust. Such emissions have not been well studied or characterized. HEI has funded two studies in this area and may undertake additional research in the future.
GLOBAL HEALTH SCIENCE including, with additional support from foundations and other sources:
- Leadership of the assessment of the Global Burden of Disease (GBD) from Outdoor and Household Air Pollution
- Assessment of the Source-Specific Impacts of Air Pollution through Global Burden of Disease from Major Air Pollution Sources (GBD MAPS), including GBD MAPS – China, which identified future coal combustion as a major source, and GBD MAPS – India, which identified household combustion as a major source.
- Analysis of the contribution of shipping to air pollution and health effects in Shanghai, China.
- Annual Publication of the State of Global Air report and website, making air pollution and health data accessible for every nation in the world.
Further details on the implementation of each of these initiatives can be found in the HEI Strategic Plan, available at: https://www.healtheffects.org/publication/hei-strategic-plan-2020-2025
References:
All Publications resulting from HEI research can be found at: http://www.healtheffects.org/publications
Journal Articles: 21 Displayed | Download in RIS Format
| Other center views: | All 57 publications | 57 publications in selected types | All 21 journal articles |
|---|
| Type | Citation | ||
|---|---|---|---|
|
|
Arjomandi M, Balmes J, Frampton M, Bromberg P, Rich D, Stark P, Alexis N, Costantini M, Hollenbeck-Pringle D, Dagincourt N, Hazucha M. RespiratoryResponses to Ozone Exposure MOSES (The MultiR Ozone Study in Older Subjects). AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2018;197(10):1319-1927. |
R835902 (Final) |
Exit Exit Exit |
|
|
Balmes J, Arjomandi M, Bromberg P, Constantini M, Dagincourt N, Hazucha M, Hollenbeck-Pringle D, Stark P, Frampton M. Ozone effects on blood biomarkers of systemic inflammation, oxidative stress, endothelial function, and thrombosis:The Multicenter Ozone Study in oldEr Subjects (MOSES). PLOS ONE 2018;14(9):e0222601. |
R835902 (Final) |
Exit Exit |
|
|
Bouma F, Janssen N, Wessling J, van Ratingen S, Strak M, Kerckhoffs J, Gehring U, Hendricx W, de Hoogh K, Vermeulen R, Hoek G. Long-term exposure to ultrafine particles and natural and cause-specific mortality. ENVIRONMENTAL INTERNATIONAL 2023;175(107960). |
R835902 (Final) |
Exit |
|
|
Chau K, Franklin M, Gauderman W. Satellite-Derived PM2.5 Composition and Its Differential Effect on Children Lung Function. REMOTE SENSING 2020;12(6). |
R835902 (Final) |
Exit Exit |
|
|
De MOira A, Pearce N, Pedersen M, Andersen A. The influence of early-life animal exposure on the risk of childhood atopic dermatitis, asthma and allergic rhinoconjunctivitis: findings from the Danish National Birth Cohort. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 2023;dyad040 |
R835902 (Final) |
Exit |
|
|
Fallah-Shorshani M, Yin X, McConnell R, Fruin S, Franklin M. Estimating traffic noise over a large urban area: An evaluation of methods. ENVIRONMENTAL INTERNATIONAL 2022;170(107583) |
R835902 (Final) |
Exit |
|
|
Fang T, Lakey P, Weber R, Shiraiwa M. Oxidative Potential of Particulate Matter and Generation of Reactive Oxygen Species in Epithelial Lining Fluid. ENVIRONMENAL SCIENCE TECHNOLOGY 2019;53(21):12784-12792. |
R835902 (Final) |
Exit |
|
|
Fang T, Huang Y, Wei J, Monterrosa J, Lakey P, Kleinman M, Digman M, Shiraiwa M. Superoxide Release by Macrophages through NADPH Oxidase Activation Dominating Chemistry by Isoprene Secondary Organic Aerosols and Quinones to Cause Oxidative Damage on Membranes. ENVIRONMENTAL SCIENCE AND TECHNOLOGY 2022;56(23):17029-17038 |
R835902 (Final) |
Exit |
|
|
Franklin M, Yin X, McConnell R, Fruin S. Association of the Built Environment With Childhood Psychosocial Stress. ENVIRONMENTAL HEALTH 2020;3(10):17634. |
R835902 (Final) |
Exit |
|
|
Groot J, Keller A, Pedersen M, Sisgaard T, Loft S, Andersen A. Indoor home environments of Danish children and the socioeconomic position and health of their parents:A descriptive study. ENVIRONMENAL INTERNATIONAL 2022;160. |
R835902 (Final) |
Exit Exit |
|
|
Mila C, Ballester J, Basagana X, Nieuwenhuigsen M, Tonne C. Estimating daily air temperature and pollution in Catalonia: A comprehensive spatiotemporal modelling of multiple exposures. ENVIRONMENTAL POLLUTION 2023;337(122501) |
R835902 (Final) |
Exit |
|
|
Pedersen M. Is ambient air pollution a Risk factor for fecundity?. EPIDEMIOLOGY 2022;36(1):68-69. |
R835902 (Final) |
Exit |
|
|
Pedersen M, Liu S, Zhang J, Zndersen Z, Brandt J, Butdz-Jorgensen E, Bonnelykke K, Frohn L, Andersen A, Ketzel M, Khan J, Stayner L, Brunekreef B, Loft S. Early-Life Exposure to Ambient Air Pollution from Multiple Sources and Asthma Incidence in Children: A Nationwide Birth Cohort Study from Denmark. ENVIRONMENTAL HEALTH PERSPECTIVES 2023;131(5):057003 |
R835902 (Final) |
|
|
|
Peters S, Bouma F, Hoek G, Janssen N, Vermeulen R. Air pollution exposure and mortality from neurodegenerative diseases in the Netherlands:A population-based cohort study. ENVIRONMENTAL RESEARCH 2024;259(119552). |
R835902 (Final) |
Exit |
|
|
Rich D, Balmes J, Frampton M, Zareba W, Stark P, Arjomandi M, Hazucha M, Costantini M, Ganz P, Hollenbeck-Pringle D, Dagincourt N, Bromberg P. Cardiovascular function and ozone exposure:The Multicenter Ozone Study in older Subjects (MOSES). ENVIRONMENTAL INTERNATIONAL 2018;119:193-202. |
R835902 (Final) |
Exit Exit |
|
|
Ripley S, Minet L, Zalzal J, Pollitt K, Gao D, Lakay P, Shiraiwa M, Maher B, Hatzopoulou M, Weicherenthal S. Predicting Spatial Variations in Multiple Measures of PM2.5 Oxidative Potential and Magnetite Nanoparticles in Toronto and Montreal, Canada. ENVIRONMENTAL SCIENCE TECHNOLOGY 2022;56(11):7256-7265. |
R835902 (Final) |
Exit Exit |
|
|
Thacher J, Poulsen A, Hvidfeldt U, Brandt J, Christensen J, Khan J, Gregor M, Sorensen M. Exposure to transportation noise and risk for cardiovascular disease in a nationwide cohort study from Denmark. ENVIRONMENAL RESEARCH 2022;211. |
R835902 (Final) |
Exit Exit |
|
|
Yin X, Fallah-Shorshani M, McConnell R, Fruin S, Franklin M. Predicting Fine Spatial Scale Traffic Noise Using Mobile Measurements and Machine Learning. ENVIRONMENTAL SCIENCE TECHNOLOGY 2020;54(20):12860-12869. |
R835902 (Final) |
Exit Exit |
|
|
Yin X, Franklin M, Fallah-Shorshani M, Shafer M, McConnell R, Fruin R. Exposure models for particulate matter elemental concentrations in Southern California. ENVIRONMENT INTERNATIONAL 2022;165(107427). |
R835902 (Final) |
Exit Exit |
|
|
Zhang J, Lim Y, So R, Jorgensen J, Mortensen L, Napolitano G, Cole-Hunter T, Loft S, Bhatt S, Hoek G, Brunekreef B, Westdorp R, Ketzel M, Brandt J, Lange T, Kilsen-Fisher T, Andersen Z. Long-term exposure to air pollution and risk of SARS-CoV-2 infection and COVID-19 hospitalisation or death:Danish nationwide cohort study. EUROPEAN RESPIRATORY JOURNAL 2023;62(1):2300280. |
R835902 (Final) |
Exit |
|
|
Zhang Z, Weichenthal S, Kwong J, Burnett R, Hatzopoulou M, Jerrett M, van Donklaar A, Bai L, Martin R, Copes R, Lakey P, Shirwiwa M, Cheng H. Long-term exposure to iron and copper in fine particulate air pollution and their combined impact on reactive oxygen species concentration in lung fluid:a population-based cohort study of cardiovascular disease incidence and mortality in Toronto, Canada. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 2021;50(2):589-601. |
R835902 (Final) |
Exit Exit |
Supplemental Keywords:
Air quality, Accountability, Global research, Public healthRelevant Websites:
Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- 2018 Progress Report
- 2017 Progress Report
- 2016 Progress Report
- 2015 Progress Report
- Original Abstract
21 journal articles for this center