Grantee Research Project Results

Cardiopulmonary Response to Particulate Exposure

EPA Grant Number: R824834C002
Subproject: this is subproject number 002 , established and managed by the Center Director under grant R824834
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Health Effects Institute (2015 - 2020)
Center Director: Greenbaum, Daniel S.
Title: Cardiopulmonary Response to Particulate Exposure
Investigators: Christiani, David
Institution: Harvard University
EPA Project Officer: Chung, Serena
Project Period: July 1, 1999 through December 31, 2000
RFA: Mickey Leland National Urban Air Toxics Research Center (NUATRC) (1997) RFA Text |  Recipients Lists
Research Category: Congressionally Mandated Center , Urban Air Toxics , Targeted Research

Objective:

Exposure to particulate matter (PM) has been associated with deleterious effects on the respiratory and cardiovascular system. This study investigates the role of PM in respiratory and cardiovascular systems in a cohort of boilermakers both with and without chronic bronchitis.

Approach:

A repeat-measurement design will monitor and assess several biological markers for exposure, such as heart rate variability, spirometry, and exhaled nitric oxide. A personal Dust Trak monitor will record PM2.5 levels continuously. Personal metal exposure (V, N, Cd, Mn, Cr, and Fe) will be measured daily. Workers during pre-exposure (layoff) served as their own controls. Subjects with chronic bronchitis were compared to non-symptomatic subjects.

Expected Results:

The expected results will clarify the relationship between exposure to particulate metals and human cardiopulmonary responses in both normal and chronic bronchitic populations. Clarification of such exposure-response relationships will have important implications for preventive efforts.

Publications and Presentations:

Publications have been submitted on this subproject: View all 2 publications for this subproject | View all 144 publications for this center

Supplemental Keywords:

air pollution, urban, particulate matter, PM2.5, bronchitis, metals, exposure, epidemiology, respiratory diseases., RFA, Health, Scientific Discipline, Air, Air Pollution, particulate matter, air toxics, Health Risk Assessment, Air Pollution Effects, Epidemiology, Risk Assessments, Biochemistry, Environmental Monitoring, health effects, urban air quality, children's health, urban air, air pollutants, human health effects, human exposure, lung inflamation, particulate exposure, urban air pollution, sensitive subgroups, PM, human health, minority children, airborne urban contaminants, biomarker, human health risk, metals

Progress and Final Reports:

2000

Final Report

Main Center Abstract and Reports:

R824834    Health Effects Institute (2015 - 2020)

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R824834C001 Air Toxics Exposures Among Teenagers in New York City and Los Angeles - A Columbia-Harvard Study (TEACH)
R824834C002 Cardiopulmonary Response to Particulate Exposure
R824834C003 VOC Exposure in an Industry Impacted Community
R824834C004 A Study of Personal Exposure to Air Toxics Among a Subset of the Residential U.S. Population (VOC Project)
R824834C005 Methods Development Project for a Study of Personal Exposures to Toxic Air Pollutants
R824834C006 Relationship Between Indoor, Outdoor and Personal Air (RIOPA)
R824834C007 Development of the "Leland Legacy" Air Sampling Pump
R824834C008 Source Apportionment of Indoor Polycyclic Aromatic Hydrocarbons (PAHs) in Urban Residences
R824834C009 Development of a Personal Cascade Impactor Sampler (PCIS)
R824834C010 Testing the Metals Hypothesis in Spokane
R828678C001 Air Toxics Exposures Among Teenagers in New York City and Los Angeles—A Columbia-Harvard Study (TEACH)
R828678C002 Cardiopulmonary Effects of Metal-Containing Particulate Exposure
R828678C003 VOC Exposure in an Industry Impacted Community
R828678C004 A Study of Personal Exposure to Air Toxics Among a Subset of the Residential U.S. Population (VOC Project)
R828678C005 Oxygenated Urban Air Toxics and Asthma Variability in Middle School Children: A Panel Study (ATAC–Air Toxics and Asthma in Children)
R828678C006 Relationship between Indoor, Outdoor and Personal Air (RIOPA). Part II: Analyses of Concentrations of Particulate Matter Species
R828678C007 Development of the “Leland Legacy” Air Sampling Pump
R828678C008 Source Apportionment of Indoor PAHs in Urban Residences 98-03B
R828678C009 Development of a Personal Cascade Impactor Sampler (PCIS)
R828678C010 Testing the Metals Hypothesis in Spokane
R828678C011 A Pilot Geospatial Analysis of Exposure to Air Pollutants (with Special Attention to Air Toxics) and Hospital Admissions in Harris County, Texas
R828678C012 Impact of Exposure to Urban Air Toxics on Asthma Utilization for the Pediatric Medicaid Population in Dearborn, Michigan
R828678C013 Field Validation of the Sioutas Sampler and Leland Legacy Pump – Joint Project with EPA’s Environmental Technology Validation Program (ETV)
R828678C014 Performance Evaluation of the 3M Charcoal Vapor Monitor for Monitor Low Ambient Concentrations of VOCs
R828678C015 RIOPA Database Development
R828678C016 Contributions of Outdoor PM Sources to Indoor and Personal Exposures: Analysis of PM Species Concentrations” Focused on the PM Speciation and Apportioning of Sources
R828678C017 The Short and Long-Term Respiratory Effects of Exposure to PAHs from Traffic in a Cohort of Asthmatic Children