Grantee Research Project Results
2013 Progress Report: CHAMACOS Cohort Project: Pesticides and PBDE on Neurobehavior and Puberty
EPA Grant Number: R834513C001Subproject: this is subproject number 001 , established and managed by the Center Director under grant R834513
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Center for Research on Early Childhood Exposure and Development in Puerto Rico
Center Director: Alshawabkeh, Akram
Title: CHAMACOS Cohort Project: Pesticides and PBDE on Neurobehavior and Puberty
Investigators: Eskenazi, Brenda , Holland, Nina T. , Sjodin, Andreas , Bradman, Asa , Johnson, Caroline , Smith, Donald , Eisen, Ellen , Chevrier, Jonathan , Harley, Kim , Arora, Manish , Lustig, Robert
Current Investigators: Eskenazi, Brenda
Institution: University of California - Berkeley
EPA Project Officer: Hahn, Intaek
Project Period: August 1, 2009 through July 31, 2014 (Extended to July 31, 2017)
Project Period Covered by this Report: June 1, 2012 through May 31,2013
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2009) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
We are examining the association of DDT, Mn, and PBDEs with neurodevelopment and onset of puberty in boys in the CHAMACOS cohort. This study directly addresses worldwide concerns that changes in onset of sexual maturation may be related to endocrine disruptors in the environment and fills a large data gap on boys. It also addresses concerns that exposure to DDT/E, PBDEs and Mn may compromise neurodevelopment.
Progress Summary:
Future Activities:
In year 5, we will complete the 11¼-year and 12-year assessments, and will complete as many 12¾ visits as we are able before funding expires. We will complete data entry and cleaning of the 10½-year questionnaire and neurodevelopment data, as well as for age 9¾, 10½, and 11¼ Tanner data. We anticipate that PBPK models to back-extrapolate levels during pregnancy for CHAM2 will be completed by March 2014. Statistical analyses of prenatal PBDEs and DDT/E exposure in CHAM2 study participants (Aims 2 and 3) will begin when these PBPK models are available.
Journal Articles on this Report : 10 Displayed | Download in RIS Format
Other subproject views: | All 148 publications | 76 publications in selected types | All 76 journal articles |
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Other center views: | All 694 publications | 167 publications in selected types | All 166 journal articles |
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Chevrier J, Gunier RB, Bradman A, Holland NT, Calafat AM, Eskenazi B, Harley KG. Maternal urinary bisphenol A during pregnancy and maternal and neonatal thyroid function in the CHAMACOS study. Environmental Health Perspectives 2013;121(1):138-144. |
R834513 (2012) R834513 (2013) R834513 (Final) R834513C001 (2012) R834513C001 (2013) |
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Ehrlich SF, Rosas LG, Ferrara A, King JC, Abrams B, Harley KG, Hedderson MM, Eskenazi B. Pregnancy glucose levels in women without diabetes or gestational diabetes and childhood cardiometabolic risk at 7 years of age. Journal of Pediatrics 2012;161(6):1016-1021. |
R834513 (2012) R834513 (2013) R834513 (Final) R834513C001 (2012) R834513C001 (2013) |
Exit |
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Ehrlich SF, Rosas LG, Ferrara A, King JC, Abrams B, Harley KG, Hedderson MM, Eskenazi B. Pregnancy glycemia in Mexican-American women without diabetes or gestational diabetes and programming for childhood obesity. American Journal of Epidemiology 2013;177(8):768-775. |
R834513 (2012) R834513 (2013) R834513 (Final) R834513C001 (2012) R834513C001 (2013) |
Exit Exit Exit |
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Eskenazi B, Chevrier J, Rauch SA, Kogut K, Harley KG, Johnson C, Trujillo C, Sjodin A, Bradman A. In utero and childhood polybrominated diphenyl ether (PBDE) exposures and neurodevelopment in the CHAMACOS study. Environmental Health Perspectives 2013;121(2):257-262. |
R834513 (2012) R834513 (2013) R834513 (2014) R834513C001 (2012) R834513C001 (2013) R834513C003 (2013) |
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Gemmill A, Gunier RB, Bradman A, Eskenazi B, Harley KG. Residential proximity to methyl bromide use and birth outcomes in an agricultural population in California. Environmental Health Perspectives 2013;121(6):737-743. |
R834513 (2013) R834513 (2014) R834513 (Final) R834513C001 (2013) R834513C001 (2014) |
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Harley KG, Aguilar Schall R, Chevrier J, Tyler K, Aguirre H, Bradman A, Holland NT, Lustig RH, Calafat AM, Eskenazi B. Prenatal and postnatal bisphenol A exposure and body mass index in childhood in the CHAMACOS cohort. Environmental Health Perspectives 2013;121(4):514-520. |
R834513 (2012) R834513 (2013) R834513 (Final) R834513C001 (2012) R834513C001 (2013) |
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Huen K, Harley K, Beckman K, Eskenazi B, Holland N. Associations of PON1 and genetic ancestry with obesity in early childhood. PLoS One 2013;8(5):e62565. |
R834513 (2013) R834513 (2014) R834513 (Final) R834513C001 (2013) R834513C003 (2014) |
Exit Exit Exit |
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Volberg V, Harley KG, Aguilar RS, Rosas LG, Huen K, Yousefi P, Dave V, Phan N, Lustig RH, Eskenazi B, Holland N. Associations between perinatal factors and adiponectin and leptin in 9-year-old Mexican-American children. Pediatric Obesity 2013;8(6):454-463. |
R834513 (2013) R834513 (2014) R834513 (Final) R834513C001 (2013) R834513C003 (2014) |
Exit Exit |
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Warner M, Mocarelli P, Brambilla P, Wesselink A, Samuels S, Signorini S, Eskenazi B. Diabetes, metabolic syndrome, and obesity in relation to serum dioxin concentrations: the Seveso Women's Health Study. Environmental Health Perspectives 2013;121(8):906-911. |
R834513 (2013) R834513 (2014) R834513 (Final) R834513C001 (2013) R834513C001 (2014) |
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Warner M, Schall RA, Harley KG, Bradman A, Barr D, Eskenazi B. In utero DDT and DDE exposure and obesity status of 7-year-old Mexican-American children in the CHAMACOS cohort. Environmental Health Perspectives 2013;121(5):631-636. |
R834513 (2013) R834513 (2014) R834513 (Final) R834513C001 (2013) R834513C001 (2014) R834513C003 (2013) |
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Supplemental Keywords:
Behavior, children's health, CHAMACOS, DDT, DDE, flame retardants, maneb,manganese, neurodevelopment, PBDEs, puberty, RFA, Health, Scientific Discipline, INTERNATIONAL COOPERATION, Health Risk Assessment, Biochemistry, Children's Health, Environmental Policy, Biology, farmworkers, pesticide exposure, flame retardants, PBDE, children's vulnerablity, neurochemical effects, harmful environmental agents, biological markers, agricultural communityRelevant Websites:
http://cerch.org/
Progress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R834513 Center for Research on Early Childhood Exposure and Development in Puerto Rico Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834513C001 CHAMACOS Cohort Project: Pesticides and PBDE on Neurobehavior and Puberty
R834513C002 Project B: Exposure Project: Mn, DDT/E and PBDE Exposure to Farmworker Children
R834513C003 Epigenetics Project
R834513C004 Community Outreach and Translation Core
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2016 Progress Report
- 2015 Progress Report
- 2014 Progress Report
- 2012 Progress Report
- 2011 Progress Report
- 2010 Progress Report
- Original Abstract
76 journal articles for this subproject
Main Center: R834513
694 publications for this center
166 journal articles for this center