Grantee Research Project Results
2015 Progress Report: Health Effects Institute (2015-2020): A Partnership for Credible and Relevant Science on the Health Effects of Air Pollution
EPA Grant Number: R835902Center: Health Effects Institute (Prior to 2000)
Center Director: Greenbaum, Daniel S.
Title: Health Effects Institute (2015-2020): A Partnership for Credible and Relevant Science on the Health Effects of Air Pollution
Investigators: Greenbaum, Daniel S. , Shaikh, Rashid , O’Keefe, Robert
Current Investigators: Greenbaum, Daniel S. , O’Keefe, Robert , Shaikh, Rashid
Institution: Health Effects Institute
EPA Project Officer: Keating, Terry
Project Period: April 1, 2015 through March 31, 2020
Project Period Covered by this Report: April 1, 2015 through March 31,2016
Project Amount: $25,000,000
RFA: Health Effects Institute (2015) RFA Text | Recipients Lists
Research Category: Air
Objective:
To support research on the health effects of emissions from motor vehicles, fuels and other sources of environmental pollution. Themes guiding the research program are Continuing Challenges of Multipollutant Science, Accountability and Transparency, Assessing Emerging Fuels and Technologies, and Global Health Science.
Progress Summary:
During the past year under award CR83590201, the Health Effects Institute (HEI) has:
- Launched three comprehensive and rigorous new studies of the effects of low levels of exposure to air pollution in a set of large and detailed population cohorts.
- Published and widely disseminated HEI Special Report 19, Diesel Emissions and Lung Cancer: An Evaluation of Recent Epidemiological Evidence for Quantitative Risk Assessment, and the Executive Summary of The Advanced Collaborative Emissions Study (ACES).
- Completed all exposures and analysis for HEI’s Multicenter Ozone Study in Older Subjects (MOSES) and entered the final report into HEI's intensive and independent review process.
- Highlighted ongoing research at the widely attended HEI Annual Conference in April (where the new ACES Centers also were announced).
Future Activities:
Looking ahead, HEI expects to make major progress in Year Two of the grant, including:
- Completing review and publication of the MOSES study, as well as studies on mechanisms of health effects and other topics.
- Completing data collection and analysis of HEI's current traffic exposure studies and receiving reports for review.
- Completing the second wave of accountability studies at the national and regional scale and studying port areas.
- Holding a workshop on fuel composition and particulate matter in late 2016.
- Launching key efforts for HEI's next major research initiative—of new studies of traffic and health—with an expert workshop in May 2016 and an RFA to be issued early in 2017.
In addition, with additional funding from other sources, HEI plans to continue its efforts regarding its Energy Research Program and its involvement in the Global Burden of Disease project regarding the burden attributed to ambient air pollution, including the launch of a State of Global Air website.
Journal Articles: 21 Displayed | Download in RIS Format
| Other center views: | All 57 publications | 57 publications in selected types | All 21 journal articles |
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Arjomandi M, Balmes J, Frampton M, Bromberg P, Rich D, Stark P, Alexis N, Costantini M, Hollenbeck-Pringle D, Dagincourt N, Hazucha M. RespiratoryResponses to Ozone Exposure MOSES (The MultiR Ozone Study in Older Subjects). AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2018;197(10):1319-1927. |
R835902 (Final) |
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Balmes J, Arjomandi M, Bromberg P, Constantini M, Dagincourt N, Hazucha M, Hollenbeck-Pringle D, Stark P, Frampton M. Ozone effects on blood biomarkers of systemic inflammation, oxidative stress, endothelial function, and thrombosis:The Multicenter Ozone Study in oldEr Subjects (MOSES). PLOS ONE 2018;14(9):e0222601. |
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Bouma F, Janssen N, Wessling J, van Ratingen S, Strak M, Kerckhoffs J, Gehring U, Hendricx W, de Hoogh K, Vermeulen R, Hoek G. Long-term exposure to ultrafine particles and natural and cause-specific mortality. ENVIRONMENTAL INTERNATIONAL 2023;175(107960). |
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Chau K, Franklin M, Gauderman W. Satellite-Derived PM2.5 Composition and Its Differential Effect on Children Lung Function. REMOTE SENSING 2020;12(6). |
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De MOira A, Pearce N, Pedersen M, Andersen A. The influence of early-life animal exposure on the risk of childhood atopic dermatitis, asthma and allergic rhinoconjunctivitis: findings from the Danish National Birth Cohort. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 2023;dyad040 |
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Fallah-Shorshani M, Yin X, McConnell R, Fruin S, Franklin M. Estimating traffic noise over a large urban area: An evaluation of methods. ENVIRONMENTAL INTERNATIONAL 2022;170(107583) |
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Fang T, Lakey P, Weber R, Shiraiwa M. Oxidative Potential of Particulate Matter and Generation of Reactive Oxygen Species in Epithelial Lining Fluid. ENVIRONMENAL SCIENCE TECHNOLOGY 2019;53(21):12784-12792. |
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Fang T, Huang Y, Wei J, Monterrosa J, Lakey P, Kleinman M, Digman M, Shiraiwa M. Superoxide Release by Macrophages through NADPH Oxidase Activation Dominating Chemistry by Isoprene Secondary Organic Aerosols and Quinones to Cause Oxidative Damage on Membranes. ENVIRONMENTAL SCIENCE AND TECHNOLOGY 2022;56(23):17029-17038 |
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Franklin M, Yin X, McConnell R, Fruin S. Association of the Built Environment With Childhood Psychosocial Stress. ENVIRONMENTAL HEALTH 2020;3(10):17634. |
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Groot J, Keller A, Pedersen M, Sisgaard T, Loft S, Andersen A. Indoor home environments of Danish children and the socioeconomic position and health of their parents:A descriptive study. Environmental International 2022;160. |
R835902 (Final) CR839981 (Final) |
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Mila C, Ballester J, Basagana X, Nieuwenhuigsen M, Tonne C. Estimating daily air temperature and pollution in Catalonia: A comprehensive spatiotemporal modelling of multiple exposures. ENVIRONMENTAL POLLUTION 2023;337(122501) |
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Pedersen M. Is ambient air pollution a Risk factor for fecundity?. EPIDEMIOLOGY 2022;36(1):68-69. |
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Pedersen M, Liu S, Zhang J, Zndersen Z, Brandt J, Butdz-Jorgensen E, Bonnelykke K, Frohn L, Andersen A, Ketzel M, Khan J, Stayner L, Brunekreef B, Loft S. Early-Life Exposure to Ambient Air Pollution from Multiple Sources and Asthma Incidence in Children: A Nationwide Birth Cohort Study from Denmark. ENVIRONMENTAL HEALTH PERSPECTIVES 2023;131(5):057003 |
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Peters S, Bouma F, Hoek G, Janssen N, Vermeulen R. Air pollution exposure and mortality from neurodegenerative diseases in the Netherlands: a population-based cohort study. Environmental Research 2024;259:119552. |
R835902 (Final) CR839981 (Final) |
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Rich D, Balmes J, Frampton M, Zareba W, Stark P, Arjomandi M, Hazucha M, Costantini M, Ganz P, Hollenbeck-Pringle D, Dagincourt N, Bromberg P. Cardiovascular function and ozone exposure:The Multicenter Ozone Study in older Subjects (MOSES). ENVIRONMENTAL INTERNATIONAL 2018;119:193-202. |
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Ripley S, Minet L, Zalzal J, Pollitt K, Gao D, Lakay P, Shiraiwa M, Maher B, Hatzopoulou M, Weicherenthal S. Predicting Spatial Variations in Multiple Measures of PM2.5 Oxidative Potential and Magnetite Nanoparticles in Toronto and Montreal, Canada. ENVIRONMENTAL SCIENCE TECHNOLOGY 2022;56(11):7256-7265. |
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Thacher J, Poulsen A, Hvidfeldt U, Brandt J, Christensen J, Khan J, Gregor M, Sorensen M. Exposure to transportation noise and risk for cardiovascular disease in a nationwide cohort study from Denmark. ENVIRONMENAL RESEARCH 2022;211. |
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Yin X, Fallah-Shorshani M, McConnell R, Fruin S, Franklin M. Predicting Fine Spatial Scale Traffic Noise Using Mobile Measurements and Machine Learning. ENVIRONMENTAL SCIENCE TECHNOLOGY 2020;54(20):12860-12869. |
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Yin X, Franklin M, Fallah-Shorshani M, Shafer M, McConnell R, Fruin R. Exposure models for particulate matter elemental concentrations in Southern California. ENVIRONMENT INTERNATIONAL 2022;165(107427). |
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Zhang J, Lim Y, So R, Jorgensen J, Mortensen L, Napolitano G, Cole-Hunter T, Loft S, Bhatt S, Hoek G, Brunekreef B, Westdorp R, Ketzel M, Brandt J, Lange T, Kilsen-Fisher T, Andersen Z. Long-term exposure to air pollution and risk of SARS-CoV-2 infection and COVID-19 hospitalisation or death:Danish nationwide cohort study. EUROPEAN RESPIRATORY JOURNAL 2023;62(1):2300280. |
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Zhang Z, Weichenthal S, Kwong J, Burnett R, Hatzopoulou M, Jerrett M, van Donklaar A, Bai L, Martin R, Copes R, Lakey P, Shirwiwa M, Cheng H. Long-term exposure to iron and copper in fine particulate air pollution and their combined impact on reactive oxygen species concentration in lung fluid:a population-based cohort study of cardiovascular disease incidence and mortality in Toronto, Canada. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 2021;50(2):589-601. |
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Supplemental Keywords:
Air quality, air pollution, accountability, global research, public healthRelevant Websites:
Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.