Grantee Research Project Results
Final Report: Project 3: Causal Estimates of Effects of Regional and National Pollution Mixtures on Health: Providing Tools for Policy Makers
EPA Grant Number: R835872C003Subproject: this is subproject number 003 , established and managed by the Center Director under grant R835872
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Regional Air Pollution Mixtures
Center Director: Koutrakis, Petros
Title: Project 3: Causal Estimates of Effects of Regional and National Pollution Mixtures on Health: Providing Tools for Policy Makers
Investigators: Schwartz, Joel , Coull, Brent , Koutrakis, Petros , Zanobetti, Antonella
Institution: Harvard University , Massachusetts Institute of Technology
EPA Project Officer: Keating, Terry
Project Period: December 1, 2015 through November 30, 2020
RFA: Air, Climate And Energy (ACE) Centers: Science Supporting Solutions (2014) RFA Text | Recipients Lists
Research Category: Air , Climate Change , Air Quality and Air Toxics , Airborne Particulate Matter Health Effects , Particulate Matter
Objective:
The basic goal of this project was to assess effects of temperature and air pollution, including at low concentrations, and to use causal modeling to help draw causal conclusions. We also sought to address questions about the potential bias due to measurement error, and in particular whether it could be result in upward bias.
Project 3 has five specific objectives. Objective 1 is to identify and estimate the causal effects of air pollution and mixtures on human health. We will use methods of causal inference to a) identify the causal effects of regional annual air pollution concentration fluctuations and temperature fluctuations during the last 16 years on human health; b) identify the causal effects of regional air pollution trends during the last 16 years; c) identify the causal effects of pollution mixtures, sources, and emissions on health; d) identify differences in these effects by modifiable factors; e) conduct a national risk assessment on the causal impact of past pollution on mortality, including the regional differences in concentration-response; and f) investigate the causal impact of AQI thresholds for PM2.5 and O3 due to behavioral adaptation. Objective 2 is to analyze relative acute toxicity of pollution mixtures. We will a) examine spatial (across regions) and temporal heterogeneity in the acute toxicity of pollution mixtures and emissions to understand which source types, atmospheric processes, and exposure factors influence the toxicity of regional mixtures and b) use causal mediation analysis to determine how much of the temperature effect on mortality is mediated by its effects of pollution concentrations, and how that varies regionally. This will allow us to obtain local- and region-specific estimates of future health effects and the benefits of changes in modifiable factors and adaptation. Objective 3 is to estimate the excess deaths resulting from air pollutant concentration changes due to weather changes in the last 20 years. We will demonstrate the extent to which public health impacts of climate change through pollution have already occurred, by using causal estimates of C-R relationships. Regional health impacts will be assessed using region-specific mortality risks estimates from Objective 1. Objective 4 is to estimate the causal health effects of low-level air pollution exposure. Specifically, we will examine whether the observed effects at low pollutant levels are due to the synergistic effect of multiple pollutants (mixtures) present at low levels. And Objective 5 is to investigate air pollution-related health effects at high and low temperatures. We will examine this by region and determine whether populations, especially those that include sensitive individuals, adapt to abrupt temperature changes.
Conclusions:
Our key findings are summarized below.
Low Dose Exposure. We addressed low dose exposures using several methods. We excluded all participants in studies who had exposures above certain limits to ensure that associations found were truly below those limits. Mostly we chose an upward limit of 10 µg/m3 for PM2.5, but in Wei 2021a we reported significant associations below 8 µg/m3. Alternatively, we used a causal dose-response model in Wei 2021b and showed a significantly higher mortality rate at a concentration of 7.3 µg/m3 than at 4.8 µg/m3. These studies clearly demonstrate that PM2.5 is producing excess deaths at concentrations below the lowest proposed level for EPA’s revision of the PM NAAQS.
National Risk Assessment. In Vodonos and Schwartz we conducted a national risk assessment which had several innovative features. While EPA uses baseline rates and exposures at the county level in their risk assessments, we estimated baseline rates at the ZIP code level, and based the risk assessment off that. We also used the curvilinear dose response association in computing how much mortality would be reduced for given reductions in PM2.5, integrating over the CRF rather than assuming linearity.
Causal Modeling. We advanced the causal modeling literature for air pollution by publishing a paper using a negative control exposure and negative control outcome to demonstrate a causal effect of short-term exposure to air pollutants using a method that addresses unmeasured confounders that are captured by the negative controls. This has never previously been done in air pollution studies. We also demonstrated that a machine learning algorithm, by changing its cost function to maximize balance rather than minimize error, can provide excellent propensity score estimates with better balance than regression results. Other studies generalized difference in differences approaches to causal modeling and developed a self-controlled design approach to survival analysis that controlled for unmeasured individual covariates.
Psychiatric Outcomes. Psychiatric outcomes had been little explored for associations with air pollutants and temperature, and we made major additions to this literature, both in the Medicare cohort, state inpatient admissions from multiple states, and in an aging cohort.
Environmental Radiation Exposure. We developed the literature on natural exposure to radiation, including particle bound radiation, on multiple outcomes ranging from pregnancy outcomes to cardiovascular and renal outcomes.
Air Pollution and Dementia. We made major advances in studies of air pollution effects on both incidence of and exacerbations of dementia.
Exposure Error. We demonstrated in simulation studies that exposure error from modern hybrid model exposure estimates downwardly bias the true effect of exposure to air pollution, and this is true for nonlinear and threshold concentration-response relationships as well as linear ones. We further used regression calibration in a study of air pollution and mortality and showed that the measurement error corrected estimate was higher than the one obtained without error correction.
Pregnancy Outcomes. We showed that air pollution affected gestational age and caused metabolic problems in women undergoing fertility treatment.
Cardiovascular Outcomes. We showed that air pollution and temperature were associated with both the incidence of cardiovascular events as well as admissions to hospital for events (not necessarily the first event) in multiple studies including ones using causal modeling.
Mixtures. EPA has recognized exposure to mixtures as a key issue in environmental health, and exposomics is likewise an important priority for NIH. We have made important contributions to this by developing a model estimating exposure to 15 different components of PM2.5, and studying them, as well as other exposures. We have used state of the art methods such as Bayesian Kernel Machine Regression and Weighted Quantile Sums and studied effects on mortality in the Medicare population as well as with biomarkers and all deaths in Massachusetts.
Disparities. Disparities in the health effects of air pollutant and environmental exposures is a key EPA priority, and we have published studies examining that.
Mechanisms. Biological plausibility is a key component of deciding whether a component has a causal effect. We have published many studies examining the association of air pollution and temperature with DNA methylation, inflammatory markers, electrocardiogram disorders, etc.
Journal Articles on this Report : 152 Displayed | Download in RIS Format
| Other subproject views: | All 155 publications | 155 publications in selected types | All 155 journal articles |
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| Other center views: | All 453 publications | 420 publications in selected types | All 419 journal articles |
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Achilleos S, Kioumourtzoglou M-A, Wu C-D, Schwartz JD, Koutrakis P, Papatheodorou SI. Acute effects of fine particulate matter constituents on mortality: a systematic review and meta-regression analysis. Environment International 2017;109:89-100. |
R835872 (2016) R835872C001 (Final) R835872C003 (Final) R834798 (Final) |
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Alahmad B, Khraishah H, Shakarchi A, Albaghdadi M, Koutrakis P, Petros J, Farouc A. Cardiovascular Mortality and Exposure to Heat in an Inherently Hot Region Implications for Climate Change. AHA Journals 2020;141(15):1271-1273 AB-. |
R835872 (2020) R835872C003 (Final) |
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Alahmad B, Shakarchi A, Khraishah H, Alseadidan M, Gasana J, Al-Hemoud A, Koutrakis P, Fox M. Extreme temperatures and mortality in Kuwait: who is vulnerable?. Science of the Total Environment 2020;732(139289). |
R835872 (2020) R835872C003 (Final) |
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Alahmad B, Vicedo-Cabrera A, Chen K, Garshick E, Bernstein A. Climate change and health in Kuwait:temperature and mortality projections under different climatic scenarios. ENVIRONMENTAL RESEARCH LETTERS 2022;17(7):074001. |
R835872 (2020) R835872C003 (Final) |
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Anand K, Vieira C, Garshick E, Wang V, Bomberg A, Gold D, Schwartz J, Vokonas P, Koutrakis P. Solar and geomagnetic activity reduces pulmonary function and enhances particulate pollution effects. SCIENCE OF THE TOTAL ENVIRONMENT 2022;838(3):156434. |
R835872 (2021) R835872C001 (Final) R835872C003 (Final) |
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Awad YA, Di Q, Wang Y, Choirat C, Coull BA, Zanobetti A, Schwartz J. Change in PM2.5 exposure and mortality among Medicare recipients:combining a semi-randomized approach and inverse probability weights in a low exposure population. Environmental Epidemiology 2019;3(4):e054. |
R835872 (2019) R835872C003 (Final) |
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Blomberg A, Nyhan M, Bind M, Vokonas P, Coull B, Schwartz J, Koutrakis P. The role of ambient particle radioactivity in inflammation and endothelial function in an elderly cohort. Epidemiology 2020;31(4):499-508. |
R835872 (2020) R835872C001 (Final) R835872C002 (Final) R835872C003 (Final) |
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Blomberg A, Li L, Schwartz J, Coull B, Koutrakis P. Exposure to particle beta radiation in greater Massachusetts and factors influencing its spatial and temporal variability. Environmental Science & Technology 2020;54(11):6575-6583. |
R835872 (2020) R835872C001 (Final) R835872C002 (Final) R835872C003 (Final) |
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Busenkell E, Collins C, Moy M, Hart J, Grady S, Coull B, Schwartz J, Koutrakis P, Harshick E. Modification of associations between indoor particulate matter and systemic inflammation in individuals with COPD. ENVIRONMENT RESEARCH 2022;209(112802). |
R835872 (2020) R835872C002 (Final) R835872C003 (Final) R834798 (Final) |
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Carter S, Rahman M, Lin J, Shu Y, Chow T, Martinez M, Eckel S, Chen J, Chen Z, Schwartz J, Pavlovic N, Lurmann F, McConnell R, Ziang A. In utero exposure to near-roadway air pollution and autism spectrum disorder in children. ENVIRONMENTAL INTERNATIONAL 2022;158(106898). |
R835872 (2020) R835872C003 (Final) |
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Colicino E, Wilson A, Frisardi MC, Prada D, Power MC, Hoxha M, Dioni L, Spiro III A, Vokonas PS, Weisskopf MG, Schwartz JD, Baccarelli AA. Telomere length, long-term black carbon exposure, and cognitive function in a cohort of older men:the VA Normative Aging Study. Environmental Health Perspectives 2017;125(1):76-81. |
R835872 (2016) R835872C003 (Final) R832416 (Final) R834798 (Final) |
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Di Q, Wang Y, Zanobetti A, Wang Y, Koutrakis P, Choirat C, Dominici F, Schwartz JD. Air pollution and mortality in the Medicare population. New England Journal of Medicine 2017;376(26):2513-2522. |
R835872 (2016) R835872 (2017) R835872C003 (Final) R835872C004 (Final) R834798 (Final) R834798C002 (Final) |
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Dong S, Abu-Awad Y, Kosheleva A, Fong K, Koutrakis P, Schwartz J. Maternal exposure to black carbon and nitrogen dioxide during pregnancy and birth weight:Using machine-learning methods to achieve balance in inverse-probability weights. ENVIRONMENTAL RESEARCH 2022;211(112987). |
R835872 (2020) R835872C003 (Final) |
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Dong S, Koutrakis P, Li L, Coull B, Schwartz J, Kosheleva A, Zanobetti A. Synergistic effects of particle radioactivity (gross beta activity) and particulate matter =< 2.5 mu m aerodynamic diameter on cardiovascular disease mortality. Journal of the American Heart Association 2022;11(20):e025470. |
R835872 (2021) R835872C001 (Final) R835872C003 (Final) |
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Dorans KS, Wilker EH, Li W, Rice MB, Ljungman PL, Schwartz J, Coull BA, Kloog I, Koutrakis P, D’Agostino RB, Massaro JM, Hoffmann U, O'Donnell J, Mittleman MA. Residential proximity to major roads, exposure to fine particulate matter, and coronary artery calcium: the Framingham Heart Study. Arteriosclerosis, Thrombosis, and Vascular Biology 2016;36(8):1679-1685. |
R835872 (2016) R835872C003 (Final) R834798 (Final) |
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dos Santos N, Zilli V, Nascimento S, Mazzilli B, Saki M, Saueia C, Saldiva De Andre C, Justo L, Tisti M, Koutrakis P. Levels of Polonium-210 in brain and pulmonary tissues:Preliminary study in autopsies conducted in the city of Sao Paulo, Brazil. SCIENTIFIC REPORTS 2020;10(1):180. |
R835872 (2020) R835872C001 (Final) R835872C003 (Final) R834798 (Final) |
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Fong KC, Hart JE, James P. A review of epidemiologic studies on greenness and health:updated literature through 2017. Current Environmental Health Reports 2018;5(1):77-87. |
R835872C003 (Final) R836156 (2018) R836156 (2019) R836156 (2020) |
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Fong KC, Kosheleva A, Kloog I, Koutrakis P, Laden F, Coull BA, Schwartz JD. Fine particulate air pollution and birthweight:differences in associations along the birthweight distribution. Epidemiology 2019;30(5):617-623. |
R835872 (2019) R835872C002 (Final) R835872C003 (Final) |
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Gaskins A, Tang Z, Hood R, Ford J, Schwartz J, Jones D, Laden F, Liang D. Periconception air pollution, metabolomic biomarkers, and fertility among women undergoing assisted reproduction. ENVIRONMENTAL INTERNATIONAL 2021;155:106666. |
R835872 (2020) R835872C003 (Final) R834798 (Final) |
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Grady ST, Koutrakis P, Hart JE, Coull BA, Schwartz J, Laden F, Zhang JJ, Gong J, Moy ML, Garshick E. Indoor black carbon of outdoor origin and oxidative stress biomarkers in patients with chronic obstructive pulmonary disease. Environment International 2018;115:188-195. |
R835872 (2018) R835872C001 (Final) R835872C003 (Final) R834798 (Final) |
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Hart JE, Grady ST, Laden F, Coull BA, Koutrakis P, Schwartz JD, Moy ML, Garshick E. Effects of indoor and ambient black carbon and PM 2.5 on pulmonary function among individuals with COPD. Environmental Health Perspectives 2018;126(12):127008. |
R835872 (2018) R835872 (2019) R835872 (2020) R835872C001 (Final) R835872C003 (Final) R834798 (Final) |
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Hood R, James P, Fong K, Minguez-Alcaron L, Coull B, Schwartz J, Kloog I, Laden F, Gasking A. The influence of fine particulate matter on the association between residential greenness and ovarian reserve. ENVIRONMENTAL RESEARCH 2021;197:111162. |
R835872 (2020) R835872C002 (Final) R835872C003 (Final) R834798 (Final) |
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Jin T, Amini H, Kosheleva A, Yazdi M, Wei T, Castro E, Di Q, Shi L, Schwartz J. Associations between long-term exposures to airborne PM2.5 components and mortality in Massachusetts:mixture analysis exploration. ENVIRONMENTAL HEALTH 2022;21(1):96. |
R835872 (2021) R835872C003 (Final) |
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Lee M, Schwartz J, Wang Y, Dominici F, Zanobetti A. Long-term effect of fine particulate matter on hospitalization with dementia. Environmental Pollution 2019;254:112. |
R835872 (2019) R835872C003 (Final) R835872C004 (Final) R834798 (Final) |
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Li L, Dominici F, Blomberg A, Bargagli-Stoffi F, Schwartz J, Coull B, Spengler J, Wei Y, Lawrence J, Koutrakis P. Exposure to unconventional oil and gas development and all-cause mortality in Medicare beneficiaries. NATURE ENERGY 2021;7(2):177-185. |
R835872 (2020) R835872C001 (Final) R835872C003 (Final) |
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Li W, Dorans KS, Wilker EH, Rice MB, Long MT, Schwartz J, Coull BA, Koutrakis P, Gold DR, Fox CS, Mittleman MA. Residential proximity to major roadways, fine particulate matter, and hepatic steatosis: the Framingham Heart Study. American Journal of Epidemiology 2017;186(7):857-865. |
R835872 (2016) R835872C003 (Final) R834798 (Final) R834798C004 (Final) |
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Li W, Dorans KS, Wilker EH, Rice MB, Kloog I, Schwartz JD, Koutrakis P, Coull BA, Gold DR, Meigs JB, Fox CS, Mittleman MA. Ambient air pollution, adipokines, and glucose homeostasis: the Framingham Heart Study. Environment International 2018;111:14-22. |
R835872 (2016) R835872C002 (Final) R835872C003 (Final) |
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Li W, Nyhan MM, Wilker EH, Vieira CL, Lin H, Schwartz JD, Gold DR, Coull BA, Aba AM, Benjamin EJ, Vasan RS. Recent exposure to particle radioactivity and biomarkers of oxidative stress and inflammation:the Framingham Heart Study. Environment International 2018;121:1210-1216. |
R835872 (2019) R835872C001 (Final) R835872C002 (Final) R835872C003 (Final) |
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MacNaughton P, Eitland E, Kloog I, Schwartz J, Allen J. Impact of particular matter exposure and surrounding “greenness” on chronic absenteeism in Massachusetts public schools. International Journal of Environmental Research and Public Health 2017;14(2):E207. |
R835872 (2016) R835872C003 (Final) R834798 (Final) |
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Makar M, Antonelli J, Di Q, Cutler D, Schwartz J, Dominici F. Estimating the causal effect of low levels of fine particulate matter on hospitalization. Epidemiology 2017;28(5):627-634. |
R835872 (2016) R835872 (2017) R835872C003 (Final) R835872C004 (Final) R835872C005 (2016) |
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McGuinn LA, Windham GC, Kalkbrenner AE, Bradley C, Di Q, Croen LA, Fallin MD, Hoffman K, Ladd-Acosta C, Schwartz J, Rappold AG, Richardson DB, Neas LM, Gammon MD, Schieve LA, Daniels JL. Early Life Exposure to Air Pollution and Autism Spectrum Disorder:Findings from a Multisite Case-Control Study. Epidemiology 2020; 31(1):103-114. |
R835872C003 (Final) |
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Nassan FL, Wang C, Kelly RS, Lasky-Su JA, Vokonas PS, Koutrakis P, Schwartz JD. Ambient PM2.5 species and ultrafine particle exposure and their differential metabolomic signatures. Environ Int 2021; 151:106447. |
R835872 (2020) R835872C003 (Final) |
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Nassan FL, Kelly RS, Kosheleva A, Koutrakis P, Vokonas PS, Lasky-Su JA, Schwartz JD. Metabolomic signatures of the long-term exposure to air pollution and temperature. Environ Health 2021; 20(1):3. |
R835872C003 (Final) |
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Nurhussien L, Kang C, Koutrakis P, Coull B, Rice M. Air Pollution Exposure and Daily Lung Function in Chronic Obstructive Pulmonary Disease Effect Modification by Eosinophil Level. ANNALS OF THE AMERICAN THORACIC SOCIETY 2022;19(5):728-736 |
R835872 (2020) R835872C003 (Final) |
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Nyhan MM, Rice M, Blomberg A, Coull BA, Garshick E, Vokonas P, Schwartz J, Gold DR, Koutrakis P. Associations between ambient particle radioactivity and lung function. Environment International 2019;130:104795. |
R835872 (2019) R835872C001 (Final) R835872C003 (Final) |
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Papatheodorou S, Yao W, Vieira C, Li L, Wylie B, Schwartz J, Koutrakis P. Residential radon exposure and hypertensive disorders of pregnancy in Massachusetts, USA: a cohort study. Environmental International 2021;146(106285). |
R835872 (2020) R835872C001 (Final) R835872C003 (Final) |
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Peralta A, Link M, Schwartz J, Luttmann-Gibson H, Dockery D, Blombarg A, Wei Y, Mittleman M, Gold D, Laden F, Coull B, Koutrakis P. Exposure to air pollution and particle radioactivity with the risk of ventricular arrhythmias. Circulation 2020;142(9):858-867. |
R835872 (2020) R835872C001 (Final) R835872C002 (Final) R835872C003 (Final) |
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Rahman M, Shu Y, Chow T, Lurmann F, Yu X, Martinez M, Carter S, Eckel S, Chen J, Chen Z, Levitt P, Schwartz J, McConnell R, Xiang A. Prenatal Exposure to Air Pollution and Autism Spectrum Disorder:Sensitive Windows of Exposure and Sex Differences. ENVIRONMENTAL HEALTH PERSPECTIVES 2022;130(1). |
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Rhee J, Dominici F, Zanobetti A, Schwartz J, Wang Y, Di Q, Christiani D. Risk of acute respiratory distress syndrome among older adults living near construction and manufacturing sites. Epidemiology 2020;31(4):468-477. |
R835872 (2020) R835872C003 (Final) |
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Rosa MJ, Hsu HH, Just AC, Brennan KJ, Bloomquist T, Kloog I, Pantic I, Garcia AM, Wilson A, Coull BA, Wright RO. Association between prenatal particulate air pollution exposure and telomere length in cord blood:Effect modification by fetal sex. Environmental Research 2019;172:495-501. |
R835872 (2019) R835872C002 (Final) R835872C003 (Final) |
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Scheerens C, Nurhussein L, Algan A, Synn A, Coull B, Koutrakis P, Rice M. The impact of personal and outdoor temperature exposure during cold and warm seasons on lung function and respiratory symptoms in COPD. ERJ - OPEN RESEARCH 2022;8(1):00574-2021 |
R835872 (2020) R835872C003 (Final) |
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Schiff J, Vieira C, Garshick E, Wang V, Blomberg A, Gold D, Schwartz J, Tracy S, Vokanas P, Koutrakis P. The role of solar and geomagnetic activity in endothelial activation and inflammation in the NAS cohort. PLOS ONE 2022;17(7) |
R835872 (2021) R835872C001 (Final) R835872C003 (Final) |
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Schwartz JD, Di Q, Requia WJ, Dominici F, Zanobetti A. A Direct Estimate of the Impact of PM2.5, NO2, and O3 Exposure on Life Expectancy Using Propensity Scores. Epidemiology 2021; 32(4):469-476. |
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Schwartz J, Yitshak-Sade M, Zanobetti A, Di Q, Dominici F, Mittleman M. A self-controlled approach to survival analysis, with application to air pollution and mortality. ENVIRONMENTAL INTERNATIONAL 2021;157(106861). |
R835872 (2020) R835872C003 (Final) |
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Schwartz J, Wei Y, Yitshak-Sade M, Di Q, Dominici F, Zanobetti A. A national difference in differences analysis of the effect of PM2.5 on annual death rates. Environ Res 2021; 194:110649. |
R835872C003 (Final) |
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Shi L, Wu X, Danesh Yazdi M, Braun D, Abu Awad Y, Wei Y, Liu P, Di Q, Wang Y, Schwartz J, Dominici F, Kioumourtzoglou M-A, Zanobetti A. Long-term effects of PM2·5 on neurological disorders in the American Medicare population:a longitudinal cohort study. The Lancet Planetary Health 2020; 4(12):e557-e565. |
R835872C003 (Final) R834677 (Final) |
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Vohra K, Vodonos A, Schwartz J, Marais EA, Sulprizio MP, Mickley LJ. Global mortality from outdoor fine particle pollution generated by fossil fuel combustion:Results from GEOS-Chem. Environ Res 2021; 195:110754. |
R835872C001 (Final) R835872C003 (Final) |
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Wang C, Cardenas A, Hutchinson J, Just A, Heiss J, Hou L, Zheng Y, Coull B, Kosheleva A, Koutrakis P, Baccarelli A, Schwartz J. Short-and intermediate-term exposure to ambient fine particulate elements and leukocyte epigenome-wide DNA methylation in older men:the Normative Aging Study. ENVIRONMENTAL INTERNATIONAL 2022;158. |
R835872 (2020) R835872C002 (Final) R835872C003 (Final) |
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Wang V, Vieira Z, Garshick E, Schwartz J, Garshick M, Vokonas P, Koutrakis P. Solar activity is associated with diastolic and systolic blood pressure in elderly adults. Journal of the American Heart Association 2021;10(21):e021006. |
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Wang Y, Shi L, Lee M, Liu P, Di Q, Zanobetti A, Schwartz JD. Long-term exposure to PM2.5 and mortality among older adults in the Southeastern US. Epidemiology 2017;28(2):207-214. |
R835872 (2016) R835872 (2017) R835872C003 (Final) R836156 (2017) R836156 (2020) |
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Ward-Caviness CK, Weaver AM, Buranosky M, Pfaff ER, Neas LM, Devlin RB, Schwartz J, Di Q, Cascio WE, Diaz-Sanchez D. Associations Between Long-Term Fine Particulate Matter Exposure and Mortality in Heart Failure Patients. J Am Heart Assoc 2020; 9(6):e012517. |
R835872C003 (Final) R834798 (Final) |
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Ward-Caviness CK, Danesh Yazdi M, Moyer J, Weaver AM, Cascio WE, Di Q, Schwartz JD, Diaz-Sanchez D. Long-Term Exposure to Particulate Air Pollution Is Associated With 30-Day Readmissions and Hospital Visits Among Patients With Heart Failure. J Am Heart Assoc 2021; 10(10):e019430. |
R835872 (2020) R835872C003 (Final) |
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Wei Y, Wang Y, Wu X, Di Q, Shi L, Koutrakis P, Zanobetti A, Dominici F, Schwartz J. Causal Effects of Air Pollution on Mortality Rate in Massachusetts. AMERICAN JOURNAL OF EPIDEMIOLOGY 2020;189(11):1316-1323. |
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Wei Y, Yazdi M, Di Q, Dominici F, Zanobetti A, Schwartz J. Emulating causal dose-response Relations between air pollutants and mortality in the Medicare population. Environmental Health 2021;270(1). |
R835872 (2020) R835872C003 (Final) |
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Wei Y, Coull B, Koutrakis P, Yang J, Li L, Zanobetti A, Schowatz J. Assessing additive effects of air pollutants on mortality rate in Massachusetts. ENVIRONMENTAL HEALTH 2021;20(1):19. |
R835872 (2020) R835872C002 (Final) R835872C003 (Final) R836156 (Final) |
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Wei Y, Qiu X, Yazdi M, Shtein A, Shi L, Yang J, Peralta A, Coull B, Schwartz J. The Impact of Exposure Measurement Error on the Estimated Concentration-Response Relationship between Long-Term Exposure to PM2.5 and Mortality. ENVIRONMENTAL HEALTH PERSPECTIVES 2022;130(7):77006. |
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Wright R, Shu HL, Coull B, Simon M, Hudda N, Schwartz J, Kloog I, Durant J. Prenatal ambient ultrafine particle exposure and childhood asthma in the Northeastern United States. American Journal of Respiratory and Critical Care Medicine 2021;204(7):788-796. |
R835872 (2020) R835872C002 (Final) R835872C003 (Final) |
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Wu X, Braun D, Schwartz J, Kioumourtzoglou M, Dominici F. Evaluating the impact of long-term exposure to fine particulate matter on mortality among the elderly. SCIENCE ADVANCES 2020;6(29):eaba5692. |
R835872 (2020) R835872C003 (Final) R835872C004 (Final) R834798 (Final) |
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Yazdi M, Wei T, Requia W, Shi L, Sabath M, Dominici F, Schwartz J. The effect of long-term exposure to air pollution and seasonal temperature on hospital admissions with cardiovascular and respiratory disease in the United States:A difference-in-differences analysis. SCIENCE OF THE TOTAL ENVIRONMENT 2022;843(156855). |
R835872 (2020) R835872C003 (Final) |
Exit Exit |
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Yitshak-Sade M, Nethery R, Schwartz JD, Mealli F, Dominici F, Di Q, Abu Awad Y, Ifergane G and Zanobetti A. PM2.5 and hospital admissions among Medicare enrollees with chronic debilitating brain disorders. Science of The Total Environment 2021; 755. |
R835872C003 (Final) |
Exit |
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Zanobetti A, Coull BA, Kloog I, Sparrow D, Vokonas PS, Gold DR, Schwartz J. Fine-scale spatial and temporal variation in temperature and arrhythmia episodes in the VA Normative Aging Study. Journal of the Air & Waste Management Association 2017;67(1):96-104. |
R835872 (2016) R835872C003 (Final) R832416 (Final) R834798 (Final) R834798C002 (Final) R834798C004 (Final) R834798C005 (Final) |
Exit Exit |
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Zanobetti A, Coull BA, Luttmann-Gibson H, van Rossem L, Rifas-Shiman SL, Kloog I, Schwartz JD, Oken E, Bobb JF, Koutrakis P, Gold DR. Ambient particle components and newborn blood pressure in Project Viva. Journal of the American Heart Association 2021; 10(1):e016935. |
R835872C002 (Final) R835872C003 (Final) |
Exit Exit |
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Zhang S, Breitner S, Cascio WE, Devlin RB, Neas LM, Ward-Caviness C, Diaz-Sanchez D, Kraus WE, Hauser ER, Schwartz J, Peters A, Schneider A. Association between short-term exposure to ambient fine particulate matter and myocardial injury in the CATHGEN cohort. Environ Pollut 2021; 275:116663. |
R835872 (2020) R835872C003 (Final) |
Exit Exit |
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Vierira CLZ, Link M, Garschick E, Peralta A, Luttman-Gibson H, Laden F, Liu M, Gold D, Koutrakis P. Solar and geomagnetic activity enhance the effects of air pollutants on atrial fibrillation. Eurspace 2022;24(5):713-720. |
R835872 (2020) R835872C001 (Final) R835872C003 (Final) R834798 (Final) |
Exit |
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Bind M-A, Peters A, Koutrakis P, Coull B, Vokonas P and Schwartz J. Quantile Regression Analysis of the Distributional Effects of Air Pollution on Blood Pressure, Heart Rate Variability, Blood Lipids, and Biomarkers of Inflammation in Elderly American Men:The Normative Aging Study. Environmental Health Perspectives 2016; 124(8):1189-1198. |
R835872C003 (Final) R834798 (Final) |
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Bind M-AC, Coull BA, Baccarelli A, Tarantini L, Cantone L, Vokonas P and Schwartz J. Distributional changes in gene-specific methylation associated with temperature. Environmental Research 2016; 150:38-46. |
R835872C003 (Final) |
Exit |
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Di Q, Dai L, Wang Y, Zanobetti A, Choirat C, Schwartz JD, Dominici F. Association of short-term exposure to air pollution with mortality in older adults. JAMA 2017;318(24):2446-2456. |
R835872C003 (Final) |
Exit |
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Peng C, Cayir A, Sanchez-Guerra M, Di Q, Wilson A, Zhong J, Kosheleva A, Trevisi L, Colicino E, Brennan K, Dereix AE. Associations of annual ambient fine particulate matter mass and components with mitochondrial DNA abundance. Epidemiology 2017;28(6):763-770. |
R835872 (2017) R835872 (2018) R835872C003 (Final) |
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Chiu YH, Hsu HH, Wilson A, Coull BA, Pendo MP, Baccarelli A, Kloog I, Schwartz J, Wright RO, Taveras EM, Wright RJ. Prenatal particulate air pollution exposure and body composition in urban preschool children:examining sensitive windows and sex-specific associations. Environmental Research 2017;158:798-805. |
R835872 (2017) R835872C002 (Final) R835872C003 (Final) |
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Jhun I, Gaffin JM, Coull BA, Huffaker MF, Petty CR, Sheehan WJ, Baxi SN, Lai PS, Kang C-M, Wolfson JM, Gold DR, Koutrakis P and Phipatanakul W. School Environmental Intervention to Reduce Particulate Pollutant Exposures for Children with Asthma. The Journal of Allergy and Clinical Immunology:In Practice 2017; 5(1):154-159.e153. |
R835872C003 (Final) |
Exit |
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Schwartz J, Fong K, Zanobetti A. A national multicity analysis of the causal effect of local pollution, NO2, and PM2.5 on mortality. Environmental Health Perspectives 2018;126(8):087004. |
R835872 (2018) R835872C003 (Final) |
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Nyhan MM, Coull BA, Blomberg AJ, Vieira CL, Garshick E, Aba A, Vokonas P, Gold DR, Schwartz J, Koutrakis P. Associations between ambient particle radioactivity and blood pressure:the NAS (Normative Aging Study). Journal of the American Heart Association 2018;7(6):e008245. |
R835872 (2018) R835872C001 (Final) R835872C002 (Final) R835872C003 (Final) |
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Ananth CV, Kioumourtzoglou MA, Huang Y, Ross Z, Friedman AM, Williams MA, Wang S, Mittleman MA, Schwartz J. Exposures to air pollution and risk of acute-onset placental abruption:a case-crossover study. Epidemiology 2018;29(5):631-638. |
R835872 (2018) R835872C003 (Final) |
Exit |
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Wurth R, Kioumourtzoglou M-A, Tucker KL, Griffith J, Manjourides J and Suh H. Fine particle sources and cognitive function in an older Puerto Rican cohort in Greater Boston:. Environmental Epidemiology 2018; 2(3):e022. |
R835872C003 (Final) |
Exit |
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Requia WJ, Adams MD, Arain A, Papatheodorou S, Koutrakis P and Mahmoud M. Global Association of Air Pollution and Cardiorespiratory Diseases:A Systematic Review, Meta-Analysis, and Investigation of Modifier Variables. American Journal of Public Health 2018; 108(S2):S123-S130. |
R835872C003 (Final) |
Exit |
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Garshick E, Grady ST, Hart JE, Coull BA, Schwartz JD, Laden F, Moy ML, Koutrakis P. Indoor black carbon and biomarkers of systemic inflammation and endothelial activation in COPD patients. Environmental Research 2018;165:358-364. |
R835872 (2018) R835872C001 (Final) R835872C002 (Final) R835872C003 (Final) |
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Rice MB, Rifas-Shiman SL, Litonjua AA, Gillman MW, Liebman N, Kloog I, Luttmann-Gibson H, Coull BA, Schwartz J, Koutrakis P, Oken E. Lifetime air pollution exposure and asthma in a pediatric birth cohort. Journal of Allergy and Clinical Immunology 2018;141(5):1932-1934. |
R835872 (2018) R835872C002 (Final) R835872C003 (Final) |
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Ljungman PL, Li W, Rice MB, Wilker EH, Schwartz J, Gold DR, Koutrakis P, Benjamin EJ, Vasan RS, Mitchell GF, Hamburg NM. Long-and short-term air pollution exposure and measures of arterial stiffness in the Framingham heart study. Environment International 2018;121:139-147. |
R835872 (2018) R835872C003 (Final) |
Exit |
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Fong K, Kloog I, Coull B, Koutrakis P, Laden F, Schwartz J, James P. Residential greenness and birthweight in the state of Massachusetts, USA. International Journal of Environmental Research and Public Health 2018;15(6):1248. |
R835872 (2018) R835872C003 (Final) R836156 (2019) R836156 (2020) |
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Yitshak-Sade M, Bobb JF, Schwartz JD, Kloog I, Zanobetti A. The association between short and long-term exposure to PM2.5 and temperature and hospital admissions in New England and the synergistic effect of the short-term exposures. Science of The Total Environment 2018;639:868-875. |
R835872 (2018) R835872C003 (Final) |
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Blomberg AJ, Coull BA, Jhun I, Vieira CL, Zanobetti A, Garshick E, Schwartz J, Koutrakis P. Effect modification of ambient particle mortality by radon:a time series analysis in 108 US cities. Journal of the Air & Waste Management Association 2019;69(3):266-276. |
R835872 (2018) R835872 (2019) R835872 (2020) R835872C001 (Final) R835872C002 (Final) R835872C003 (Final) R834798 (Final) |
Exit Exit |
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Vieira CL, Alvares D, Blomberg A, Schwartz J, Coull B, Huang S, Koutrakis P. Geomagnetic disturbances driven by solar activity enhance total and cardiovascular mortality risk in 263 US cities. Environmental Health 2019;18(1):83. |
R835872 (2019) R835872C001 (Final) R835872C003 (Final) R834798 (Final) |
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Gaskins AJ, Minguez-Alarcon L, Fong KC, Abu Awad Y, Di Q, Chavarro JE, Ford JB, Coull BA, Schwartz J, Kloog I, Attaman J. Supplemental folate and the relationship between traffic-related air pollution and livebirth among women undergoing assisted reproduction. American Journal of Epidemiology 2019;188(9):1595-1604. |
R835872 (2019) R835872C002 (Final) R835872C003 (Final) R834798 (Final) |
Exit Exit |
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Wei Y, Wang Y, Di Q, Choirat C, Wang Y, Koutrakis P, Zanobetti A, Dominici F and Schwartz JD. Short term exposure to fine particulate matter and hospital admission risks and costs in the Medicare population:time stratified, case crossover study. BMJ 2019; 367:l6258. |
R835872 (2019) R835872C003 (Final) R835872C004 (Final) R834798 (Final) |
Exit |
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Borge R, Requia WJ, Yague C, Jhun I and Koutrakis P. Impact of weather changes on air quality and related mortality in Spain over a 25year period [1993-2017]. Environ Int 2019; 133(Pt B):105272. |
R835872 (2020) R835872C001 (Final) R835872C003 (Final) R834798 (Final) |
Exit Exit |
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Achilleos S, Al-Ozairi E, Alahmad B, Garshick E, Neophytou AM, Bouhamra W, Yassin MF and Koutrakis P. Acute effects of air pollution on mortality:A 17-year analysis in Kuwait. Environment International 2019; 126:476-483. |
R835872 (2020) R835872C003 (Final) |
Exit Exit |
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Rice MB, Li W, Schwartz J, Di Q, Kloog I, Koutrakis P, Gold DR, Hallowell RW, Zhang C, O'Connor G, Washko GR. Ambient air pollution exposure and risk and progression of interstitial lung abnormalities:the Framingham Heart Study. Thorax 2019;74(11):1063-1069. |
R835872 (2019) R835872C003 (Final) |
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Rice MB, Li W, Wilker EH, Gold DR, Schwartz J, Zanobetti A, Koutrakis P, Kloog I, Washko GR, O'Connor GT, Mittleman MA. Association of outdoor temperature with lung function in a temperate climate. European Respiratory Journal 2019;53(1):1800612. |
R835872 (2018) R835872C003 (Final) |
Exit |
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Wei Y, Wang Y, Lin C-K, Yin K, Yang J, Shi L, Li L, Zanobetti A, Schwartz JD. Associations between seasonal temperature and dementia-associated hospitalizations in New England. Environment International 2019;126:228-233. |
R835872 (2019) R835872C003 (Final) |
Exit |
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Yitshak-Sade M, Blomberg AJ, Zanobetti A, Schwartz JD, Coull BA, Kloog I, Dominici F and Koutrakis P. County-level radon exposure and all-cause mortality risk among Medicare beneficiaries. Environ Int 2019; 130:104865. |
R835872 (2019) R835872C001 (Final) R835872C003 (Final) R835872C004 (Final) |
Exit |
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Harris MH, Gold DR, Rifas-Shiman SL, Melly SJ, Zanobetti A, Coull BA, Schwartz JD, Gryparis A, Kloog I, Koutrakis P, Bellinger DC, White RF, Sagiv SK and Oken E. Erratum:Prenatal and Childhood Traffic-Related Pollution Exposure and Childhood Cognition in the Project Viva Cohort (Massachusetts, USA). Environ Health Perspect 2019; 127(6):69001. |
R835872C003 (Final) |
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Yitshak-Sade M, Kloog I, Zanobetti A, Schwartz JD. Estimating the causal effect of annual PM2.5 exposure on mortality rates in the Northeastern and mid-Atlantic states. Environmental Epidemiology 2019;3(4):e052. |
R835872 (2019) R835872C003 (Final) |
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Gaskins AJ, Minguez-Alarcon L, Fong KC, Abdelmessih S, Coull BA, Chavarro JE, Schwartz J, Kloog I, Souter I, Hauser R, Laden F. Exposure to fine particulate matter and ovarian reserve among women from a fertility clinic. Epidemiology 2019;30(4):486-491. |
R835872 (2019) R835872C002 (Final) R835872C003 (Final) |
Exit |
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Rhee J, Dominici F, Zanobetti A, Schwartz J, Wang Y, Di Q, Balmes J, Christiani DC. Impact of long-term exposures to ambient PM2.5 and ozone on ARDS risk for older adults in the United States. Chest 2019; 156(1):71-79. |
R835872 (2018) R835872 (2019) R835872C003 (Final) R835872C004 (Final) |
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Gao X, Colicino E, Shen J, Kioumourtzoglou MA, Just AC, Nwanaji-Enwerem JC, Coull B, Lin X, Vokonas P, Zheng Y, Hou L. Impacts of air pollution, temperature, and relative humidity on leukocyte distribution:an epigenetic perspective. Environment International 2019;126:395-405. |
R835872 (2019) R835872C003 (Final) |
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Yazdi MD, Wang Y, Di Q, Zanobetti A, Schwartz J. Long-term exposure to PM2.5 and ozone and hospital admissions of Medicare participants in the Southeast USA. Environment International 2019;130:104879. |
R835872 (2019) R835872C003 (Final) |
Exit |
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Yitshak-Sade M, James P, Kloog I, Hart JE, Schwartz JD, Laden F, Lane KJ, Fabian MP, Fong KC and Zanobetti A. Neighborhood Greenness Attenuates the Adverse Effect of PM2.5 on Cardiovascular Mortality in Neighborhoods of Lower Socioeconomic Status. Int J Environ Res Public Health 2019; 16(5). |
R835872C003 (Final) |
Exit |
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Fleisch AF, Aris IM, Rifas-Shiman SL, Coull BA, Luttmann-Gibson H, Koutrakis P, Schwartz JD, Kloog I, Gold DR, Oken E. Prenatal exposure to traffic pollution and childhood body mass index trajectory. Frontiers in Endocrinology 2019;9:771. |
R835872 (2018) R835872 (2019) R835872C002 (Final) R835872C003 (Final) |
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Fong KC, Di Q, Kloog I, Laden F, Coull BA, Koutrakis P, Schwartz JD. Relative toxicities of major particulate matter constituents on birthweight in Massachusetts. Environmental Epidemiology 2019;3(3). |
R835872 (2019) R835872C002 (Final) R835872C003 (Final) |
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Li W, Dorans KS, Wilker EH, Rice MB, Ljungman PL, Schwartz JD, Coull BA, Koutrakis P, Gold DR, Keaney Jr JF, Vasan RS. Short-term exposure to ambient air pollution and circulating biomarkers of endothelial cell activation:The Framingham heart study. Environmental Research 2019;171:36-43. |
R835872 (2018) R835872C002 (Final) R835872C003 (Final) |
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Gaskins AJ, Fong KC, Abu Awad Y, Di Q, Minguez-Alarcon L, Chavarro JE, Ford JB, Coull BA, Schwartz J, Kloog I, Souter I. Time-varying exposure to air pollution and outcomes of in vitro fertilization among couples from a fertility clinic. Environmental Health Perspectives 2019;127(7):077002. |
R835872 (2019) R835872C002 (Final) R835872C003 (Final) |
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Kioumourtzoglou M-A, Raz R, Wilson A, Fluss R, Nirel R, Broday DM, Yuval, Hacker MR, McElrath TF, Grotto I, Koutrakis P and Weisskopf MG. Traffic-related Air Pollution and Pregnancy Loss:. Epidemiology 2019; 30(1):4-10. |
R835872C003 (Final) |
Exit |
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Gaffin JM, Hauptman M, Petty CR, Haktanir-Abul M, Gunnlaugsson S, Lai PS, Baxi SN, Permaul P, Sheehan WJ, Wolfson JM, Coull BA, Gold DR, Koutrakis P and Phipatanakul W. Differential Effect of School-Based Pollution Exposure in Children With Asthma Born Prematurely. Chest 2020; 158(4):1361-1363. |
R835872 (2020) R835872C002 (Final) R835872C003 (Final) R834798 (Final) |
Exit Exit |
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Cserbik D, Chen JC, McConnell R, Berhane K, Sowell ER, Schwartz J, Hackman DA, Kan E, Fan CC and Herting MM. Fine particulate matter exposure during childhood relates to hemispheric-specific differences in brain structure. Environ Int 2020; 143:105933. |
R835872 (2020) R835872C003 (Final) R835441 (Final) |
Exit Exit |
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Gaskins AJ, Minguez-Alarcon L, Williams PL, Chavarro JE, Schwartz JD, Kloog I, Souter I, Hauser R, Laden F and Team ES. Ambient air pollution and risk of pregnancy loss among women undergoing assisted reproduction. Environ Res 2020; 191:110201. |
R835872C003 (Final) |
Exit Exit |
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Papatheodorou S, Gold DR, Blomberg AJ, Hacker M, Wylie BJ, Requia WJ, Oken E, Fleisch AF, Schwartz JD and Koutrakis P. Ambient particle radioactivity and gestational diabetes:A cohort study of more than 1 million pregnant women in Massachusetts, USA. Science of The Total Environment 2020; 733. |
R835872C001 (Final) R835872C003 (Final) |
Exit |
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Vieira CLZ, Garshick E, Alvares D, Schwartz J, Huang S, Vokonas P, Gold DR and Koutrakis P. Association between ambient beta particle radioactivity and lower hemoglobin concentrations in a cohort of elderly men. Environment International 2020; 139. |
R835872C001 (Final) R835872C003 (Final) |
Exit |
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Wang C, Koutrakis P, Gao X, Baccarelli A and Schwartz J. Associations of annual ambient PM2.5 components with DNAm PhenoAge acceleration in elderly men:The Normative Aging Study. Environmental Pollution 2020; 258. |
R835872C003 (Final) |
Exit |
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Huang S, Garshick E, Weschler LB, Hong C, Li J, Li L, Qu F, Gao D, Zhou Y, Sundell J, Zhang Y and Koutrakis P. Home environmental and lifestyle factors associated with asthma, rhinitis and wheeze in children in Beijing, China. Environ Pollut 2020; 256:113426. |
R835872C001 (Final) R835872C003 (Final) |
Exit |
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Qiu X, Wei Y, Wang Y, Di Q, Sofer T, Awad YA, Schwartz J. Inverse probability weighted distributed lag effects of short-term exposure to PM2.5 and ozone on CVD hospitalizations in New England Medicare participants-Exploring the causal effects. Environmental Research 2020;182:109095. |
R835872 (2019) R835872C003 (Final) |
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Rosofsky AS, Fabian MP, Ettinger de Cuba S, Sandel M, Coleman S, Levy JI, Coull BA, Hart JE and Zanobetti A. Prenatal Ambient Particulate Matter Exposure and Longitudinal Weight Growth Trajectories in Early Childhood. Int J Environ Res Public Health 2020; 17(4). |
R835872C002 (Final) R835872C003 (Final) |
Exit |
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Qiu X, Fong KC, Shi L, Papatheodorou S, Di Q, Just A, Kosheleva A, Messerlian C and Schwartz JD. Prenatal exposure to particulate air pollution and gestational age at delivery in Massachusetts neonates 2001–2015. Environmental Epidemiology 2020; 4(5). |
R835872C003 (Final) |
Exit |
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Fong KC, Yitshak-Sade M, Lane KJ, Fabian MP, Kloog I, Schwartz JD, Coull BA, Koutrakis P, Hart JE, Laden F and Zanobetti A. Racial disparities in associations between neighborhood demographic polarization and birth weight. International Journal of Environmental Research and Public Health 2020; 17(9). |
R835872C002 (Final) R835872C003 (Final) |
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Huang S, Xiong J, Vieira CLZ, Blomberg AJ, Gold DR, Coull BA, Sarosiek K, Schwartz JD, Wolfson JM, Li J and Koutrakis P. Short-term exposure to ambient particle gamma radioactivity is associated with increased risk for all-cause non-accidental and cardiovascular mortality. Sci Total Environ 2020; 721:137793. |
R835872C001 (Final) R835872C002 (Final) R835872C003 (Final) |
Exit Exit |
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Huang S, Garshick E, Vieira CL, Grady ST, Schwartz JD, Coull BA, Hart JE, Laden F, Koutrakis P. Short-term exposures to particulate matter gamma radiation activities and biomarkers of systemic inflammation and endothelial activation in COPD patients. Environmental Research 2020;180:108841. |
R835872 (2019) R835872C001 (Final) R835872C002 (Final) R835872C003 (Final) |
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Vodonos A and Schwartz J. Estimation of excess mortality due to long-term exposure to PM2.5 in continental United States using a high-spatiotemporal resolution model. Environ Res 2021; 196:110904. |
R835872 (2020) R835872C003 (Final) |
Exit Exit |
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Weinberger KR, Wu X, Sun S, Spangler KR, Nori-Sarma A, Schwartz J, Requia W, Sabath BM, Braun D, Zanobetti A, Dominici F and Wellenius GA. Heat warnings, mortality, and hospital admissions among older adults in the United States. Environ Int 2021; 157:106834. |
R835872 (2020) R835872C003 (Final) |
Exit Exit |
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Shi L, Steenland K, Li H, Liu P, Zhang Y, Lyles RH, Requia WJ, Ilango SD, Chang HH, Wingo T, Weber RJ and Schwartz J. A national cohort study (2000-2018) of long-term air pollution exposure and incident dementia in older adults in the United States. Nat Commun 2021; 12(1):6754. |
R835872C003 (Final) |
Exit |
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Lu W, Hackman DA and Schwartz J. Ambient air pollution associated with lower academic achievement among US children:A nationwide panel study of school districts. Environ Epidemiol 2021; 5(6):e174. |
R835872C003 (Final) |
Exit |
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Wei Y, Tiwari AS, Li L, Solanki B, Sarkar J, Mavalankar D and Schwartz J. Assessing mortality risk attributable to high ambient temperatures in Ahmedabad, 1987 to 2017. Environ Res 2021; 198:111232. |
R835872C003 (Final) |
Exit |
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Peralta AA, Schwartz J, Gold DR, Coull B and Koutrakis P. Associations between PM2.5 metal components and QT interval length in the Normative Aging Study. Environ Res 2021; 195:110827. |
R835872C002 (Final) R835872C003 (Final) |
Exit |
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Qian Y, Li H, Rosenberg A, Li Q, Sarnat J, Papatheodorou S, Schwartz J, Liang D, Liu Y, Liu P and Shi L. Long-Term Exposure to Low-Level NO2 and Mortality among the Elderly Population in the Southeastern United States. Environ Health Perspect 2021; 129(12):127009. |
R835872C003 (Final) |
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Yazdi MD, Wang Y, Di Q, Requia WJ, Wei Y, Shi L, Sabath MB, Dominici F, Coull B, Evans JS, Koutrakis P and Schwartz JD. Long-term effect of exposure to lower concentrations of air pollution on mortality among US Medicare participants and vulnerable subgroups:a doubly-robust approach. The Lancet Planetary Health 2021; 5(10):e689-e697. |
R835872C003 (Final) |
Exit |
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deSouza P, Braun D, Parks RM, Schwartz J, Dominici F and Kioumourtzoglou M-A. Nationwide Study of Short-Term Exposure to Fine Particulate Matter and Cardiovascular Hospitalizations among Medicaid Enrollees. Epidemiology 2021; 32(1):6-13. |
R835872C003 (Final) |
Exit |
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Gao X, Coull B, Lin X, Vokonas P, Spiro A, Hou L, Schwartz J and Baccarelli AA. Short-term air pollution, cognitive performance and nonsteroidal anti-inflammatory drug use in the Veterans Affairs Normative Aging Study. Nature Aging 2021; 1(5):430-437. |
R835872C002 (Final) R835872C003 (Final) |
Exit |
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Gao X, Koutrakis P, Coull B, Lin X, Vokonas P, Schwartz J and Baccarelli AA. Short-term exposure to PM2.5 components and renal health:Findings from the Veterans Affairs Normative Aging Study. J Hazard Mater 2021; 420:126557. |
R835872C002 (Final) R835872C003 (Final) |
Exit Exit |
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Shi L, Rosenberg A, Wang Y, Liu P, Danesh Yazdi M, Requia W, Steenland K, Chang H, Sarnat JA, Wang W, Zhang K, Zhao J and Schwartz J. Low-Concentration Air Pollution and Mortality in American Older Adults:A National Cohort Analysis (2001-2017). Environ Sci Technol 2022; 56(11):7194-7202. |
R835872 (2020) R835872C003 (Final) |
Exit Exit |
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Wei Y, Qiu X, Sabath MB, Yazdi MD, Yin K, Li L, Peralta AA, Wang C, Koutrakis P, Zanobetti A, Dominici F and Schwartz JD. Air Pollutants and Asthma Hospitalization in the Medicaid Population. Am J Respir Crit Care Med 2022; 205(9):1075-1083. |
R835872C003 (Final) |
Exit |
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Qiu X, Danesh-Yazdi M, Weisskopf M, Kosheleva A, Spiro AS, Wang C, Coull BA, Koutrakis P and Schwartz JD. Associations between Air Pollution and Psychiatric Symptoms in The Normative Aging Study. Environ Res Lett 2022; 17(3). |
R835872C003 (Final) |
Exit |
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Jin T, Di Q, Requia WJ, Danesh Yazdi M, Castro E, Ma T, Wang Y, Zhang H, Shi L and Schwartz J. Associations between long-term air pollution exposure and the incidence of cardiovascular diseases among American older adults. Environ Int 2022; 170:107594. |
R835872C003 (Final) |
Exit |
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Tracy SM, Vieira CLZ, Garshick E, Wang VA, Alahmad B, Eid R, Schwartz J, Schiff JE, Vokonas P and Koutrakis P. Associations between solar and geomagnetic activity and peripheral white blood cells in the Normative Aging Study. Environ Res 2022; 204(Pt B):112066. |
R835872C001 (Final) R835872C003 (Final) |
Exit |
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Leung M, Weisskopf MG, Laden F, Coull BA, Modest AM, Hacker MR, Wylie BJ, Wei Y, Schwartz J and Papatheodorou S. Exposure to PM2.5 during Pregnancy and Fetal Growth in Eastern Massachusetts, USA. Environ Health Perspect 2022; 130(1):17004. |
R835872C002 (Final) R835872C003 (Final) |
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Vieira CL, Chen K, Garshick E, Liu M, Vokonas P, Ljungman P, Schwartz J, Koutrakis P. Geomagnetic disturbances reduce heart rate variability in the Normative Aging Study. Science of the Total Environment 2022;839:156235. |
R835872C001 (Final) R835872C003 (Final) |
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Li H, Deng W, Small R, Schwartz J, Liu J and Shi L. Health effects of air pollutant mixtures on overall mortality among the elderly population using Bayesian kernel machine regression (BKMR). Chemosphere 2022; 286(Pt 1):131566. |
R835872C003 (Final) |
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Requia WJ, Papatheodorou S, Koutrakis P, Mukherjee R and Roig HL. Increased preterm birth following maternal wildfire smoke exposure in Brazil. Int J Hyg Environ Health 2022; 240:113901. |
R835872C003 (Final) |
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Liao NS, Van Den Eeden SK, Sidney S, Deosaransingh K, Schwartz J, Uong SP and Alexeeff SE. Joint associations between neighborhood walkability, greenness, and particulate air pollution on cardiovascular mortality among adults with a history of stroke or acute myocardial infarction. Environ Epidemiol 2022; 6(2):e200. |
R835872C003 (Final) |
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Li J, Wang Y, Steenland K, Liu P, van Donkelaar A, Martin RV, Chang HH, Caudle WM, Schwartz J, Koutrakis P and Shi L. Long-term effects of PM2.5 components on incident dementia in the northeastern United States. Innovation (Camb) 2022; 3(2):100208. |
R835872C003 (Final) |
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Vanoli J, Coull BA, Ettinger de Cuba S, Fabian PM, Carnes F, Massaro MA, Poblacion A, Bellocco R, Kloog I, Schwartz J, Laden F and Zanobetti A. Postnatal exposure to PM2.5 and weight trajectories in early childhood. Environ Epidemiol 2022; 6(1):e181. |
R835872C002 (Final) R835872C003 (Final) |
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Requia WJ, Kill E, Papatheodorou S, Koutrakis P and Schwartz JD. Prenatal exposure to wildfire-related air pollution and birth defects in Brazil. J Expo Sci Environ Epidemiol 2022; 32(4):596-603. |
R835872C003 (Final) |
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Vohra K, Marais EA, Bloss WJ, Schwartz J, Mickley LJ, Damme MV, Clarisse L and Coheur P-F. Rapid rise in premature mortality due to anthropogenic air pollution in fast-growing tropical cities from 2005 to 2018. Science Advances 2022; 8. |
R835872C001 (Final) R835872C003 (Final) |
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Qiu X, Wei Y, Weisskopf M, Spiro A, Shi L, Castro E, Coull B, Koutrakis P and Schwartz J. Air pollution, climate conditions and risk of hospital admissions for psychotic disorders in U.S. residents. Environ Res 2023; 216(Pt 2):114636. |
R835872C003 (Final) R836156 (Final) |
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Shi L, Zhu Q, Wang Y, Hao H, Zhang H, Schwartz J, Amini H, van Donkelaar A, Martin RV, Steenland K, Sarnat JA, Caudle WM, Ma T, Li H, Chang HH, Liu JZ, Wingo T, Mao X, Russell AG, Weber RJ and Liu P. Incident dementia and long-term exposure to constituents of fine particle air pollution:A national cohort study in the United States. Proc Natl Acad Sci U S A 2023; 120(1):e2211282119. |
R835872C003 (Final) |
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Feng Y, Wei Y, Coull BA and Schwartz JD. Measurement error correction for ambient PM(2.5) exposure using stratified regression calibration: Effects on all-cause mortality. Environ Res 2023; 216(Pt 4):114792. |
R835872C003 (Final) |
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Wang VA, Leung M, Li L, Modest AM, Schwartz J, Coull BA, Hacker MR, Wylie BJ, Koutrakis P and Papatheodorou S. Prenatal exposure to ambient particle radioactivity and fetal growth in Eastern Massachusetts. Air Quality, Atmosphere & Health 2023; 16:805-815. |
R835872C001 (Final) R835872C003 (Final) |
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Peralta AA, Gold DR, Yazdi MD, Wei Y and Schwartz J. The role of short-term air pollution and temperature on arterial stiffness in a longitudinal closed cohort of elderly individuals. Environ Res 2023; 216(Pt 2):114597. |
R835872C003 (Final) |
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Klompmaker JO, Hart JE, James P, Sabath MB, Wu X, Zanobetti A, Dominici F and Laden F. Air pollution and cardiovascular disease hospitalization-Are associations modified by greenness, temperature and humidity? Environ Int 2021; 156:106715. |
R835872C003 (Final) |
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Peralta AA, Schwartz J, Gold DR, Coull B, Koutrakis P. Associations between acute and long-term exposure to PM2.5 components and temperature with QT interval length in the VA Normative Aging Study. European Journal of Preventive Cardiology 2021. |
R835872C002 (Final) R835872C003 (Final) |
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Huang S, Koutrakis P, Grady ST, Vieira CLZ, Schwartz JD, Coull BA, Hart JE, Laden F, Zhang JJ and Garshick E. Effects of particulate matter gamma radiation on oxidative stress biomarkers in COPD patients. J Expo Sci Environ Epidemiol 2020. |
R835872C001 (Final) R835872C002 (Final) R835872C003 (Final) |
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Mukharesh L, Greco KF, Banzon T, Koutrakis P, Li L, Hauptman M, Phipatanakul W and Gaffin JM. Environmental radon and childhood asthma. 2022; 57(12):3165-3168. |
R835872C001 (Final) R835872C003 (Final) |
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Cowell WJ, Brunst KJ, Malin AJ, Coull BA, Gennings C, Kloog I, Lipton L, Wright RO, Enlow MB, Wright RJ. Prenatal exposure to PM2.5 and cardiac vagal tone during infancy:findings from a multiethnic birth cohort. Environmental Health Perspectives. 2019;127(10):107007. |
R835872C002 (Final) R835872C003 (Final) |
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Gao X, Koutrakis P, Blomberg AJ, Coull B, Vokonas P, Schwartz J, Baccarelli AA. Short-term ambient particle radioactivity level and renal function in older men:Insight from the Normative Aging Study. Environment International 2019;131:105018. |
R835872 (2019) R835872C001 (Final) R835872C003 (Final) |
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Chu MT, Ettinger de Cuba S, Fabian MP, Lane KJ, James-Todd T, Williams DR, Coull BA, Carnes F, Massaro M, Levy JI, Laden F, Sandel M, Adamkiewicz G and Zanobetti A. The immigrant birthweight paradox in an urban cohort:Role of immigrant enclaves and ambient air pollution. J Expo Sci Environ Epidemiol 2022. |
R835872C003 (Final) |
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Supplemental Keywords:
Air pollution, particle components, causal modeling, self controlled design, difference in differences, concentration-response function, low exposure, cardiovascular disease, respiratory disease, dementia, neurological disease, birthweight, arterial stiffness, measurement error, regression calibration, inflammation, asthma, radioactivity, solar activity, lung function, psychosis, mental health.Progress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R835872 Regional Air Pollution Mixtures Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R835872C001 Project 1: Regional Air Pollution Mixtures: The Past and Future Impacts of Emission Controls and Climate Change on Air Quality and Health
R835872C002 Project 2: Air Pollutant Mixtures in Eastern Massachusetts: Spatial Multi-resolution Analysis of Trends, Effects of Modifiable Factors, Climate and Particle-induced Mortality
R835872C003 Project 3: Causal Estimates of Effects of Regional and National Pollution Mixtures on Health: Providing Tools for Policy Makers
R835872C004 A Causal Inference Framework to Support Policy Decisions by Evaluating the Effectiveness of Past Air Pollution Control Strategies for the Entire United States
R835872C005 Project 5: Projecting and Quantifying Future Changes in Socioeconomic Drivers of Air Pollution and its Health-Related Impacts
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
155 publications for this subproject
155 journal articles for this subproject
Main Center: R835872
453 publications for this center
419 journal articles for this center
155 journal articles for this subproject
Main Center: R835872
453 publications for this center
419 journal articles for this center