Grantee Research Project Results
2010 Progress Report: Epigenetics Project
EPA Grant Number: R834513C003Subproject: this is subproject number 003 , established and managed by the Center Director under grant R834513
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Center for Integrative Research on Childhood Leukemia and the Environment - 2015
Center Director: Metayer, Catherine
Title: Epigenetics Project
Investigators: Eskenazi, Brenda , Holland, Nina T.
Current Investigators: Eskenazi, Brenda
Institution: University of California - Berkeley
EPA Project Officer: Hahn, Intaek
Project Period: August 1, 2009 through July 31, 2014 (Extended to July 31, 2017)
Project Period Covered by this Report: August 1, 2010 through May 31,2011
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2009) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
In Project C (R834513C003), we are investigating the effects of exposure on the epigenome and its relationship with pubertal onset. This year, we have continued to assess global methylation in DNA isolated from banked clot specimens of CHAMACOS children using three different assay methods: pyrosequencing (Alu and LINE-1 repeats) and Illumina Infinium. Preliminary analyses suggest that global methylation patterns are likely fluctuating throughout early childhood. If verified through expanded analysis, the opposite directions of the change in global DNA methylation by LINE-1 and Illumina 27k assays may highlight the importance of using site-specific methylation data. Furthermore, we have found that global DNA methylation may be modified by prenatal exposure to PBDEs, providing a potential mechanism by which PBDEs and possibly other toxicants affect health.
- To analyze global DNA methylation in newborn children by three different assays.
- To determine ontogenetic changes in global DNA methylation in blood of children between birth and 12 years.
- To investigate the relationship of in utero and 9-year-old blood concentrations of DDT/E and PBDEs with global DNA methylation.
- To determine whether global methylation is associated with onset of puberty and hormonal changes.
- To examine site-specific methylation in relation to age, sex, exposure to DDT/E and PBDEs and puberty onset.
Progress Summary:
Future Activities:
Journal Articles on this Report : 7 Displayed | Download in RIS Format
Other subproject views: | All 77 publications | 38 publications in selected types | All 38 journal articles |
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Other center views: | All 694 publications | 167 publications in selected types | All 166 journal articles |
Supplemental Keywords:
RFA, Scientific Discipline, Health, INTERNATIONAL COOPERATION, Health Risk Assessment, Biochemistry, Children's Health, Environmental Policy, Biology, farmworkers, pesticide exposure, flame retardants, PBDE, children's vulnerablity, neurochemical effects, harmful environmental agents, biological markers, agricultural communityRelevant Websites:
Progress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R834513 Center for Integrative Research on Childhood Leukemia and the Environment - 2015 Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834513C001 CHAMACOS Cohort Project: Pesticides and PBDE on Neurobehavior and Puberty
R834513C002 Project B: Exposure Project: Mn, DDT/E and PBDE Exposure to Farmworker Children
R834513C003 Epigenetics Project
R834513C004 Community Outreach and Translation Core
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2016 Progress Report
- 2015 Progress Report
- 2014 Progress Report
- 2013 Progress Report
- 2012 Progress Report
- 2011 Progress Report
- Original Abstract
38 journal articles for this subproject
Main Center: R834513
694 publications for this center
166 journal articles for this center