Grantee Research Project Results
2017 Progress Report: Health Effects Institute (2015-2020): A Partnership for Credible and Relevant Science on the Health Effects of Air Pollution
EPA Grant Number: R835902Center: Health Effects Institute (Prior to 2000)
Center Director: Greenbaum, Daniel S.
Title: Health Effects Institute (2015-2020): A Partnership for Credible and Relevant Science on the Health Effects of Air Pollution
Investigators: Greenbaum, Daniel S. , O’Keefe, Robert , Shaikh, Rashid
Institution: Health Effects Institute
EPA Project Officer: Keating, Terry
Project Period: April 1, 2015 through March 31, 2020
Project Period Covered by this Report: April 1, 2017 through March 31,2018
Project Amount: $25,000,000
RFA: Health Effects Institute (2015) RFA Text | Recipients Lists
Research Category: Air
Objective:
To support research on the health effects of emissions from motor vehicles, fuels, and other sources of environmental pollution. Themes guiding the research program are:
- Continuing Challenges of Multipollutant Science
- Accountability and Transparency
- Assessing Emerging Fuels and Technologies
- Global Health Science.
Progress Summary:
- Published the results of the Multicenter Ozone Study in Elderly Subjects (MOSES), the largest most rigorous study to investigate short term exposure of older, healthy volunteers to near ambient ozone levels and cardiovascular responses.
- Three teams continue to implement multipollutant studies in large populations to estimate the effects of exposure to low concentrations. The teams have completed a number of initial steps, including agreements for data access and plans for exposure assessments. A special oversight group has been established to augment the Research Committee and an independent QA/QC auditor has been hired.
- Initiated the process for conducting an update to the 2010 review of the health effects of traffic related air pollution, including the identification of review panel members.
- Published a study (Barratt) aimed at enhancing exposure assessment for traffic-related air pollution.
- Published a study (Russell) on the impact of air pollution regulations on air quality and emergency department visitis in Atlanta, 1993-2013.
- Published a summary of a 2016 workshop on the effects of fuel composition on PM emissions.
Future Activities:
- HEI will make provisions to provide full access to MOSES data to interested scientists.
- Final reports are expected from a series of studies focused on exposure to traffic related air pollution.
- Continued progress on low level exposure studies and review of traffic related air pollution.
Journal Articles: 20 Displayed | Download in RIS Format
Other center views: | All 56 publications | 56 publications in selected types | All 20 journal articles |
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Arjomandi M, Balmes J, Frampton M, Bromberg P, Rich D, Stark P, Alexis N, Costantini M, Hollenbeck-Pringle D, Dagincourt N, Hazucha M. RespiratoryResponses to Ozone Exposure MOSES (The MultiR Ozone Study in Older Subjects). AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2018;197(10):1319-1927. |
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Balmes J, Arjomandi M, Bromberg P, Constantini M, Dagincourt N, Hazucha M, Hollenbeck-Pringle D, Stark P, Frampton M. Ozone effects on blood biomarkers of systemic inflammation, oxidative stress, endothelial function, and thrombosis:The Multicenter Ozone Study in oldEr Subjects (MOSES). PLOS ONE 2018;14(9):e0222601. |
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Bouma F, Janssen N, Wessling J, van Ratingen S, Strak M, Kerckhoffs J, Gehring U, Hendricx W, de Hoogh K, Vermeulen R, Hoek G. Long-term exposure to ultrafine particles and natural and cause-specific mortality. ENVIRONMENTAL INTERNATIONAL 2023;175(107960). |
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Chau K, Franklin M, Gauderman W. Satellite-Derived PM2.5 Composition and Its Differential Effect on Children Lung Function. REMOTE SENSING 2020;12(6). |
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De MOira A, Pearce N, Pedersen M, Andersen A. The influence of early-life animal exposure on the risk of childhood atopic dermatitis, asthma and allergic rhinoconjunctivitis: findings from the Danish National Birth Cohort. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 2023;dyad040 |
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Fallah-Shorshani M, Yin X, McConnell R, Fruin S, Franklin M. Estimating traffic noise over a large urban area: An evaluation of methods. ENVIRONMENTAL INTERNATIONAL 2022;170(107583) |
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Fang T, Lakey P, Weber R, Shiraiwa M. Oxidative Potential of Particulate Matter and Generation of Reactive Oxygen Species in Epithelial Lining Fluid. ENVIRONMENAL SCIENCE TECHNOLOGY 2019;53(21):12784-12792. |
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Fang T, Huang Y, Wei J, Monterrosa J, Lakey P, Kleinman M, Digman M, Shiraiwa M. Superoxide Release by Macrophages through NADPH Oxidase Activation Dominating Chemistry by Isoprene Secondary Organic Aerosols and Quinones to Cause Oxidative Damage on Membranes. ENVIRONMENTAL SCIENCE AND TECHNOLOGY 2022;56(23):17029-17038 |
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Franklin M, Yin X, McConnell R, Fruin S. Association of the Built Environment With Childhood Psychosocial Stress. ENVIRONMENTAL HEALTH 2020;3(10):17634. |
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Groot J, Keller A, Pedersen M, Sisgaard T, Loft S, Andersen A. Indoor home environments of Danish children and the socioeconomic position and health of their parents:A descriptive study. ENVIRONMENAL INTERNATIONAL 2022;160. |
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Mila C, Ballester J, Basagana X, Nieuwenhuigsen M, Tonne C. Estimating daily air temperature and pollution in Catalonia: A comprehensive spatiotemporal modelling of multiple exposures. ENVIRONMENTAL POLLUTION 2023;337(122501) |
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Pedersen M. Is ambient air pollution a Risk factor for fecundity?. EPIDEMIOLOGY 2022;36(1):68-69. |
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Pedersen M, Liu S, Zhang J, Zndersen Z, Brandt J, Butdz-Jorgensen E, Bonnelykke K, Frohn L, Andersen A, Ketzel M, Khan J, Stayner L, Brunekreef B, Loft S. Early-Life Exposure to Ambient Air Pollution from Multiple Sources and Asthma Incidence in Children: A Nationwide Birth Cohort Study from Denmark. ENVIRONMENTAL HEALTH PERSPECTIVES 2023;131(5):057003 |
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Rich D, Balmes J, Frampton M, Zareba W, Stark P, Arjomandi M, Hazucha M, Costantini M, Ganz P, Hollenbeck-Pringle D, Dagincourt N, Bromberg P. Cardiovascular function and ozone exposure:The Multicenter Ozone Study in older Subjects (MOSES). ENVIRONMENTAL INTERNATIONAL 2018;119:193-202. |
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Ripley S, Minet L, Zalzal J, Pollitt K, Gao D, Lakay P, Shiraiwa M, Maher B, Hatzopoulou M, Weicherenthal S. Predicting Spatial Variations in Multiple Measures of PM2.5 Oxidative Potential and Magnetite Nanoparticles in Toronto and Montreal, Canada. ENVIRONMENTAL SCIENCE TECHNOLOGY 2022;56(11):7256-7265. |
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Thacher J, Poulsen A, Hvidfeldt U, Brandt J, Christensen J, Khan J, Gregor M, Sorensen M. Exposure to transportation noise and risk for cardiovascular disease in a nationwide cohort study from Denmark. ENVIRONMENAL RESEARCH 2022;211. |
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Yin X, Fallah-Shorshani M, McConnell R, Fruin S, Franklin M. Predicting Fine Spatial Scale Traffic Noise Using Mobile Measurements and Machine Learning. ENVIRONMENTAL SCIENCE TECHNOLOGY 2020;54(20):12860-12869. |
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Yin X, Franklin M, Fallah-Shorshani M, Shafer M, McConnell R, Fruin R. Exposure models for particulate matter elemental concentrations in Southern California. ENVIRONMENT INTERNATIONAL 2022;165(107427). |
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Zhang J, Lim Y, So R, Jorgensen J, Mortensen L, Napolitano G, Cole-Hunter T, Loft S, Bhatt S, Hoek G, Brunekreef B, Westdorp R, Ketzel M, Brandt J, Lange T, Kilsen-Fisher T, Andersen Z. Long-term exposure to air pollution and risk of SARS-CoV-2 infection and COVID-19 hospitalisation or death:Danish nationwide cohort study. EUROPEAN RESPIRATORY JOURNAL 2023;62(1):2300280. |
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Zhang Z, Weichenthal S, Kwong J, Burnett R, Hatzopoulou M, Jerrett M, van Donklaar A, Bai L, Martin R, Copes R, Lakey P, Shirwiwa M, Cheng H. Long-term exposure to iron and copper in fine particulate air pollution and their combined impact on reactive oxygen species concentration in lung fluid:a population-based cohort study of cardiovascular disease incidence and mortality in Toronto, Canada. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 2021;50(2):589-601. |
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Supplemental Keywords:
air quality, accountability, global research, public healthRelevant Websites:
Welcome to the Health Effects Institute Exit
Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.