Grantee Research Project Results
2018 Progress Report: Health Effects Institute (2015-2020): A Partnership for Credible and Relevant Science on the Health Effects of Air Pollution
EPA Grant Number: R835902Center: Health Effects Institute (Prior to 2000)
Center Director: Greenbaum, Daniel S.
Title: Health Effects Institute (2015-2020): A Partnership for Credible and Relevant Science on the Health Effects of Air Pollution
Investigators: Greenbaum, Daniel S. , O’Keefe, Robert , Shaikh, Rashid
Institution: Health Effects Institute
EPA Project Officer: Keating, Terry
Project Period: April 1, 2015 through March 31, 2020
Project Period Covered by this Report: April 1, 2018 through March 31,2019
Project Amount: $25,000,000
RFA: Health Effects Institute (2015) RFA Text | Recipients Lists
Research Category: Air
Objective:
To support research on the health effects of emissions from motor vehicles, fuels, and other sources of environmental pollution. Themes guiding the research program are Continuing Challenges of Multipollutant Science; Accountability and Transparency; Assessing Emerging Fuels and Technologies; and Global Health Science.
Progress Summary:
During the past year under Award CR83590201, HEI has made significant progress in meeting its goals. HEI’s ongoing studies are summarized in Table 1 and highlights of HEI activities include:
- HEI-funded investigators have continued research at a brisk rate in three comprehensive and rigorous studies on the effects of low levels of exposure to air pollution in very large cohorts, resulting in important new publications in peer reviewed journals. HEI held a workshop with sponsors during the annual conference in May 2018. And, HEI asked the US and Canadian investigators to submit a Phase 1 Reports describing the work completed during the first two years of their projects; HEI has set up an independent expert panel to review this work and to publish separate commentaries on the two reports.
- In follow-up to the 2017 publication of the results of the Multicenter Ozone Study in oldEr Subjects (MOSES), HEI posted all the data in a publicly accessible form at the Harvard Dataverse repository; a few unused biological samples from the study were also made publicly available.Additional data analysis continued to look at effect of air pollution exposures prior to coming to the clinical laboratory for ozone exposures; this work is currently in review and will be published in 2020 along with a commentary.
- To improve our understanding of exposure and health effects from traffic related air pollution, research continued under a number of studies, including the three news studies funded in 2018. HEI also published a noteworthy study of real-world vehicle emissions for two tunnels, one in Hong Kong and the other in the United States (detailed data from this study have also been made available at the Harvard Dataverse).
- A special HEI panel, charged with reviewing the current state of the science concerning the health effects from exposure to traffic related air pollution continued its discussions in meetings and conference calls; the panel has developed a systematic review protocol, similar to those being used by the NIEHS and WHO, and developed strategies for searching for publications and extracting relevant information; this process has been difficult because of the challenges of applying systematic review methods to observational studies and because an upsurge in the number of papers published in this area. The panel’s work will continue during the next 18 months when its report is expected to be published.
- To improve our understanding of air pollution exposure, HEI issued RFA 19-1 to solicit studies focused on improving exposure assessment of outdoor air pollutants, with a focus on those that exhibit a high level of variation in space and time, by applying emerging technologies and novel approaches, especially those with applicability to long-term epidemiology studies. The awardees of this RFA will be announced in late 2019 or early 2020.
- Under its accountability program, HEI completed, reviewed and published several studies. Additionally, HEI published an RFA, and reviewed applications, for a third wave of accountability studies. The awardees of this RFA will be announced during fall, 2019.
- HEI continued research in a number of cross cutting areas.
In addition, with separate funding from other sources, HEI continued its Global Health program (including disease burdens attributed to ambient air pollution sources in developing countries, publication of a State of Global Air website, and continued involvement with the Global Burden of Disease project).
Future Activities:
Highlights of the activities for the subsequent reporting period include:
- Research on health effects at low levels of air pollution will continue during the next year. HEI will publish the Phase 1 reports, along with commentaries by the review panel, for the US and Canadian studies. Also, the investigators are expected to publish their results in peer-reviewed journals.
- HEI will publish the Phase 2 MOSES report, with a commentary; this research is investigating effects of air pollution exposures among subjects prior to their coming to the clinical laboratory for ozone exposures.
- In the area of exposures and health effects from traffic related air pollution, the traffic literature review will publish the review protocol during summer 2019, and the panel will continue its work at an accelerated pace, with the goal of having a draft of several parts of the report by spring 2020.
- In order to improve assessment of air pollution exposure, three to five new studies, funded under RFA 19-1 will begin work in spring 2019.
- Accountability – HEI expects report from a study looking at the impact of air quality actions in health in Southern California, which will enter the review and publication phase. HEI also expects three to four new studies, funded under RFA 18-1, to start.
- Work will continue on more than 20 other HEI supported studies, funded under various programs, during the year. HEI expects to publish a number of important reports.
- HEI will continue to work on several cross-cutting areas, including finding the best mechanisms for data sharing and data access.
- In addition, with separate funding from other sources, HEI plans to continue its Global Health program (including disease burdens attributed to ambient air pollution sources in developing countries, publication of a State of Global Air website, and continued involvement with the Global Burden of Disease project).
Journal Articles: 21 Displayed | Download in RIS Format
| Other center views: | All 57 publications | 57 publications in selected types | All 21 journal articles |
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Arjomandi M, Balmes J, Frampton M, Bromberg P, Rich D, Stark P, Alexis N, Costantini M, Hollenbeck-Pringle D, Dagincourt N, Hazucha M. RespiratoryResponses to Ozone Exposure MOSES (The MultiR Ozone Study in Older Subjects). AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2018;197(10):1319-1927. |
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Balmes J, Arjomandi M, Bromberg P, Constantini M, Dagincourt N, Hazucha M, Hollenbeck-Pringle D, Stark P, Frampton M. Ozone effects on blood biomarkers of systemic inflammation, oxidative stress, endothelial function, and thrombosis:The Multicenter Ozone Study in oldEr Subjects (MOSES). PLOS ONE 2018;14(9):e0222601. |
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Bouma F, Janssen N, Wessling J, van Ratingen S, Strak M, Kerckhoffs J, Gehring U, Hendricx W, de Hoogh K, Vermeulen R, Hoek G. Long-term exposure to ultrafine particles and natural and cause-specific mortality. ENVIRONMENTAL INTERNATIONAL 2023;175(107960). |
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Chau K, Franklin M, Gauderman W. Satellite-Derived PM2.5 Composition and Its Differential Effect on Children Lung Function. REMOTE SENSING 2020;12(6). |
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De MOira A, Pearce N, Pedersen M, Andersen A. The influence of early-life animal exposure on the risk of childhood atopic dermatitis, asthma and allergic rhinoconjunctivitis: findings from the Danish National Birth Cohort. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 2023;dyad040 |
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Fallah-Shorshani M, Yin X, McConnell R, Fruin S, Franklin M. Estimating traffic noise over a large urban area: An evaluation of methods. ENVIRONMENTAL INTERNATIONAL 2022;170(107583) |
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Fang T, Lakey P, Weber R, Shiraiwa M. Oxidative Potential of Particulate Matter and Generation of Reactive Oxygen Species in Epithelial Lining Fluid. ENVIRONMENAL SCIENCE TECHNOLOGY 2019;53(21):12784-12792. |
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Fang T, Huang Y, Wei J, Monterrosa J, Lakey P, Kleinman M, Digman M, Shiraiwa M. Superoxide Release by Macrophages through NADPH Oxidase Activation Dominating Chemistry by Isoprene Secondary Organic Aerosols and Quinones to Cause Oxidative Damage on Membranes. ENVIRONMENTAL SCIENCE AND TECHNOLOGY 2022;56(23):17029-17038 |
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Franklin M, Yin X, McConnell R, Fruin S. Association of the Built Environment With Childhood Psychosocial Stress. ENVIRONMENTAL HEALTH 2020;3(10):17634. |
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Groot J, Keller A, Pedersen M, Sisgaard T, Loft S, Andersen A. Indoor home environments of Danish children and the socioeconomic position and health of their parents:A descriptive study. Environmental International 2022;160. |
R835902 (Final) CR839981 (Final) |
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Mila C, Ballester J, Basagana X, Nieuwenhuigsen M, Tonne C. Estimating daily air temperature and pollution in Catalonia: A comprehensive spatiotemporal modelling of multiple exposures. ENVIRONMENTAL POLLUTION 2023;337(122501) |
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Pedersen M. Is ambient air pollution a Risk factor for fecundity?. EPIDEMIOLOGY 2022;36(1):68-69. |
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Pedersen M, Liu S, Zhang J, Zndersen Z, Brandt J, Butdz-Jorgensen E, Bonnelykke K, Frohn L, Andersen A, Ketzel M, Khan J, Stayner L, Brunekreef B, Loft S. Early-Life Exposure to Ambient Air Pollution from Multiple Sources and Asthma Incidence in Children: A Nationwide Birth Cohort Study from Denmark. ENVIRONMENTAL HEALTH PERSPECTIVES 2023;131(5):057003 |
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Peters S, Bouma F, Hoek G, Janssen N, Vermeulen R. Air pollution exposure and mortality from neurodegenerative diseases in the Netherlands: a population-based cohort study. Environmental Research 2024;259:119552. |
R835902 (Final) CR839981 (Final) |
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Rich D, Balmes J, Frampton M, Zareba W, Stark P, Arjomandi M, Hazucha M, Costantini M, Ganz P, Hollenbeck-Pringle D, Dagincourt N, Bromberg P. Cardiovascular function and ozone exposure:The Multicenter Ozone Study in older Subjects (MOSES). ENVIRONMENTAL INTERNATIONAL 2018;119:193-202. |
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Ripley S, Minet L, Zalzal J, Pollitt K, Gao D, Lakay P, Shiraiwa M, Maher B, Hatzopoulou M, Weicherenthal S. Predicting Spatial Variations in Multiple Measures of PM2.5 Oxidative Potential and Magnetite Nanoparticles in Toronto and Montreal, Canada. ENVIRONMENTAL SCIENCE TECHNOLOGY 2022;56(11):7256-7265. |
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Thacher J, Poulsen A, Hvidfeldt U, Brandt J, Christensen J, Khan J, Gregor M, Sorensen M. Exposure to transportation noise and risk for cardiovascular disease in a nationwide cohort study from Denmark. ENVIRONMENAL RESEARCH 2022;211. |
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Yin X, Fallah-Shorshani M, McConnell R, Fruin S, Franklin M. Predicting Fine Spatial Scale Traffic Noise Using Mobile Measurements and Machine Learning. ENVIRONMENTAL SCIENCE TECHNOLOGY 2020;54(20):12860-12869. |
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Yin X, Franklin M, Fallah-Shorshani M, Shafer M, McConnell R, Fruin R. Exposure models for particulate matter elemental concentrations in Southern California. ENVIRONMENT INTERNATIONAL 2022;165(107427). |
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Zhang J, Lim Y, So R, Jorgensen J, Mortensen L, Napolitano G, Cole-Hunter T, Loft S, Bhatt S, Hoek G, Brunekreef B, Westdorp R, Ketzel M, Brandt J, Lange T, Kilsen-Fisher T, Andersen Z. Long-term exposure to air pollution and risk of SARS-CoV-2 infection and COVID-19 hospitalisation or death:Danish nationwide cohort study. EUROPEAN RESPIRATORY JOURNAL 2023;62(1):2300280. |
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Zhang Z, Weichenthal S, Kwong J, Burnett R, Hatzopoulou M, Jerrett M, van Donklaar A, Bai L, Martin R, Copes R, Lakey P, Shirwiwa M, Cheng H. Long-term exposure to iron and copper in fine particulate air pollution and their combined impact on reactive oxygen species concentration in lung fluid:a population-based cohort study of cardiovascular disease incidence and mortality in Toronto, Canada. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 2021;50(2):589-601. |
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Supplemental Keywords:
Air quality, Accountability, Global research, Public healthRelevant Websites:
Welcome to the Health Effects Institute Exit
Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.