Grantee Research Project Results
2014 Progress Report: Epigenetics Project
EPA Grant Number: R834513C003Subproject: this is subproject number 003 , established and managed by the Center Director under grant R834513
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Center for Integrative Research on Childhood Leukemia and the Environment - 2015
Center Director: Metayer, Catherine
Title: Epigenetics Project
Investigators: Eskenazi, Brenda , Bradman, Asa , Holland, Nina T. , Johnson, Caroline , Harley, Kim , Arora, Manish , Lustig, Robert , Sjodin, Andreas , Smith, Donald , Chevrier, Jonathan
Current Investigators: Eskenazi, Brenda
Institution: University of California - Berkeley
EPA Project Officer: Hahn, Intaek
Project Period: August 1, 2009 through July 31, 2014 (Extended to July 31, 2017)
Project Period Covered by this Report: August 1, 2009 through July 31,2014
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2009) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
In Project C, we are investigating the effects of exposure on the epigenome and its relationship with pubertal onset.
Progress Summary:
Future Activities:
In the next year, we plan to finalize the analyses of complex multi-dimensional data from 450K Beadchips, and to focus on validation of the found hits by assessment of expression of these genes by Nanostring and qPCR, as well as by alternative platform such as targeted bisulfite pyrosequencing or next generation sequencing. Several manuscripts currently in preparation will be submitted for publication.
Journal Articles on this Report : 8 Displayed | Download in RIS Format
Other subproject views: | All 77 publications | 38 publications in selected types | All 38 journal articles |
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Other center views: | All 694 publications | 167 publications in selected types | All 166 journal articles |
Type | Citation | ||
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Chadwick LH, Sawa A, Yang IV, Baccarelli A, Breakefield XO, Deng H-W, Dolinoy DC, Fallin MD, Holland NT, Houseman EA, Lomvardas S, Rao M, Satterlee JS, Tyson FL, Vijayanand P, Greally JM. New insights and updated guidelines for epigenome-wide association studies. Neuroepigenetics 2015;1:14-19. |
R834513 (2014) R834513 (2015) R834513C003 (2014) R834513C003 (2015) |
Exit Exit Exit |
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Dave V, Yousefi P, Huen K, Volberg V, Holland N. Relationship between expression and methylation of obesity-related genes in children. Mutagenesis 2015;30(3):411-420. |
R834513 (2013) R834513 (2014) R834513 (2015) R834513 (Final) R834513C003 (2013) R834513C003 (2014) R834513C003 (2015) |
Exit Exit Exit |
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Holland N, Lizarraga D, Huen K. Recent progress in the genetics and epigenetics of paraoxonase: why it is relevant to children's environmental health. Current Opinion in Pediatrics 2015;27(2):240-247. |
R834513 (2013) R834513 (2014) R834513 (2015) R834513 (Final) R834513C003 (2013) R834513C003 (2014) R834513C003 (2015) R834513C004 (2013) |
Exit Exit Exit |
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Huen K, Harley K, Beckman K, Eskenazi B, Holland N. Associations of PON1 and genetic ancestry with obesity in early childhood. PLoS One 2013;8(5):e62565. |
R834513 (2013) R834513 (2014) R834513 (Final) R834513C001 (2013) R834513C003 (2014) |
Exit Exit Exit |
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Huen K, Yousefi P, Bradman A, Yan L, Harley KG, Kogut K, Eskenazi B, Holland N. Effects of age, sex, and persistent organic pollutants on DNA methylation in children. Environmental and Molecular Mutagenesis 2014;55(3):209-222. |
R834513 (2012) R834513 (2013) R834513 (2014) R834513 (2015) R834513 (Final) R834513C001 (2015) R834513C003 (2010) R834513C003 (2012) R834513C003 (2014) |
Exit Exit |
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Volberg V, Harley KG, Aguilar RS, Rosas LG, Huen K, Yousefi P, Dave V, Phan N, Lustig RH, Eskenazi B, Holland N. Associations between perinatal factors and adiponectin and leptin in 9-year-old Mexican-American children. Pediatric Obesity 2013;8(6):454-463. |
R834513 (2013) R834513 (2014) R834513 (Final) R834513C001 (2013) R834513C003 (2014) |
Exit Exit |
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Volberg V, Heggeseth B, Harley K, Huen K, Yousefi P, Dave V, Tyler K, Vedar M, Eskenazi B, Holland N. Adiponectin and leptin trajectories in Mexican-American children from birth to 9 years of age. PLoS One 2013;8(10):e77964 (8 pp.). |
R834513 (2014) R834513C003 (2014) |
Exit Exit |
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Yousefi P, Huen K, Schall RA, Decker A, Elboudwarej E, Quach H, Barcellos L, Holland N. Considerations for normalization of DNA methylation data by Illumina 450K BeadChip assay in population studies. Epigenetics 2013;8(11):1141-1152. |
R834513 (2012) R834513 (2013) R834513 (2014) R834513 (2015) R834513 (Final) R834513C003 (2012) R834513C003 (2013) R834513C003 (2014) R834513C003 (2015) |
Exit Exit Exit |
Supplemental Keywords:
epigenetics, methylation, DDT, DDE, PBDEs, flame retardants, manganese, maneb, puberty, RFA, Scientific Discipline, Health, INTERNATIONAL COOPERATION, Health Risk Assessment, Biochemistry, Children's Health, Environmental Policy, Biology, farmworkers, pesticide exposure, flame retardants, PBDE, children's vulnerablity, neurochemical effects, harmful environmental agents, biological markers, agricultural communityRelevant Websites:
Center for Environmental Research and Children's Health Exit
Progress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R834513 Center for Integrative Research on Childhood Leukemia and the Environment - 2015 Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834513C001 CHAMACOS Cohort Project: Pesticides and PBDE on Neurobehavior and Puberty
R834513C002 Project B: Exposure Project: Mn, DDT/E and PBDE Exposure to Farmworker Children
R834513C003 Epigenetics Project
R834513C004 Community Outreach and Translation Core
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2016 Progress Report
- 2015 Progress Report
- 2013 Progress Report
- 2012 Progress Report
- 2011 Progress Report
- 2010 Progress Report
- Original Abstract
38 journal articles for this subproject
Main Center: R834513
694 publications for this center
166 journal articles for this center