Main Title |
Induction of Gastrointestinal Tract Nuclear Anomalies in B6C3F1 Mice by 3-Chloro-4-(Dichloromethyl)-5-Hydroxy-2(5H)-Furanone and 3,4-(Dichloro)-5-Hydroxy-2(5H)-Furanone, Mutagenic Byproducts of Chlorine Disinfection. |
Author |
Daniel, F. B. ;
Olson, G. R. ;
Stober, J. A. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Pathology Associates, Inc., Cincinnati, OH. |
Publisher |
c1991 |
Year Published |
1991 |
Report Number |
EPA/600/J-92/123; |
Stock Number |
PB92-164938 |
Additional Subjects |
Gastrointestinal system ;
Mutations ;
Chlorine ;
Disinfection ;
Cell nucleus ;
Bioassay ;
Carcinogens ;
Mutagens ;
Salmonella ;
Epichlorhydrin ;
Methylnitrosourea ;
Micronucleus tests ;
Reprints ;
Furanones
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB92-164938 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
Two chlorinated hydroxylated furanones, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) and 3,4-(dichloro)-5-hydroxy-2(5H)-furanone (MA), potent bacterial mutagens and by-products of chlorine disinfection, induce nuclear anomalies in the gastrointestinal tract of B6C3F1 mice. In this bioassay the two chlorohydroxyfuranones were approximately comparable to the epichlorohydrin (EPI), a known rodent gastrointestinal tract carcinogen but were much less potent than methylnitrosourea (MNU). The duodenum was the most sensitive tissue responding by both increased numbers of nuclear anomalies per mouse and increased incidence of animals presenting the aberrations 24 hours after a single oral dose of 0.38 and 0.46 mmol/kg of MX and MA respectively. The proximal colon responded to MX but not MA and neither compound produced increased nuclear anomalies in the forestomach. Although this is the first study demonstrating that chlorohydroxyfuranones are capable of inducing genotoxicity in vivo it is clear that their potency in the gastrointestinal tract nuclear anomalies assay is not comensurate with their extreme mutagenicity in Salmonella. |
Supplementary Notes |
Pub. in Environmental and Molecular Mutagenesis 17, n1 p32-39 Jan 91. See also PB92-164896. Prepared in cooperation with Pathology Associates, Inc., Cincinnati, OH. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Induction of Gastrointestinal Tract Nuclear Anomalies in B6C3F1 Mice by 3-Chloro-4-(Dichloromethyl)-5-Hydroxy-2(5H)-Furanone and 3,4-(Dichloro)-5-Hydroxy-2(5H)-Furanone, Mutagenic Byproducts of Chlorine Disinfection. |
Category Codes |
57Y; 57F |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
214321517 |
Origin |
NTIS |
Type |
CAT |