Grantee Research Project Results
2008 Progress Report: Biomarkers Of Health Risks Associated With Environmental Exposure To Arsenic
EPA Grant Number: R832735Title: Biomarkers Of Health Risks Associated With Environmental Exposure To Arsenic
Investigators: Stýblo, Miroslav , García-Vargas, Gonzalo G , Del Razo, Luz M.
Current Investigators: Stýblo, Miroslav , García-Vargas, Gonzalo G , Del Razo, Luz M. , Loomis, Dana , Ethan, Lange , Drobna, Zuzana
Institution: University of North Carolina at Chapel Hill
Current Institution: University of North Carolina at Chapel Hill , University of Nevada - Reno
EPA Project Officer: Callan, Richard
Project Period: February 13, 2006 through February 12, 2009 (Extended to February 12, 2010)
Project Period Covered by this Report: February 13, 2008 through February 12,2009
Project Amount: $749,988
RFA: Early Indicators of Environmentally Induced Disease (2004) RFA Text | Recipients Lists
Research Category: Human Health
Objective:
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To examine interindividual variations in urinary profiles of methylarsonite (MAsIII) and dimethylarsinite (DMAsIII), the toxic metabolites of arsenic (As), in individuals exposed to inorganic As (iAs) in drinking water.
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To characterize the relationship between the urinary levels of MAsIII and DNAsIII and markers of carcinogenic and diabetogenic effects of iAs.
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To examine the role of genetic polymorphism for arsenic (+3 oxidation state) methyltransferase (AS3MT) in modulation of the metabolism and adverse health effects of iAs.
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To study the genotype-phenotype relationship using recombinant genetic variants of AS3MT.
Progress Summary:
The main part of this project is a population-based study carried out in two arseniasis endemic areas of
Future Activities:
The single goal of the last year on the project is to analyze the data collected in the population study in
Journal Articles on this Report : 3 Displayed | Download in RIS Format
Other project views: | All 19 publications | 9 publications in selected types | All 9 journal articles |
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Hernandez-Zavala A, Valenzuela OL, Matousek T, Drobna Z, Dedina J, Garcia-Vargas GG, Thomas DJ, Del Razo LM, Styblo M. Speciation of arsenic in exfoliated urinary bladder epithelial cells from individuals exposed to arsenic in drinking water. Environmental Health Perspectives 2008;116(12):1656-1660. |
R832735 (2007) R832735 (2008) R832735 (Final) |
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Hernandez-Zavala A, Matousek T, Drobna Z, Paul DS, Walton F, Adair BM, Dedina J, Thomas DJ, Styblo M. Speciation analysis of arsenic in biological matrices by automated hydride generation-cryotrapping-atomic absorption spectrometry with multiple microflame quartz tube atomizer (multiatomizer). Journal of Analytical Atomic Spectrometry 2008;23(3):342-351. |
R832735 (2006) R832735 (2007) R832735 (2008) R832735 (Final) |
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Hester SD, Drobna Z, Andrews DMK, Liu J, Waalkes MP, Thomas DJ, Styblo M. Expression of AS3MT alters transcriptional profiles in human urothelial cells exposed to arsenite. Human & Experimental Toxicology 2009;28(1):49-61. |
R832735 (2008) |
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Supplemental Keywords:
human health, sensitive populations, dose-response, carcinogen, chemicals, toxics, metals, metalloids, trace elements, gene, epidemiology, toxicology, medicine, analytical chemistry, biochemistry, analytical, spectrometry, pollutants/toxics, water, scientific discipline, arsenic, drinking water, health risk assessment, biochemistry, water pollutants, genetics, bioavailability, biomarkers, drinking water contaminants, health effects, cancer, genotype distribution, RFA, Scientific Discipline, Water, POLLUTANTS/TOXICS, Genetics, Health Risk Assessment, Arsenic, Biochemistry, Water Pollutants, Drinking Water, health effects, biomarkers, genotype distribution, bioavailability, drinking water monitoring, cancerProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.