Grantee Research Project Results
2017 Progress Report: Center for the Study of Childhood Asthma in the Urban Environment (CCAUE)
EPA Grant Number: R836152Center: Center for the Study of Childhood Asthma in the Urban Environment
Center Director: Hansel, Nadia
Title: Center for the Study of Childhood Asthma in the Urban Environment (CCAUE)
Investigators: Hansel, Nadia , Diette, Greg
Current Investigators: Hansel, Nadia , Diette, Greg , McCormack, Meredith , Koehler, Kirsten , Polotsky, Seva
Institution: The Johns Hopkins University
EPA Project Officer: Callan, Richard
Project Period: September 1, 2015 through August 31, 2019 (Extended to August 31, 2021)
Project Period Covered by this Report: September 1, 2016 through August 31,2017
Project Amount: $1,200,000
RFA: Children's Environmental Health and Disease Prevention Research Centers (2014) RFA Text | Recipients Lists
Research Category: Human Health , Children's Health
Objective:
Due to the importance of understanding the role of air pollution in contributing to the lung health disparities identified in low(er) income settings; we have chosen to focus on the impact of particulate matter (PM2.5, PM, and nitrogen dioxide [NO2]) exposures and the comorbidity of obesity on asthma, by observing poor dietary intake (low anti-oxidant, pro-inflammatory diet), sleep apnea, and disease severity as factors that are common in low(er) income communities and that may increase susceptibility to air pollution exposure. The aims of the Center, led by Center Director and Co-Director, Drs. Hansel and Diette, will be answered in three projects that are observational, interventional, and biological (listed below) that are individually supported by the Center’s Administrative, Environmental, Data, and Community Outreach Cores:
Project 1 – Obesity as a susceptibility factor for the asthmatic response to pollutants (Project Leader: Meredith McCormack, MD, MHS; Nadia Hansel, MD MPH). Through both an observational cohort and intervention study, this project aims to identify why obese children with asthma have increased susceptibility to air pollution compared to lean counterparts. We will examine the leading candidate mediators of the increased susceptibility to PM among overweight children, based on our own and others’ findings.
Project 2 – Novel exposure metrics for assessing the effects of ultrafine and fine PM on asthma in children. (Project Leaders: Kirsten Koehler). The goal of this project is to determine which potentially modifiable factors of fine PM (PM2.5), including ultrafine particles, and micro-environmental and peak exposures are associated with asthma symptoms in children. A second, related objective is to evaluate the effects of these fine PM factors on overweight children with asthma. Together, such evidence will allow us to build individualized environmental intervention strategies that target susceptible populations.
Project 3 – The role of obesity in biological responses to particulate matter in mice. (Project Leader: Vsevolod (Seva) Polotsky). We will utilize established models of diet-induced obesity and PM exposure in the non-atopic obesity-prone mouse strain C56BL/6J, and mouse models of sleep apnea, including a novel model of sleep apnea due to isolated tongue adiposity to understand underlying mechanistic pathways conferring susceptibility to PM exposure.
Progress Summary:
In the last 12 months of the grant, the Co-Program Directors, Nadia N Hansel, MD MPH and Gregory B. Diette, MD, have assembled a well-trained staff providing essential support to the faculty, students, and researchers with premises similar to the objectives of the Johns Hopkins University’s (JHU) Obesity (Enhances) Susceptibility to Pollutant Effects in Asthma Research Programs. A central point of focus of the Center has been to cultivate the central framework that promotes responsible governance of the Center’s Cores and Projects. During this reporting time, we have applied ongoing quality management activities, promoting the development of data management, safety management, and statistical analysis plans, and cooperative agreements and other administrative documents. These dynamic documents, include best practice project guidelines and Standard Operating Procedures (SOPs), and Manual of Procedures (MOP) that facilitate the Center’s scientific integrity. These documents are routinely monitored by key team members, making certain that they are reassessed and up to date. The reinforced quality management infrastructure that has taken shape during this year has had positive developmental impacts within the project team members and other research staff in preforming their work more effectively, accomplishing the overall direction of the Center’s Cores and Projects.
Core A: The Administrative Core (CAC)
This year Core A continued to develop the Center’s internal communication plans, ensuring that thorough collaboration between the leaders of the three projects and four cores is occurring, with proficient exchanges of ideas and knowledge. Also within this reporting period, Core A has successfully organized meetings and facilitated the logistical coordination for each meeting (catering, hotel, printing, transportation contracts), making certain that faculty, students, and researchers across the Center’s Cores and Projects have been properly aided. On November 3, 2016, Core A organized the annual Outside Advisory Board meeting.
Core B: The Environmental Assessments Core (EAC)
As the centralized Environmental Core, the EAC has carried out all exposure assessment activities and data collection and has provided specialized and technical expertise for sampling methodology in support of the Center’s Projects. During the last period, the focus of the EAC was on expediting the environmental data collection for the projects and on the expansion of the Standard Operating Procedures (SOPs). During the past year, proper collection of environmental data has continued to be crucial to the success of the Center’s projects, and the EAC has contributed substantially to this objective during the weekly meetings between the project teams evaluating the exposure assessment strategies and logistics.
Core C: The Data Management Core (DMC)
The focus of the past period has been on the development of data management, data security procedures, and the many Standard Operating Procedures (SOPs) that were implemented to cover the electronic data capture (EDC) interface REDCap. Over the past year, the DMC has developed a comprehensive collection of implemented quality management procedures that range from data quality control to documentation records to data validation policy. In addition to the quality management, the DMC has established a recruitment and retention report that has been distributed and reviewed weekly. This report was developed to keep the PIs and key staff members focused on the recruitment goals. Currently, the DMC is working in coordination with the EAC on managing the quality of environmental data, confirming the data quality management plan (QMP) for the different types of pollutants (PM2.5, PM10, NO2, air nicotine, and black carbon) for which data will be collected.
Core D: The Community Engagement Core (CEC)
Last year, the CEC established relationships with Community Engagement Programs through the Institute for Clinical and Translational Research (ICTR), the Community Research Advisory Council (C-RAC), and Medicine for the Greater Good (MGG), at JHU and also with a number of community stakeholders. Through these relationships, the CEC has built partnerships between our research taking place in the communities and the residents of these diverse communities as well as with JHU.
Future Activities:
Our future activities include the following:
- We will continue to increase participant recruitment, enrollment, and follow-up compliance.
- We will continue to have weekly to biweekly calls between the Cores and the JHU research teams.
- The Administrative Core will continue scheduling and organizing the Outside Advisory Board meetings and streamlining specific organizational elements to accomplish the goals of the Center.
- The Environmental Core will continue with the development of the exposure assessment protocols and advancing the interpretation of the exposure assessments for all environmental samples.
- The Data Core will work on the expansion of REDCap to include environmental and biospecimen data and monitor the quality of the environmental exposures and clinic outcomes data that are collected.
- The Community Core will continue to build on the established partnerships with the communities’ stakeholders by participating in community engagement programs, i.e. health fairs and other community events that will take place in both urban inner city Baltimore and the other targeted communities, and also will encourage feedback from the communities to ensure that the projects are informed and strengthened by community input.
Journal Articles: 48 Displayed | Download in RIS Format
Other center views: | All 73 publications | 48 publications in selected types | All 48 journal articles |
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Belli AJ, Bose S, Aggarwal N, DaSilva C, Thapa S, Grammer L, Paulin LM, Hansel NN. Indoor particulate matter exposure is associated with increased black carbon content in airway macrophages of former smokers with COPD. Environmental Research 2016;150:398-402. |
R836152 (2019) R836152 (2020) R836150 (2017) R836150 (2019) R836150 (2020) |
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Berger S, Pho H, Fleury-Curado T, Bevans-Fonti S, Younas H, Shin M, Jun J, Anokye-Danso F, ahima R, Enquist L, Mendelowitz D, Schwartz A, Polotsky V. Intranasal Leptin Relieves Sleep-disordered Breathing in Mice with Diet-induced Obesity. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2019;199(6):773-783. |
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Berman JD, McCormack MC, Koehler KA, Connolly F, Clemons-Erby D, Davis MF, Gummerson C, Leaf PJ, Jones TD, Curriero FC. School environmental conditions and links to academic performance and absenteeism in urban, mid-Atlantic public schools. International Journal of Hygiene and Environmental Health 2018;221(5):800-808. |
R836152 (Final) R835639 (2016) R835639 (2017) R835639 (2018) |
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Brigham EP, Matsui EC, Appel LJ, Bull DA, Curtin-Brosnan J, Zhai S, White K, Charleston JB, Hansel NN, Diette GB, McCormack MC. A pilot feeding study for adults with asthma: the healthy eating better breathing trial. PLoS One 2017;12(7):e0180068 (14 pp.). |
R836152 (2018) R836152 (2020) |
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Brigham EP, Steffen LM, London SJ, Boyce D, Diette GB, Hansel NN, Rice J, McCormack MC. Diet pattern and respiratory morbidity in the Atherosclerosis Risk in Communities Study. Annals of the American Thoracic Society 2018;15(6):675-682. |
R836152 (2018) R836152 (2020) |
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Brigham E, Woo H, McCormack M, Rice J, Koehler K, Vulcain T, Wu T, Koch A, Sharma S, Kolandooz F, Bose S, Hanson C, Romero K, Diette G, Hansel N. Omega-3 and Omega-6 Intake Modifies Asthma Severity and Response to Indoor Air Pollution in Children. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2019;199(12):1478-1486. |
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Caballero-Eraso C, Shin M, Pho H, Kim L, Pichard L, Wu Z, Gu C, Berger S, Pham L, Yeung H, Shirahata M, Schwartz A, Tang W, Sham J, Polotsky V. Leptin acts in the carotid bodies to increase minute ventilation during wakefulness and sleep and augment the hypoxic ventilatory response. JOURNAL OF PHYSIOLOGY-LONDON 2019;597(1):151-172. |
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Davis MF, Ludwig S, Brigham EP, McCormack MC, Matsui EC. Effect of home exposure to Staphylococcus aureus on asthma in adolescents. Journal of Allergy and Clinical Immunology 2018;141(1):402-405.e10. |
R836152 (2018) R836152 (2020) R836152 (Final) R834510 (Final) |
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Fleury Curado T, Fishbein K, Pho H, Brennick M, Dergacheva O, Sennes LU, Pham LV, Ladenheim EE, Spencer R, Mendelowitz D, Schwartz AR, Polotsky VY. Chemogenetic stimulation of the hypoglossal neurons improves upper airway patency. Scientific Reports 2017;7:44392. |
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Fleury Curado T, Pho H, Berger S, Caballero-Eraso C, Shin MK, Sennes LU, Pham L, Schwartz AR, Polotsky VY. Sleep-disordered breathing in C57BL/6J mice with diet-induced obesity. Sleep 2018;41(8).zsy089 (9 pp.). |
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Fricke K, Vieira M, Younas H, Shin MK, Bevans-Fonti S, Berger S, Lee R, D’Alessio FR, Zhong Q, Nelson A, Loube J. Sanchez I, Hansel NN, Mitzner W, Polotsky VY. High fat diet induces airway hyperresponsiveness in mice. Scientific Reports 2018;8(1):6404 (6 pp.). |
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Galiatsatos P, Kineza C, Hwang S, Pietri J, Brigham E, Putcha N, Rand CS, McCormack M, Hansel NN. Neighbourhood characteristics and health outcomes:evaluating the association between socioeconomic status, tobacco store density and health outcomes in Baltimore City. Tobacco Control 2018;27(e1):e19-e24. |
R836152 (2018) R836152 (2019) R836152 (2020) R836150 (2018) R836150 (2020) |
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Grant T, McCormack M, Peng R, Keet C, Davis M, Newman M, Balcer-Whaley S, Matsui E. Comprehensive home environmental intervention did not reduce allergen concentrations or controller medication requirements among children in Baltimore. JOURNAL OF ASTHMA 2022;1-10 |
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Grant T, LIlley T, McCormack M, Rathouz P, Pent R, Keeo C, Rule A, Davis M, Balcer-Whaley S, Newman M, Matsui E. Indoor environmental exposures and obstructive lung disease phenotypes among children with asthma living in poor urban neighborhoods. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2023;151(3):716. |
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Gu C, Loube J, Lee R, Bevans-Fonti S, Wu T, Barmine J, Jun J, McCormack M, Hansel N, Mitzner W, Polotsky V. Metformin Alleviates Airway Hyperresponsiveness in a Moe Model of Diet-Induced Obesity. FRONTIERS IN PHYSIOLOGY 2022;13(883275). |
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Javaheri S, Barbe F, Campos-Rodriguez F, Dempsey JA, Khayat R, Javaheri S, Malhotra A, Martinez-Garcia MA, Mehra R, Pack AI, Polotsky VY, Redline S, Somers VK. Sleep apnea: types, mechanisms, and clinical cardiovascular consequences. Journal of the American College of Cardiology 2017;69(7):841-858. |
R836152 (2017) R836152 (2020) |
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Kaviany P, Brighham E, Collaco J, Rice J, Woo H, Wood M, Koehl R, Wu T, Eakin M, koehler K, Hansel N, McCormack M. Patterns and predictors of air purifier adherence in children with asthma living in low-income, urban Households. JOURNAL OF ASTHMA 2022;59(5):946-955 |
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Lambert AA, Putcha N, Drummond MB, Boriek AM, Hanania NA, Kim V, Kinney GL, McDonald MN, Brigham EP, Wise RA, McCormack MC, Hansel NN, COPDGene Investigators. Obesity is associated with increased morbidity in moderate to severe COPD. Chest 2017;151(1):68-77. |
R836152 (2019) R836152 (2020) R836150 (2017) R836150 (2019) R836150 (2020) |
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Lemoine S, Brigham E, Woo H, Hanson C, McCormack M, Koch A, Putcha N, hansel N. Omega-3 fatty acid intake and prevalent respiratory symptoms among adults with COPD. BMC PULMONARY MEDICINE 2019;19. |
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Levy JI, Quiros-Alcala L, Fabian MP, Basra K, Hansel NN. Established and emerging environmental contributors to disparities in asthma and chronic obstructive pulmonary disease. Current Epidemiology Reports 2018;5(2):114-124. |
R836152 (2018) R836152 (2019) R836152 (2020) R836150 (2019) R836150 (2020) R836156 (2018) R836156 (2019) R836156 (2020) |
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Lu KD, Phipatanakul W, Perzanowski MS, Balcer-Whaley S, Matsui EC. Atopy, but not obesity is associated with asthma severity among children with persistent asthma. Journal of Asthma 2016;53(10):1033-1044. |
R836152 (2017) R836152 (2020) |
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McCormack MC, Belli AJ, Waugh D, Matsui EC, Peng RD, Williams DL, Paulin L, Saha A, Aloe CM, Diette GB, Breysse PN, Hansel NN. Respiratory effects of indoor heat and the interaction with air pollution in chronic obstructive pulmonary disease. Annals of the American Thoracic Society 2016;13(12):2125-2131. |
R836152 (2018) R836152 (2019) R836152 (2020) R836150 (2019) R836150 (2020) |
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McCormack MC, Paulin LM, Gummerson CE, Peng RD, Diette GB, Hansel NN. Colder temperature is associated with increased COPD morbidity. European Respiratory Journal 2017;49(6):1601501. |
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McCormack M, Balsubramanian A, Wise R, Keet C, Matsui E, Peng R. Reply by McCormack et al. to Townsend and Cowl, and to Miller et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2022;206(6):795-796. |
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Mesarwi OA, Shin MK, Bevans-Fonti S, Schlesinger C, Shaw J, Polotsky VY. Hepatocyte hypoxia inducible factor-1 mediates the development of liver fibrosis in a mouse model of nonalcoholic fatty liver disease. PLoS One 2016;11(12):e0168572. |
R836152 (2017) R836152 (2020) |
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Nnodum BN, McCormack MC, Putcha N, Hwang S, Paulin LM, Brigham EP, Fawzy A, Romero K, Diette GB, Hansel NN. Impact of physical activity on reporting of childhood asthma symptoms. Lung 2017;195(6):693-698. |
R836152 (2018) R836152 (2020) |
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Paulin LM, Williams DA, Peng R, Diette GB, McCormack MC, Breysse P, Hansel NN. 24-h Nitrogen dioxide concentration is associated with cooking behaviors and an increase in rescue medication use in children with asthma. Environmental Research 2017;159:118-123. |
R836152 (2018) R836152 (2020) |
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Peters KO, Williams AL, Abubaker S, Curtin-Brosnan J, McCormack MC, Peng R, Breysse PN, Matsui EC, Hansel NN, Diette GB, Strickland PT. Predictors of polycyclic aromatic hydrocarbon exposure and internal dose in inner city Baltimore children. Journal of Exposure Science and Environmental Epidemiology 2017;27(3):290-298. |
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Pham LV, Polotsky VY. Genome-wide association studies in obstructive sleep apnea. Will we catch a black cat in a dark room? American Journal of Respiratory and Critical Care Medicine 2016;194(7):789-791. |
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Pham LV, Miele CH, Schwartz NG, Arias RS, Rattner A, Gilman RH, Miranda JJ, Polotsky VY, Checkley W, Schwartz AR. Cardiometabolic correlates of sleep disordered breathing in Andean highlanders. European Respiratory Journal 2017;49(6):1601705 (20 pp.). |
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Pham LV, Meinzen C, Arias RS, Schwartz NG, Rattner A, Miele CH, Smith PL, Schneider H, Miranda JJ, Gilman RH, Polotsky VY, Checkley W, Schwartz AR. Cross-sectional comparison of sleep-disordered breathing in native Peruvian highlanders and lowlanders. High Altitude Medicine & Biology 2017;18(1):11-19. |
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Rice JL, Brigham E, Dineen R, Muqueeth S, O'Keefe G, Regenold S, Koehler K, Rule A, McCormack M, Hansel NN, Diette GB. The feasibility of an air purifier and secondhand smoke education intervention in homes of inner city pregnant women and infants living with a smoker. Environmental Research 2018;160:524-530. |
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Shin M, Eraso C, Mu Y, Gu C, Yeung B, Kim L, Liu X, Wu Z, Paudel O, Prchard L, Shirahata M, Tang W, Sham J, Polotsky V. Leptin Induces Hypertension Acting on Transient Receptor Potential Melastatin 7 Channel in the Carotid Body. CIRCULATION RESEARCH 2019;125(11):989-1002. |
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Shin M-K, Han W, Joo H, Bevans-Fonti S, Shiota M, Stefanovski D, Polotsky VY. Effect of adrenal medullectomy on metabolic responses to chronic intermittent hypoxia in the frequently sampled intravenous glucose tolerance test. Journal of Applied Physiology 2017;122(4):767-774. |
R836152 (2017) R836152 (2020) |
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Stauber CE, Ortiz GM, Loomis DP, Sobsey MD. A randomized controlled trial of the concrete biosand filter and its impact on diarrheal disease in Bonao, Dominican Republic. American Journal of Tropical Medicine and Hygiene 2009;80(2):286-293. |
R836152 (2017) R836152 (2020) SU832463 (Final) |
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Tejwani V, McCormack A, Suresh K, Woo H, Xu N, Davis M, Brigham E, Hansel N, McCormack M, D'Alessio F. Dexamethasone-Induced FKBP51 Expression in CD4+ T-Lymphocytes Is Uniquely Associated With Worse Asthma Control in Obese Children With Asthma. FRONTIERS IN IMMUNOLOGY 2021;12(74482) |
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Wu TD, Brigham EP, Peng R, Koehler K, Rand C, Matsui EC, Diette GB, Hansel NN, McCormack MC. Overweight/obesity enhances associations between secondhand smoke exposure and asthma morbidity in children. The Journal of Allergy and Clinical Immunology: In Practice 2018;6(6):2157-2159.e5. |
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Wu T, Fawzy A, Brigham E, McCormack M, Rosas I, Villareal D, Hanania N. Association of Triglyceride-Glucose Index and Lung Health A Population-Based Study. CHEST 2021;160(3):1026-1034 |
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Wu T, Zaeh S, Eakin M, Koehler K, Davis M, Wohn C, Diibor I, Psoter K, Cronister C, Connolly F, Stein M, McCormack M. Association of School Infrastructure on Health and Achievement Among Children With Asthma. ACADEMIC PEDIATRICS 2023;23(4):814-820. |
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Zaeh S, McCormack M, Eakin M. Key policies to support asthma medication management for children. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY 2019;123(5):428-429 |
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Zaeh S, Koehler K, Eakin M, WOhn C, Diibor I, Eckmann T, Wu T, Clemons-Erby D, Gummerson C, Green T, Wood M, Majid E, Stein M, Rule A, Davis M, McCormack M. Indoor Air Quality Prior to and Following School Building Renovation in a Mid-Atlantic School District. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2021;18(22). |
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Fawzy A, Putcha N, Paulin LM, Aaron CP, Labaki WW, Han MK, Wise RA, Kanner RE, Bowler RP, Barr RG, Hansel NN. Association of thrombocytosis with COPD morbidity:the SPIROMICS and COPDGene cohorts. Respiratory Research 2018;19(1):20. |
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Galiatsatos P, Brigham EP, Pietri J, Littleton K, Hwang S, Grant MC, Hansel NN, Chen ES. The effect of community socioeconomic status on sepsis-attributable mortality. Journal of Critical Care 2018;46:129-133. |
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Younas H, Vieira M, Gu C, Lee R, Shin MK, Berger S, Loube J, Nelson A, Bevans-Fonti S, Zhong Q, D’Alessio FR. Caloric restriction prevents the development of airway hyperresponsiveness in mice on a high fat diet. Scientific reports 2019;9(1):1-9. |
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Raju S, Keet CA, Paulin LM, Matsui EC, Peng RD, Hansel NN, McCormack MC. Rural residence and poverty are independent risk factors for chronic obstructive pulmonary disease in the United States. American journal of respiratory and critical care medicine. 2019;199(8):961-969. |
R836152 (2019) R836152 (2020) R836150 (2019) R836150 (2020) |
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Tsou PY, McCormack MC, Matsui EC, Peng RD, Diette GB, Hansel NN, Davis MF. The effect of dog allergen exposure on asthma morbidity among inner‐city children with asthma. Pediatric Allergy and Immunology 2020;31(2):210-3. |
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Wu TD, Fawzy A, Kinney GL, Bon J, Neupane M, Tejwani V, Hansel NN, Wise RA, Putcha N, McCormack MC. Metformin use and respiratory outcomes in asthma-COPD overlap. Respiratory research 2021;22(1):1-8. |
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Afshar-Mohajer N, Wu TD, Shade R, Brigham E, Woo H, Wood M, Koehl R, Koehler K, Kirkness J, Hansel NN, Ramchandran G. Obesity, tidal volume, and pulmonary deposition of fine particulate matter in children with asthma. European Respiratory Journal 2022;59(3). |
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Progress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R836152C001 Investigating obesity as a susceptibility factor for air pollution in childhood
R836152C002 Novel exposure metrics for assessing the effects of ultrafine and fine particulate matter on asthma in children
R836152C003 The Role of Obesity in Biological Responses to Particulate Matter in Mice
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2020 Progress Report
- 2019 Progress Report
- 2018 Progress Report
- 2016 Progress Report
- Original Abstract
48 journal articles for this center